Bergenin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.171445
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.144931
IGF2 insulin-like growth factor 2 0.122986
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.115893
SVIL supervillin 0.111128
MT2A metallothionein 2A 0.0972588
AKAP12 A kinase (PRKA) anchor protein 12 0.0715645
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0707623
ERRFI1 ERBB receptor feedback inhibitor 1 0.0602335
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.05309
EPAS1 endothelial PAS domain protein 1 0.0524532
DSPP dentin sialophosphoprotein 0.0485365
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0482795
RUNX1 runt-related transcription factor 1 0.0474607
SAMD4A sterile alpha motif domain containing 4A 0.04674
GK glycerol kinase 0.0465211
TIMP1 TIMP metallopeptidase inhibitor 1 0.0462582
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0438675
IGFBP1 insulin-like growth factor binding protein 1 0.0412937
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0399562
ATXN1 ataxin 1 0.0391454
FAM13A family with sequence similarity 13, member A 0.0379724
GRB10 growth factor receptor-bound protein 10 0.0377004
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0371637
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0354453
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0353043
MCL1 myeloid cell leukemia 1 0.0352138
BCL2L1 BCL2-like 1 0.033845
FOXP1 forkhead box P1 0.033642
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0332645
RAI14 retinoic acid induced 14 0.0315905
ITGB5 integrin, beta 5 0.0304679
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0302346
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0298909
TNS1 tensin 1 0.0292543
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0286127
ARFGEF3 ARFGEF family member 3 0.0279742
TBC1D22A TBC1 domain family, member 22A 0.0278628
SYNE1 spectrin repeat containing, nuclear envelope 1 0.027358
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0271838
MBNL2 muscleblind-like splicing regulator 2 0.0271096
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0262226
DUSP6 dual specificity phosphatase 6 0.0261803
SMYD3 SET and MYND domain containing 3 0.0260311
JAK1 Janus kinase 1 0.0256872
ARHGAP21 Rho GTPase activating protein 21 0.0255452
DDIT4 DNA-damage-inducible transcript 4 0.0252944
MTSS1 metastasis suppressor 1 0.0251164
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0249453
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0240809
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0239621
FAM107B family with sequence similarity 107, member B 0.0239004
ZBTB38 zinc finger and BTB domain containing 38 0.0235169
MACF1 microtubule-actin crosslinking factor 1 0.0234685
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0233205
TCIM transcriptional and immune response regulator 0.0231006
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0229797
FAM117B family with sequence similarity 117, member B 0.0229513
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0227992
PCBP1 poly(rC) binding protein 1 0.0223715
EHBP1 EH domain binding protein 1 0.02235
BCAS3 breast carcinoma amplified sequence 3 0.0222543
AHNAK AHNAK nucleoprotein 0.0219265
ANKRD11 ankyrin repeat domain 11 0.0218815
SMAD3 SMAD family member 3 0.0217545
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0211351
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0211044
PDGFB platelet-derived growth factor beta polypeptide 0.0208693
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.020868
ZEB1 zinc finger E-box binding homeobox 1 0.0208337
PAWR PRKC, apoptosis, WT1, regulator 0.0207034
FERMT1 fermitin family member 1 0.0205713
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.020283
SHB Src homology 2 domain containing adaptor protein B 0.020245
FRMD5 FERM domain containing 5 0.0201983
ATF3 activating transcription factor 3 0.0200708
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0200538
KRT23 keratin 23, type I 0.019701
CCDC88A coiled-coil domain containing 88A 0.0194801
HPCAL1 hippocalcin-like 1 0.0194616
OGA O-GlcNAcase 0.0194492
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0194364
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0193768
KLF6 Kruppel-like factor 6 0.0193595
YME1L1 YME1-like 1 ATPase 0.0193577
ENKUR enkurin, TRPC channel interacting protein 0.0193191
RABGAP1L RAB GTPase activating protein 1-like 0.0192002
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.01897
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0188155
TLE4 transducin-like enhancer of split 4 0.0184791
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0184736
DNAH17 dynein, axonemal, heavy chain 17 0.0184316
TMEM181 transmembrane protein 181 0.0184277
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0178917
ESYT2 extended synaptotagmin-like protein 2 0.0177279
RASA2 RAS p21 protein activator 2 0.0177001
KYNU kynureninase 0.017698
