Bergenin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.186283
CD44 CD44 molecule (Indian blood group) 0.125041
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.10761
ELL2 elongation factor, RNA polymerase II, 2 0.101611
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.089751
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0897167
ZEB2 zinc finger E-box binding homeobox 2 0.0849687
SMAD3 SMAD family member 3 0.0838556
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0822665
ARHGAP5 Rho GTPase activating protein 5 0.0680472
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0657678
TGM2 transglutaminase 2 0.065028
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0633825
EFNA5 ephrin-A5 0.0608641
NAMPT nicotinamide phosphoribosyltransferase 0.0600302
NAV2 neuron navigator 2 0.059341
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0528864
DOCK5 dedicator of cytokinesis 5 0.0505466
FNDC3B fibronectin type III domain containing 3B 0.0493583
STK38L serine/threonine kinase 38 like 0.0491333
HIPK2 homeodomain interacting protein kinase 2 0.0475671
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0469103
LHFPL2 lipoma HMGIC fusion partner-like 2 0.04637
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0459396
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0452252
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0447718
FAM13A family with sequence similarity 13, member A 0.0435367
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.043109
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0410421
NTN4 netrin 4 0.0406292
WWTR1 WW domain containing transcription regulator 1 0.0400904
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0391796
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0382969
ANKRD28 ankyrin repeat domain 28 0.038158
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0371372
SIK3 SIK family kinase 3 0.0367834
ADD3 adducin 3 (gamma) 0.0367762
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0365183
PELI1 pellino E3 ubiquitin protein ligase 1 0.0364091
BASP1 brain abundant, membrane attached signal protein 1 0.0350847
VEGFC vascular endothelial growth factor C 0.0349189
BACE2 beta-site APP-cleaving enzyme 2 0.034225
H1-0 H1.0 linker histone 0.0341959
IL1R1 interleukin 1 receptor, type I 0.0339997
HAS2 hyaluronan synthase 2 0.0329976
ZBTB38 zinc finger and BTB domain containing 38 0.0329748
CTNND1 catenin (cadherin-associated protein), delta 1 0.0326473
SPRED2 sprouty-related, EVH1 domain containing 2 0.0324546
IRAK2 interleukin-1 receptor-associated kinase 2 0.0323989
FBXL13 F-box and leucine-rich repeat protein 13 0.0321163
MAST4 microtubule associated serine/threonine kinase family member 4 0.0316704
DSCAM Down syndrome cell adhesion molecule 0.0316507
TOP1 topoisomerase (DNA) I 0.0316055
KLF6 Kruppel-like factor 6 0.0314944
RAD51B RAD51 paralog B 0.0307412
RAP1B RAP1B, member of RAS oncogene family 0.0291132
ZC3H12C zinc finger CCCH-type containing 12C 0.0290165
AMPD3 adenosine monophosphate deaminase 3 0.0284779
PFKP phosphofructokinase, platelet 0.0284317
ERRFI1 ERBB receptor feedback inhibitor 1 0.0283946
PRELID2 PRELI domain containing 2 0.0283062
NRP1 neuropilin 1 0.0282548
ESYT2 extended synaptotagmin-like protein 2 0.0280329
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0277384
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0276372
AHNAK AHNAK nucleoprotein 0.0270524
PTPRM protein tyrosine phosphatase, receptor type, M 0.0269042
TMCC3 transmembrane and coiled-coil domain family 3 0.0265578
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0264083
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0262201
ATP13A3 ATPase type 13A3 0.0256323
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0254901
FHL2 four and a half LIM domains 2 0.0253741
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0252354
TUT7 terminal uridylyl transferase 7 0.0249217
PTBP3 polypyrimidine tract binding protein 3 0.0249039
ANTXR2 anthrax toxin receptor 2 0.0248496
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0248419
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0248065
NPC1 Niemann-Pick disease, type C1 0.0247239
RNF24 ring finger protein 24 0.0245409
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0244376
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0243863
IL6ST interleukin 6 signal transducer 0.0242645
CA12 carbonic anhydrase XII 0.0242631
KIAA1217 KIAA1217 0.0242069
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0238694
JMJD1C jumonji domain containing 1C 0.0236038
FAM107B family with sequence similarity 107, member B 0.023601
CORO1C coronin, actin binding protein, 1C 0.0235239
EPS8 epidermal growth factor receptor pathway substrate 8 0.0235065
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.023323
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0230487
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0229971
EZR ezrin 0.022518
DPYSL3 dihydropyrimidinase-like 3 0.0223925
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0223011
