| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bestatin (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACACA | acetyl-CoA carboxylase alpha | 0.125343 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.124423 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0787392 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0775886 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0666593 |
| CDK12 | cyclin-dependent kinase 12 | 0.0555475 |
| CLTC | clathrin, heavy chain (Hc) | 0.0552677 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0493187 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.046263 |
| VMP1 | vacuole membrane protein 1 | 0.0439824 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0430899 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0395257 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0384873 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0363547 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | 0.0361207 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0350907 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0349643 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.034855 |
| NCOA3 | nuclear receptor coactivator 3 | 0.034593 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0344861 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.033198 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0331096 |
| PTK2 | protein tyrosine kinase 2 | 0.0327013 |
| SMYD3 | SET and MYND domain containing 3 | 0.0325504 |
| DTNA | dystrobrevin, alpha | 0.0310255 |
| TTC6 | tetratricopeptide repeat domain 6 | 0.0306013 |
| ASPH | aspartate beta-hydroxylase | 0.0304666 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0298672 |
| CEP250 | centrosomal protein 250kDa | 0.0282176 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0278082 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.026868 |
| SHROOM3 | shroom family member 3 | 0.0261908 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0261685 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0259008 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0257591 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0255679 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.025339 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0251453 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0250329 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0249956 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0244996 |
| NCOA6 | nuclear receptor coactivator 6 | 0.024443 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0239395 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0233343 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0232558 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0220456 |
| RABGAP1 | RAB GTPase activating protein 1 | 0.0207459 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0205321 |
| VCP | valosin containing protein | 0.0201694 |
| MIPOL1 | mirror-image polydactyly 1 | 0.019957 |
| TCF12 | transcription factor 12 | 0.0199203 |
| ENAH | enabled homolog (Drosophila) | 0.0198665 |
| UQCC1 | ubiquinol-cytochrome c reductase complex assembly factor 1 | 0.019636 |
| NEBL | nebulette | 0.0195858 |
| MED13L | mediator complex subunit 13-like | 0.0195078 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0194125 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.019269 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0191269 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0189464 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0183784 |
| FOXP1 | forkhead box P1 | 0.0181356 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0180678 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 0.0178918 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0178748 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0177746 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0176318 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0175275 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0173413 |
| PRKCA | protein kinase C, alpha | 0.0169965 |
| MSI2 | musashi RNA-binding protein 2 | 0.0169216 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.016919 |
| MYO5B | myosin VB | 0.0168594 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0166645 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0165852 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0165554 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0165031 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0164508 |
| SEPTIN11 | septin 11 | 0.0164493 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0162754 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0162321 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0162312 |
| PARD3 | par-3 family cell polarity regulator | 0.0162032 |
| PLCB4 | phospholipase C, beta 4 | 0.0161606 |
| JMJD1C | jumonji domain containing 1C | 0.0161069 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.016013 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0157727 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0157545 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0156604 |
| RESF1 | retroelement silencing factor 1 | 0.0156312 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0155861 |
| AHR | aryl hydrocarbon receptor | 0.0155859 |
| SEPTIN9 | septin 9 | 0.015407 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.015372 |
| EFNA5 | ephrin-A5 | 0.0153584 |
| AEBP2 | AE binding protein 2 | 0.0150819 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0148522 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 0.0147705 |
| COBL | cordon-bleu WH2 repeat protein | 0.0147583 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0147075 |
| ZBTB7C | zinc finger and BTB domain containing 7C | 0.0146917 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL23 | ribosomal protein L23 | -0.147381 |
| RPL19 | ribosomal protein L19 | -0.0967902 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0709946 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0648825 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0592297 |
| NDRG1 | N-myc downstream regulated 1 | -0.0546125 |
| MT2A | metallothionein 2A | -0.0507428 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0500265 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0480027 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0440434 |
| PTMA | prothymosin, alpha | -0.0410263 |
| RPL35A | ribosomal protein L35a | -0.0351084 |
| TMSB10 | thymosin beta 10 | -0.0316499 |
| RPS19 | ribosomal protein S19 | -0.0284923 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.028067 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.02641 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0262119 |
| TMEM165 | transmembrane protein 165 | -0.0253648 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0249425 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0248933 |
| B2M | beta-2-microglobulin | -0.0247821 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0247731 |
| RPS3 | ribosomal protein S3 | -0.0246417 |
| VEGFA | vascular endothelial growth factor A | -0.0244801 |
| S100A8 | S100 calcium binding protein A8 | -0.0243375 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0238212 |
| S100A9 | S100 calcium binding protein A9 | -0.0220486 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0218354 |
| ACTG1 | actin gamma 1 | -0.0214272 |
| RPLP1 | ribosomal protein, large, P1 | -0.0213103 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0210877 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0207686 |
| RPS8 | ribosomal protein S8 | -0.0206172 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0203539 |
| RPS6 | ribosomal protein S6 | -0.0202908 |
| RPL12 | ribosomal protein L12 | -0.0202172 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0200652 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0199563 |
| RPL37A | ribosomal protein L37a | -0.0194558 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0193483 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0192299 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0183863 |
| ZNF292 | zinc finger protein 292 | -0.0180235 |
| PKM | pyruvate kinase, muscle | -0.0175626 |
| YBX1 | Y box binding protein 1 | -0.0173238 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0166846 |
| TPD52 | tumor protein D52 | -0.016585 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0165414 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0162482 |
| IER3 | immediate early response 3 | -0.0162138 |
| RPL35 | ribosomal protein L35 | -0.016101 |
| RPL8 | ribosomal protein L8 | -0.0160196 |
| CCNI | cyclin I | -0.0158095 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0157929 |
| DSPP | dentin sialophosphoprotein | -0.0157762 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0157247 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.015324 |
| FBXO32 | F-box protein 32 | -0.0152817 |
| HLA-B | major histocompatibility complex, class I, B | -0.0151757 |
| GOLGA4 | golgin A4 | -0.0151208 |
| AREG | amphiregulin | -0.0149501 |
| RPS12 | ribosomal protein S12 | -0.0149375 |
| SLFN5 | schlafen family member 5 | -0.0149277 |
| RPLP0 | ribosomal protein, large, P0 | -0.0149074 |
| RPL36 | ribosomal protein L36 | -0.0148498 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0146594 |
| VIM | vimentin | -0.0144545 |
| LDHA | lactate dehydrogenase A | -0.0143459 |
| ANXA2 | annexin A2 | -0.0142981 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0141903 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0140643 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0140425 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0138514 |
| RPL34 | ribosomal protein L34 | -0.0138386 |
| SMAD3 | SMAD family member 3 | -0.0136059 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0135838 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0133717 |
| S100A14 | S100 calcium binding protein A14 | -0.0133503 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0133478 |
| TXNRD1 | thioredoxin reductase 1 | -0.0132317 |
| EGR1 | early growth response 1 | -0.0131623 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0131487 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0131105 |
| SDC4 | syndecan 4 | -0.0129762 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0128598 |
| RPL28 | ribosomal protein L28 | -0.0127581 |
| RPL7A | ribosomal protein L7a | -0.0125098 |
| FTL | ferritin, light polypeptide | -0.0124846 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.012464 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0124572 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0123629 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0123316 |
| PFDN4 | prefoldin subunit 4 | -0.0121846 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0121765 |
| RPS27 | ribosomal protein S27 | -0.0121566 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0120792 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0119373 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0119184 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0117801 |
| ENO1 | enolase 1, (alpha) | -0.011674 |
