Bestatin (hydrochloride)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0626664
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0552645
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0533847
CALR calreticulin 0.0508035
ZBTB20 zinc finger and BTB domain containing 20 0.0428773
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.042607
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0407754
PDE4D phosphodiesterase 4D, cAMP-specific 0.0374494
CANX calnexin 0.0363265
CPOX coproporphyrinogen oxidase 0.0356547
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0353928
VMP1 vacuole membrane protein 1 0.033334
PCBP2 poly(rC) binding protein 2 0.0313436
BCAS3 breast carcinoma amplified sequence 3 0.0275001
ARL15 ADP-ribosylation factor-like 15 0.0266729
ANXA1 annexin A1 0.026369
TPM3 tropomyosin 3 0.0261761
YAP1 Yes-associated protein 1 0.0238733
ZNF148 zinc finger protein 148 0.0236746
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0233326
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0231313
EZR ezrin 0.0223027
AREG amphiregulin 0.0222594
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0222187
BIRC3 baculoviral IAP repeat containing 3 0.0214582
EEF2 eukaryotic translation elongation factor 2 0.0209637
PEG10 paternally expressed 10 0.0209354
PDIA6 protein disulfide isomerase family A, member 6 0.0208728
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0204546
TXNRD1 thioredoxin reductase 1 0.0204118
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0197634
EXOC6B exocyst complex component 6B 0.0196471
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0192697
ERRFI1 ERBB receptor feedback inhibitor 1 0.0192532
AHNAK AHNAK nucleoprotein 0.0191857
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.018869
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0186856
RPL3 ribosomal protein L3 0.0183358
PREPL prolyl endopeptidase-like 0.0178167
DSCAM Down syndrome cell adhesion molecule 0.0173167
ASPH aspartate beta-hydroxylase 0.0170428
EIF4A2 eukaryotic translation initiation factor 4A2 0.0168
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0165594
OXR1 oxidation resistance 1 0.0165454
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0164473
NRXN3 neurexin 3 0.0163283
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.016045
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0160232
EIF4B eukaryotic translation initiation factor 4B 0.0158703
HLA-A major histocompatibility complex, class I, A 0.0158589
SFTPA2 surfactant protein A2 0.0158133
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0157331
NEK7 NIMA-related kinase 7 0.0156956
EEF1G eukaryotic translation elongation factor 1 gamma 0.0156762
SERINC1 serine incorporator 1 0.0156673
MYH9 myosin, heavy chain 9, non-muscle 0.0155283
RNF13 ring finger protein 13 0.0155199
ARRDC3 arrestin domain containing 3 0.0153445
FBXL17 F-box and leucine-rich repeat protein 17 0.0152821
ARB2A ARB2 cotranscriptional regulator A 0.0150397
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0149723
MSH6 mutS homolog 6 0.0149435
EPHA6 EPH receptor A6 0.0149112
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0147816
WDPCP WD repeat containing planar cell polarity effector 0.0147727
LRMDA leucine rich melanocyte differentiation associated 0.0146628
KIF1B kinesin family member 1B 0.0144798
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0143401
PHC3 polyhomeotic homolog 3 (Drosophila) 0.014313
MAML3 mastermind-like 3 (Drosophila) 0.0143001
WNK1 WNK lysine deficient protein kinase 1 0.014285
PICALM phosphatidylinositol binding clathrin assembly protein 0.0142613
PLEC plectin 0.0140374
OGA O-GlcNAcase 0.0139561
FER fer (fps/fes related) tyrosine kinase 0.013686
HYOU1 hypoxia up-regulated 1 0.0135263
TRIP12 thyroid hormone receptor interactor 12 0.0135054
CHD4 chromodomain helicase DNA binding protein 4 0.0135008
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0134791
PDIA3 protein disulfide isomerase family A, member 3 0.013455
SET SET nuclear proto-oncogene 0.0134379
ATP11A ATPase, class VI, type 11A 0.0133657
FDXR ferredoxin reductase 0.0132899
HEXIM1 hexamethylene bis-acetamide inducible 1 0.0132222
NCEH1 neutral cholesterol ester hydrolase 1 0.0131881
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0131775
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0130805
MBNL1 muscleblind-like splicing regulator 1 0.0130427
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0130281
SEC23A Sec23 homolog A (S. cerevisiae) 0.012989
MCL1 myeloid cell leukemia 1 0.0129327
NCOR2 nuclear receptor corepressor 2 0.0128876
TNRC6B trinucleotide repeat containing 6B 0.0128064
ELOVL5 ELOVL fatty acid elongase 5 0.0128059
TBC1D5 TBC1 domain family, member 5 0.0127065
PTEN phosphatase and tensin homolog 0.0124954
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0124911
