Bestatin (hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAI14 retinoic acid induced 14 0.0159223
ABI3BP ABI family, member 3 (NESH) binding protein 0.0133684
PDLIM5 PDZ and LIM domain 5 0.0129753
NRIP1 nuclear receptor interacting protein 1 0.0127195
NAV2 neuron navigator 2 0.0125145
RNF217 ring finger protein 217 0.0116792
GRB10 growth factor receptor-bound protein 10 0.0112801
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.01047
SLC35F3 solute carrier family 35, member F3 0.0100578
ZCCHC7 zinc finger, CCHC domain containing 7 0.00935543
IARS1 isoleucyl-tRNA synthetase 1 0.00884906
SPIRE1 spire-type actin nucleation factor 1 0.00825385
LMO7 LIM domain 7 0.00802627
ZC3H12C zinc finger CCCH-type containing 12C 0.00760345
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.00760099
CNTNAP3 contactin associated protein-like 3 0.00702481
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.00676021
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.00655955
ABLIM3 actin binding LIM protein family, member 3 0.00648531
PPARG peroxisome proliferator-activated receptor gamma 0.00640698
RABGAP1L RAB GTPase activating protein 1-like 0.00639464
LRRC49 leucine rich repeat containing 49 0.00620392
ANKIB1 ankyrin repeat and IBR domain containing 1 0.00604457
ADAM19 ADAM metallopeptidase domain 19 0.00604135
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.00598522
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00596695
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.00592194
RAD51B RAD51 paralog B 0.00590739
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.00569235
BMAL2 basic helix-loop-helix ARNT like 2 0.00553954
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.00550208
PYGL phosphorylase, glycogen, liver 0.00540033
EFNA5 ephrin-A5 0.00529516
TNS3 tensin 3 0.00526376
COL5A1 collagen, type V, alpha 1 0.00526198
ITGB8 integrin, beta 8 0.00524401
NTSR1 neurotensin receptor 1 (high affinity) 0.00524132
EFCAB13 EF-hand calcium binding domain 13 0.00521305
BBS9 Bardet-Biedl syndrome 9 0.00519379
SCFD2 sec1 family domain containing 2 0.00514773
STXBP5 syntaxin binding protein 5 (tomosyn) 0.00514024
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0051039
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.00497393
FAM107B family with sequence similarity 107, member B 0.00495041
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0048441
IRAK2 interleukin-1 receptor-associated kinase 2 0.00483186
RBBP8 retinoblastoma binding protein 8 0.00479078
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.00478162
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.00474344
EHBP1 EH domain binding protein 1 0.00459998
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.00459827
EXOC4 exocyst complex component 4 0.00455802
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.0045542
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.00446806
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.00437593
AGO2 argonaute RISC catalytic component 2 0.00434574
DENND1A DENN/MADD domain containing 1A 0.00431164
DNHD1 dynein heavy chain domain 1 0.00429881
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.00429175
TMEM117 transmembrane protein 117 0.00429087
IL33 interleukin 33 0.00428969
PLXNA3 plexin A3 0.00428526
OSBP2 oxysterol binding protein 2 0.00428169
KIAA1671 KIAA1671 0.00427599
CLASP2 cytoplasmic linker associated protein 2 0.00426352
NEMP2 nuclear envelope integral membrane protein 2 0.00426278
CCM2 cerebral cavernous malformation 2 0.00425286
ANO1 anoctamin 1, calcium activated chloride channel 0.00422962
SEC23IP SEC23 interacting protein 0.00422856
NHLRC3 NHL repeat containing 3 0.00422762
MROH1 maestro heat-like repeat family member 1 0.00422451
RHBDD1 rhomboid domain containing 1 0.00419734
PTPRG protein tyrosine phosphatase, receptor type, G 0.00417938
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.00416347
FRMD4A FERM domain containing 4A 0.0041519
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.00414232
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.00413504
VEGFA vascular endothelial growth factor A 0.0041078
ARHGAP21 Rho GTPase activating protein 21 0.00409572
BACE2 beta-site APP-cleaving enzyme 2 0.00409021
ERICH1 glutamate-rich 1 0.00408843
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.00408643
KRBOX4 KRAB box domain containing 4 0.00407717
SMOX spermine oxidase 0.00404577
ATG10 autophagy related 10 0.00400054
BTBD10 BTB (POZ) domain containing 10 0.00399634
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.00399342
INPP1 inositol polyphosphate-1-phosphatase 0.00398558
TVP23C-CDRT4 TVP23C-CDRT4 readthrough 0.0039457
ZNF621 zinc finger protein 621 0.0039441
ANKRD36 ankyrin repeat domain 36 0.003942
GALK2 galactokinase 2 0.00393323
ANTXR2 anthrax toxin receptor 2 0.00393276
RNF38 ring finger protein 38 0.00393083
