Bergenin Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/66065
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Genes

200 proteins with high or low expression in Bergenin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 1.37
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.77
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.74
ZNF12 zinc finger protein 12 0.66
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 0.58
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.57
VRK1 vaccinia related kinase 1 0.55
CCDC14 coiled-coil domain containing 14 0.54
RASAL1 RAS protein activator like 1 (GAP1 like) 0.53
WDR90 WD repeat domain 90 0.51
F3 coagulation factor III (thromboplastin, tissue factor) 0.51
GGACT gamma-glutamylamine cyclotransferase 0.5
TSLIG1 tRNA splicing ligase complex subunit 1 0.43
KIAA1210 KIAA1210 0.42
PRRX2 paired related homeobox 2 0.42
GPN3 GPN-loop GTPase 3 0.4
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 0.39
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.38
ODC1 ornithine decarboxylase 1 0.38
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 0.38
TXNL4B thioredoxin-like 4B 0.38
XTBD1 XRN2 binding domain containing 1 0.38
PUS10 pseudouridylate synthase 10 0.38
LMLN leishmanolysin-like (metallopeptidase M8 family) 0.38
UVRAG UV radiation resistance associated 0.38
COX18 COX18 cytochrome c oxidase assembly factor 0.37
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 0.37
SOX4 SRY (sex determining region Y)-box 4 0.36
PTCD2 pentatricopeptide repeat domain 2 0.36
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.36
TENT2 terminal nucleotidyltransferase 2 0.36
DYM dymeclin 0.34
SYTL3 synaptotagmin-like 3 0.34
SMAD1 SMAD family member 1 0.34
SRD5A3 steroid 5 alpha-reductase 3 0.33
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.33
HPS1 Hermansky-Pudlak syndrome 1 0.32
IFITM3 interferon induced transmembrane protein 3 0.31
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 0.31
MGA MGA, MAX dimerization protein 0.31
ZNF551 zinc finger protein 551 0.3
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.3
MSX2 msh homeobox 2 0.3
DMTF1 cyclin D binding myb-like transcription factor 1 0.3
YAF2 YY1 associated factor 2 0.3
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.3
MYH16 myosin, heavy chain 16 pseudogene 0.29
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.29
FOXM1 forkhead box M1 0.29
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.29
TOR1AIP2 torsin A interacting protein 2 0.29
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 0.28
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.28
ZWILCH zwilch kinetochore protein 0.28
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.28
ZNF777 zinc finger protein 777 0.27
SCARA3 scavenger receptor class A, member 3 0.27
MT-CO2 cytochrome c oxidase subunit II 0.27
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.27
KLK6 kallikrein-related peptidase 6 0.27
DYNLL2 dynein, light chain, LC8-type 2 0.27
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.27
SPOP speckle-type POZ protein 0.27
CPA4 carboxypeptidase A4 0.27
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.27
FOXO1 forkhead box O1 0.27
ZNF652 zinc finger protein 652 0.27
BET1 Bet1 golgi vesicular membrane trafficking protein 0.27
AMMECR1L AMMECR1-like 0.27
PAK5 p21 (RAC1) activated kinase 5 0.26
KCTD1 potassium channel tetramerization domain containing 1 0.26
ZNF324 zinc finger protein 324 0.26
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.26
SHCBP1 SHC SH2-domain binding protein 1 0.26
TUB tubby bipartite transcription factor 0.26
TCEA2 transcription elongation factor A (SII), 2 0.26
TMEM186 transmembrane protein 186 0.26
ZNF566 zinc finger protein 566 0.26
HOXB7 homeobox B7 0.26
VSIR V-set immunoregulatory receptor 0.25
MAGEA2 melanoma antigen family A2 0.25
COPZ1 coatomer protein complex, subunit zeta 1 0.25
METTL6 methyltransferase like 6 0.25
CENPH centromere protein H 0.25
FLNB filamin B, beta 0.25
UBE2S ubiquitin-conjugating enzyme E2S 0.25
RAD51B RAD51 paralog B 0.25
ZIC5 Zic family member 5 0.25
TMEM131L transmembrane 131 like 0.25
SLC35F2 solute carrier family 35, member F2 0.25
C3ORF38 chromosome 3 open reading frame 38 0.25
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 0.24
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.24
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.24
MCM8 minichromosome maintenance complex component 8 0.24
MPDU1 mannose-P-dolichol utilization defect 1 0.24
SH2D5 SH2 domain containing 5 0.24
SBNO2 strawberry notch homolog 2 (Drosophila) 0.24
F2R coagulation factor II (thrombin) receptor 0.24
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.24

