Bestatin (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0713249
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0621137
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.060004
RAD51B RAD51 paralog B 0.0596815
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517544
TENM3 teneurin transmembrane protein 3 0.0439129
COL5A2 collagen, type V, alpha 2 0.0433443
ZNF608 zinc finger protein 608 0.0433191
MCL1 myeloid cell leukemia 1 0.0415489
RPL31 ribosomal protein L31 0.0392494
P4HB prolyl 4-hydroxylase, beta polypeptide 0.036365
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0360399
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0341956
PCBP2 poly(rC) binding protein 2 0.0340935
FAT1 FAT atypical cadherin 1 0.0325361
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.032353
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0322421
PDIA3 protein disulfide isomerase family A, member 3 0.0315005
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0303283
ZBTB20 zinc finger and BTB domain containing 20 0.0298536
PKM pyruvate kinase, muscle 0.0296849
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0296298
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0290813
APLP2 amyloid beta (A4) precursor-like protein 2 0.0280094
RCC1 regulator of chromosome condensation 1 0.0275935
SFPQ splicing factor proline/glutamine-rich 0.0271583
WNK1 WNK lysine deficient protein kinase 1 0.0267414
LCOR ligand dependent nuclear receptor corepressor 0.0264952
LDHA lactate dehydrogenase A 0.0261679
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0259692
ENO1 enolase 1, (alpha) 0.0257988
RPL37A ribosomal protein L37a 0.0254419
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0253223
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.025303
TJP1 tight junction protein 1 0.0249702
FNDC3B fibronectin type III domain containing 3B 0.0249066
NRDC nardilysin convertase 0.0248908
IGF2 insulin-like growth factor 2 0.0248101
TCP1 t-complex 1 0.0247033
INTS6 integrator complex subunit 6 0.0246409
KTN1 kinectin 1 (kinesin receptor) 0.0245528
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0245498
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0244938
SET SET nuclear proto-oncogene 0.0243958
HHIP hedgehog interacting protein 0.0241375
HDAC4 histone deacetylase 4 0.0240316
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0239599
CALR calreticulin 0.0238792
LDHB lactate dehydrogenase B 0.023857
PLEC plectin 0.0235121
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0234816
PTPRG protein tyrosine phosphatase, receptor type, G 0.0229729
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0228989
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0226501
RPL3 ribosomal protein L3 0.0224416
RPS3 ribosomal protein S3 0.0221007
CMIP c-Maf inducing protein 0.0218796
FAM193A family with sequence similarity 193, member A 0.021767
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0217472
USP9X ubiquitin specific peptidase 9, X-linked 0.0215393
ZSWIM6 zinc finger, SWIM-type containing 6 0.0214154
TNRC18 trinucleotide repeat containing 18 0.0213588
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0213321
DST dystonin 0.0211553
PDIA6 protein disulfide isomerase family A, member 6 0.0208664
DSCAM Down syndrome cell adhesion molecule 0.0208374
NFIB nuclear factor I/B 0.0207806
PUM1 pumilio RNA-binding family member 1 0.0207657
USP47 ubiquitin specific peptidase 47 0.0207519
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0206653
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0205727
ASPH aspartate beta-hydroxylase 0.0204576
AHCYL2 adenosylhomocysteinase-like 2 0.0204178
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0202634
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0202469
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0202166
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0201678
SKIL SKI-like proto-oncogene 0.0199291
UBAP2 ubiquitin associated protein 2 0.0198866
KDM4C lysine (K)-specific demethylase 4C 0.0197498
AKAP9 A kinase (PRKA) anchor protein 9 0.0196317
RPS18 ribosomal protein S18 0.0196086
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0195246
UBE3A ubiquitin protein ligase E3A 0.0195024
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0192504
MAML3 mastermind-like 3 (Drosophila) 0.0192348
AUTS2 autism susceptibility candidate 2 0.0189905
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0188491
USP34 ubiquitin specific peptidase 34 0.0187334
WDFY3 WD repeat and FYVE domain containing 3 0.0187258
N4BP2L2 NEDD4 binding protein 2-like 2 0.0186906
COPB1 coatomer protein complex, subunit beta 1 0.0186525
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0185787
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0185003
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0183838
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0183695
CNOT3 CCR4-NOT transcription complex, subunit 3 0.0183302
