Bestatin (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.164329
FRMD4A FERM domain containing 4A 0.131197
NAMPT nicotinamide phosphoribosyltransferase 0.0834233
TXNRD1 thioredoxin reductase 1 0.0774389
MYH9 myosin, heavy chain 9, non-muscle 0.0744905
APP amyloid beta (A4) precursor protein 0.0728584
SOD2 superoxide dismutase 2, mitochondrial 0.0657528
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0614571
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0593709
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0565554
G0S2 G0/G1 switch 2 0.0550686
FAT1 FAT atypical cadherin 1 0.0545756
CANX calnexin 0.0544397
LDHA lactate dehydrogenase A 0.050387
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0473313
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0473268
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0470212
PDE4D phosphodiesterase 4D, cAMP-specific 0.0438746
EXT1 exostosin glycosyltransferase 1 0.042902
SPTBN1 spectrin, beta, non-erythrocytic 1 0.042508
KYNU kynureninase 0.0404637
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0396692
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0382842
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0372473
RNF213 ring finger protein 213 0.0372413
TSHZ2 teashirt zinc finger homeobox 2 0.0370489
PBX1 pre-B-cell leukemia homeobox 1 0.0357689
PLEC plectin 0.0354744
GPC6 glypican 6 0.0349968
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0339987
GLIS3 GLIS family zinc finger 3 0.0331003
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0324921
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0324067
FAM20C family with sequence similarity 20, member C 0.0319355
INTS6 integrator complex subunit 6 0.031647
NFE2L1 nuclear factor, erythroid 2-like 1 0.0316372
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0313504
ARRDC3 arrestin domain containing 3 0.0306299
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0303886
FNDC3B fibronectin type III domain containing 3B 0.0302252
ERRFI1 ERBB receptor feedback inhibitor 1 0.0301264
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0295918
SMAD3 SMAD family member 3 0.0295893
VCAM1 vascular cell adhesion molecule 1 0.0293862
FN1 fibronectin 1 0.0293587
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0287504
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0286745
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0281056
AHNAK AHNAK nucleoprotein 0.0279689
DSCAM Down syndrome cell adhesion molecule 0.0275806
COG5 component of oligomeric golgi complex 5 0.0273923
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0271175
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0266277
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0265088
MCL1 myeloid cell leukemia 1 0.026494
PDLIM5 PDZ and LIM domain 5 0.0263775
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0258891
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0256997
TGM2 transglutaminase 2 0.0244303
COL5A1 collagen, type V, alpha 1 0.0243662
CXCL8 chemokine (C-X-C motif) ligand 8 0.0240998
EPAS1 endothelial PAS domain protein 1 0.0237111
SDC4 syndecan 4 0.0236501
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.0234792
SETX senataxin 0.0230747
EEF2 eukaryotic translation elongation factor 2 0.0227224
HIPK2 homeodomain interacting protein kinase 2 0.0223828
KDM4C lysine (K)-specific demethylase 4C 0.0220456
RIGI RNA sensor RIG-I 0.021566
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0214546
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0211815
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.021068
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210582
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0210213
DST dystonin 0.0207726
KANK1 KN motif and ankyrin repeat domains 1 0.0204665
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0203607
FLNA filamin A, alpha 0.0203045
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.020301
CXCL2 chemokine (C-X-C motif) ligand 2 0.0200872
SEPTIN9 septin 9 0.0198617
GPC5 glypican 5 0.019497
TNS1 tensin 1 0.0194804
TRIP12 thyroid hormone receptor interactor 12 0.0190162
PTPRD protein tyrosine phosphatase, receptor type, D 0.0189321
ZBTB41 zinc finger and BTB domain containing 41 0.0187541
UBAP2L ubiquitin associated protein 2-like 0.0186525
PALLD palladin, cytoskeletal associated protein 0.0185269
DDIT4 DNA-damage-inducible transcript 4 0.0184368
GDA guanine deaminase 0.0181853
FBXL17 F-box and leucine-rich repeat protein 17 0.0181357
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0179988
PTGR1 prostaglandin reductase 1 0.0178551
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0177393
EXOC4 exocyst complex component 4 0.0176727
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0176621
ETV6 ets variant 6 0.0175713
