Bergenin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.23836
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.137649
PTMA prothymosin, alpha 0.101193
COL3A1 collagen, type III, alpha 1 0.0875115
TMSB10 thymosin beta 10 0.0740058
RPS16 ribosomal protein S16 0.0719726
RPS12 ribosomal protein S12 0.0667251
ENO1 enolase 1, (alpha) 0.0653981
B2M beta-2-microglobulin 0.0636092
RPS8 ribosomal protein S8 0.0635958
RPS6 ribosomal protein S6 0.0625055
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0624357
ACTG1 actin gamma 1 0.0599813
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0570077
SNX6 sorting nexin 6 0.0568274
JMJD1C jumonji domain containing 1C 0.0553915
EIF1 eukaryotic translation initiation factor 1 0.0539876
RPL19 ribosomal protein L19 0.0520624
MDK midkine (neurite growth-promoting factor 2) 0.0514115
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0492493
H1-0 H1.0 linker histone 0.0484844
RPS19 ribosomal protein S19 0.0453628
FN1 fibronectin 1 0.0446147
PGK1 phosphoglycerate kinase 1 0.0443003
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0440023
RPLP1 ribosomal protein, large, P1 0.0437959
TPT1 tumor protein, translationally-controlled 1 0.0423429
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0421215
ANKRD12 ankyrin repeat domain 12 0.0402595
RPS25 ribosomal protein S25 0.0400933
RPS2 ribosomal protein S2 0.0399335
AKAP9 A kinase (PRKA) anchor protein 9 0.0396973
RPL11 ribosomal protein L11 0.0395457
RPL37A ribosomal protein L37a 0.0388618
ISG15 ISG15 ubiquitin-like modifier 0.038315
RPS3 ribosomal protein S3 0.0376059
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0371377
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0362787
KMT2C lysine (K)-specific methyltransferase 2C 0.0360898
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0348566
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0346242
SCAF11 SR-related CTD-associated factor 11 0.0344157
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0341944
RPL26 ribosomal protein L26 0.0333446
WSB1 WD repeat and SOCS box containing 1 0.0332008
AKAP12 A kinase (PRKA) anchor protein 12 0.0324569
RPL30 ribosomal protein L30 0.0317738
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.031508
RPLP0 ribosomal protein, large, P0 0.0312671
FTL ferritin, light polypeptide 0.0311757
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0309765
RPL12 ribosomal protein L12 0.0306425
HSPB1 heat shock 27kDa protein 1 0.0305376
IGF2 insulin-like growth factor 2 0.0305317
RPL5 ribosomal protein L5 0.0303287
SQSTM1 sequestosome 1 0.0298051
PCDH18 protocadherin 18 0.0294248
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290384
RPL35A ribosomal protein L35a 0.0289096
DCP1A decapping mRNA 1A 0.028871
WWOX WW domain containing oxidoreductase 0.0288689
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0287905
TAOK1 TAO kinase 1 0.0287675
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0287436
RPL9 ribosomal protein L9 0.0286504
ZCCHC7 zinc finger, CCHC domain containing 7 0.02855
NBEAL1 neurobeachin-like 1 0.0282034
FOXG1 forkhead box G1 0.0281828
ZFP36L1 ZFP36 ring finger protein-like 1 0.0281751
MT2A metallothionein 2A 0.0277835
RPL37 ribosomal protein L37 0.0277632
RSL1D1 ribosomal L1 domain containing 1 0.0277425
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0274102
COL1A2 collagen, type I, alpha 2 0.0273594
SPTSSA serine palmitoyltransferase, small subunit A 0.0266893
RPL31 ribosomal protein L31 0.026256
RPS27A ribosomal protein S27a 0.0260845
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0258515
CEP350 centrosomal protein 350kDa 0.0254409
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0253486
REST RE1-silencing transcription factor 0.0250848
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0249694
DARS1 aspartyl-tRNA synthetase 1 0.0248724
STMN1 stathmin 1 0.0248095
RPS24 ribosomal protein S24 0.0245979
ZFR zinc finger RNA binding protein 0.0244761
PDIA3 protein disulfide isomerase family A, member 3 0.0243985
DDIT4 DNA-damage-inducible transcript 4 0.0242722
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0242522
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0240923
ZNF146 zinc finger protein 146 0.0240398
NSD3 nuclear receptor binding SET domain protein 3 0.0239045
EAPP E2F-associated phosphoprotein 0.023833
ZC3H12B zinc finger CCCH-type containing 12B 0.0237432
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0236893
FST follistatin 0.0236891
SFTPA2 surfactant protein A2 0.0236313
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0235669
PHF14 PHD finger protein 14 0.0234671
CALR calreticulin 0.0234485

decreased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 -0.13326
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0896524
ADGRV1 adhesion G protein-coupled receptor V1 -0.0802261
COL11A1 collagen, type XI, alpha 1 -0.075057
