Bergenin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.18879
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.157674
AKAP12 A kinase (PRKA) anchor protein 12 0.136789
TM4SF1 transmembrane 4 L six family member 1 0.0777453
EIF1 eukaryotic translation initiation factor 1 0.0651668
ACTG1 actin gamma 1 0.0538586
HLA-A major histocompatibility complex, class I, A 0.0494169
CAVIN1 caveolae associated protein 1 0.0481308
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0471716
FTH1 ferritin, heavy polypeptide 1 0.0451441
MCL1 myeloid cell leukemia 1 0.0430294
STC1 stanniocalcin 1 0.042892
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0420757
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0405733
RPL4 ribosomal protein L4 0.0384317
PYGL phosphorylase, glycogen, liver 0.0373663
HLA-B major histocompatibility complex, class I, B 0.0341863
LOC102724023 ES1 protein homolog, mitochondrial 0.0329018
JUN jun proto-oncogene 0.0327528
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0305384
SNX14 sorting nexin 14 0.029283
IL6 interleukin 6 0.0277336
ANGPTL4 angiopoietin-like 4 0.0275672
ERRFI1 ERBB receptor feedback inhibitor 1 0.0274444
RPS2 ribosomal protein S2 0.0268544
TPT1 tumor protein, translationally-controlled 1 0.0266999
HLA-E major histocompatibility complex, class I, E 0.0256448
CCL5 chemokine (C-C motif) ligand 5 0.0251881
FMNL2 formin-like 2 0.0246345
PRDX1 peroxiredoxin 1 0.0245672
RACK1 receptor for activated C kinase 1 0.0240642
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0237633
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0231378
SAMD4A sterile alpha motif domain containing 4A 0.0219879
FLNB filamin B, beta 0.0219653
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0214185
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0212565
SQSTM1 sequestosome 1 0.0206409
LAMC2 laminin, gamma 2 0.0205359
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0204349
RPL26 ribosomal protein L26 0.020043
RPL3 ribosomal protein L3 0.0198968
PCBP1 poly(rC) binding protein 1 0.0197473
GOLGA4 golgin A4 0.0194108
ZFHX3 zinc finger homeobox 3 0.0191535
BASP1 brain abundant, membrane attached signal protein 1 0.0187312
PLAUR plasminogen activator, urokinase receptor 0.0186958
TIMP1 TIMP metallopeptidase inhibitor 1 0.0186743
ATF4 activating transcription factor 4 0.0186319
RPL37A ribosomal protein L37a 0.0184946
BRD2 bromodomain containing 2 0.0184761
MT1X metallothionein 1X 0.0182117
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0181634
RPL37 ribosomal protein L37 0.0177755
INHBA inhibin, beta A 0.0177664
NIPBL Nipped-B homolog (Drosophila) 0.0175063
EGR1 early growth response 1 0.0166236
EPAS1 endothelial PAS domain protein 1 0.016466
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0160474
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0159627
RPS3 ribosomal protein S3 0.0156387
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.015555
ENO1 enolase 1, (alpha) 0.0155078
SEC31A SEC31 homolog A (S. cerevisiae) 0.0153888
RPS12 ribosomal protein S12 0.0152168
DSE dermatan sulfate epimerase 0.0151017
BTG1 B-cell translocation gene 1, anti-proliferative 0.0148999
RAB7A RAB7A, member RAS oncogene family 0.0148562
RPS17 ribosomal protein S17 0.0147047
ITGA6 integrin, alpha 6 0.0146972
TCIM transcriptional and immune response regulator 0.0144228
HSPA8 heat shock 70kDa protein 8 0.0143226
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0141243
RPL13A ribosomal protein L13a 0.0140875
ADM adrenomedullin 0.0140162
LDHA lactate dehydrogenase A 0.0140136
IER3 immediate early response 3 0.0139592
RIGI RNA sensor RIG-I 0.0139271
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.0138469
RPS27A ribosomal protein S27a 0.0137828
AHNAK2 AHNAK nucleoprotein 2 0.0136658
NEBL nebulette 0.0135082
AKAP17A A kinase (PRKA) anchor protein 17A 0.0134276
ANO6 anoctamin 6 0.0134019
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.013171
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0130629
RPS8 ribosomal protein S8 0.0130342
CD44 CD44 molecule (Indian blood group) 0.012981
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0129779
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.012742
SOD2 superoxide dismutase 2, mitochondrial 0.0124892
FYTTD1 forty-two-three domain containing 1 0.0122387
NNMT nicotinamide N-methyltransferase 0.0121509
NDRG1 N-myc downstream regulated 1 0.0119796
TERF2IP telomeric repeat binding factor 2, interacting protein 0.0119342
MORF4L2 mortality factor 4 like 2 0.0118913
FAM110C family with sequence similarity 110, member C 0.0118532
PGK1 phosphoglycerate kinase 1 0.011579
PMM2 phosphomannomutase 2 0.0114975
CSNK1A1 casein kinase 1, alpha 1 0.011437

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.149922
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.121423
