Bergenin_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.115688
PM20D1 peptidase M20 domain containing 1 0.0999839
PDLIM5 PDZ and LIM domain 5 0.0808472
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0752373
KYNU kynureninase 0.0655043
PSD3 pleckstrin and Sec7 domain containing 3 0.0627489
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0589273
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0587457
COL4A5 collagen, type IV, alpha 5 0.0570116
NPAS2 neuronal PAS domain protein 2 0.052962
COL8A1 collagen, type VIII, alpha 1 0.0523078
GRAMD1B GRAM domain containing 1B 0.0521061
NAMPT nicotinamide phosphoribosyltransferase 0.0518555
TRIO trio Rho guanine nucleotide exchange factor 0.051711
ZEB2 zinc finger E-box binding homeobox 2 0.0495136
COL5A2 collagen, type V, alpha 2 0.046365
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0457325
NEK7 NIMA-related kinase 7 0.0432851
MYOF myoferlin 0.0426432
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0418006
GDA guanine deaminase 0.0416105
DOCK4 dedicator of cytokinesis 4 0.0408539
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0391535
PDE10A phosphodiesterase 10A 0.0378896
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0372583
ESYT2 extended synaptotagmin-like protein 2 0.036576
ELL2 elongation factor, RNA polymerase II, 2 0.0352724
COL4A6 collagen, type IV, alpha 6 0.0347697
LIMCH1 LIM and calponin homology domains 1 0.0341015
CD109 CD109 molecule 0.0322066
FMNL2 formin-like 2 0.030898
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0302481
SAMD4A sterile alpha motif domain containing 4A 0.0294698
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0263409
TGFBR1 transforming growth factor, beta receptor 1 0.0255164
FNDC3A fibronectin type III domain containing 3A 0.0237203
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0236149
AGFG1 ArfGAP with FG repeats 1 0.0229566
FLNB filamin B, beta 0.0229383
DNER delta/notch-like EGF repeat containing 0.022922
ITPRID2 ITPR interacting domain containing 2 0.0227675
SMAD2 SMAD family member 2 0.0223024
AKAP13 A kinase (PRKA) anchor protein 13 0.0220969
SMOC1 SPARC related modular calcium binding 1 0.0220704
BCAR3 breast cancer anti-estrogen resistance 3 0.021971
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218861
RGS2 regulator of G-protein signaling 2 0.0216644
CTIF CBP80/20-dependent translation initiation factor 0.021598
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.020911
DST dystonin 0.020153
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0198621
ERRFI1 ERBB receptor feedback inhibitor 1 0.0195666
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0194179
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0192299
ATP13A3 ATPase type 13A3 0.0192196
EPHA4 EPH receptor A4 0.0191115
PDE4D phosphodiesterase 4D, cAMP-specific 0.0188072
ANXA1 annexin A1 0.0186958
PYGL phosphorylase, glycogen, liver 0.0186697
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0182095
TGFBI transforming growth factor, beta-induced, 68kDa 0.0180994
DOCK5 dedicator of cytokinesis 5 0.0180532
MAML3 mastermind-like 3 (Drosophila) 0.0180512
BMP6 bone morphogenetic protein 6 0.0175373
NCKAP1 NCK-associated protein 1 0.0173931
DISP1 dispatched homolog 1 (Drosophila) 0.017101
CARD16 caspase recruitment domain family, member 16 0.0169314
CXCL8 chemokine (C-X-C motif) ligand 8 0.0167197
EZR ezrin 0.0165498
CHL1 cell adhesion molecule L1-like 0.0165325
NBAS neuroblastoma amplified sequence 0.0164709
ARHGAP29 Rho GTPase activating protein 29 0.016248
FAM13A family with sequence similarity 13, member A 0.0161244
ZC3H11A zinc finger CCCH-type containing 11A 0.0160702
P3H2 prolyl 3-hydroxylase 2 0.0159292
BDNF brain-derived neurotrophic factor 0.0158209
FNDC3B fibronectin type III domain containing 3B 0.015757
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0155667
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0149373
PLCB4 phospholipase C, beta 4 0.0149128
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0148818
PTPRM protein tyrosine phosphatase, receptor type, M 0.0146017
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0144926
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.014361
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0142157
PRELID2 PRELI domain containing 2 0.0141967
TNPO1 transportin 1 0.0141937
MALT1 MALT1 paracaspase 0.0141895
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0139598
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0138823
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0136302
CEP170 centrosomal protein 170kDa 0.013571
TNIP1 TNFAIP3 interacting protein 1 0.0135375
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0134674
USP9X ubiquitin specific peptidase 9, X-linked 0.0134535