C2ORF42 chromosome 2 open reading frame 42 0.0182734
EIF1 eukaryotic translation initiation factor 1 0.0182414
SCFD1 sec1 family domain containing 1 0.018207

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116362
SHROOM3 shroom family member 3 -0.0779872
RPL11 ribosomal protein L11 -0.0484273
TMSB10 thymosin beta 10 -0.0482505
RPS24 ribosomal protein S24 -0.0468051
NAP1L1 nucleosome assembly protein 1-like 1 -0.0448571
WSB1 WD repeat and SOCS box containing 1 -0.0448457
RPL12 ribosomal protein L12 -0.0436009
RPS21 ribosomal protein S21 -0.0432445
HMGB1 high mobility group box 1 -0.0429547
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0423249
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.041633
IFI6 interferon, alpha-inducible protein 6 -0.0412592
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0412209
KDM3A lysine (K)-specific demethylase 3A -0.0406586
TXNRD1 thioredoxin reductase 1 -0.039955
RPL34 ribosomal protein L34 -0.0393775
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0378024
RPL26 ribosomal protein L26 -0.0375566
MYL12B myosin, light chain 12B, regulatory -0.0368944
CDH18 cadherin 18, type 2 -0.0364933
CENPF centromere protein F, 350/400kDa -0.0362076
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0357708
GAB2 GRB2-associated binding protein 2 -0.0351027
H1-0 H1.0 linker histone -0.0350143
SOX4 SRY (sex determining region Y)-box 4 -0.034648
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0344838
STAT1 signal transducer and activator of transcription 1, 91kDa -0.034081
ENAH enabled homolog (Drosophila) -0.0337364
FAM162A family with sequence similarity 162, member A -0.0333771
RPL18 ribosomal protein L18 -0.033297
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0328755
CENPE centromere protein E, 312kDa -0.0328743
RPL28 ribosomal protein L28 -0.0324689
RPL30 ribosomal protein L30 -0.0323724
ZNF217 zinc finger protein 217 -0.0321196
RPL32 ribosomal protein L32 -0.0320044
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0319369
ZMYM2 zinc finger, MYM-type 2 -0.0317811
MT2A metallothionein 2A -0.0317412
RPLP1 ribosomal protein, large, P1 -0.0302529
RPS28 ribosomal protein S28 -0.0291341
SLIT2 slit homolog 2 (Drosophila) -0.0288687
TBC1D32 TBC1 domain family, member 32 -0.0287572
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0279959
RPL19 ribosomal protein L19 -0.0279493
RPL13A ribosomal protein L13a -0.0279072
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0277455
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0275245
TENM2 teneurin transmembrane protein 2 -0.0274437
TUBB tubulin, beta class I -0.0268243
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0267001
MIS18BP1 MIS18 binding protein 1 -0.0263041
RSL1D1 ribosomal L1 domain containing 1 -0.0260708
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0260555
KIAA1958 KIAA1958 -0.0259965
CAVIN1 caveolae associated protein 1 -0.025605
HMGB2 high mobility group box 2 -0.0254768
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0249841
KIAA1328 KIAA1328 -0.0248016
TMEM41B transmembrane protein 41B -0.0244928
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0244451
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0237578
RBM25 RNA binding motif protein 25 -0.0235704
BRWD1 bromodomain and WD repeat domain containing 1 -0.0232202
ANXA2 annexin A2 -0.0230981
SBF2 SET binding factor 2 -0.0230968
KMT2C lysine (K)-specific methyltransferase 2C -0.0229145
MARCHF6 membrane associated ring-CH-type finger 6 -0.0226612
MIPOL1 mirror-image polydactyly 1 -0.0224499
ITSN1 intersectin 1 (SH3 domain protein) -0.0223489
RPL36A ribosomal protein L36a -0.0222066
H3-3B H3.3 histone B -0.0221885
RPL14 ribosomal protein L14 -0.0219204
BRWD3 bromodomain and WD repeat domain containing 3 -0.0218953
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0218057
RPS4X ribosomal protein S4, X-linked -0.0216761
NEBL nebulette -0.0216247
SEPTIN7 septin 7 -0.0213485
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0212692
NSD3 nuclear receptor binding SET domain protein 3 -0.0207762
RPLP2 ribosomal protein, large, P2 -0.0207358
FOXO3 forkhead box O3 -0.020522
PDE4D phosphodiesterase 4D, cAMP-specific -0.0202518
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0201323
RFX7 regulatory factor X, 7 -0.019856
LCORL ligand dependent nuclear receptor corepressor-like -0.0198152
PHACTR4 phosphatase and actin regulator 4 -0.0197892
PHIP pleckstrin homology domain interacting protein -0.0196923
RPS15 ribosomal protein S15 -0.0195391
ARB2A ARB2 cotranscriptional regulator A -0.0191895
RPL36 ribosomal protein L36 -0.0191208
PABPN1 poly(A) binding protein, nuclear 1 -0.0190925
WDR45B WD repeat domain 45B -0.0190915
RPS6 ribosomal protein S6 -0.0190827
ARHGAP32 Rho GTPase activating protein 32 -0.0190778
POGZ pogo transposable element with ZNF domain -0.0190084
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0190062
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0187965
RRBP1 ribosome binding protein 1 -0.0187835