Bestatin (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.061191
TXNRD1 thioredoxin reductase 1 0.0569775
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0469189
KYNU kynureninase 0.0458153
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0359784
AKAP12 A kinase (PRKA) anchor protein 12 0.0342217
CEMIP cell migration inducing protein, hyaluronan binding 0.0318452
PLEC plectin 0.0262818
DSCAM Down syndrome cell adhesion molecule 0.0261095
MCL1 myeloid cell leukemia 1 0.0254474
POTEF POTE ankyrin domain family, member F 0.0238785
SMYD3 SET and MYND domain containing 3 0.0235659
TRIO trio Rho guanine nucleotide exchange factor 0.0223696
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0223078
AHNAK AHNAK nucleoprotein 0.0220414
TGM2 transglutaminase 2 0.0219495
SMAD3 SMAD family member 3 0.0218723
SLC35F3 solute carrier family 35, member F3 0.0214458
OSMR oncostatin M receptor 0.0210298
MSN moesin 0.0203139
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0199585
EXOC6B exocyst complex component 6B 0.0199436
NRIP1 nuclear receptor interacting protein 1 0.0192965
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0190188
SOD2 superoxide dismutase 2, mitochondrial 0.0182172
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0181444
VMP1 vacuole membrane protein 1 0.0179881
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0177218
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0175574
TNIP1 TNFAIP3 interacting protein 1 0.0175256
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0172707
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0172484
ACTN4 actinin, alpha 4 0.0165721
GRAMD1B GRAM domain containing 1B 0.0163035
SFTPA2 surfactant protein A2 0.0160015
BMAL2 basic helix-loop-helix ARNT like 2 0.0157438
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0156567
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0156205
RTN4 reticulon 4 0.015548
ARHGAP26 Rho GTPase activating protein 26 0.0151828
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.015019
CMIP c-Maf inducing protein 0.0143395
NPC1 Niemann-Pick disease, type C1 0.0142332
FOXP1 forkhead box P1 0.0139974
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0134074
CTSL cathepsin L 0.0133926
MYO9A myosin IXA 0.0130607
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0129932
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0128558
BCL2L1 BCL2-like 1 0.0127724
CA8 carbonic anhydrase VIII 0.0127317
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0126529
BIRC3 baculoviral IAP repeat containing 3 0.0126513
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0123942
MYH9 myosin, heavy chain 9, non-muscle 0.0122777
MYO1B myosin IB 0.012012
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0116169
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0116053
APP amyloid beta (A4) precursor protein 0.0116037
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0115684
LAMC2 laminin, gamma 2 0.0115466
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0115365
KRT7 keratin 7, type II 0.0113199
ADAM17 ADAM metallopeptidase domain 17 0.0111405
EEF2 eukaryotic translation elongation factor 2 0.0109195
CD59 CD59 molecule, complement regulatory protein 0.0108765
SRPK2 SRSF protein kinase 2 0.0108604
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.0106667
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0103393
EEF1G eukaryotic translation elongation factor 1 gamma 0.0103287
SCAPER S-phase cyclin A-associated protein in the ER 0.0102059
SPIDR scaffolding protein involved in DNA repair 0.0100824
NAV2 neuron navigator 2 0.0100736
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0100051
CAMKMT calmodulin-lysine N-methyltransferase 0.00990221
BMERB1 bMERB domain containing 1 0.00989828
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.00946762
RPH3AL rabphilin 3A-like (without C2 domains) 0.00946262
ANKRD36 ankyrin repeat domain 36 0.00945447
KDM7A lysine (K)-specific demethylase 7A 0.00931496
ACTN1 actinin, alpha 1 0.00931473
NRP1 neuropilin 1 0.00921492
SH3KBP1 SH3-domain kinase binding protein 1 0.00914772
FAT1 FAT atypical cadherin 1 0.0089354
EREG epiregulin 0.00892475
ANKRD33B ankyrin repeat domain 33B 0.00891673
TBL1X transducin (beta)-like 1X-linked 0.00878983
ARHGAP5 Rho GTPase activating protein 5 0.00867628
TMEM156 transmembrane protein 156 0.00865598
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.00863233
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.00861784
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.00861386
ACACA acetyl-CoA carboxylase alpha 0.00861103
AGFG1 ArfGAP with FG repeats 1 0.00859095
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.00855052
XDH xanthine dehydrogenase 0.00852168
EVI5 ecotropic viral integration site 5 0.0085103
SGMS1 sphingomyelin synthase 1 0.00849447