MT1X metallothionein 1X 0.0174839
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0174584
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0169948

decreased expression

Symbol Name Standardized Value
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.204442
APOB apolipoprotein B -0.147085
APOA2 apolipoprotein A-II -0.125764
FNDC3B fibronectin type III domain containing 3B -0.117328
FN1 fibronectin 1 -0.110759
C3 complement component 3 -0.108051
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0925101
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0914608
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0900794
EML4 echinoderm microtubule associated protein like 4 -0.0872182
LRMDA leucine rich melanocyte differentiation associated -0.0866574
SLC38A2 solute carrier family 38, member 2 -0.0835834
AHSG alpha-2-HS-glycoprotein -0.0819615
RPS24 ribosomal protein S24 -0.0777483
PTPRM protein tyrosine phosphatase, receptor type, M -0.0763886
TMSB10 thymosin beta 10 -0.0730305
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0712385
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0708304
SESTD1 SEC14 and spectrin domains 1 -0.0702225
HMGA1 high mobility group AT-hook 1 -0.0690121
RPL11 ribosomal protein L11 -0.0646457
TPT1 tumor protein, translationally-controlled 1 -0.0618991
RPL35A ribosomal protein L35a -0.0606138
RPL23 ribosomal protein L23 -0.060549
RPS6 ribosomal protein S6 -0.0591179
RPL37A ribosomal protein L37a -0.0584097
RPS21 ribosomal protein S21 -0.0557616
A2M alpha-2-macroglobulin -0.0556767
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0542701
VEGFA vascular endothelial growth factor A -0.0542117
ZFAND3 zinc finger, AN1-type domain 3 -0.0526171
SOX5 SRY (sex determining region Y)-box 5 -0.0506057
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0492287
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0491545
MAML2 mastermind-like 2 (Drosophila) -0.0490428
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0479486
ITGAV integrin, alpha V -0.0478747
RPL31 ribosomal protein L31 -0.0472445
LYZ lysozyme -0.0472388
RBM39 RNA binding motif protein 39 -0.046791
TM4SF1 transmembrane 4 L six family member 1 -0.0467794
RPL34 ribosomal protein L34 -0.0457023
FTL ferritin, light polypeptide -0.0443475
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0442415
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0440769
RPLP2 ribosomal protein, large, P2 -0.0437737
SOD2 superoxide dismutase 2, mitochondrial -0.0434137
PTPRK protein tyrosine phosphatase, receptor type, K -0.0431794
APOE apolipoprotein E -0.0429565
NPAS2 neuronal PAS domain protein 2 -0.0425318
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0423228
EXT1 exostosin glycosyltransferase 1 -0.0423226
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0417981
GNAS GNAS complex locus -0.0417691
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0413883
CALR calreticulin -0.0403577
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0399798
RPL26 ribosomal protein L26 -0.0399331
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0393463
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0391974
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0390704
UBC ubiquitin C -0.039031
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.038927
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0387516
GPC6 glypican 6 -0.036774
RPS13 ribosomal protein S13 -0.0364319
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0362616
DTNA dystrobrevin, alpha -0.0361593
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.036
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0359303
RPS14 ribosomal protein S14 -0.0358704
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0358592
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0356767
CALD1 caldesmon 1 -0.0355899
TF transferrin -0.0355599
PTMA prothymosin, alpha -0.03555
RPS29 ribosomal protein S29 -0.0353979
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0344683
GMDS GDP-mannose 4,6-dehydratase -0.0340423
RPL37 ribosomal protein L37 -0.0339551
CYB5R3 cytochrome b5 reductase 3 -0.033879
GSE1 Gse1 coiled-coil protein -0.033665
NKD1 naked cuticle homolog 1 (Drosophila) -0.0336041
PLIN2 perilipin 2 -0.0335311
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0333985
TPM4 tropomyosin 4 -0.0331947
RPS8 ribosomal protein S8 -0.0328979
SETD5 SET domain containing 5 -0.0326117
RPL5 ribosomal protein L5 -0.0325815
FBF1 Fas (TNFRSF6) binding factor 1 -0.0319422
RPS11 ribosomal protein S11 -0.0316212
KIF21A kinesin family member 21A -0.0314729
STAU1 staufen double-stranded RNA binding protein 1 -0.0310582
RPL9 ribosomal protein L9 -0.030997
ZFHX3 zinc finger homeobox 3 -0.0309206
ACTN4 actinin, alpha 4 -0.0307799
ANKRD10 ankyrin repeat domain 10 -0.0306706
WDR45B WD repeat domain 45B -0.030658
TRIM26 tripartite motif containing 26 -0.0306517
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.030244