Berberine (chloride hydrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.118414
FN1 fibronectin 1 0.0799419
IGFBP3 insulin-like growth factor binding protein 3 0.073178
INPP5F inositol polyphosphate-5-phosphatase F 0.066587
FNDC3B fibronectin type III domain containing 3B 0.0581245
POTEF POTE ankyrin domain family, member F 0.0440683
DST dystonin 0.0439954
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0435147
JMJD1C jumonji domain containing 1C 0.0426398
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0393708
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0373148
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.037229
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0323538
KMT2E lysine (K)-specific methyltransferase 2E 0.0309671
SPAG9 sperm associated antigen 9 0.0288388
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0254506
KPNB1 karyopherin (importin) beta 1 0.0253928
LEF1 lymphoid enhancer-binding factor 1 0.023085
TENM1 teneurin transmembrane protein 1 0.0226063
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0223768
CD109 CD109 molecule 0.0220903
EGR1 early growth response 1 0.0215586
VEGFA vascular endothelial growth factor A 0.0208468
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0207686
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0206205
RPS6 ribosomal protein S6 0.0206152
GOLGB1 golgin B1 0.0202984
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.020264
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0202098
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.02018
PHF21A PHD finger protein 21A 0.0201099
ZNF292 zinc finger protein 292 0.0198706
UBE2H ubiquitin-conjugating enzyme E2H 0.0189348
MAML2 mastermind-like 2 (Drosophila) 0.0188843
KTN1 kinectin 1 (kinesin receptor) 0.0187442
APOLD1 apolipoprotein L domain containing 1 0.0185053
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0184684
SKAP2 src kinase associated phosphoprotein 2 0.0183645
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0183446
IL1RAP interleukin 1 receptor accessory protein 0.0175742
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0174314
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0173189
CSNK1E casein kinase 1, epsilon 0.0171747
KMT2C lysine (K)-specific methyltransferase 2C 0.0170281
OSBPL10 oxysterol binding protein-like 10 0.016724
SEPTIN7 septin 7 0.0166799
BACE2 beta-site APP-cleaving enzyme 2 0.0166687
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.0162738
QKI QKI, KH domain containing, RNA binding 0.0162607
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0162489
TPM4 tropomyosin 4 0.0162385
RBM39 RNA binding motif protein 39 0.0161855
IGBP1 immunoglobulin (CD79A) binding protein 1 0.0159705
MATR3 matrin 3 0.015967
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0159167
CCNL1 cyclin L1 0.0158635
CSNK1G3 casein kinase 1, gamma 3 0.0157611
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0157109
HDAC9 histone deacetylase 9 0.0155978
EGLN1 egl-9 family hypoxia-inducible factor 1 0.015507
CEP350 centrosomal protein 350kDa 0.0154966
LRRC58 leucine rich repeat containing 58 0.0154774
SOX6 SRY (sex determining region Y)-box 6 0.0154434
TRAF1 TNF receptor-associated factor 1 0.0152233
ZC3H6 zinc finger CCCH-type containing 6 0.015129
DYNLT3 dynein, light chain, Tctex-type 3 0.0149205
NOP58 NOP58 ribonucleoprotein 0.0147538
BPTF bromodomain PHD finger transcription factor 0.0146819
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0146529
MACROD2 MACRO domain containing 2 0.0145185
INSIG2 insulin induced gene 2 0.0144417
GOLM2 golgi membrane protein 2 0.01438
TRIM56 tripartite motif containing 56 0.0140587
NT5E 5'-nucleotidase, ecto (CD73) 0.0140055
FMNL2 formin-like 2 0.0136997
RAB2A RAB2A, member RAS oncogene family 0.013686
ARHGAP5 Rho GTPase activating protein 5 0.0136162
DSTN destrin (actin depolymerizing factor) 0.0135624
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0134959
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 0.0133413
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0133131
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0132993
NRDC nardilysin convertase 0.0132814
EYA1 EYA transcriptional coactivator and phosphatase 1 0.013261
LIMS1 LIM and senescent cell antigen-like domains 1 0.0132367
PTBP3 polypyrimidine tract binding protein 3 0.0131098
PRKCSH protein kinase C substrate 80K-H 0.0131085
TRIM2 tripartite motif containing 2 0.0129944
HPS5 Hermansky-Pudlak syndrome 5 0.0129138
NSUN6 NOP2/Sun domain family, member 6 0.0127213
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0127071
KCTD3 potassium channel tetramerization domain containing 3 0.0126645
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.012593
PLCB4 phospholipase C, beta 4 0.012568
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0124811
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0124801
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.0124106
