Bergenin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bergenin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bergenin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.057149
SMAD3 SMAD family member 3 0.0416738
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0331513
ANXA2 annexin A2 0.0294089
ARHGAP21 Rho GTPase activating protein 21 0.023796
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0235947
SLMAP sarcolemma associated protein 0.0221301
SQSTM1 sequestosome 1 0.0219579
APLP2 amyloid beta (A4) precursor-like protein 2 0.0219321
SET SET nuclear proto-oncogene 0.0217073
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0216992
AKAP12 A kinase (PRKA) anchor protein 12 0.0211795
BIRC2 baculoviral IAP repeat containing 2 0.0211447
RAB10 RAB10, member RAS oncogene family 0.020996
FTL ferritin, light polypeptide 0.0205918
RPS12 ribosomal protein S12 0.0199632
ANXA1 annexin A1 0.0198979
RPS3 ribosomal protein S3 0.0194355
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0186598
CTTN cortactin 0.0184559
AREG amphiregulin 0.0183128
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0181711
CAB39 calcium binding protein 39 0.018097
EPN2 epsin 2 0.0180034
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0179306
CAMTA1 calmodulin binding transcription activator 1 0.0179201
SON SON DNA binding protein 0.0177735
EPAS1 endothelial PAS domain protein 1 0.0175884
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0175525
EIF4A1 eukaryotic translation initiation factor 4A1 0.0175408
PRRC2B proline-rich coiled-coil 2B 0.0171665
TJP1 tight junction protein 1 0.0169136
MYH9 myosin, heavy chain 9, non-muscle 0.016779
GSN gelsolin 0.0166749
DUSP6 dual specificity phosphatase 6 0.0164295
H1-4 H1.4 linker histone, cluster member 0.0164231
TM4SF1 transmembrane 4 L six family member 1 0.0164083
ETNK1 ethanolamine kinase 1 0.016278
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0162412
KMT2C lysine (K)-specific methyltransferase 2C 0.0160853
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.016078
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0158119
WBP11 WW domain binding protein 11 0.0157448
CAPRIN2 caprin family member 2 0.0156949
RO60 Ro60, Y RNA binding protein 0.0156727
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0156698
UBB ubiquitin B 0.0155026
CAVIN1 caveolae associated protein 1 0.0154121
FBXL4 F-box and leucine-rich repeat protein 4 0.0153383
LMNA lamin A/C 0.0152945
RRM2 ribonucleotide reductase M2 0.0150351
RPL26 ribosomal protein L26 0.0148516
SFXN1 sideroflexin 1 0.0145589
RIOK3 RIO kinase 3 0.0144754
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0144583
S100A10 S100 calcium binding protein A10 0.0142054
XRN2 5'-3' exoribonuclease 2 0.0140724
CXCL8 chemokine (C-X-C motif) ligand 8 0.0140694
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0139713
KLF6 Kruppel-like factor 6 0.0138402
RPL4 ribosomal protein L4 0.0136078
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0135951
PLAUR plasminogen activator, urokinase receptor 0.0134947
DGKD diacylglycerol kinase, delta 130kDa 0.0134304
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0134078
ARFGEF3 ARFGEF family member 3 0.0131817
RPS2 ribosomal protein S2 0.0131388
B2M beta-2-microglobulin 0.0129734
ASPH aspartate beta-hydroxylase 0.0128605
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0128014
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.012671
SVIL supervillin 0.012668
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0126188
UBXN7 UBX domain protein 7 0.0124838
LAMB3 laminin, beta 3 0.0124404
CUL4B cullin 4B 0.0124125
KDM6B lysine (K)-specific demethylase 6B 0.0123946
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0123371
AK4 adenylate kinase 4 0.0121737
PTPRF protein tyrosine phosphatase, receptor type, F 0.0121343
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0120421
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0120007
TOP1 topoisomerase (DNA) I 0.0119846
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0119541
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0119392
SAFB scaffold attachment factor B 0.0119374
IDS iduronate 2-sulfatase 0.0119335
FLNB filamin B, beta 0.0119039
CCDC186 coiled-coil domain containing 186 0.0118087
COPA coatomer protein complex, subunit alpha 0.0117831
EIF2A eukaryotic translation initiation factor 2A, 65kDa 0.0117718
TBC1D15 TBC1 domain family, member 15 0.011743
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0117207
ENO1 enolase 1, (alpha) 0.0116802
EMP1 epithelial membrane protein 1 0.0116789
RPL3 ribosomal protein L3 0.0116409
BRD2 bromodomain containing 2 0.0115607
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0114996
CLEC1B C-type lectin domain family 1, member B 0.0113666
METTL16 methyltransferase like 16 0.0113567

decreased expression

Symbol Name Standardized Value
DST dystonin -0.0770208
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.065541
IGF2 insulin-like growth factor 2 -0.0612168
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.05953