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0220672
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0220212
ARHGAP42 Rho GTPase activating protein 42 0.0218527

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.15353
IGFBP3 insulin-like growth factor binding protein 3 -0.14303
CXCL8 chemokine (C-X-C motif) ligand 8 -0.131618
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128475
FN1 fibronectin 1 -0.123298
SDK1 sidekick cell adhesion molecule 1 -0.115194
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.107337
CDH13 cadherin 13 -0.106144
P4HB prolyl 4-hydroxylase, beta polypeptide -0.09956
NRG1 neuregulin 1 -0.0915527
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0782975
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0763773
VIM vimentin -0.0734908
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.073352
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0719736
VEGFA vascular endothelial growth factor A -0.0711304
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0697988
GPC6 glypican 6 -0.0682547
MEF2A myocyte enhancer factor 2A -0.0674025
DPYD dihydropyrimidine dehydrogenase -0.0663592
FTL ferritin, light polypeptide -0.061012
PKM pyruvate kinase, muscle -0.0599259
LDHA lactate dehydrogenase A -0.0591648
MTSS1 metastasis suppressor 1 -0.0574004
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0560866
GOLGA4 golgin A4 -0.0533136
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0529795
MAML3 mastermind-like 3 (Drosophila) -0.0523748
DLG1 discs, large homolog 1 (Drosophila) -0.0509493
HMGA1 high mobility group AT-hook 1 -0.0505915
POTEF POTE ankyrin domain family, member F -0.0496133
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0488141
MRPS6 mitochondrial ribosomal protein S6 -0.0477732
RPL35A ribosomal protein L35a -0.0474957
TFPI2 tissue factor pathway inhibitor 2 -0.0463264
PSD3 pleckstrin and Sec7 domain containing 3 -0.0463113
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0437554
PTMA prothymosin, alpha -0.0433045
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0431667
EFCAB13 EF-hand calcium binding domain 13 -0.0410242
FBN1 fibrillin 1 -0.0406152
EGR1 early growth response 1 -0.0403423
RPS6 ribosomal protein S6 -0.0400904
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.040026
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0397589
LMAN1 lectin, mannose-binding, 1 -0.0394062
DDIT3 DNA-damage-inducible transcript 3 -0.0394033
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0389665
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0389332
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.038259
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0377573
RPLP1 ribosomal protein, large, P1 -0.0373799
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0371647
ENO2 enolase 2 (gamma, neuronal) -0.0368751
RPS19 ribosomal protein S19 -0.0365118
USP34 ubiquitin specific peptidase 34 -0.0364992
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0359842
TBC1D22A TBC1 domain family, member 22A -0.0354396
CDK14 cyclin-dependent kinase 14 -0.0353298
RPL23 ribosomal protein L23 -0.0353174
PDIA3 protein disulfide isomerase family A, member 3 -0.0352694
RPS24 ribosomal protein S24 -0.0345755
RPL31 ribosomal protein L31 -0.0342125
S100A6 S100 calcium binding protein A6 -0.0339526
LOC112694756 uncharaterized LOC112694756 -0.0338668
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0337429
VRK2 vaccinia related kinase 2 -0.0335685
DNER delta/notch-like EGF repeat containing -0.0335438
MECOM MDS1 and EVI1 complex locus -0.0325078
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0322945
NDRG1 N-myc downstream regulated 1 -0.03212
NAV3 neuron navigator 3 -0.0320056
TTC3 tetratricopeptide repeat domain 3 -0.0318421
DIAPH2 diaphanous-related formin 2 -0.0315036
B2M beta-2-microglobulin -0.0310545
RPS23 ribosomal protein S23 -0.0309576
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0307718
TMEM165 transmembrane protein 165 -0.0306862
PCBP2 poly(rC) binding protein 2 -0.0305865
RPL37A ribosomal protein L37a -0.0303571
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0300513
EEF2 eukaryotic translation elongation factor 2 -0.0298878
DENND1A DENN/MADD domain containing 1A -0.0298115
CALR calreticulin -0.0297792
MSRB3 methionine sulfoxide reductase B3 -0.0297655
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297616
ARF4 ADP-ribosylation factor 4 -0.0296773
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0296614
RPL34 ribosomal protein L34 -0.0294388
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0293848
TNS3 tensin 3 -0.0290309
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0289414
EIF1 eukaryotic translation initiation factor 1 -0.0289173
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0285667
ATG7 autophagy related 7 -0.0284743
SOD2 superoxide dismutase 2, mitochondrial -0.0284202
TRPS1 trichorhinophalangeal syndrome I -0.0280185
RPL32 ribosomal protein L32 -0.0279514
IFI6 interferon, alpha-inducible protein 6 -0.027896
CUX1 cut-like homeobox 1 -0.0278113