Berberine (chloride hydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berberine (chloride hydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berberine (chloride hydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.192621
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0942156
OXR1 oxidation resistance 1 0.0805013
ANXA1 annexin A1 0.0724034
FERMT1 fermitin family member 1 0.0684184
TXNRD1 thioredoxin reductase 1 0.066785
LMO7 LIM domain 7 0.0667422
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0576181
NEK7 NIMA-related kinase 7 0.0557377
GCLC glutamate-cysteine ligase, catalytic subunit 0.0550665
RBM25 RNA binding motif protein 25 0.0511726
TPR translocated promoter region, nuclear basket protein 0.0492687
AREG amphiregulin 0.0481958
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0449414
RNF43 ring finger protein 43 0.0444109
CLTC clathrin, heavy chain (Hc) 0.0438895
EZR ezrin 0.041471
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0412661
UBE3C ubiquitin protein ligase E3C 0.0390687
LAMC2 laminin, gamma 2 0.0377359
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0365224
FAT1 FAT atypical cadherin 1 0.0350291
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0343994
GOLGA4 golgin A4 0.0343653
MARK3 MAP/microtubule affinity-regulating kinase 3 0.034116
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0340284
RNF145 ring finger protein 145 0.0339611
FAM3C family with sequence similarity 3, member C 0.0336551
TOP1 topoisomerase (DNA) I 0.0333859
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0332838
ARHGAP42 Rho GTPase activating protein 42 0.0323486
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0316653
STRN3 striatin, calmodulin binding protein 3 0.0314022
PDLIM5 PDZ and LIM domain 5 0.0307174
ZFAND3 zinc finger, AN1-type domain 3 0.0304143
DST dystonin 0.0300703
WAC WW domain containing adaptor with coiled-coil 0.0298333
GPBP1 GC-rich promoter binding protein 1 0.0294505
SCFD1 sec1 family domain containing 1 0.0291799
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0291315
DSPP dentin sialophosphoprotein 0.0290383
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0289281
CARD16 caspase recruitment domain family, member 16 0.0286229
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0285214
NFXL1 nuclear transcription factor, X-box binding-like 1 0.028513
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0276082
RUNX2 runt-related transcription factor 2 0.0274387
BIRC6 baculoviral IAP repeat containing 6 0.0273061
TXNIP thioredoxin interacting protein 0.027073
HMGB2 high mobility group box 2 0.027005
AOPEP aminopeptidase O (putative) 0.0269694
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0269028
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0267704
FNBP4 formin binding protein 4 0.0267034
PDE4B phosphodiesterase 4B, cAMP-specific 0.0266287
PTBP2 polypyrimidine tract binding protein 2 0.0265575
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0264453
KMT2C lysine (K)-specific methyltransferase 2C 0.0264262
ZNF638 zinc finger protein 638 0.0262424
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0259344
HDAC2 histone deacetylase 2 0.0257918
MED13L mediator complex subunit 13-like 0.0255817
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.02537
PDIA3 protein disulfide isomerase family A, member 3 0.0250013
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0249996
TOP2B topoisomerase (DNA) II beta 180kDa 0.0246948
POTEF POTE ankyrin domain family, member F 0.0246416
AVL9 AVL9 homolog (S. cerevisiase) 0.0246021
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0243976
ESYT2 extended synaptotagmin-like protein 2 0.0242176
ITGA6 integrin, alpha 6 0.0241697
KTN1 kinectin 1 (kinesin receptor) 0.0241205
NCKAP1 NCK-associated protein 1 0.0240406
CSDE1 cold shock domain containing E1, RNA-binding 0.0239428
ZFC3H1 zinc finger, C3H1-type containing 0.0239081
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0238145
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0237949
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0235376
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0234456
NCOR1 nuclear receptor corepressor 1 0.0233673
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0233263
MYOF myoferlin 0.0233167
CHD1 chromodomain helicase DNA binding protein 1 0.0232786
NKTR natural killer cell triggering receptor 0.0228934
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0227748
NPEPPS aminopeptidase puromycin sensitive 0.0227518
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0227269
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0227135
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0226967
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0225555
DSCAM Down syndrome cell adhesion molecule 0.0225353
CD2AP CD2-associated protein 0.0225149
NEMF nuclear export mediator factor 0.0224163
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0223799
