Berberine (chloride hydrate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TENM1 teneurin transmembrane protein 1 0.0727301
SASH1 SAM and SH3 domain containing 1 0.0619466
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0580333
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0511078
CNKSR3 CNKSR family member 3 0.0475679
GRIK1 glutamate receptor, ionotropic, kainate 1 0.0475485
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0461435
SNTG1 syntrophin, gamma 1 0.0449162
FHIT fragile histidine triad 0.039093
RIMS2 regulating synaptic membrane exocytosis 2 0.0373001
PCDH9 protocadherin 9 0.0363564
TXNRD1 thioredoxin reductase 1 0.0353071
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0341464
PEG10 paternally expressed 10 0.0341017
DNAH5 dynein, axonemal, heavy chain 5 0.0340624
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0333729
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0330625
NCKAP5 NCK-associated protein 5 0.032181
H1-0 H1.0 linker histone 0.0318763
NAMPT nicotinamide phosphoribosyltransferase 0.030097
RIT2 Ras-like without CAAX 2 0.0284923
TRIO trio Rho guanine nucleotide exchange factor 0.028444
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0284279
TCF12 transcription factor 12 0.0275291
AGMO alkylglycerol monooxygenase 0.0266988
HDAC9 histone deacetylase 9 0.0260499
JAZF1 JAZF zinc finger 1 0.0252594
ELL2 elongation factor, RNA polymerase II, 2 0.0251584
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0251297
ADGRL2 adhesion G protein-coupled receptor L2 0.0249138
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0247236
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0243283
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0242259
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0237902
SINHCAF SIN3-HDAC complex associated factor 0.0237269
SLC35F4 solute carrier family 35, member F4 0.0236357
SCARB2 scavenger receptor class B, member 2 0.0234889
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0232017
RAD51B RAD51 paralog B 0.0228469
LSAMP limbic system-associated membrane protein 0.0225234
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0224108
CA8 carbonic anhydrase VIII 0.0223839
TUBB tubulin, beta class I 0.0221635
ERRFI1 ERBB receptor feedback inhibitor 1 0.0217231
NPAS3 neuronal PAS domain protein 3 0.0215083
DST dystonin 0.0212432
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0210059
TOX thymocyte selection-associated high mobility group box 0.0208592
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 0.0203526
ZNF804A zinc finger protein 804A 0.0202056
KLF7 Kruppel-like factor 7 (ubiquitous) 0.019841
EFNA5 ephrin-A5 0.0198173
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0195779
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0194659
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0193284
IGF1R insulin-like growth factor 1 receptor 0.0192578
NOVA1 neuro-oncological ventral antigen 1 0.0190818
TPM4 tropomyosin 4 0.0190002
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0189959
PDE4B phosphodiesterase 4B, cAMP-specific 0.0185227
FAT1 FAT atypical cadherin 1 0.018423
SOD2 superoxide dismutase 2, mitochondrial 0.018368
PCBP3 poly(rC) binding protein 3 0.0179028
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0178878
AOPEP aminopeptidase O (putative) 0.0178422
GLCCI1 glucocorticoid induced 1 0.0176735
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0176056
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0175598
TPK1 thiamin pyrophosphokinase 1 0.0173189
KIAA0825 KIAA0825 0.0171137
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0170169
TRAPPC9 trafficking protein particle complex 9 0.0169691
CANX calnexin 0.0169541
PRC1 protein regulator of cytokinesis 1 0.0168906
RAD21 RAD21 homolog (S. pombe) 0.0167313
THSD7A thrombospondin, type I, domain containing 7A 0.0166175
ETV6 ets variant 6 0.0165677
MIPOL1 mirror-image polydactyly 1 0.0165165
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0164576
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0164493
SAMD3 sterile alpha motif domain containing 3 0.0163743
RNF213 ring finger protein 213 0.0162584
GPC5 glypican 5 0.0160815
TOX3 TOX high mobility group box family member 3 0.0160811
TBC1D5 TBC1 domain family, member 5 0.0157856
SLC44A5 solute carrier family 44, member 5 0.0157368
DACH1 dachshund family transcription factor 1 0.0156554
NCOA7 nuclear receptor coactivator 7 0.0156044
TMEM178B transmembrane protein 178B 0.0154488
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0154073
FBXL17 F-box and leucine-rich repeat protein 17 0.0153382
INHBA inhibin, beta A 0.0152151
CHD7 chromodomain helicase DNA binding protein 7 0.0151996
RLIM ring finger protein, LIM domain interacting 0.0151159
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0151123
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0150687
ARF1 ADP-ribosylation factor 1 0.0150307
FOXP2 forkhead box P2 0.0149839
