| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Berberine (chloride hydrate) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Berberine (chloride hydrate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.115654 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.107742 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0984378 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0962563 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0948694 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0818414 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.077038 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.073923 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0722547 |
| YBX1 | Y box binding protein 1 | 0.0719544 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0719195 |
| ZFP36 | ZFP36 ring finger protein | 0.0716391 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0715287 |
| INTS6 | integrator complex subunit 6 | 0.0691574 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0675902 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0618453 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0611654 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0595952 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0589109 |
| FMNL2 | formin-like 2 | 0.0581768 |
| PCBP2 | poly(rC) binding protein 2 | 0.0573103 |
| DST | dystonin | 0.0565897 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0561936 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0560177 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0558764 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0551846 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0538067 |
| FBL | fibrillarin | 0.0535052 |
| ZNF638 | zinc finger protein 638 | 0.0532555 |
| CTBP2 | C-terminal binding protein 2 | 0.0527552 |
| POTEF | POTE ankyrin domain family, member F | 0.0519103 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0516062 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.0513201 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0479595 |
| BRD2 | bromodomain containing 2 | 0.0472637 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0458105 |
| NAV2 | neuron navigator 2 | 0.0443005 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0438885 |
| SET | SET nuclear proto-oncogene | 0.0437015 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0421862 |
| TPM3 | tropomyosin 3 | 0.0421288 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0420096 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0415531 |
| ERBIN | erbb2 interacting protein | 0.0414384 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0411125 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0404976 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0399272 |
| PKM | pyruvate kinase, muscle | 0.0392844 |
| JMJD1C | jumonji domain containing 1C | 0.0389491 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0387251 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0384624 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0381715 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.038114 |
| PTK2 | protein tyrosine kinase 2 | 0.037655 |
| VEGFA | vascular endothelial growth factor A | 0.0374143 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0373672 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.037299 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.037027 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.036291 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0359604 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0354397 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0353821 |
| UBAP2 | ubiquitin associated protein 2 | 0.0351127 |
| SEPTIN9 | septin 9 | 0.0351057 |
| CA8 | carbonic anhydrase VIII | 0.0349972 |
| CCDC88A | coiled-coil domain containing 88A | 0.0347522 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0343162 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0342334 |
| UTRN | utrophin | 0.034058 |
| MORF4L2 | mortality factor 4 like 2 | 0.0339115 |
| MSN | moesin | 0.0338425 |
| AHNAK | AHNAK nucleoprotein | 0.0333979 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0333121 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.033289 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0328943 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0325971 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0322801 |
| LDHA | lactate dehydrogenase A | 0.0310512 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0308902 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0306728 |
| USP34 | ubiquitin specific peptidase 34 | 0.0306545 |
| ANO6 | anoctamin 6 | 0.0306429 |
| XPO1 | exportin 1 | 0.0302395 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.02952 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0293726 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0293556 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0292955 |
| ADM | adrenomedullin | 0.029104 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0289784 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0288283 |
| PTEN | phosphatase and tensin homolog | 0.0288104 |
| SPAG9 | sperm associated antigen 9 | 0.0287324 |
| GOLGA4 | golgin A4 | 0.0286089 |
| NOTCH2 | notch 2 | 0.0285674 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0284652 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0283502 |
| QKI | QKI, KH domain containing, RNA binding | 0.0283422 |
| GOLGB1 | golgin B1 | 0.0281032 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0280873 |
