Bergenin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTPRD protein tyrosine phosphatase, receptor type, D 0.128735
LSAMP limbic system-associated membrane protein 0.119205
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.112401
NALF1 NALCN channel auxiliary factor 1 0.109656
VCL vinculin 0.101597
ACTG1 actin gamma 1 0.0991035
COL1A1 collagen, type I, alpha 1 0.0883253
FMN1 formin 1 0.0833824
VIM vimentin 0.0769082
RPS6 ribosomal protein S6 0.0701377
RPS12 ribosomal protein S12 0.0654706
NPAS2 neuronal PAS domain protein 2 0.0638981
RPL37A ribosomal protein L37a 0.0631007
TPT1 tumor protein, translationally-controlled 1 0.061839
RPS3 ribosomal protein S3 0.0588132
TLE4 transducin-like enhancer of split 4 0.057476
RAD51B RAD51 paralog B 0.0542784
PTMA prothymosin, alpha 0.0542769
TMSB10 thymosin beta 10 0.0537543
EIF1 eukaryotic translation initiation factor 1 0.0508811
SYT1 synaptotagmin I 0.0494074
RPL23 ribosomal protein L23 0.0486644
ZSWIM6 zinc finger, SWIM-type containing 6 0.0486276
EXT1 exostosin glycosyltransferase 1 0.0481652
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.047778
THSD4 thrombospondin, type I, domain containing 4 0.0467861
RPL19 ribosomal protein L19 0.045895
BCAS3 breast carcinoma amplified sequence 3 0.0442036
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0441487
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0438919
BPTF bromodomain PHD finger transcription factor 0.0435826
FTL ferritin, light polypeptide 0.0433875
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.04192
ZBTB20 zinc finger and BTB domain containing 20 0.0414362
RPL34 ribosomal protein L34 0.0393182
RPL27 ribosomal protein L27 0.0391666
SMYD3 SET and MYND domain containing 3 0.0391427
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0378485
PCBP2 poly(rC) binding protein 2 0.0375392
PDE10A phosphodiesterase 10A 0.0369254
RPS2 ribosomal protein S2 0.0367545
PLAT plasminogen activator, tissue 0.0363806
B2M beta-2-microglobulin 0.0356606
RPL36 ribosomal protein L36 0.0354932
RPLP1 ribosomal protein, large, P1 0.0350068
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0334747
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0329567
GSE1 Gse1 coiled-coil protein 0.0329311
PDE4D phosphodiesterase 4D, cAMP-specific 0.0329193
ANKRD12 ankyrin repeat domain 12 0.0325346
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0325325
RPL26 ribosomal protein L26 0.032436
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0323138
RPS17 ribosomal protein S17 0.0320879
RPS27A ribosomal protein S27a 0.0320045
RPS19 ribosomal protein S19 0.0317717
EFNA5 ephrin-A5 0.0315652
DNMBP dynamin binding protein 0.0314444
LPP LIM domain containing preferred translocation partner in lipoma 0.0311543
RPS23 ribosomal protein S23 0.0311419
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0306578
RPL31 ribosomal protein L31 0.0305708
RPS29 ribosomal protein S29 0.0304857
KLF6 Kruppel-like factor 6 0.0304236
RPL7A ribosomal protein L7a 0.0300961
RPL18 ribosomal protein L18 0.0298997
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0294888
ARB2A ARB2 cotranscriptional regulator A 0.0294316
RPS8 ribosomal protein S8 0.0294265
RPLP0 ribosomal protein, large, P0 0.0293054
MYO6 myosin VI 0.0291814
RSL1D1 ribosomal L1 domain containing 1 0.0291091
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0288537
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0288001
HLA-A major histocompatibility complex, class I, A 0.0287958
GATA3 GATA binding protein 3 0.0286802
PRRC2C proline-rich coiled-coil 2C 0.0283566
ZMIZ1 zinc finger, MIZ-type containing 1 0.0281061
SET SET nuclear proto-oncogene 0.0280572
AKAP12 A kinase (PRKA) anchor protein 12 0.0279813
SLIT2 slit homolog 2 (Drosophila) 0.0278878
RPL9 ribosomal protein L9 0.0278184
ADAR adenosine deaminase, RNA-specific 0.0277642
RPL12 ribosomal protein L12 0.0276682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0273695
ZNF804A zinc finger protein 804A 0.0273473
SCAPER S-phase cyclin A-associated protein in the ER 0.0270299
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0270221
TBX2 T-box 2 0.0266784
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0265587
ARHGAP9 Rho GTPase activating protein 9 0.0264391
RPL37 ribosomal protein L37 0.026433
RPL13A ribosomal protein L13a 0.026203
UNC5C unc-5 homolog C (C. elegans) 0.0257579
RPL30 ribosomal protein L30 0.0255869
PTPRK protein tyrosine phosphatase, receptor type, K 0.025449
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0254256
CTNND1 catenin (cadherin-associated protein), delta 1 0.0252593
IFI6 interferon, alpha-inducible protein 6 0.0251512
RABGAP1L RAB GTPase activating protein 1-like 0.0251241

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.388582
IGF2 insulin-like growth factor 2 -0.0968186
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.079284
LPIN1 lipin 1 -0.0628818
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0524906