DISC1 disrupted in schizophrenia 1 0.0149798
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.0149504

decreased expression

Symbol Name Standardized Value
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.135131
NDRG1 N-myc downstream regulated 1 -0.130761
CALCA calcitonin-related polypeptide alpha -0.115874
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.108273
STC1 stanniocalcin 1 -0.0854574
RPS6 ribosomal protein S6 -0.0695863
RPS21 ribosomal protein S21 -0.0671014
PDE10A phosphodiesterase 10A -0.0630404
RPL37A ribosomal protein L37a -0.0609379
MT2A metallothionein 2A -0.0603332
RPS8 ribosomal protein S8 -0.0573013
KTN1 kinectin 1 (kinesin receptor) -0.0547615
RPS3 ribosomal protein S3 -0.0541716
MATR3 matrin 3 -0.0526807
RPS12 ribosomal protein S12 -0.0525619
RPL26 ribosomal protein L26 -0.0524716
PTMA prothymosin, alpha -0.0518518
GPC6 glypican 6 -0.0474516
ACTG1 actin gamma 1 -0.0459976
NALF1 NALCN channel auxiliary factor 1 -0.0454333
RPS19 ribosomal protein S19 -0.0449963
NAP1L1 nucleosome assembly protein 1-like 1 -0.043964
TENT5A terminal nucleotidyltransferase 5A -0.0434579
RPS2 ribosomal protein S2 -0.0428994
RPL37 ribosomal protein L37 -0.0428775
CPE carboxypeptidase E -0.0418713
PRRC2C proline-rich coiled-coil 2C -0.0415307
PNN pinin, desmosome associated protein -0.0411367
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0399106
RPS17 ribosomal protein S17 -0.0397662
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0395948
RPL11 ribosomal protein L11 -0.0385127
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0382519
ATP5F1B ATP synthase F1 subunit beta -0.0381185
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0373639
RPL8 ribosomal protein L8 -0.0372753
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0371787
PFN1 profilin 1 -0.0368683
IFI6 interferon, alpha-inducible protein 6 -0.0363542
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0362898
VEGFA vascular endothelial growth factor A -0.0362104
RPS25 ribosomal protein S25 -0.0360442
SMOC1 SPARC related modular calcium binding 1 -0.0357036
S100A9 S100 calcium binding protein A9 -0.0351134
CENPF centromere protein F, 350/400kDa -0.0346217
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.033975
ENO1 enolase 1, (alpha) -0.0337637
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0333358
ADAR adenosine deaminase, RNA-specific -0.0329768
ATP5F1E ATP synthase F1 subunit epsilon -0.0328179
ISG15 ISG15 ubiquitin-like modifier -0.0327696
SET SET nuclear proto-oncogene -0.0324147
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0322264
RPL7 ribosomal protein L7 -0.0320652
RORA RAR-related orphan receptor A -0.0318665
RACK1 receptor for activated C kinase 1 -0.031361
PAEP progestagen-associated endometrial protein -0.0313139
CHD1L chromodomain helicase DNA binding protein 1-like -0.0309106
PNISR PNN-interacting serine/arginine-rich protein -0.0308482
SNAP25 synaptosomal-associated protein, 25kDa -0.0306032
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0304021
EIF5B eukaryotic translation initiation factor 5B -0.0303595
RPLP1 ribosomal protein, large, P1 -0.0301399
TCERG1 transcription elongation regulator 1 -0.0298106
MCL1 myeloid cell leukemia 1 -0.0293759
LOC112694756 uncharaterized LOC112694756 -0.0288374
SCFD1 sec1 family domain containing 1 -0.0286245
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0286171
HM13 histocompatibility (minor) 13 -0.0283519
SIK3 SIK family kinase 3 -0.028226
BCLAF1 BCL2-associated transcription factor 1 -0.0280851
RPL38 ribosomal protein L38 -0.0280651
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0277241
NANOS1 nanos homolog 1 (Drosophila) -0.027718
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0276598
TMSB10 thymosin beta 10 -0.0275881
RPS23 ribosomal protein S23 -0.0273983
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0271323
TPT1 tumor protein, translationally-controlled 1 -0.0268352
DSTN destrin (actin depolymerizing factor) -0.0262565
SRSF4 serine/arginine-rich splicing factor 4 -0.0260472
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0259954
PCM1 pericentriolar material 1 -0.0259926
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0258018
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0255034
RPL21 ribosomal protein L21 -0.0253488
ST18 suppression of tumorigenicity 18, zinc finger -0.0253223
RPS29 ribosomal protein S29 -0.0252933
MCTP1 multiple C2 domains, transmembrane 1 -0.0251968
COX6C cytochrome c oxidase subunit VIc -0.0248186
SRSF11 serine/arginine-rich splicing factor 11 -0.0246302
XPO1 exportin 1 -0.0246082
GRAMD4 GRAM domain containing 4 -0.0245378
TRA2B transformer 2 beta homolog (Drosophila) -0.0243078
PABPN1 poly(A) binding protein, nuclear 1 -0.024303
RPS15 ribosomal protein S15 -0.0242369
RPL36AL ribosomal protein L36a-like -0.0240515
ESRRG estrogen-related receptor gamma -0.0239295
CALR calreticulin -0.0239274
PPME1 protein phosphatase methylesterase 1 -0.0238862