Bergenin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.257679
VIM vimentin 0.128956
PLAT plasminogen activator, tissue 0.112702
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0917157
FLNB filamin B, beta 0.0613231
CSTB cystatin B (stefin B) 0.0550217
THBS2 thrombospondin 2 0.051493
AKAP12 A kinase (PRKA) anchor protein 12 0.0512632
FSTL1 follistatin-like 1 0.0509647
EFNA5 ephrin-A5 0.0506017
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0457785
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0439495
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0413522
AHNAK2 AHNAK nucleoprotein 2 0.0392313
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0383731
SEPTIN9 septin 9 0.0361748
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0347855
ACER3 alkaline ceramidase 3 0.0333878
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0326772
DOCK5 dedicator of cytokinesis 5 0.0296948
TM4SF1 transmembrane 4 L six family member 1 0.0296692
CDH13 cadherin 13 0.0290317
CAVIN1 caveolae associated protein 1 0.0277316
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0276989
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0275941
MT2A metallothionein 2A 0.0267478
ERRFI1 ERBB receptor feedback inhibitor 1 0.0257589
RABGAP1L RAB GTPase activating protein 1-like 0.0255274
LOC102724023 ES1 protein homolog, mitochondrial 0.0253658
COL3A1 collagen, type III, alpha 1 0.0253613
SYTL3 synaptotagmin-like 3 0.0252266
CD44 CD44 molecule (Indian blood group) 0.0248166
DGKG diacylglycerol kinase, gamma 90kDa 0.0247697
ELL2 elongation factor, RNA polymerase II, 2 0.0247245
HLA-A major histocompatibility complex, class I, A 0.0246564
DUSP6 dual specificity phosphatase 6 0.0245286
BACE2 beta-site APP-cleaving enzyme 2 0.0240708
SMYD3 SET and MYND domain containing 3 0.0235209
PTMA prothymosin, alpha 0.0234678
RPL37A ribosomal protein L37a 0.0234119
RAI1 retinoic acid induced 1 0.0230523
HLA-B major histocompatibility complex, class I, B 0.0229306
ASPH aspartate beta-hydroxylase 0.0229133
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0225528
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0223092
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0222303
BCL2L1 BCL2-like 1 0.0221106
ANTXR2 anthrax toxin receptor 2 0.0218314
SMAD3 SMAD family member 3 0.0211701
PBX3 pre-B-cell leukemia homeobox 3 0.0211609
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0205759
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0205688
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.020468
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0200759
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0196457
SYNJ2 synaptojanin 2 0.0195889
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0192933
E2F7 E2F transcription factor 7 0.0192396
RPS2 ribosomal protein S2 0.0191801
DNMBP dynamin binding protein 0.0191004
TPT1 tumor protein, translationally-controlled 1 0.019004
RACK1 receptor for activated C kinase 1 0.0184941
NT5E 5'-nucleotidase, ecto (CD73) 0.0184363
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0183775
TPM3 tropomyosin 3 0.0178792
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0177082
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0176389
ACTG1 actin gamma 1 0.0175715
SPDL1 spindle apparatus coiled-coil protein 1 0.0175544
DCLK2 doublecortin-like kinase 2 0.0175339
GCC2 GRIP and coiled-coil domain containing 2 0.0175107
CD59 CD59 molecule, complement regulatory protein 0.0174498
LMNA lamin A/C 0.0174295
TM4SF19 transmembrane 4 L six family member 19 0.01708
MYO9A myosin IXA 0.0170457
RPS3 ribosomal protein S3 0.0169482
HDAC9 histone deacetylase 9 0.0168358
RPL12 ribosomal protein L12 0.0166744
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0165333
ZMYND8 zinc finger, MYND-type containing 8 0.0165001
KRT81 keratin 81, type II 0.015989
F3 coagulation factor III (thromboplastin, tissue factor) 0.0158496
MCFD2 multiple coagulation factor deficiency 2 0.0158444
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0156991
RPS27A ribosomal protein S27a 0.0156552
P4HB prolyl 4-hydroxylase, beta polypeptide 0.015636
CEP112 centrosomal protein 112kDa 0.0155498
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0154593
ANKRD36 ankyrin repeat domain 36 0.0150858
RPS8 ribosomal protein S8 0.0147238
PFKP phosphofructokinase, platelet 0.014487
NAV1 neuron navigator 1 0.0142274
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0141231
EIF1 eukaryotic translation initiation factor 1 0.0141051
RIN2 Ras and Rab interactor 2 0.0140354
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0139167
KIF18B kinesin family member 18B 0.0138847
TBC1D2 TBC1 domain family, member 2 0.0138173
RPL26 ribosomal protein L26 0.0138008
PLIN3 perilipin 3 0.0137551

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.134691
FBN1 fibrillin 1 -0.117061
FNDC3B fibronectin type III domain containing 3B -0.109772
COL8A1 collagen, type VIII, alpha 1 -0.106051