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0486502
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.047982
MEIS2 Meis homeobox 2 -0.04696
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.045574
GOLGA4 golgin A4 -0.0433733
ADGRG6 adhesion G protein-coupled receptor G6 -0.0416645
NRG1 neuregulin 1 -0.0399158
MAP1B microtubule-associated protein 1B -0.0391559
WDR45B WD repeat domain 45B -0.0390544
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.039006
SPAG9 sperm associated antigen 9 -0.0387205
HELZ helicase with zinc finger -0.0374998
LCORL ligand dependent nuclear receptor corepressor-like -0.0372986
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.0364324
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0356735
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.035047
NUP58 nucleoporin 58 -0.0343458
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0341161
MARCHF6 membrane associated ring-CH-type finger 6 -0.0334553
ZNF292 zinc finger protein 292 -0.0331593
TNRC6B trinucleotide repeat containing 6B -0.0320816
COPA coatomer protein complex, subunit alpha -0.0320668
OGA O-GlcNAcase -0.0316292
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0316034
MBNL2 muscleblind-like splicing regulator 2 -0.029892
COL3A1 collagen, type III, alpha 1 -0.0295162
GARS1 glycyl-tRNA synthetase 1 -0.0292919
C1ORF21 chromosome 1 open reading frame 21 -0.0291738
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0289112
FAM13A family with sequence similarity 13, member A -0.0285482
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0281347
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0274339
TENT5A terminal nucleotidyltransferase 5A -0.026791
NCAM2 neural cell adhesion molecule 2 -0.0267378
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0267146
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -0.0266474
NAMPT nicotinamide phosphoribosyltransferase -0.0266112
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0261458
ZFAND3 zinc finger, AN1-type domain 3 -0.0261182
NDRG1 N-myc downstream regulated 1 -0.0259394
AFF4 AF4/FMR2 family, member 4 -0.0255722
CEMIP cell migration inducing protein, hyaluronan binding -0.0254463
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0252491
CDC27 cell division cycle 27 -0.025083
IARS1 isoleucyl-tRNA synthetase 1 -0.0246806
FRMD4A FERM domain containing 4A -0.0245288
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0244967
NPEPPS aminopeptidase puromycin sensitive -0.024361
DLC1 DLC1 Rho GTPase activating protein -0.0243223
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0242172
VEGFA vascular endothelial growth factor A -0.022804
ANKRD17 ankyrin repeat domain 17 -0.0223936
DSCAM Down syndrome cell adhesion molecule -0.0222105
FNDC3B fibronectin type III domain containing 3B -0.0213337
MORF4L2 mortality factor 4 like 2 -0.0213327
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0213284
KIF21A kinesin family member 21A -0.0213187
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0212958
GPC5 glypican 5 -0.0212847
NBEA neurobeachin -0.0212286
PHF3 PHD finger protein 3 -0.0211715
ACBD3 acyl-CoA binding domain containing 3 -0.0211429
DENND1A DENN/MADD domain containing 1A -0.0209232
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0207076
TOB1 transducer of ERBB2, 1 -0.0205726
PDIA6 protein disulfide isomerase family A, member 6 -0.0205268
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0204535
CARD16 caspase recruitment domain family, member 16 -0.0203748
KMT2C lysine (K)-specific methyltransferase 2C -0.0203333
ATF6 activating transcription factor 6 -0.0203053
TENT4A terminal nucleotidyltransferase 4A -0.0202255
CCND1 cyclin D1 -0.0201782
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0198738
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0198682
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.019513
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0194436
ESYT2 extended synaptotagmin-like protein 2 -0.0194305
PCDH9 protocadherin 9 -0.0194047
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0193919
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0193714
ZNF451 zinc finger protein 451 -0.0193444
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0193115
SEC31A SEC31 homolog A (S. cerevisiae) -0.0192361
PRPF3 pre-mRNA processing factor 3 -0.0191652
UBE2O ubiquitin-conjugating enzyme E2O -0.0189397
ENAH enabled homolog (Drosophila) -0.0186787
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.018654
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0185971
CDC73 cell division cycle 73 -0.0185433
CEP95 centrosomal protein 95kDa -0.0184425
BIRC6 baculoviral IAP repeat containing 6 -0.0184053
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0183902
ARF1 ADP-ribosylation factor 1 -0.0182173
CALR calreticulin -0.0181018
RLIM ring finger protein, LIM domain interacting -0.017975