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0676863
ITGAV integrin, alpha V -0.0632146
MED13L mediator complex subunit 13-like -0.06203
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0619967
ADAM9 ADAM metallopeptidase domain 9 -0.0615473
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0600312
MYO10 myosin X -0.0546922
KCTD16 potassium channel tetramerization domain containing 16 -0.0523925
PGAP1 post-GPI attachment to proteins 1 -0.0519699
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.049528
PRR16 proline rich 16 -0.0483599
ANKRD33B ankyrin repeat domain 33B -0.0482906
CDC73 cell division cycle 73 -0.0479501
FNDC3B fibronectin type III domain containing 3B -0.0475979
ZEB2 zinc finger E-box binding homeobox 2 -0.0474624
STRN3 striatin, calmodulin binding protein 3 -0.0456694
SHROOM3 shroom family member 3 -0.0440579
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0438731
BMPR1A bone morphogenetic protein receptor, type IA -0.0428802
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0427641
QKI QKI, KH domain containing, RNA binding -0.0412058
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0408582
IGF1R insulin-like growth factor 1 receptor -0.0408142
GPC3 glypican 3 -0.0403915
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0396875
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0392677
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0385665
PUM1 pumilio RNA-binding family member 1 -0.0379724
ENAH enabled homolog (Drosophila) -0.0373464
RBM20 RNA binding motif protein 20 -0.036938
NTM neurotrimin -0.03691
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0363181
ZNF292 zinc finger protein 292 -0.0361562
TRPS1 trichorhinophalangeal syndrome I -0.0349314
TBL1X transducin (beta)-like 1X-linked -0.0349008
COL5A2 collagen, type V, alpha 2 -0.0344573
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.034176
WDR43 WD repeat domain 43 -0.0341404
TBC1D12 TBC1 domain family, member 12 -0.034109
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0336393
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0334025
RHEB Ras homolog enriched in brain -0.0327647
ZNF385D zinc finger protein 385D -0.0323719
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0319628
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0308112
AFF1 AF4/FMR2 family, member 1 -0.0301843
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0298159
FUBP1 far upstream element (FUSE) binding protein 1 -0.0294013
RFX7 regulatory factor X, 7 -0.0293676
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0292931
CHD1 chromodomain helicase DNA binding protein 1 -0.0290941
SLIT2 slit homolog 2 (Drosophila) -0.0288413
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0286364
PTK2 protein tyrosine kinase 2 -0.0285261
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0283578
TRIO trio Rho guanine nucleotide exchange factor -0.0281695
OPHN1 oligophrenin 1 -0.0277721
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0271957
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0271029
TMEM39A transmembrane protein 39A -0.0269729
HBP1 HMG-box transcription factor 1 -0.0268016
DST dystonin -0.0267651
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0267144
RBM39 RNA binding motif protein 39 -0.0260552
FAM171B family with sequence similarity 171, member B -0.0260006
JARID2 jumonji, AT rich interactive domain 2 -0.0258599
MCTP1 multiple C2 domains, transmembrane 1 -0.0257112
ZFAND3 zinc finger, AN1-type domain 3 -0.0256703
PTBP2 polypyrimidine tract binding protein 2 -0.0256581
HMCN1 hemicentin 1 -0.0255241
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0254611
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0253211
PICALM phosphatidylinositol binding clathrin assembly protein -0.0252829
ZNF608 zinc finger protein 608 -0.0252054
SPAG9 sperm associated antigen 9 -0.0250886
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0250801
CALCR calcitonin receptor -0.0250035
TFG TRK-fused gene -0.0249344
NELL2 NEL-like 2 (chicken) -0.0249129
SFPQ splicing factor proline/glutamine-rich -0.0248095
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0247508
USP3 ubiquitin specific peptidase 3 -0.0247153
UBN2 ubinuclein 2 -0.0246423
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0245337
RAB10 RAB10, member RAS oncogene family -0.0245139
POGZ pogo transposable element with ZNF domain -0.0241563
STAG2 stromal antigen 2 -0.0240877
ADGRL2 adhesion G protein-coupled receptor L2 -0.0239253
RLF rearranged L-myc fusion -0.0238374
BRWD1 bromodomain and WD repeat domain containing 1 -0.0238216
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.023819
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.02362
EWSR1 EWS RNA-binding protein 1 -0.0233847
PDGFC platelet derived growth factor C -0.0232721
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.023105
SAMD4A sterile alpha motif domain containing 4A -0.0230574