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0124501
RIMS2 regulating synaptic membrane exocytosis 2 0.0124069
NRDC nardilysin convertase 0.0123643

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188027
VIM vimentin -0.163072
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.133627
TMSB10 thymosin beta 10 -0.108706
ACTG1 actin gamma 1 -0.097551
TPT1 tumor protein, translationally-controlled 1 -0.0658315
TPI1 triosephosphate isomerase 1 -0.0628863
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0599596
HMGA2 high mobility group AT-hook 2 -0.0597041
MYL12B myosin, light chain 12B, regulatory -0.0572109
ANKRD12 ankyrin repeat domain 12 -0.0535149
MKI67 marker of proliferation Ki-67 -0.0480415
PTMA prothymosin, alpha -0.0472629
CENPF centromere protein F, 350/400kDa -0.0436007
NAP1L1 nucleosome assembly protein 1-like 1 -0.0418042
ANKRD28 ankyrin repeat domain 28 -0.0409705
IFIH1 interferon induced with helicase C domain 1 -0.0401313
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0387986
TUBA1B tubulin, alpha 1b -0.0379805
SMC4 structural maintenance of chromosomes 4 -0.0378036
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0373868
RPL35A ribosomal protein L35a -0.0373477
RAB7A RAB7A, member RAS oncogene family -0.0370413
RPS21 ribosomal protein S21 -0.0364219
RPL34 ribosomal protein L34 -0.0351061
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0348438
TMEM123 transmembrane protein 123 -0.0345114
NLGN1 neuroligin 1 -0.032669
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0325303
HMGB1 high mobility group box 1 -0.0314804
TAS2R14 taste receptor, type 2, member 14 -0.0313725
KPNB1 karyopherin (importin) beta 1 -0.0307951
CBX3 chromobox homolog 3 -0.0306276
YBX3 Y box binding protein 3 -0.0304419
SLC38A2 solute carrier family 38, member 2 -0.0297316
RPS8 ribosomal protein S8 -0.0297179
RPS24 ribosomal protein S24 -0.0294659
HMGA1 high mobility group AT-hook 1 -0.0294261
PRDX1 peroxiredoxin 1 -0.0292061
RPL23 ribosomal protein L23 -0.0291053
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0282328
RPL9 ribosomal protein L9 -0.0280053
RASAL2 RAS protein activator like 2 -0.0274268
HSPB1 heat shock 27kDa protein 1 -0.0268338
CLDN1 claudin 1 -0.0267251
BCHE butyrylcholinesterase -0.0267145
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0266865
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0266348
VDAC1 voltage-dependent anion channel 1 -0.0265105
TUBB tubulin, beta class I -0.0263549
RPL26 ribosomal protein L26 -0.0263386
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0263288
EDARADD EDAR-associated death domain -0.0262998
MAP1B microtubule-associated protein 1B -0.0262147
H1-0 H1.0 linker histone -0.0261412
RPLP0 ribosomal protein, large, P0 -0.0260443
RPL12 ribosomal protein L12 -0.0257694
JMJD1C jumonji domain containing 1C -0.0257354
MTAP methylthioadenosine phosphorylase -0.0256523
DLC1 DLC1 Rho GTPase activating protein -0.0245885
EHBP1 EH domain binding protein 1 -0.0245096
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0244393
S100A10 S100 calcium binding protein A10 -0.0242651
CENPE centromere protein E, 312kDa -0.0239725
RPS6 ribosomal protein S6 -0.0239067
ADIPOR2 adiponectin receptor 2 -0.0238901
TM4SF1 transmembrane 4 L six family member 1 -0.0234689
KIF5B kinesin family member 5B -0.0234672
RPL19 ribosomal protein L19 -0.0234046
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0228168
RPLP2 ribosomal protein, large, P2 -0.0226717
NHSL1 NHS-like 1 -0.0226335
GNAS GNAS complex locus -0.0225798
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0222143
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0215739
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0209066
PCDH7 protocadherin 7 -0.0206822
H3-3B H3.3 histone B -0.0205545
RPL38 ribosomal protein L38 -0.0195477
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0194725
RACK1 receptor for activated C kinase 1 -0.0194121
KLF6 Kruppel-like factor 6 -0.0191981
SGO2 shugoshin 2 -0.0191544
RBM25 RNA binding motif protein 25 -0.0191069
RPS27A ribosomal protein S27a -0.0190328
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0186791
OSBPL8 oxysterol binding protein-like 8 -0.0185274
PRR11 proline rich 11 -0.0183844
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0183572
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0179919
RPL37 ribosomal protein L37 -0.0178604
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -0.0177778
RPS19 ribosomal protein S19 -0.0177164
RPL32 ribosomal protein L32 -0.0175671
RPL37A ribosomal protein L37a -0.0175495
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0175297
AFF4 AF4/FMR2 family, member 4 -0.0174953
EGR1 early growth response 1 -0.0173038
ZNF804A zinc finger protein 804A -0.0172148
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0170998