| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Berberine (chloride hydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Berberine (chloride hydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.117383 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.104783 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0986895 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0877638 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0800898 |
| VIM | vimentin | 0.0772637 |
| MMP12 | matrix metallopeptidase 12 | 0.0753158 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0719366 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0709773 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0699455 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0690555 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.066919 |
| FAM20C | family with sequence similarity 20, member C | 0.0669025 |
| UBC | ubiquitin C | 0.0548884 |
| EML5 | echinoderm microtubule associated protein like 5 | 0.0520984 |
| AHNAK | AHNAK nucleoprotein | 0.0518573 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0498994 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0482743 |
| FHIT | fragile histidine triad | 0.0449587 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0439056 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0399138 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0388444 |
| HLA-E | major histocompatibility complex, class I, E | 0.0384214 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0368664 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0365467 |
| JUN | jun proto-oncogene | 0.0363657 |
| HDAC9 | histone deacetylase 9 | 0.0357936 |
| TMEM178B | transmembrane protein 178B | 0.0347588 |
| CADM1 | cell adhesion molecule 1 | 0.0346195 |
| ATM | ATM serine/threonine kinase | 0.034332 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0341827 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.033937 |
| CDH13 | cadherin 13 | 0.0339076 |
| LDHA | lactate dehydrogenase A | 0.0311627 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0308145 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0301031 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0294849 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0292457 |
| RND3 | Rho family GTPase 3 | 0.0291264 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.029088 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0290338 |
| FNIP1 | folliculin interacting protein 1 | 0.0289883 |
| MYO9A | myosin IXA | 0.0288449 |
| FBXO32 | F-box protein 32 | 0.0287759 |
| HMGA2 | high mobility group AT-hook 2 | 0.0286743 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0280565 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0280362 |
| AGBL1 | ATP/GTP binding protein-like 1 | 0.0266367 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0266225 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.025837 |
| CD109 | CD109 molecule | 0.025596 |
| IFI44L | interferon-induced protein 44-like | 0.0254907 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0254393 |
| SMYD3 | SET and MYND domain containing 3 | 0.0253936 |
| LYST | lysosomal trafficking regulator | 0.0252693 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0250912 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0247486 |
| EGFR | epidermal growth factor receptor | 0.0246531 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0239823 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0237883 |
| MYO1E | myosin IE | 0.0234618 |
| COL7A1 | collagen, type VII, alpha 1 | 0.023363 |
| PDE10A | phosphodiesterase 10A | 0.0233475 |
| SQSTM1 | sequestosome 1 | 0.0229043 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0224301 |
| LPCAT2 | lysophosphatidylcholine acyltransferase 2 | 0.0224129 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0220896 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0216955 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0216865 |
| AFF3 | AF4/FMR2 family, member 3 | 0.021408 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.021326 |
| CANX | calnexin | 0.0211994 |
| DENND1A | DENN/MADD domain containing 1A | 0.0208471 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0205329 |
| PCBP3 | poly(rC) binding protein 3 | 0.0204499 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0204055 |
| FBN1 | fibrillin 1 | 0.0202147 |
| TWIST2 | twist family bHLH transcription factor 2 | 0.020194 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0200521 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0198556 |
| RAI14 | retinoic acid induced 14 | 0.0197784 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.0195484 |
| EPAS1 | endothelial PAS domain protein 1 | 0.019266 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0192425 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0192352 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0192073 |
| CALR | calreticulin | 0.0190824 |
| HM13 | histocompatibility (minor) 13 | 0.0189819 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0189487 |
| KIAA1217 | KIAA1217 | 0.0188566 |
| MTSS1 | metastasis suppressor 1 | 0.0188025 |
| PDE8A | phosphodiesterase 8A | 0.0186051 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0185529 |
| VMP1 | vacuole membrane protein 1 | 0.018476 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0184652 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.018446 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0184013 |
| ARRDC3 | arrestin domain containing 3 | 0.0179343 |
| STK10 | serine/threonine kinase 10 | 0.0178986 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0178764 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.236148 |
| NDRG1 | N-myc downstream regulated 1 | -0.203149 |
| MT2A | metallothionein 2A | -0.198895 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.130585 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125643 |
| COL1A1 | collagen, type I, alpha 1 | -0.0865027 |
| ZNF292 | zinc finger protein 292 | -0.08084 |
| GOLGA4 | golgin A4 | -0.0786626 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0765761 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0753649 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0741539 |
| TMSB10 | thymosin beta 10 | -0.0710458 |
| HLA-B | major histocompatibility complex, class I, B | -0.0690852 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.065161 |
| CD44 | CD44 molecule (Indian blood group) | -0.0646451 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0641102 |
| ANGPTL4 | angiopoietin-like 4 | -0.0594753 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0588956 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0568107 |
| COL6A2 | collagen, type VI, alpha 2 | -0.056544 |
| SETD5 | SET domain containing 5 | -0.0539196 |
| RBM39 | RNA binding motif protein 39 | -0.0521963 |
| CENPF | centromere protein F, 350/400kDa | -0.0518865 |
| ANLN | anillin, actin binding protein | -0.0504301 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0486261 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0484973 |
| MSN | moesin | -0.0479705 |
| FRMD4A | FERM domain containing 4A | -0.0470542 |
| COL1A2 | collagen, type I, alpha 2 | -0.0467098 |
| PTMA | prothymosin, alpha | -0.0435592 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0429299 |
| PGK1 | phosphoglycerate kinase 1 | -0.0429059 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0423243 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0412112 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0400066 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0389894 |
| XPO1 | exportin 1 | -0.038878 |
| RPS2 | ribosomal protein S2 | -0.0387014 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0385641 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0373627 |
| TGM2 | transglutaminase 2 | -0.0372119 |
| GLIS3 | GLIS family zinc finger 3 | -0.0369148 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0360271 |
| CALD1 | caldesmon 1 | -0.035799 |
| TFG | TRK-fused gene | -0.0355449 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0339417 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0338633 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0337306 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0335563 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0333048 |
| DIAPH3 | diaphanous-related formin 3 | -0.0332318 |
| SEC24D | SEC24 family member D | -0.0325683 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0324101 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.032409 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0321746 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0320028 |
| MKI67 | marker of proliferation Ki-67 | -0.0319993 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.031811 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0317799 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0315273 |
| GLG1 | golgi glycoprotein 1 | -0.0314601 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0314328 |
| CLTC | clathrin, heavy chain (Hc) | -0.0312448 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0309672 |
| SPAG9 | sperm associated antigen 9 | -0.030393 |
| DSTN | destrin (actin depolymerizing factor) | -0.0303846 |
| CDC73 | cell division cycle 73 | -0.0300157 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0299181 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0298482 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0298352 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0297515 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0297111 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0294824 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0294687 |
| RPS19 | ribosomal protein S19 | -0.0294256 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0291857 |
| RPL35A | ribosomal protein L35a | -0.0291218 |
| COL5A3 | collagen, type V, alpha 3 | -0.0291077 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0289765 |
| RPS6 | ribosomal protein S6 | -0.0288414 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0288389 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0287826 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0286264 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0285857 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0285497 |
| RNF24 | ring finger protein 24 | -0.0280927 |
| CTSB | cathepsin B | -0.0279613 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0278974 |
| NCKAP1 | NCK-associated protein 1 | -0.0278924 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.027801 |
| CENPE | centromere protein E, 312kDa | -0.0275928 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0275423 |
| SEPTIN7 | septin 7 | -0.0272673 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0271154 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0270982 |
| IL1B | interleukin 1, beta | -0.0270195 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0269241 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0269076 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0269023 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0268239 |
