Berberine (chloride hydrate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0921038
MAML2 mastermind-like 2 (Drosophila) 0.0867022
NEBL nebulette 0.0741349
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0693671
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0648492
SDK1 sidekick cell adhesion molecule 1 0.0624653
CEMIP cell migration inducing protein, hyaluronan binding 0.0608403
FAT1 FAT atypical cadherin 1 0.0571653
EHBP1 EH domain binding protein 1 0.0571093
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.05532
ZBTB20 zinc finger and BTB domain containing 20 0.0523962
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0513497
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0508326
VCL vinculin 0.0507831
FNDC3B fibronectin type III domain containing 3B 0.0484566
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0465839
INTS6 integrator complex subunit 6 0.0443035
PTPRK protein tyrosine phosphatase, receptor type, K 0.0440043
NCEH1 neutral cholesterol ester hydrolase 1 0.0430205
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0429663
GMDS GDP-mannose 4,6-dehydratase 0.0417899
ZSWIM6 zinc finger, SWIM-type containing 6 0.0417794
SMAD3 SMAD family member 3 0.041584
MYO1E myosin IE 0.0398272
SAMD4A sterile alpha motif domain containing 4A 0.0388354
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0384394
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0370787
CTBP2 C-terminal binding protein 2 0.0365448
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0361454
NKD1 naked cuticle homolog 1 (Drosophila) 0.035661
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0356293
EXOC4 exocyst complex component 4 0.0352685
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0351026
CADPS Ca++-dependent secretion activator 0.0344572
RAD51B RAD51 paralog B 0.0339179
OSBPL10 oxysterol binding protein-like 10 0.0338089
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0338032
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0332275
IFRD1 interferon-related developmental regulator 1 0.0316015
PRELID2 PRELI domain containing 2 0.0299928
LPP LIM domain containing preferred translocation partner in lipoma 0.0298985
CDK13 cyclin-dependent kinase 13 0.0296194
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0293695
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0293445
EGFR epidermal growth factor receptor 0.0288962
ETV6 ets variant 6 0.0287353
HDAC4 histone deacetylase 4 0.028191
DOCK4 dedicator of cytokinesis 4 0.0276705
PDLIM5 PDZ and LIM domain 5 0.0276467
RUNX1 runt-related transcription factor 1 0.0274022
ZBTB38 zinc finger and BTB domain containing 38 0.0271442
NFIA nuclear factor I/A 0.0271291
NABP1 nucleic acid binding protein 1 0.0270868
DLG1 discs, large homolog 1 (Drosophila) 0.0269934
PARD3B par-3 family cell polarity regulator beta 0.0269318
NAV2 neuron navigator 2 0.0268138
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.025205
PICALM phosphatidylinositol binding clathrin assembly protein 0.0249405
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0246784
RCOR1 REST corepressor 1 0.0244354
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0241674
CEMIP2 cell migration inducing hyaluronidase 2 0.0241132
MALT1 MALT1 paracaspase 0.0239867
SMAD2 SMAD family member 2 0.023851
SETX senataxin 0.0238151
ZNF638 zinc finger protein 638 0.0236631
PKP4 plakophilin 4 0.0236611
UBASH3B ubiquitin associated and SH3 domain containing B 0.0234994
AHNAK AHNAK nucleoprotein 0.0234485
PCLO piccolo presynaptic cytomatrix protein 0.0229349
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0227756
ATXN1 ataxin 1 0.0226598
MSI2 musashi RNA-binding protein 2 0.0222324
CPNE1 copine I 0.0221847
TBC1D5 TBC1 domain family, member 5 0.0220804
ADAM19 ADAM metallopeptidase domain 19 0.021957
OXSR1 oxidative stress responsive 1 0.0219308
TJP1 tight junction protein 1 0.0218088
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0217838
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0217779
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0217464
ZHX2 zinc fingers and homeoboxes 2 0.0214597
VMP1 vacuole membrane protein 1 0.0214113
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0213252
BCL2L1 BCL2-like 1 0.0213004
APLP2 amyloid beta (A4) precursor-like protein 2 0.0212359
TAS2R14 taste receptor, type 2, member 14 0.0211842
NHSL1 NHS-like 1 0.0211594
UBAP2 ubiquitin associated protein 2 0.0211022
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0210458
ARHGAP32 Rho GTPase activating protein 32 0.0209305
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0207757
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0207249
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0207243
SHB Src homology 2 domain containing adaptor protein B 0.0206898
