Bergenin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL3 ribosomal protein L3 0.0530345
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0436148
TXNRD1 thioredoxin reductase 1 0.0430375
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0396464
ZNF608 zinc finger protein 608 0.039415
MACROD2 MACRO domain containing 2 0.0377967
DSCAM Down syndrome cell adhesion molecule 0.0339411
EZR ezrin 0.0334421
RBM25 RNA binding motif protein 25 0.0320063
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0303579
AHCYL2 adenosylhomocysteinase-like 2 0.02932
RRBP1 ribosome binding protein 1 0.0290152
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0273034
H1-4 H1.4 linker histone, cluster member 0.0270011
GCLM glutamate-cysteine ligase, modifier subunit 0.0256587
SBF2 SET binding factor 2 0.0256128
CSF1 colony stimulating factor 1 (macrophage) 0.0253468
TXNIP thioredoxin interacting protein 0.0245019
YEATS2 YEATS domain containing 2 0.0243491
DNM1L dynamin 1-like 0.024028
TRIO trio Rho guanine nucleotide exchange factor 0.0232199
GSE1 Gse1 coiled-coil protein 0.0231462
FAM13A family with sequence similarity 13, member A 0.0230798
FAM91A1 family with sequence similarity 91, member A1 0.0230295
SMC3 structural maintenance of chromosomes 3 0.0228139
RNF213 ring finger protein 213 0.0226953
BLTP1 bridge-like lipid transfer protein family member 1 0.0223805
ECPAS Ecm29 proteasome adaptor and scaffold 0.0218551
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0217535
RSF1 remodeling and spacing factor 1 0.0206216
ZMYM2 zinc finger, MYM-type 2 0.0205854
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0205687
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0203154
SFTPA2 surfactant protein A2 0.0201642
ANKRD36 ankyrin repeat domain 36 0.0201214
FRYL FRY-like 0.019693
ITFG1 integrin alpha FG-GAP repeat containing 1 0.019488
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0194254
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0187318
UBAP2L ubiquitin associated protein 2-like 0.0185778
PCBP1 poly(rC) binding protein 1 0.0184444
WASL Wiskott-Aldrich syndrome-like 0.0183794
KDM4C lysine (K)-specific demethylase 4C 0.0182711
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0181695
SUCO SUN domain containing ossification factor 0.0180839
DENND5A DENN/MADD domain containing 5A 0.0180302
YAP1 Yes-associated protein 1 0.0179347
FUBP3 far upstream element (FUSE) binding protein 3 0.0179056
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0177474
HELZ helicase with zinc finger 0.0177209
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0176366
CHSY1 chondroitin sulfate synthase 1 0.0173313
ARRDC3 arrestin domain containing 3 0.0173249
KIF5C kinesin family member 5C 0.0172821
PICALM phosphatidylinositol binding clathrin assembly protein 0.0172519
CUL4A cullin 4A 0.0172409
CHD1L chromodomain helicase DNA binding protein 1-like 0.0172058
SLMAP sarcolemma associated protein 0.0172048
RAB18 RAB18, member RAS oncogene family 0.0171848
NXN nucleoredoxin 0.0170599
TPD52 tumor protein D52 0.0169682
MT2A metallothionein 2A 0.0166938
ENO1 enolase 1, (alpha) 0.0166936
RPS2 ribosomal protein S2 0.0166848
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0166231
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0164914
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.0164826
RIOK3 RIO kinase 3 0.016482
HIPK3 homeodomain interacting protein kinase 3 0.0164396
KPNA5 karyopherin alpha 5 (importin alpha 6) 0.0162433
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0161951
CDK19 cyclin-dependent kinase 19 0.016175
USP37 ubiquitin specific peptidase 37 0.0160142
SDK1 sidekick cell adhesion molecule 1 0.0160082
LRRC7 leucine rich repeat containing 7 0.0159245
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0158004
ANXA2 annexin A2 0.015734
FCHSD2 FCH and double SH3 domains 2 0.015685
PCBP2 poly(rC) binding protein 2 0.0156178
APLP2 amyloid beta (A4) precursor-like protein 2 0.0155375
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0155084
ATG10 autophagy related 10 0.0154953
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0154862
NCOA2 nuclear receptor coactivator 2 0.0154035
ARF4 ADP-ribosylation factor 4 0.0153556
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.0153394
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.0152815
MBNL1 muscleblind-like splicing regulator 1 0.0151836
KDM5D lysine (K)-specific demethylase 5D 0.0151516
MYH10 myosin, heavy chain 10, non-muscle 0.0150899
TBC1D5 TBC1 domain family, member 5 0.0150853
MYO5A myosin VA (heavy chain 12, myoxin) 0.0150508
NONO non-POU domain containing, octamer-binding 0.0150457
DCAF6 DDB1 and CUL4 associated factor 6 0.0149892
FLNA filamin A, alpha 0.0149889
DTNBP1 dystrobrevin binding protein 1 0.0149809
TBC1D20 TBC1 domain family, member 20 0.0149618
PLK2 polo-like kinase 2 0.014915
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0149131
MACO1 macoilin 1 0.0148632