GRAMD1B GRAM domain containing 1B -0.112218
TXNRD1 thioredoxin reductase 1 -0.0898849
PM20D1 peptidase M20 domain containing 1 -0.0872432
PDE4D phosphodiesterase 4D, cAMP-specific -0.0819899
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0763582
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0753918
ZFAND3 zinc finger, AN1-type domain 3 -0.0678761
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0650987
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0600258
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0573325
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0533308
UBASH3B ubiquitin associated and SH3 domain containing B -0.0487879
BICC1 BicC family RNA binding protein 1 -0.0467986
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0466342
SLC38A2 solute carrier family 38, member 2 -0.0447862
PFN1 profilin 1 -0.0443222
PKM pyruvate kinase, muscle -0.043856
THSD4 thrombospondin, type I, domain containing 4 -0.0431825
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.043072
PTK2 protein tyrosine kinase 2 -0.042928
DENND4A DENN/MADD domain containing 4A -0.0408827
RPL23 ribosomal protein L23 -0.0406981
RPS21 ribosomal protein S21 -0.0403891
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0399805
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.039936
CMIP c-Maf inducing protein -0.0398525
DST dystonin -0.039702
ANKRD11 ankyrin repeat domain 11 -0.0388943
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0384911
TRIO trio Rho guanine nucleotide exchange factor -0.0383606
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0360247
USP3 ubiquitin specific peptidase 3 -0.0360075
PARD3 par-3 family cell polarity regulator -0.0360071
CALR calreticulin -0.0359043
EFNA5 ephrin-A5 -0.0354066
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0344703
FNDC3B fibronectin type III domain containing 3B -0.034242
FGB fibrinogen beta chain -0.0342069
FTL ferritin, light polypeptide -0.0320119
SVIL supervillin -0.0314143
ADAM9 ADAM metallopeptidase domain 9 -0.0314038
PDIA6 protein disulfide isomerase family A, member 6 -0.0308994
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0304459
WDR43 WD repeat domain 43 -0.0302855
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0302399
NEGR1 neuronal growth regulator 1 -0.0300929
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0300702
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0298866
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0298806
ECT2 epithelial cell transforming 2 -0.0298036
RBM39 RNA binding motif protein 39 -0.029778
KYNU kynureninase -0.0294014
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0292093
CHN1 chimerin 1 -0.0286078
RHEB Ras homolog enriched in brain -0.0285674
ZNF207 zinc finger protein 207 -0.0285512
HMGA1 high mobility group AT-hook 1 -0.028157
SMOC1 SPARC related modular calcium binding 1 -0.0274665
ZNF292 zinc finger protein 292 -0.0272588
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0272338
TPM1 tropomyosin 1 (alpha) -0.0271475
RPL19 ribosomal protein L19 -0.0270494
OLA1 Obg-like ATPase 1 -0.0265797
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0264991
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0263203
MRTFA myocardin related transcription factor A -0.0261905
SMAD2 SMAD family member 2 -0.0260606
YBX1 Y box binding protein 1 -0.0259587
HDAC9 histone deacetylase 9 -0.025703
ACTN1 actinin, alpha 1 -0.025665
LPP LIM domain containing preferred translocation partner in lipoma -0.0255644
PLS3 plastin 3 -0.0254559
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0253999
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.025347
CANX calnexin -0.0250451
DOCK4 dedicator of cytokinesis 4 -0.0249675
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0249179
PTMA prothymosin, alpha -0.0247592
RTN4 reticulon 4 -0.0244321
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.02436
RPS19 ribosomal protein S19 -0.0243326
TMEM131 transmembrane protein 131 -0.0242175
CYRIB CYFIP related Rac1 interactor B -0.0237169
SERF2 small EDRK-rich factor 2 -0.0235575
MORF4L1 mortality factor 4 like 1 -0.0235267
IPO7 importin 7 -0.0234364
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0233999
BICD1 bicaudal D homolog 1 (Drosophila) -0.0233426
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0233298
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0232456
YME1L1 YME1-like 1 ATPase -0.0232432
FUS FUS RNA binding protein -0.0232111
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0231476
NFE2L2 nuclear factor, erythroid 2-like 2 -0.023084
OSBPL9 oxysterol binding protein-like 9 -0.0230277
TRA2B transformer 2 beta homolog (Drosophila) -0.0229488
MAP1B microtubule-associated protein 1B -0.0228701
ADGRG6 adhesion G protein-coupled receptor G6 -0.022859