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0132876
MARCHF1 membrane associated ring-CH-type finger 1 0.0132603
ARB2A ARB2 cotranscriptional regulator A 0.0131135
NCAM1 neural cell adhesion molecule 1 0.0130677
CCDC68 coiled-coil domain containing 68 0.01303

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.210782
VIM vimentin -0.187905
TPT1 tumor protein, translationally-controlled 1 -0.157168
PTMA prothymosin, alpha -0.153696
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.147373
TMSB10 thymosin beta 10 -0.120194
RPS6 ribosomal protein S6 -0.116145
RPL35A ribosomal protein L35a -0.109525
RPLP1 ribosomal protein, large, P1 -0.100966
RPS8 ribosomal protein S8 -0.10085
RPS24 ribosomal protein S24 -0.0960122
RPL31 ribosomal protein L31 -0.0950824
FTL ferritin, light polypeptide -0.0947637
RPL37A ribosomal protein L37a -0.0887386
HLA-B major histocompatibility complex, class I, B -0.0785483
RPS23 ribosomal protein S23 -0.0714387
RPS13 ribosomal protein S13 -0.0712854
RPL34 ribosomal protein L34 -0.067221
RPS29 ribosomal protein S29 -0.0667332
RPL7A ribosomal protein L7a -0.0664056
RPS19 ribosomal protein S19 -0.0662106
RPL19 ribosomal protein L19 -0.0642967
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0642961
RPL26 ribosomal protein L26 -0.0642166
RPS27A ribosomal protein S27a -0.0635035
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0631384
RPL38 ribosomal protein L38 -0.0629729
RPS25 ribosomal protein S25 -0.0617981
RPL12 ribosomal protein L12 -0.0613708
RPL11 ribosomal protein L11 -0.0588978
RPL37 ribosomal protein L37 -0.0587705
RPL36A ribosomal protein L36a -0.0576066
RPS12 ribosomal protein S12 -0.0568971
RPL23 ribosomal protein L23 -0.0568864
B2M beta-2-microglobulin -0.0546838
RPLP2 ribosomal protein, large, P2 -0.0545266
EIF1 eukaryotic translation initiation factor 1 -0.0533224
RPL9 ribosomal protein L9 -0.0531379
CTSL cathepsin L -0.0510116
RPS16 ribosomal protein S16 -0.0500528
PKM pyruvate kinase, muscle -0.0488864
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0476327
RPL13A ribosomal protein L13a -0.0458014
VDAC1 voltage-dependent anion channel 1 -0.0451373
RPS14 ribosomal protein S14 -0.0449629
ACTG1 actin gamma 1 -0.0445876
RPS21 ribosomal protein S21 -0.043914
RPLP0 ribosomal protein, large, P0 -0.0436054
RPS27 ribosomal protein S27 -0.0428268
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.042141
RPL36 ribosomal protein L36 -0.0421177
RPS17 ribosomal protein S17 -0.0416611
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0413921
RPS3 ribosomal protein S3 -0.039124
RPS11 ribosomal protein S11 -0.0390015
S100A10 S100 calcium binding protein A10 -0.037678
S100A6 S100 calcium binding protein A6 -0.0374006
NALF1 NALCN channel auxiliary factor 1 -0.0371164
PDIA3 protein disulfide isomerase family A, member 3 -0.0370241
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0359625
RPS20 ribosomal protein S20 -0.0354994
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0354194
RPL27A ribosomal protein L27a -0.0349003
GNAS GNAS complex locus -0.0348056
STC1 stanniocalcin 1 -0.0340311
LDHA lactate dehydrogenase A -0.0333217
ENO1 enolase 1, (alpha) -0.0332488
RPS5 ribosomal protein S5 -0.0331046
SQSTM1 sequestosome 1 -0.0328087
HLA-A major histocompatibility complex, class I, A -0.0327957
RPL8 ribosomal protein L8 -0.0325921
RPL35 ribosomal protein L35 -0.032458
NAP1L1 nucleosome assembly protein 1-like 1 -0.0322169
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.032154
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0320348
CALR calreticulin -0.0316403
WARS1 tryptophanyl-tRNA synthetase 1 -0.0308485
KPNB1 karyopherin (importin) beta 1 -0.0302161
VCL vinculin -0.0301667
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.029832
CDH13 cadherin 13 -0.029804
TPM4 tropomyosin 4 -0.0295969
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0291824
RPL32 ribosomal protein L32 -0.0290166
EEF2 eukaryotic translation elongation factor 2 -0.0288404
RPS10 ribosomal protein S10 -0.0286783
POTEF POTE ankyrin domain family, member F -0.0285361
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0279474
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0273444
RPL28 ribosomal protein L28 -0.0271211
RPS15 ribosomal protein S15 -0.0270755
NDRG1 N-myc downstream regulated 1 -0.0267965
RPL7 ribosomal protein L7 -0.0265582
RPL30 ribosomal protein L30 -0.0264741
RAN RAN, member RAS oncogene family -0.0262275
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0259812
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0259626
WSB1 WD repeat and SOCS box containing 1 -0.0256545
RPL10A ribosomal protein L10a -0.0256188
IFIH1 interferon induced with helicase C domain 1 -0.0255931