low expression

Symbol Name Standardized Value
MYH4 myosin, heavy chain 4, skeletal muscle -1.38
PIP prolactin-induced protein -0.98
MEX3A mex-3 RNA binding family member A -0.76
LYPD3 LY6/PLAUR domain containing 3 -0.76
NGFR nerve growth factor receptor -0.73
SESN1 sestrin 1 -0.72
ZNF587 zinc finger protein 587 -0.64
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -0.62
EIF3C eukaryotic translation initiation factor 3, subunit C -0.59
ZFP62 ZFP62 zinc finger protein -0.59
SEMG1 semenogelin I -0.56
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -0.53
OASL 2'-5'-oligoadenylate synthetase-like -0.52
BCL6 B-cell CLL/lymphoma 6 -0.52
SYNPO synaptopodin -0.48
TMSB10 thymosin beta 10 -0.47
MSRB2 methionine sulfoxide reductase B2 -0.47
KLHDC8B kelch domain containing 8B -0.47
ZNF236 zinc finger protein 236 -0.46
MISP3 MISP family member 3 -0.46
COL2A1 collagen, type II, alpha 1 -0.46
TACSTD2 tumor-associated calcium signal transducer 2 -0.46
CDC42SE2 CDC42 small effector 2 -0.46
FRS2 fibroblast growth factor receptor substrate 2 -0.45
KANK3 KN motif and ankyrin repeat domains 3 -0.44
TMEM184B transmembrane protein 184B -0.43
SEPTIN5 septin 5 -0.42
ACTBL2 actin, beta-like 2 -0.42
WSB1 WD repeat and SOCS box containing 1 -0.42
FTL ferritin, light polypeptide -0.42
SPHK2 sphingosine kinase 2 -0.41
TMOD2 tropomodulin 2 (neuronal) -0.41
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -0.41
DBNL drebrin-like -0.41
PER1 period circadian clock 1 -0.41
MREG melanoregulin -0.4
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.4
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.4
NFE2L1 nuclear factor, erythroid 2-like 1 -0.4
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1 -0.4
PFDN1 prefoldin subunit 1 -0.4
GGT7 gamma-glutamyltransferase 7 -0.4
MAP2 microtubule-associated protein 2 -0.39
ZNF624 zinc finger protein 624 -0.39
BCKDK branched chain ketoacid dehydrogenase kinase -0.38
MADD MAP-kinase activating death domain -0.38
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -0.38
PHF1 PHD finger protein 1 -0.37
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.37
HBA1 hemoglobin, alpha 1 -0.37
ZNF57 zinc finger protein 57 -0.36
NOS1 nitric oxide synthase 1 (neuronal) -0.36
RNASET2 ribonuclease T2 -0.36
KCTD12 potassium channel tetramerization domain containing 12 -0.36
ZNF525 zinc finger protein 525 -0.36
CALU calumenin -0.36
PEA15 phosphoprotein enriched in astrocytes 15 -0.35
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.35
APOE apolipoprotein E -0.35
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.35
L1CAM L1 cell adhesion molecule -0.35
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.35
CTSL cathepsin L -0.34
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 -0.34
FN1 fibronectin 1 -0.34
MYZAP myocardial zonula adherens protein -0.34
GRAMD2B GRAM domain containing 2B -0.34
FAM174A family with sequence similarity 174, member A -0.34
CCSAP centriole, cilia and spindle-associated protein -0.33
SULF2 sulfatase 2 -0.33
PSAP prosaposin -0.33
NDRG1 N-myc downstream regulated 1 -0.33
ATL1 atlastin GTPase 1 -0.32
BAHCC1 BAH domain and coiled-coil containing 1 -0.32
ZYX zyxin -0.32
NFE2L2 nuclear factor, erythroid 2-like 2 -0.32
RUSC2 RUN and SH3 domain containing 2 -0.32
ZBTB3 zinc finger and BTB domain containing 3 -0.32
TSC22D4 TSC22 domain family, member 4 -0.32
PPP1R3D protein phosphatase 1, regulatory subunit 3D -0.32
COPRS coordinator of PRMT5, differentiation stimulator -0.31
ADIRF adipogenesis regulatory factor -0.31
TNNI3 troponin I type 3 (cardiac) -0.31
ENY2 enhancer of yellow 2 homolog (Drosophila) -0.31
LRRC49 leucine rich repeat containing 49 -0.31
JAG1 jagged 1 -0.31
TBC1D25 TBC1 domain family, member 25 -0.31
KDM6B lysine (K)-specific demethylase 6B -0.31
NSFL1C NSFL1 (p97) cofactor (p47) -0.3
APOLTP apolipoprotein lipid transfer particle homolog -0.3
PXN paxillin -0.3
GCC1 GRIP and coiled-coil domain containing 1 -0.3
C2CD4C C2 calcium-dependent domain containing 4C -0.3
NFXL1 nuclear transcription factor, X-box binding-like 1 -0.3
ZFYVE1 zinc finger, FYVE domain containing 1 -0.3
MCTP2 multiple C2 domains, transmembrane 2 -0.3
ZNF654 zinc finger protein 654 -0.3
ZNF503 zinc finger protein 503 -0.3
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -0.29
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -0.29