| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Berberine (chloride hydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Berberine (chloride hydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.21284 |
| HMGA2 | high mobility group AT-hook 2 | 0.138901 |
| CD44 | CD44 molecule (Indian blood group) | 0.12139 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.100319 |
| ATP13A3 | ATPase type 13A3 | 0.0838199 |
| MYO10 | myosin X | 0.0773375 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0743029 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0714084 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0697618 |
| GLIS3 | GLIS family zinc finger 3 | 0.0611 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.056727 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0530711 |
| MED13L | mediator complex subunit 13-like | 0.0517294 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0509586 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0497722 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0475526 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0473047 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0472274 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0452289 |
| SPAG9 | sperm associated antigen 9 | 0.0450191 |
| SMAD3 | SMAD family member 3 | 0.0443117 |
| COL5A2 | collagen, type V, alpha 2 | 0.0438239 |
| DST | dystonin | 0.0434514 |
| EMP1 | epithelial membrane protein 1 | 0.0431994 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0423555 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0416802 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0401011 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0389081 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0388616 |
| ASPH | aspartate beta-hydroxylase | 0.0386628 |
| MMP12 | matrix metallopeptidase 12 | 0.0381778 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0381741 |
| FRMD6 | FERM domain containing 6 | 0.0379489 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0370925 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0346275 |
| FMNL2 | formin-like 2 | 0.0345133 |
| CA12 | carbonic anhydrase XII | 0.0336822 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0335091 |
| ANXA2 | annexin A2 | 0.0331028 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.032907 |
| FOXO3 | forkhead box O3 | 0.0328175 |
| NAV2 | neuron navigator 2 | 0.0326895 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0321567 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0320334 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0315831 |
| RPL13A | ribosomal protein L13a | 0.0312243 |
| NAA16 | N(alpha)-acetyltransferase 16, NatA auxiliary subunit | 0.0310755 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0306922 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0302064 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0301678 |
| GPHN | gephyrin | 0.0298661 |
| RND3 | Rho family GTPase 3 | 0.0295018 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0293659 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0293075 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0291795 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0291541 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0281863 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0281 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0279532 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0275377 |
| ANXA5 | annexin A5 | 0.0273051 |
| MTSS1 | metastasis suppressor 1 | 0.0270354 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0266831 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.02661 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0264195 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0263816 |
| VEGFA | vascular endothelial growth factor A | 0.0257467 |
| RPL3 | ribosomal protein L3 | 0.0256392 |
| RPL31 | ribosomal protein L31 | 0.0255927 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0253695 |
| USP3 | ubiquitin specific peptidase 3 | 0.0253537 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0253326 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0248921 |
| DUSP10 | dual specificity phosphatase 10 | 0.0248734 |
| YBX1 | Y box binding protein 1 | 0.0242505 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0240092 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0239677 |
| FAM13A | family with sequence similarity 13, member A | 0.0238265 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0236167 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.023588 |
| POTEF | POTE ankyrin domain family, member F | 0.0235238 |
| PDS5A | PDS5 cohesin associated factor A | 0.0231206 |
| ADM | adrenomedullin | 0.0230867 |
| PKM | pyruvate kinase, muscle | 0.0230752 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0230345 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0230294 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0229768 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0229279 |
| JUN | jun proto-oncogene | 0.0227675 |
| RPL7A | ribosomal protein L7a | 0.0226648 |
| SEPTIN9 | septin 9 | 0.0225049 |
| SET | SET nuclear proto-oncogene | 0.0224462 |
| NOTCH2 | notch 2 | 0.0222325 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0221319 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0219371 |
| PHIP | pleckstrin homology domain interacting protein | 0.0219354 |
| RPL10A | ribosomal protein L10a | 0.0217418 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0216385 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0215685 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0215549 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.200684 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.16945 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.127494 |
| TMSB10 | thymosin beta 10 | -0.126041 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.121204 |
| INHBA | inhibin, beta A | -0.111964 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.108411 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.104601 |
| PRSS23 | protease, serine, 23 | -0.0905613 |
| COL1A2 | collagen, type I, alpha 2 | -0.0835114 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0763933 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0695182 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0693632 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0676287 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0658105 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0620011 |
| CDH13 | cadherin 13 | -0.0595483 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0593631 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0585299 |
| COL1A1 | collagen, type I, alpha 1 | -0.0581578 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0555797 |
| COL5A3 | collagen, type V, alpha 3 | -0.0531621 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0528172 |
| MT2A | metallothionein 2A | -0.0526206 |
| MMP1 | matrix metallopeptidase 1 | -0.0488952 |
| TPI1 | triosephosphate isomerase 1 | -0.0474736 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.047275 |
| PFN1 | profilin 1 | -0.046126 |
| OXR1 | oxidation resistance 1 | -0.0456532 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0424349 |
| NCKAP5 | NCK-associated protein 5 | -0.0420771 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0407471 |
| ACTG1 | actin gamma 1 | -0.0399215 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0398942 |
| PDE8A | phosphodiesterase 8A | -0.0395831 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0390511 |
| ITGA1 | integrin, alpha 1 | -0.0379506 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.037219 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0371386 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0369097 |
| NDRG1 | N-myc downstream regulated 1 | -0.036425 |
| CDK6 | cyclin-dependent kinase 6 | -0.0348903 |
| VIM | vimentin | -0.0343115 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0339774 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0334366 |
| RNF24 | ring finger protein 24 | -0.0322659 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0318625 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0318179 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0300102 |
| CLTC | clathrin, heavy chain (Hc) | -0.0300062 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0296451 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.029434 |
| HLA-B | major histocompatibility complex, class I, B | -0.0293175 |
| S100A10 | S100 calcium binding protein A10 | -0.0292406 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0289737 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0288933 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0285436 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0283768 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.028184 |
| S100A6 | S100 calcium binding protein A6 | -0.0281751 |
| LOXL2 | lysyl oxidase-like 2 | -0.0280972 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.0278104 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0274105 |
| CCDC102B | coiled-coil domain containing 102B | -0.0273871 |
| SCFD1 | sec1 family domain containing 1 | -0.0273496 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0270582 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0267701 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0267643 |
| RPL9 | ribosomal protein L9 | -0.0264422 |
| CHSY1 | chondroitin sulfate synthase 1 | -0.0258397 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0254928 |
| PGK1 | phosphoglycerate kinase 1 | -0.0253976 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.025223 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0251062 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0247641 |
| GPATCH2L | G patch domain containing 2-like | -0.0247301 |
| RPL34 | ribosomal protein L34 | -0.0246303 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0244514 |
| PRRX1 | paired related homeobox 1 | -0.0244001 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.0243743 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0243063 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0241975 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0241399 |
| SRGN | serglycin | -0.0240142 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0239403 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0239378 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0239292 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0237564 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0236459 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0235642 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0233762 |
| TMEM263 | transmembrane protein 263 | -0.0232326 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0232165 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0230764 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0229963 |
| ZBTB7A | zinc finger and BTB domain containing 7A | -0.0229739 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0227281 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0224191 |
| TUBA1B | tubulin, alpha 1b | -0.022405 |
| S100A9 | S100 calcium binding protein A9 | -0.0223209 |
