| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bestatin (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.24607 |
| FN1 | fibronectin 1 | 0.135696 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.135479 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.132411 |
| DSPP | dentin sialophosphoprotein | 0.119275 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.103088 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0959134 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0916284 |
| C3 | complement component 3 | 0.0873111 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0762706 |
| SDC4 | syndecan 4 | 0.073258 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0708014 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0647391 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0585182 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0573133 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0553951 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0546636 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0503874 |
| PEG3 | paternally expressed 3 | 0.0447663 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0427483 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0415587 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0413615 |
| ITGA1 | integrin, alpha 1 | 0.0389943 |
| PEG10 | paternally expressed 10 | 0.0388676 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0386065 |
| SVIL | supervillin | 0.038302 |
| SFTPA2 | surfactant protein A2 | 0.037597 |
| PLEC | plectin | 0.0341634 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0339656 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0332768 |
| CFB | complement factor B | 0.0332196 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.033135 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0326834 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0319408 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0310084 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0308416 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0302276 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0299361 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0297524 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0293735 |
| MCL1 | myeloid cell leukemia 1 | 0.0286297 |
| RAI14 | retinoic acid induced 14 | 0.0278493 |
| A2M | alpha-2-macroglobulin | 0.0275783 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0274565 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0274215 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.026508 |
| CALR | calreticulin | 0.0264645 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0262097 |
| PLAC8 | placenta-specific 8 | 0.0261293 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0258217 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0255959 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0254338 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0249045 |
| FAT1 | FAT atypical cadherin 1 | 0.0245638 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.024436 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0241989 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0240854 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0239405 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0239037 |
| SMAD3 | SMAD family member 3 | 0.0232733 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0229437 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0228945 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0228552 |
| CANX | calnexin | 0.0224949 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.0224753 |
| BCL2L1 | BCL2-like 1 | 0.0222742 |
| FABP1 | fatty acid binding protein 1, liver | 0.0221411 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0219694 |
| TRIM26 | tripartite motif containing 26 | 0.0218082 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0217047 |
| PCBP2 | poly(rC) binding protein 2 | 0.0216551 |
| TF | transferrin | 0.0215581 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0215283 |
| RRBP1 | ribosome binding protein 1 | 0.0212297 |
| LDHA | lactate dehydrogenase A | 0.0211368 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0210655 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0209391 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0209209 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0205722 |
| ACTN4 | actinin, alpha 4 | 0.0205201 |
| HLF | hepatic leukemia factor | 0.020513 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0205042 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0203668 |
| RTN4 | reticulon 4 | 0.0201893 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0199325 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0196786 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0196295 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0195604 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.019441 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0193101 |
| FAM107B | family with sequence similarity 107, member B | 0.0191968 |
| YAP1 | Yes-associated protein 1 | 0.0191874 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0191341 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0190438 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0185084 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0183067 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0182777 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0181907 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0180537 |
| DST | dystonin | 0.0180496 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.329005 |
| APOA2 | apolipoprotein A-II | -0.0613867 |
| MT2A | metallothionein 2A | -0.0453239 |
| RPL37A | ribosomal protein L37a | -0.0373198 |
| PLIN2 | perilipin 2 | -0.0365053 |
| RPS24 | ribosomal protein S24 | -0.0359329 |
| HMGA1 | high mobility group AT-hook 1 | -0.0326564 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0295711 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0295343 |
| RPS8 | ribosomal protein S8 | -0.0285739 |
| RPL26 | ribosomal protein L26 | -0.0279934 |
| NDRG1 | N-myc downstream regulated 1 | -0.0264728 |
| DTNA | dystrobrevin, alpha | -0.0261196 |
| INSIG2 | insulin induced gene 2 | -0.0258182 |
| RPS6 | ribosomal protein S6 | -0.0257355 |
| TMSB10 | thymosin beta 10 | -0.0242665 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.02421 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0238435 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0219703 |
| RPL23 | ribosomal protein L23 | -0.0218475 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.020938 |
| RPL9 | ribosomal protein L9 | -0.0208293 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0200014 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0197948 |
| MSI2 | musashi RNA-binding protein 2 | -0.0196624 |
| RPL12 | ribosomal protein L12 | -0.0190234 |
| RPL28 | ribosomal protein L28 | -0.0182773 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0179534 |
| JMJD1C | jumonji domain containing 1C | -0.0178029 |
| HELZ | helicase with zinc finger | -0.0177886 |
| DSTN | destrin (actin depolymerizing factor) | -0.0177678 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0177056 |
| APOE | apolipoprotein E | -0.0173661 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0172615 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0172147 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0165871 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0165695 |
| RBM39 | RNA binding motif protein 39 | -0.0164752 |
| SMAP1 | small ArfGAP 1 | -0.0164229 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0162706 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0161193 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0160096 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0159894 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.015964 |
| NUMB | numb homolog (Drosophila) | -0.0159308 |
| GPC3 | glypican 3 | -0.0158816 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0157929 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0154771 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0154586 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0152361 |
| GRK3 | G protein-coupled receptor kinase 3 | -0.0151912 |
| RPL35A | ribosomal protein L35a | -0.0149985 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0149653 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0149619 |
| SIK3 | SIK family kinase 3 | -0.0149479 |
| WDR45B | WD repeat domain 45B | -0.0148311 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0146943 |
| RPL37 | ribosomal protein L37 | -0.01467 |
| LMNA | lamin A/C | -0.0145361 |
| RPL27 | ribosomal protein L27 | -0.0144229 |
| RPLP2 | ribosomal protein, large, P2 | -0.0144144 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.014377 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.014322 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0142334 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0142216 |
| RPS14 | ribosomal protein S14 | -0.014062 |
| RPL34 | ribosomal protein L34 | -0.0139842 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0139254 |
| RPS25 | ribosomal protein S25 | -0.013889 |
| CFDP1 | craniofacial development protein 1 | -0.0138078 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0137025 |
| RPS19 | ribosomal protein S19 | -0.0136615 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0136223 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0135262 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0134175 |
| TJP1 | tight junction protein 1 | -0.0132615 |
| RPL36A | ribosomal protein L36a | -0.013196 |
| RAB6A | RAB6A, member RAS oncogene family | -0.013002 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0129358 |
| CHKA | choline kinase alpha | -0.0128751 |
| NOP58 | NOP58 ribonucleoprotein | -0.0127801 |
| MAP1B | microtubule-associated protein 1B | -0.012696 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0126486 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0125925 |
| ABLIM1 | actin binding LIM protein 1 | -0.012575 |
| MYO6 | myosin VI | -0.0125702 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0125085 |
| FAM162A | family with sequence similarity 162, member A | -0.012481 |
| BMERB1 | bMERB domain containing 1 | -0.0124251 |
| RPL5 | ribosomal protein L5 | -0.0123795 |
| NBAS | neuroblastoma amplified sequence | -0.0122361 |
| S100A6 | S100 calcium binding protein A6 | -0.0121937 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0121431 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0120106 |
| PSMA1 | proteasome (prosome, macropain) subunit, alpha type, 1 | -0.0119813 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | -0.0119769 |
| RPS10 | ribosomal protein S10 | -0.0119728 |
| SBF2 | SET binding factor 2 | -0.0119533 |
| NGLY1 | N-glycanase 1 | -0.0119127 |
| RPS27 | ribosomal protein S27 | -0.0118702 |