LPP LIM domain containing preferred translocation partner in lipoma 0.0175536
SAMD9 sterile alpha motif domain containing 9 0.0174682
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.01745

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.190373
VIM vimentin -0.174342
FTL ferritin, light polypeptide -0.135204
B2M beta-2-microglobulin -0.12793
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113818
RPS6 ribosomal protein S6 -0.104158
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0853
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0826996
MT2A metallothionein 2A -0.0783014
HLA-B major histocompatibility complex, class I, B -0.0712694
TPT1 tumor protein, translationally-controlled 1 -0.0672565
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0609139
HSPB1 heat shock 27kDa protein 1 -0.0564111
PFN1 profilin 1 -0.0563713
RPL34 ribosomal protein L34 -0.0540342
RPS8 ribosomal protein S8 -0.0534557
RPL35A ribosomal protein L35a -0.0515702
CENPF centromere protein F, 350/400kDa -0.0493699
RPL12 ribosomal protein L12 -0.0487119
S100A6 S100 calcium binding protein A6 -0.0479833
RPLP2 ribosomal protein, large, P2 -0.0476506
CCL2 chemokine (C-C motif) ligand 2 -0.0455406
RRBP1 ribosome binding protein 1 -0.0455041
RPL28 ribosomal protein L28 -0.0453776
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0451102
RPL23 ribosomal protein L23 -0.0448576
RPS21 ribosomal protein S21 -0.0446476
RPS24 ribosomal protein S24 -0.0442649
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0442504
RPL19 ribosomal protein L19 -0.0435134
RPL37A ribosomal protein L37a -0.0426314
GOLGA4 golgin A4 -0.0420444
RTN4 reticulon 4 -0.0417362
UGCG UDP-glucose ceramide glucosyltransferase -0.0405906
GNAS GNAS complex locus -0.0404453
PTMA prothymosin, alpha -0.0403607
CTSD cathepsin D -0.0402703
S100A10 S100 calcium binding protein A10 -0.0400288
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0398317
EIF1 eukaryotic translation initiation factor 1 -0.0397621
IFITM3 interferon induced transmembrane protein 3 -0.0394158
UBC ubiquitin C -0.0388957
RPS19 ribosomal protein S19 -0.0387861
ARL4C ADP-ribosylation factor-like 4C -0.0387281
RPS13 ribosomal protein S13 -0.0384082
RPL9 ribosomal protein L9 -0.0382119
MAP1B microtubule-associated protein 1B -0.0380922
CKAP4 cytoskeleton-associated protein 4 -0.035498
HM13 histocompatibility (minor) 13 -0.0353269
HMGB1 high mobility group box 1 -0.0352101
CBX3 chromobox homolog 3 -0.0347518
PRRC2C proline-rich coiled-coil 2C -0.0337785
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0337376
RPL38 ribosomal protein L38 -0.0329131
RPS5 ribosomal protein S5 -0.0320189
CD44 CD44 molecule (Indian blood group) -0.0315001
RPL35 ribosomal protein L35 -0.0312433
TUBA1B tubulin, alpha 1b -0.0312397
RPL8 ribosomal protein L8 -0.0306636
SERF2 small EDRK-rich factor 2 -0.0302357
S100A11 S100 calcium binding protein A11 -0.0298563
ADM adrenomedullin -0.0296817
LITAF lipopolysaccharide-induced TNF factor -0.0295885
DIAPH3 diaphanous-related formin 3 -0.0291755
RPL26 ribosomal protein L26 -0.0290929
RPS2 ribosomal protein S2 -0.0290928
TFPI2 tissue factor pathway inhibitor 2 -0.0288747
RPL30 ribosomal protein L30 -0.0286993
MGST1 microsomal glutathione S-transferase 1 -0.0285551
LY6E lymphocyte antigen 6 complex, locus E -0.0285301
RPS14 ribosomal protein S14 -0.0284796
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0280701
RPL11 ribosomal protein L11 -0.0279704
SRSF11 serine/arginine-rich splicing factor 11 -0.0278982
RPLP1 ribosomal protein, large, P1 -0.0276962
RAB2A RAB2A, member RAS oncogene family -0.0276204
FRMD5 FERM domain containing 5 -0.0276092
IFI27 interferon, alpha-inducible protein 27 -0.0274873
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0271542
TPR translocated promoter region, nuclear basket protein -0.0268728
CYBA cytochrome b-245, alpha polypeptide -0.0267859
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0267417
CSF1 colony stimulating factor 1 (macrophage) -0.0267387
RPL27A ribosomal protein L27a -0.0266333
HLA-C major histocompatibility complex, class I, C -0.0265502
IFI6 interferon, alpha-inducible protein 6 -0.0264132
RPS15 ribosomal protein S15 -0.0263586
RPL37 ribosomal protein L37 -0.026322
CALU calumenin -0.0263013
PLIN2 perilipin 2 -0.0262059
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0260177
ATP5F1B ATP synthase F1 subunit beta -0.0258447
RAB1A RAB1A, member RAS oncogene family -0.0256829
EIF5B eukaryotic translation initiation factor 5B -0.0254988
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0254483
SETD5 SET domain containing 5 -0.0254149
HLA-A major histocompatibility complex, class I, A -0.0252491
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0252292
CA12 carbonic anhydrase XII -0.0251805
RBM25 RNA binding motif protein 25 -0.0251491