NRP2 neuropilin 2 0.0123857
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0123842
FNIP1 folliculin interacting protein 1 0.0123116

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.250046
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.141377
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132723
UBC ubiquitin C -0.125109
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115075
TMSB10 thymosin beta 10 -0.11131
FRMD4A FERM domain containing 4A -0.0687677
RPL23 ribosomal protein L23 -0.0685965
RPS27A ribosomal protein S27a -0.0659236
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0647443
FLNA filamin A, alpha -0.0632464
EEF2 eukaryotic translation elongation factor 2 -0.0616321
FMN1 formin 1 -0.0615707
TM4SF1 transmembrane 4 L six family member 1 -0.0606735
RPS3 ribosomal protein S3 -0.0584498
MT2A metallothionein 2A -0.0560341
PTMA prothymosin, alpha -0.053614
CD44 CD44 molecule (Indian blood group) -0.0505207
RASAL2 RAS protein activator like 2 -0.0477203
SLC39A11 solute carrier family 39, member 11 -0.0453479
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0437798
ACTG1 actin gamma 1 -0.0434724
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0430855
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0429793
CTTN cortactin -0.0403879
LSAMP limbic system-associated membrane protein -0.0400845
PTPRM protein tyrosine phosphatase, receptor type, M -0.0369516
RPL32 ribosomal protein L32 -0.0368155
FLNB filamin B, beta -0.0367948
LOC112694756 uncharaterized LOC112694756 -0.0360635
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0360073
PCBP2 poly(rC) binding protein 2 -0.035227
ICAM1 intercellular adhesion molecule 1 -0.0350105
PRELID2 PRELI domain containing 2 -0.0348008
NLGN1 neuroligin 1 -0.0335572
ENO1 enolase 1, (alpha) -0.0329211
ACTN4 actinin, alpha 4 -0.0325141
MYH9 myosin, heavy chain 9, non-muscle -0.0318019
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0312478
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0309229
FUS FUS RNA binding protein -0.0306325
EMP1 epithelial membrane protein 1 -0.0302779
ZFAND3 zinc finger, AN1-type domain 3 -0.0300221
PMEL premelanosome protein -0.0292842
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0288126
MSI2 musashi RNA-binding protein 2 -0.0283942
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0283889
RPS21 ribosomal protein S21 -0.0281032
RHOA ras homolog family member A -0.0280715
CCND1 cyclin D1 -0.0279055
RPS24 ribosomal protein S24 -0.0277974
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0276013
RPLP2 ribosomal protein, large, P2 -0.0273363
TXNRD1 thioredoxin reductase 1 -0.0265006
RPL12 ribosomal protein L12 -0.0257701
EXOC6B exocyst complex component 6B -0.0254789
LAMP2 lysosomal-associated membrane protein 2 -0.0249954
PEX5L peroxisomal biogenesis factor 5-like -0.0246916
NAV2 neuron navigator 2 -0.0245682
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0236598
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0236149
ANKRD28 ankyrin repeat domain 28 -0.0232845
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0232246
RNF213 ring finger protein 213 -0.0228014
BBX bobby sox homolog (Drosophila) -0.0227148
EXT1 exostosin glycosyltransferase 1 -0.0226793
PTPRG protein tyrosine phosphatase, receptor type, G -0.0225949
NAP1L1 nucleosome assembly protein 1-like 1 -0.0225572
HMGA2 high mobility group AT-hook 2 -0.0225186
RUNX1 runt-related transcription factor 1 -0.0224971
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0217578
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0217241
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0216714
COMMD10 COMM domain containing 10 -0.0216262
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0215372
RACK1 receptor for activated C kinase 1 -0.0214685
IFI6 interferon, alpha-inducible protein 6 -0.0212925
RPS13 ribosomal protein S13 -0.0212113
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0211545
SMC4 structural maintenance of chromosomes 4 -0.0211066
DOCK3 dedicator of cytokinesis 3 -0.0210708
ACTN1 actinin, alpha 1 -0.0210626
RPL34 ribosomal protein L34 -0.0210332
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0210102
RAD51B RAD51 paralog B -0.020986
RPL36A ribosomal protein L36a -0.0209429
LMNA lamin A/C -0.0208974
SRSF1 serine/arginine-rich splicing factor 1 -0.0208148
ELL2 elongation factor, RNA polymerase II, 2 -0.0207704
INTS6 integrator complex subunit 6 -0.0205753
DIAPH2 diaphanous-related formin 2 -0.0205514
POU2F1 POU class 2 homeobox 1 -0.0204178
RPS19 ribosomal protein S19 -0.0203448
PDE4D phosphodiesterase 4D, cAMP-specific -0.0203067
CALR calreticulin -0.0200974
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0200747
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0200218
ATG7 autophagy related 7 -0.0198295
AHNAK AHNAK nucleoprotein -0.0196268
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0196042