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0223487
GSK3B glycogen synthase kinase 3 beta 0.0223043
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0221062
MTREX Mtr4 exosome RNA helicase 0.0220734
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0220634
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0220186

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.181819
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.137938
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.132698
IER3 immediate early response 3 -0.120978
EGR1 early growth response 1 -0.117815
PTMA prothymosin, alpha -0.106218
TMSB10 thymosin beta 10 -0.105938
VCL vinculin -0.101267
TPT1 tumor protein, translationally-controlled 1 -0.095293
FLOT1 flotillin 1 -0.0870867
FHIT fragile histidine triad -0.0865726
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0789433
RCOR1 REST corepressor 1 -0.0780003
RPL34 ribosomal protein L34 -0.0744513
LAMA4 laminin, alpha 4 -0.0702493
MPRIP myosin phosphatase Rho interacting protein -0.0626074
RPS27A ribosomal protein S27a -0.0618187
HMGA2 high mobility group AT-hook 2 -0.0616167
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0614638
GPC5 glypican 5 -0.0601679
RPL35A ribosomal protein L35a -0.0589489
RPL37A ribosomal protein L37a -0.0572183
UBC ubiquitin C -0.0555876
RPLP2 ribosomal protein, large, P2 -0.0548559
LOC102724023 ES1 protein homolog, mitochondrial -0.0540205
RPL26 ribosomal protein L26 -0.0525694
RPL23 ribosomal protein L23 -0.0506049
ANXA2 annexin A2 -0.0500722
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0499966
RPS24 ribosomal protein S24 -0.0478118
EEF2 eukaryotic translation elongation factor 2 -0.047769
CUX1 cut-like homeobox 1 -0.0465207
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0439524
FHL2 four and a half LIM domains 2 -0.0434739
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0430365
CMIP c-Maf inducing protein -0.0429641
RPS25 ribosomal protein S25 -0.0428821
RPS12 ribosomal protein S12 -0.0428044
AHNAK AHNAK nucleoprotein -0.0427682
RPS17 ribosomal protein S17 -0.0415771
RPS3 ribosomal protein S3 -0.0411558
RPL9 ribosomal protein L9 -0.0411328
RPS8 ribosomal protein S8 -0.0409933
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0407415
LAMB3 laminin, beta 3 -0.0406178
ACTN4 actinin, alpha 4 -0.0405281
CCSER1 coiled-coil serine-rich protein 1 -0.0401717
RPS5 ribosomal protein S5 -0.0394502
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0393757
S100A6 S100 calcium binding protein A6 -0.038695
ITGB4 integrin, beta 4 -0.0372449
NUP50 nucleoporin 50kDa -0.0371156
NTSR1 neurotensin receptor 1 (high affinity) -0.036336
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0356378
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0354858
RPS29 ribosomal protein S29 -0.0353338
RPS21 ribosomal protein S21 -0.035213
RPS13 ribosomal protein S13 -0.0348301
SQSTM1 sequestosome 1 -0.0342431
LOC112694756 uncharaterized LOC112694756 -0.0342072
DUSP4 dual specificity phosphatase 4 -0.0332683
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0328099
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0326452
RPL19 ribosomal protein L19 -0.0325606
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0322479
JARID2 jumonji, AT rich interactive domain 2 -0.031722
RPLP0 ribosomal protein, large, P0 -0.0315319
NDRG1 N-myc downstream regulated 1 -0.0313354
RPL37 ribosomal protein L37 -0.0310301
RPS23 ribosomal protein S23 -0.0308568
RPS19 ribosomal protein S19 -0.0305911
RPL12 ribosomal protein L12 -0.0301104
RPS6 ribosomal protein S6 -0.0298073
CTSB cathepsin B -0.0286243
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0282894
RPS15 ribosomal protein S15 -0.0282361
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0281752
CHRM3 cholinergic receptor, muscarinic 3 -0.0279877
EFNB2 ephrin-B2 -0.0274174
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0270539
KLF6 Kruppel-like factor 6 -0.0270439
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0269982
GPHN gephyrin -0.026895
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0267554
RAB7A RAB7A, member RAS oncogene family -0.0266147
RPLP1 ribosomal protein, large, P1 -0.0264149
KLF5 Kruppel-like factor 5 (intestinal) -0.0262495
RPS20 ribosomal protein S20 -0.0259245
RPL27A ribosomal protein L27a -0.0256563
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0254959
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0253965
TPM4 tropomyosin 4 -0.0253545
RPL38 ribosomal protein L38 -0.0253093
RASAL2 RAS protein activator like 2 -0.0252613
CREB5 cAMP responsive element binding protein 5 -0.025179
TRAF3 TNF receptor-associated factor 3 -0.0251651
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0250921
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0249109
KDM4B lysine (K)-specific demethylase 4B -0.0249028
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0247556