NEBL nebulette 0.00391605
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.00390002
DHFR dihydrofolate reductase 0.00386351
CFAP44 cilia and flagella associated protein 44 0.00383963
THSD4 thrombospondin, type I, domain containing 4 0.00383728
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0038277

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139415
ENO1 enolase 1, (alpha) -0.130757
B2M beta-2-microglobulin -0.114396
TMSB10 thymosin beta 10 -0.111822
FLNB filamin B, beta -0.108534
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0973787
PTMA prothymosin, alpha -0.0919708
MT2A metallothionein 2A -0.0791188
LDHA lactate dehydrogenase A -0.078873
AHNAK AHNAK nucleoprotein -0.072665
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0717385
PGK1 phosphoglycerate kinase 1 -0.0684445
UBC ubiquitin C -0.067992
KRT17 keratin 17, type I -0.0678879
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0675068
CLU clusterin -0.0672432
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0623824
S100A10 S100 calcium binding protein A10 -0.0610788
NDRG1 N-myc downstream regulated 1 -0.0604193
TMSB4X thymosin beta 4, X-linked -0.0603681
LMNA lamin A/C -0.0598569
TPT1 tumor protein, translationally-controlled 1 -0.059442
ITGA6 integrin, alpha 6 -0.0591131
RPS21 ribosomal protein S21 -0.0585773
POTEF POTE ankyrin domain family, member F -0.0569216
IFITM3 interferon induced transmembrane protein 3 -0.0568211
RPS8 ribosomal protein S8 -0.0554089
EMP1 epithelial membrane protein 1 -0.0538589
MYOF myoferlin -0.0536173
RPS27A ribosomal protein S27a -0.0511593
RPLP2 ribosomal protein, large, P2 -0.0502565
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0499374
NAMPT nicotinamide phosphoribosyltransferase -0.0497362
ANXA2 annexin A2 -0.049192
RPS3 ribosomal protein S3 -0.0478557
CD44 CD44 molecule (Indian blood group) -0.0475986
STC1 stanniocalcin 1 -0.0474517
IFITM1 interferon induced transmembrane protein 1 -0.0470915
RPS6 ribosomal protein S6 -0.0466533
MYH9 myosin, heavy chain 9, non-muscle -0.0465594
CAV1 caveolin 1, caveolae protein, 22kDa -0.0463503
PKM pyruvate kinase, muscle -0.0461638
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0461179
GNAS GNAS complex locus -0.0452371
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0449965
LOC112694756 uncharaterized LOC112694756 -0.0447471
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0440209
ASPH aspartate beta-hydroxylase -0.0439687
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0433029
RPLP1 ribosomal protein, large, P1 -0.0418588
HLA-B major histocompatibility complex, class I, B -0.0416021
RPL23 ribosomal protein L23 -0.0403493
RPS19 ribosomal protein S19 -0.0397085
S100A6 S100 calcium binding protein A6 -0.0392825
RPL11 ribosomal protein L11 -0.0391138
EZR ezrin -0.0390939
CANX calnexin -0.0388572
RPS13 ribosomal protein S13 -0.0381177
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0378887
CALR calreticulin -0.0377695
NAP1L1 nucleosome assembly protein 1-like 1 -0.037241
PRRC2C proline-rich coiled-coil 2C -0.0369313
H1-0 H1.0 linker histone -0.0364304
RPS12 ribosomal protein S12 -0.0361767
ANXA1 annexin A1 -0.0361567
SERINC3 serine incorporator 3 -0.0356484
RPL12 ribosomal protein L12 -0.0349482
RPL37 ribosomal protein L37 -0.0343347
YBX3 Y box binding protein 3 -0.0341399
IFI6 interferon, alpha-inducible protein 6 -0.0341328
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0340622
ACTN4 actinin, alpha 4 -0.0340377
SAMD9 sterile alpha motif domain containing 9 -0.0338977
S100A9 S100 calcium binding protein A9 -0.0335888
TXNIP thioredoxin interacting protein -0.0328035
EEF2 eukaryotic translation elongation factor 2 -0.0320338
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0319423
KTN1 kinectin 1 (kinesin receptor) -0.0316937
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0315305
RPS24 ribosomal protein S24 -0.0314334
RPL8 ribosomal protein L8 -0.0314306
RPS25 ribosomal protein S25 -0.031366
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0309483
MBNL1 muscleblind-like splicing regulator 1 -0.0306234
CALU calumenin -0.0304932
RPL37A ribosomal protein L37a -0.0298961
HLA-E major histocompatibility complex, class I, E -0.0294885
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0291589
RPL19 ribosomal protein L19 -0.0287948
PLAT plasminogen activator, tissue -0.0286153
TM4SF1 transmembrane 4 L six family member 1 -0.0285675
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0284214
RACK1 receptor for activated C kinase 1 -0.0282069
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0269533
TOP1 topoisomerase (DNA) I -0.0262991
IFI27 interferon, alpha-inducible protein 27 -0.0261281
YBX1 Y box binding protein 1 -0.025806
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0257438
KRT14 keratin 14, type I -0.0257327
RPL7A ribosomal protein L7a -0.0253479