| NRDC | nardilysin convertase | 0.0279905 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.177715 |
| CD44 | CD44 molecule (Indian blood group) | -0.144734 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.143248 |
| TMSB10 | thymosin beta 10 | -0.119492 |
| ACTN4 | actinin, alpha 4 | -0.106495 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0918431 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0683196 |
| ACTG1 | actin gamma 1 | -0.0675478 |
| VCL | vinculin | -0.0600501 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0587313 |
| TMEM41B | transmembrane protein 41B | -0.0529368 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0526811 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0522949 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0519988 |
| KLF6 | Kruppel-like factor 6 | -0.0509708 |
| PTMA | prothymosin, alpha | -0.0478477 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0475054 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0461788 |
| FHL2 | four and a half LIM domains 2 | -0.0458298 |
| RPS24 | ribosomal protein S24 | -0.0446163 |
| RTN4 | reticulon 4 | -0.0433953 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0423336 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0417057 |
| MT2A | metallothionein 2A | -0.0416131 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0413449 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0406109 |
| PSMC4 | proteasome (prosome, macropain) 26S subunit, ATPase, 4 | -0.0396507 |
| EGR1 | early growth response 1 | -0.0388488 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0369376 |
| CARD18 | caspase recruitment domain family, member 18 | -0.0368116 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0364475 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | -0.0354499 |
| OSMR | oncostatin M receptor | -0.0343883 |
| RPS16 | ribosomal protein S16 | -0.0329135 |
| RPL35A | ribosomal protein L35a | -0.0306155 |
| ANGPTL4 | angiopoietin-like 4 | -0.0304762 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0300178 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0296982 |
| RPS21 | ribosomal protein S21 | -0.0294293 |
| ITGB5 | integrin, beta 5 | -0.0294189 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0293271 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0291243 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | -0.0287375 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0268669 |
| CDCP1 | CUB domain containing protein 1 | -0.0267235 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0261884 |
| TMEM123 | transmembrane protein 123 | -0.0260303 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0255166 |
| KLHL5 | kelch-like family member 5 | -0.0254513 |
| TUBB | tubulin, beta class I | -0.025313 |
| IL6ST | interleukin 6 signal transducer | -0.0251779 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.025126 |
| ANXA2 | annexin A2 | -0.0242132 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0241214 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0233077 |
| CTSD | cathepsin D | -0.0230624 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0230561 |
| FAM3C | family with sequence similarity 3, member C | -0.0229786 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.0228443 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0225999 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0225881 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0225335 |
| RPL36A | ribosomal protein L36a | -0.0223123 |
| RPLP2 | ribosomal protein, large, P2 | -0.0221944 |
| EGFR | epidermal growth factor receptor | -0.0219104 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | -0.0218891 |
| TIMM50 | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) | -0.0218469 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0216722 |
| IER3 | immediate early response 3 | -0.0215072 |
| RPL38 | ribosomal protein L38 | -0.0214059 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0214053 |
| MYL12B | myosin, light chain 12B, regulatory | -0.021297 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0210666 |
| ODF2L | outer dense fiber of sperm tails 2-like | -0.0210632 |
| RPS13 | ribosomal protein S13 | -0.0210528 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0209231 |
| BCL2L1 | BCL2-like 1 | -0.0207922 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0206725 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0206399 |
| PYGB | phosphorylase, glycogen; brain | -0.0206133 |
| PLAC8 | placenta-specific 8 | -0.0203746 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.020221 |
| RPL12 | ribosomal protein L12 | -0.0202073 |
| ATG7 | autophagy related 7 | -0.020195 |
| CAVIN1 | caveolae associated protein 1 | -0.0201693 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0199648 |
| ZNF217 | zinc finger protein 217 | -0.0199147 |
| CTPS1 | CTP synthase 1 | -0.0198595 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0194151 |
| AFAP1 | actin filament associated protein 1 | -0.0193895 |
| SYTL2 | synaptotagmin-like 2 | -0.0193702 |
| HLA-B | major histocompatibility complex, class I, B | -0.0193683 |
| DDX50 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 | -0.019365 |
| TSG101 | tumor susceptibility 101 | -0.01917 |
| PRSS23 | protease, serine, 23 | -0.0190596 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0189456 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0185582 |
| CLTA | clathrin, light chain A | -0.0185539 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0182619 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.0182363 |