YAP1 Yes-associated protein 1 0.0206673
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0205334
USP34 ubiquitin specific peptidase 34 0.0204958
PATJ PATJ crumbs cell polarity complex component 0.0204751
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0204038

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.27328
FTL ferritin, light polypeptide -0.237559
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.149301
TMSB10 thymosin beta 10 -0.13293
RPS6 ribosomal protein S6 -0.0931238
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0907097
RPL12 ribosomal protein L12 -0.083997
B2M beta-2-microglobulin -0.0781113
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0762
RPS3 ribosomal protein S3 -0.0741764
GOLGA4 golgin A4 -0.0725782
EIF1 eukaryotic translation initiation factor 1 -0.0725365
RPLP1 ribosomal protein, large, P1 -0.0686904
RPL35A ribosomal protein L35a -0.0674281
TPT1 tumor protein, translationally-controlled 1 -0.0669201
RPL23 ribosomal protein L23 -0.0666831
RPS13 ribosomal protein S13 -0.0658564
RPS12 ribosomal protein S12 -0.0642825
EPCAM epithelial cell adhesion molecule -0.0642192
UBC ubiquitin C -0.0620897
LOC102724023 ES1 protein homolog, mitochondrial -0.0611785
RPLP2 ribosomal protein, large, P2 -0.0610671
RPS21 ribosomal protein S21 -0.0608154
KRT18 keratin 18, type I -0.0594884
RPL37A ribosomal protein L37a -0.0579969
RPS19 ribosomal protein S19 -0.0575081
CST3 cystatin C -0.0561655
RPS27A ribosomal protein S27a -0.0532277
RPL18 ribosomal protein L18 -0.0520967
RPL28 ribosomal protein L28 -0.0519383
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0507858
RPL32 ribosomal protein L32 -0.050443
GSTP1 glutathione S-transferase pi 1 -0.0492049
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.049065
RPL19 ribosomal protein L19 -0.0488291
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0470413
S100A6 S100 calcium binding protein A6 -0.0466857
RPS25 ribosomal protein S25 -0.0457588
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0455283
RPS8 ribosomal protein S8 -0.0448196
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0447832
RPL8 ribosomal protein L8 -0.0447793
RPS5 ribosomal protein S5 -0.0444448
MATR3 matrin 3 -0.0438202
KRT8 keratin 8, type II -0.0436109
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0435676
S100A10 S100 calcium binding protein A10 -0.0432437
RPL26 ribosomal protein L26 -0.0432027
RPS11 ribosomal protein S11 -0.0421234
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0420731
ACTG1 actin gamma 1 -0.0414601
RPL31 ribosomal protein L31 -0.041233
RPS2 ribosomal protein S2 -0.0406436
TMSB4X thymosin beta 4, X-linked -0.0405982
NAMPT nicotinamide phosphoribosyltransferase -0.0398196
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0396252
H3-3B H3.3 histone B -0.0388777
RPL36 ribosomal protein L36 -0.0380447
ZNF292 zinc finger protein 292 -0.0375936
RPL37 ribosomal protein L37 -0.0366558
H1-0 H1.0 linker histone -0.0365285
LOC112694756 uncharaterized LOC112694756 -0.0364568
KMT2E lysine (K)-specific methyltransferase 2E -0.036336
RPL11 ribosomal protein L11 -0.036204
PERP PERP, TP53 apoptosis effector -0.0358657
RPS17 ribosomal protein S17 -0.0352622
RAB1A RAB1A, member RAS oncogene family -0.0350621
RPS14 ribosomal protein S14 -0.034964
SQSTM1 sequestosome 1 -0.0346136
RACK1 receptor for activated C kinase 1 -0.0341428
PLAUR plasminogen activator, urokinase receptor -0.0339591
RPL13A ribosomal protein L13a -0.033942
RPL15 ribosomal protein L15 -0.0338162
EEF2 eukaryotic translation elongation factor 2 -0.03366
GARS1 glycyl-tRNA synthetase 1 -0.033481
RPL36A ribosomal protein L36a -0.0332242
RPL34 ribosomal protein L34 -0.033066
RPL7A ribosomal protein L7a -0.0330492
RPLP0 ribosomal protein, large, P0 -0.0329522
RAD21 RAD21 homolog (S. pombe) -0.0329245
PRRC2C proline-rich coiled-coil 2C -0.0327753
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0324875
KRT19 keratin 19, type I -0.032209
ATP5F1E ATP synthase F1 subunit epsilon -0.0321175
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0313932
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0312064
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0312029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0311473
RPL30 ribosomal protein L30 -0.0310573
RPS29 ribosomal protein S29 -0.030837
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0304514
SEPTIN7 septin 7 -0.0303922
RPS15 ribosomal protein S15 -0.0299923
RPS16 ribosomal protein S16 -0.0295897
CCND1 cyclin D1 -0.0284962
RPL27A ribosomal protein L27a -0.0282889
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0281708
RHEB Ras homolog enriched in brain -0.027929
TRA2A transformer 2 alpha homolog (Drosophila) -0.0278686
RPS27 ribosomal protein S27 -0.0278058