TMSB10 thymosin beta 10 -0.101834
POTEF POTE ankyrin domain family, member F -0.100589
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0933288
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0895207
AUTS2 autism susceptibility candidate 2 -0.0886601
SOD2 superoxide dismutase 2, mitochondrial -0.0886313
UBC ubiquitin C -0.0872679
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0868628
LOX lysyl oxidase -0.0853204
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0848079
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0830422
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0802475
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0695948
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0652305
DST dystonin -0.0623674
PKM pyruvate kinase, muscle -0.060158
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0588525
SDK1 sidekick cell adhesion molecule 1 -0.0579588
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0569769
LDHA lactate dehydrogenase A -0.0560529
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0555486
GPC6 glypican 6 -0.0554579
LOXL2 lysyl oxidase-like 2 -0.054736
MSI2 musashi RNA-binding protein 2 -0.0541734
COPA coatomer protein complex, subunit alpha -0.0536171
COL1A2 collagen, type I, alpha 2 -0.0525713
ADAM9 ADAM metallopeptidase domain 9 -0.052256
COL5A2 collagen, type V, alpha 2 -0.0507324
TRIO trio Rho guanine nucleotide exchange factor -0.0506173
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0497093
MAP4 microtubule-associated protein 4 -0.0485388
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0477856
SPAG9 sperm associated antigen 9 -0.0458084
RIGI RNA sensor RIG-I -0.0436406
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0434013
SAMD9 sterile alpha motif domain containing 9 -0.0422275
JAZF1 JAZF zinc finger 1 -0.0421195
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0406449
ZNF207 zinc finger protein 207 -0.0399978
LOC112694756 uncharaterized LOC112694756 -0.0395598
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0394605
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0384336
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0380411
FNDC3A fibronectin type III domain containing 3A -0.0378836
TIMP2 TIMP metallopeptidase inhibitor 2 -0.037714
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0376518
IFIH1 interferon induced with helicase C domain 1 -0.0368442
VEGFA vascular endothelial growth factor A -0.0364516
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0363991
ABI3BP ABI family, member 3 (NESH) binding protein -0.0362893
AFF4 AF4/FMR2 family, member 4 -0.0362208
MAP1B microtubule-associated protein 1B -0.0360035
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0358951
CYLD cylindromatosis (turban tumor syndrome) -0.0357033
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0356808
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0356097
ADM adrenomedullin -0.0355375
HILPDA hypoxia inducible lipid droplet-associated -0.0353504
DPYSL3 dihydropyrimidinase-like 3 -0.0351733
MYOF myoferlin -0.0344135
BHLHE40 basic helix-loop-helix family, member e40 -0.0343725
WTAP Wilms tumor 1 associated protein -0.0336847
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0335852
ACTN4 actinin, alpha 4 -0.0335537
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0330843
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0328941
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0327404
TSC22D2 TSC22 domain family, member 2 -0.0324175
TAPBP TAP binding protein (tapasin) -0.0321063
HELZ helicase with zinc finger -0.0320129
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0316907
NT5C2 5'-nucleotidase, cytosolic II -0.0309293
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0307861
TAGLN2 transgelin 2 -0.0307465
WARS1 tryptophanyl-tRNA synthetase 1 -0.0305663
PICALM phosphatidylinositol binding clathrin assembly protein -0.0302346
USP9X ubiquitin specific peptidase 9, X-linked -0.0298245
KDM6A lysine (K)-specific demethylase 6A -0.02978
KCTD9 potassium channel tetramerization domain containing 9 -0.0296419
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0296121
BBX bobby sox homolog (Drosophila) -0.0292933
ARL15 ADP-ribosylation factor-like 15 -0.0292851
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0291332
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0290178
SQSTM1 sequestosome 1 -0.0288984
SOX9 SRY (sex determining region Y)-box 9 -0.0288178
ADAM17 ADAM metallopeptidase domain 17 -0.0284278
OPTN optineurin -0.0283159
MEIS2 Meis homeobox 2 -0.0282676
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0281383
COL5A1 collagen, type V, alpha 1 -0.0275951
MED13L mediator complex subunit 13-like -0.0275782
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0275349
UBE2H ubiquitin-conjugating enzyme E2H -0.0274913
LCOR ligand dependent nuclear receptor corepressor -0.0274877
IARS1 isoleucyl-tRNA synthetase 1 -0.0273235