decreased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific -0.263403
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.193246
CPED1 cadherin-like and PC-esterase domain containing 1 -0.162254
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133108
PTMA prothymosin, alpha -0.127568
BMP10 bone morphogenetic protein 10 -0.127123
SSBP2 single-stranded DNA binding protein 2 -0.115309
TMSB4X thymosin beta 4, X-linked -0.114523
FOXP1 forkhead box P1 -0.102211
DLG1 discs, large homolog 1 (Drosophila) -0.101968
TPT1 tumor protein, translationally-controlled 1 -0.10179
ZEB1 zinc finger E-box binding homeobox 1 -0.0950084
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0892368
RPL35A ribosomal protein L35a -0.0846367
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0816292
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0795694
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0791399
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0774775
TJP1 tight junction protein 1 -0.0725847
NBEA neurobeachin -0.0711139
EGFR epidermal growth factor receptor -0.0700067
VCL vinculin -0.0696607
AHNAK AHNAK nucleoprotein -0.0674583
LDHA lactate dehydrogenase A -0.0670827
CAMKMT calmodulin-lysine N-methyltransferase -0.0660403
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.06602
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0647242
GARS1 glycyl-tRNA synthetase 1 -0.0636841
PDE4D phosphodiesterase 4D, cAMP-specific -0.0632785
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0624503
IARS1 isoleucyl-tRNA synthetase 1 -0.0550517
ZFAND3 zinc finger, AN1-type domain 3 -0.0550145
EFNA5 ephrin-A5 -0.0537427
NFIA nuclear factor I/A -0.0521181
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0509616
DPYD dihydropyrimidine dehydrogenase -0.050148
RPL34 ribosomal protein L34 -0.0500648
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.049617
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0494983
PDE7B phosphodiesterase 7B -0.0493622
RPS24 ribosomal protein S24 -0.0487382
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0486355
RPL9 ribosomal protein L9 -0.0479961
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0465128
ASXL1 additional sex combs like transcriptional regulator 1 -0.0456007
PKM pyruvate kinase, muscle -0.0449387
ECT2 epithelial cell transforming 2 -0.0441884
NCEH1 neutral cholesterol ester hydrolase 1 -0.0440554
DENND1A DENN/MADD domain containing 1A -0.0439436
TCF12 transcription factor 12 -0.0436582
INTS6 integrator complex subunit 6 -0.0429868
NEBL nebulette -0.0419765
ANKRD11 ankyrin repeat domain 11 -0.0418846
SLC38A2 solute carrier family 38, member 2 -0.0418297
S100A6 S100 calcium binding protein A6 -0.0416674
PARD3 par-3 family cell polarity regulator -0.0415631
CCND1 cyclin D1 -0.0412698
CUX1 cut-like homeobox 1 -0.041245
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0407804
RPL31 ribosomal protein L31 -0.0405163
CLIC4 chloride intracellular channel 4 -0.0403261
BMP2K BMP2 inducible kinase -0.0403064
RPS13 ribosomal protein S13 -0.0402892
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0391413
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0388571
KPNB1 karyopherin (importin) beta 1 -0.0386284
EVI5 ecotropic viral integration site 5 -0.0385074
RPL26 ribosomal protein L26 -0.0382887
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0363441
TSC22D1 TSC22 domain family, member 1 -0.0357806
UBE3C ubiquitin protein ligase E3C -0.0357176
RPL13A ribosomal protein L13a -0.0348976
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0341461
KIAA2026 KIAA2026 -0.0339123
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0338365
LPP LIM domain containing preferred translocation partner in lipoma -0.033738
KDM4B lysine (K)-specific demethylase 4B -0.0334377
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0333729
RHOA ras homolog family member A -0.0332411
TBCA tubulin folding cofactor A -0.0328146
S100A4 S100 calcium binding protein A4 -0.0323142
MSRB3 methionine sulfoxide reductase B3 -0.0321012
MEF2A myocyte enhancer factor 2A -0.0316573
DNMBP dynamin binding protein -0.0311705
ZMYND8 zinc finger, MYND-type containing 8 -0.0310857
CLIP1 CAP-GLY domain containing linker protein 1 -0.0309007
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0308381
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0308297
SRRM2 serine/arginine repetitive matrix 2 -0.0304599
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0303189
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0298449
ONECUT2 one cut homeobox 2 -0.0298432
LOC112694756 uncharaterized LOC112694756 -0.0294728
TAOK1 TAO kinase 1 -0.0288996
RPL5 ribosomal protein L5 -0.028746
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0287423
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0285409
TTC17 tetratricopeptide repeat domain 17 -0.0281648
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0280639
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0280152