TMSB10 thymosin beta 10 -0.0580201
LDHA lactate dehydrogenase A -0.057852
ATM ATM serine/threonine kinase -0.0558952
DNER delta/notch-like EGF repeat containing -0.054441
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0527894
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0495158
TRIO trio Rho guanine nucleotide exchange factor -0.0492444
VIM vimentin -0.0482459
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0480237
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0479797
FNDC3B fibronectin type III domain containing 3B -0.0472646
IGFBP3 insulin-like growth factor binding protein 3 -0.0472224
ZBTB20 zinc finger and BTB domain containing 20 -0.0468848
ZMYND8 zinc finger, MYND-type containing 8 -0.0460672
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.045741
ANKRD11 ankyrin repeat domain 11 -0.0456888
SMYD3 SET and MYND domain containing 3 -0.0449175
RAD51B RAD51 paralog B -0.0445863
RIGI RNA sensor RIG-I -0.0434998
ZNF638 zinc finger protein 638 -0.0425537
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0383238
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0380246
NCOR1 nuclear receptor corepressor 1 -0.037915
ERBIN erbb2 interacting protein -0.0378607
PKM pyruvate kinase, muscle -0.037094
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0358337
ATG7 autophagy related 7 -0.034686
THSD4 thrombospondin, type I, domain containing 4 -0.033174
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0329499
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0325667
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0322121
SAMD4A sterile alpha motif domain containing 4A -0.0321006
ZNF609 zinc finger protein 609 -0.0320735
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0319191
NALCN sodium leak channel, non selective -0.0318498
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0318482
PHF20 PHD finger protein 20 -0.031656
ZNF207 zinc finger protein 207 -0.031449
NDRG1 N-myc downstream regulated 1 -0.0313095
SPAG9 sperm associated antigen 9 -0.0308672
LOC112694756 uncharaterized LOC112694756 -0.0308522
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0308053
TAS2R14 taste receptor, type 2, member 14 -0.030652
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0306262
FTH1 ferritin, heavy polypeptide 1 -0.0304741
VMP1 vacuole membrane protein 1 -0.0304064
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0298931
AFF4 AF4/FMR2 family, member 4 -0.0297828
FBXL17 F-box and leucine-rich repeat protein 17 -0.0296367
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0293941
PHF21A PHD finger protein 21A -0.0293578
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0293355
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0292752
TPM4 tropomyosin 4 -0.0291292
PICALM phosphatidylinositol binding clathrin assembly protein -0.0291177
IL1RAP interleukin 1 receptor accessory protein -0.0280872
MAP1B microtubule-associated protein 1B -0.0279108
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0273664
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0273087
BPTF bromodomain PHD finger transcription factor -0.0271833
RPLP1 ribosomal protein, large, P1 -0.0271557
EGR1 early growth response 1 -0.0271329
ZBTB38 zinc finger and BTB domain containing 38 -0.0267199
RSF1 remodeling and spacing factor 1 -0.026713
WARS1 tryptophanyl-tRNA synthetase 1 -0.0265725
FMN1 formin 1 -0.0265666
AEBP2 AE binding protein 2 -0.0262894
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0262176
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0260332
NSD1 nuclear receptor binding SET domain protein 1 -0.0259009
TPT1 tumor protein, translationally-controlled 1 -0.025674
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0255896
IFIH1 interferon induced with helicase C domain 1 -0.0255581
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0255559
KMT2E lysine (K)-specific methyltransferase 2E -0.0255264
CD44 CD44 molecule (Indian blood group) -0.0255244
SOD2 superoxide dismutase 2, mitochondrial -0.0253431
RNF213 ring finger protein 213 -0.0252123
SCAPER S-phase cyclin A-associated protein in the ER -0.0251598
RSRC1 arginine/serine-rich coiled-coil 1 -0.0247931
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0247505
HMGA2 high mobility group AT-hook 2 -0.0247331
TMEM123 transmembrane protein 123 -0.0247001
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0246872
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0245402
UGCG UDP-glucose ceramide glucosyltransferase -0.0242223
DSE dermatan sulfate epimerase -0.0241949
MAML2 mastermind-like 2 (Drosophila) -0.0240548
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0238862
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0236958
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0236286
VDAC1 voltage-dependent anion channel 1 -0.0234998
R3HDM1 R3H domain containing 1 -0.0234953
RAI14 retinoic acid induced 14 -0.0234663
DPYD dihydropyrimidine dehydrogenase -0.0232256
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0231754