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00841434
THSD4 thrombospondin, type I, domain containing 4 0.00837233

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.09401
TMSB10 thymosin beta 10 -0.0937609
IGFBP3 insulin-like growth factor binding protein 3 -0.0897883
PDE4D phosphodiesterase 4D, cAMP-specific -0.0867945
NDRG1 N-myc downstream regulated 1 -0.0808194
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0772857
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0731591
VIM vimentin -0.0648546
CA12 carbonic anhydrase XII -0.0471039
RPS19 ribosomal protein S19 -0.0445167
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0443999
RPS6 ribosomal protein S6 -0.0440007
PTMA prothymosin, alpha -0.0417329
BASP1 brain abundant, membrane attached signal protein 1 -0.0415173
AUTS2 autism susceptibility candidate 2 -0.0407813
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0371362
S100A6 S100 calcium binding protein A6 -0.0349757
HIP1 huntingtin interacting protein 1 -0.0333821
HELZ helicase with zinc finger -0.0325404
MT2A metallothionein 2A -0.0322126
RPL37A ribosomal protein L37a -0.0320119
SPAG9 sperm associated antigen 9 -0.0287167
GRB10 growth factor receptor-bound protein 10 -0.0286655
RPLP1 ribosomal protein, large, P1 -0.0283972
IGFBP4 insulin-like growth factor binding protein 4 -0.0277192
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0275107
MORF4L2 mortality factor 4 like 2 -0.0271889
SP100 SP100 nuclear antigen -0.026765
MYO1E myosin IE -0.0262947
KCTD9 potassium channel tetramerization domain containing 9 -0.0262483
FAM13A family with sequence similarity 13, member A -0.0259406
USP3 ubiquitin specific peptidase 3 -0.0258178
HILPDA hypoxia inducible lipid droplet-associated -0.0252805
ACTG1 actin gamma 1 -0.0241005
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0240339
EFNA5 ephrin-A5 -0.023681
TOP2A topoisomerase (DNA) II alpha 170kDa -0.023254
RND3 Rho family GTPase 3 -0.0232303
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0230635
RAB1A RAB1A, member RAS oncogene family -0.0218532
GPC6 glypican 6 -0.0216393
GOLGA4 golgin A4 -0.0215819
TPT1 tumor protein, translationally-controlled 1 -0.0215309
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0214303
EGFR epidermal growth factor receptor -0.0212998
ANKRD11 ankyrin repeat domain 11 -0.0212977
RPS8 ribosomal protein S8 -0.0211575
BTG1 B-cell translocation gene 1, anti-proliferative -0.020961
LDHA lactate dehydrogenase A -0.0206523
FBXO11 F-box protein 11 -0.02045
RPL12 ribosomal protein L12 -0.0204399
ALCAM activated leukocyte cell adhesion molecule -0.0201361
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0199252
IER3 immediate early response 3 -0.0198498
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0198446
KDM3A lysine (K)-specific demethylase 3A -0.0194477
RPL26 ribosomal protein L26 -0.0193115
FTH1 ferritin, heavy polypeptide 1 -0.0189822
RPL23 ribosomal protein L23 -0.0188479
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0186669
RPS16 ribosomal protein S16 -0.0185186
SEC24A SEC24 family member A -0.0179086
FMNL2 formin-like 2 -0.017866
ANXA2 annexin A2 -0.0173464
GOLGB1 golgin B1 -0.0172886
WDR45B WD repeat domain 45B -0.017282
LOXL2 lysyl oxidase-like 2 -0.0171206
IFI6 interferon, alpha-inducible protein 6 -0.0171063
UBE2O ubiquitin-conjugating enzyme E2O -0.0170902
RPL19 ribosomal protein L19 -0.0169667
ANXA1 annexin A1 -0.0169433
FA2H fatty acid 2-hydroxylase -0.0167955
RPL35A ribosomal protein L35a -0.0167642
ADM adrenomedullin -0.0167043
MAML3 mastermind-like 3 (Drosophila) -0.0164438
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0160057
MT1X metallothionein 1X -0.0159477
FNDC3B fibronectin type III domain containing 3B -0.0155876
FLNB filamin B, beta -0.0155544
LMNA lamin A/C -0.0155376
TBC1D22A TBC1 domain family, member 22A -0.0155301
RPS27A ribosomal protein S27a -0.0155266
RACK1 receptor for activated C kinase 1 -0.0153969
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0152423
USP34 ubiquitin specific peptidase 34 -0.0151038
CTBP2 C-terminal binding protein 2 -0.0149268
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0148972
SETD5 SET domain containing 5 -0.0147183
RPS11 ribosomal protein S11 -0.0146269
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0144882
MYOF myoferlin -0.0144851
NAP1L1 nucleosome assembly protein 1-like 1 -0.0144733
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0144328
RPL18 ribosomal protein L18 -0.0144236
RBM39 RNA binding motif protein 39 -0.014271
RPLP2 ribosomal protein, large, P2 -0.0141673
ZMYND8 zinc finger, MYND-type containing 8 -0.014144
SRP54 signal recognition particle 54kDa -0.0141199
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0140771
EIF1 eukaryotic translation initiation factor 1 -0.0140533