Bestatin (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.081374
EZR ezrin 0.0783158
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0622474
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.055459
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0524317
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0510178
CEMIP cell migration inducing protein, hyaluronan binding 0.0455496
FLNB filamin B, beta 0.0440539
PKM pyruvate kinase, muscle 0.0433259
LDHA lactate dehydrogenase A 0.0399552
FAT1 FAT atypical cadherin 1 0.0398715
AKAP13 A kinase (PRKA) anchor protein 13 0.0390333
PTBP3 polypyrimidine tract binding protein 3 0.0367381
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0356656
PCBP2 poly(rC) binding protein 2 0.0355744
MX1 MX dynamin-like GTPase 1 0.0352887
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0342
MYH9 myosin, heavy chain 9, non-muscle 0.0336523
MCL1 myeloid cell leukemia 1 0.032232
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0321522
TNIP1 TNFAIP3 interacting protein 1 0.0301149
EPHA2 EPH receptor A2 0.0299373
CLDN4 claudin 4 0.029937
PDLIM5 PDZ and LIM domain 5 0.0294777
ITPRID2 ITPR interacting domain containing 2 0.0293189
RPS18 ribosomal protein S18 0.029068
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0275813
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.027493
MBNL1 muscleblind-like splicing regulator 1 0.0271259
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0271058
RNF213 ring finger protein 213 0.0258275
DSPP dentin sialophosphoprotein 0.0253495
POTEF POTE ankyrin domain family, member F 0.024858
NRDC nardilysin convertase 0.0243381
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0243327
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0238189
NCOR2 nuclear receptor corepressor 2 0.0232569
KMT2E lysine (K)-specific methyltransferase 2E 0.0232315
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0230095
EEF1G eukaryotic translation elongation factor 1 gamma 0.0229549
RPL3 ribosomal protein L3 0.0223949
F3 coagulation factor III (thromboplastin, tissue factor) 0.0219993
CALB1 calbindin 1, 28kDa 0.0218326
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0216914
EIF4B eukaryotic translation initiation factor 4B 0.0215869
BACE2 beta-site APP-cleaving enzyme 2 0.0214487
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.021214
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0210194
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0206403
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0205569
ITGB4 integrin, beta 4 0.0204549
WARS1 tryptophanyl-tRNA synthetase 1 0.0204081
XPO1 exportin 1 0.0203599
GDF15 growth differentiation factor 15 0.0200116
ZNF638 zinc finger protein 638 0.0199871
ITGA6 integrin, alpha 6 0.0196851
CCNL1 cyclin L1 0.0193607
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0192514
ERRFI1 ERBB receptor feedback inhibitor 1 0.0189371
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0189011
IQGAP2 IQ motif containing GTPase activating protein 2 0.0187808
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0186053
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0182347
SFTPA2 surfactant protein A2 0.0181165
PTPRG protein tyrosine phosphatase, receptor type, G 0.0175158
PLAC8 placenta-specific 8 0.0174646
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0174478
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0172379
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.01722
ANXA11 annexin A11 0.0171426
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0170121
NSD1 nuclear receptor binding SET domain protein 1 0.0168152
ZCCHC7 zinc finger, CCHC domain containing 7 0.0166799
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0166488
VCL vinculin 0.0166263
PTK2 protein tyrosine kinase 2 0.0165337
MYO1E myosin IE 0.016317
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0162677
LARP1 La ribonucleoprotein domain family, member 1 0.0161652
CLOCK clock circadian regulator 0.0160987
KTN1 kinectin 1 (kinesin receptor) 0.016071
ERBIN erbb2 interacting protein 0.0160267
CANX calnexin 0.0159842
CDK6 cyclin-dependent kinase 6 0.0159097
ZYX zyxin 0.0159026
SKAP2 src kinase associated phosphoprotein 2 0.0158059
HLA-B major histocompatibility complex, class I, B 0.0157942
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0155112
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.015479
AHCYL2 adenosylhomocysteinase-like 2 0.0154477
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0153976
MX2 MX dynamin-like GTPase 2 0.0153776
SMAD3 SMAD family member 3 0.0153158
VMP1 vacuole membrane protein 1 0.0153072
SRPK2 SRSF protein kinase 2 0.0151816
SFPQ splicing factor proline/glutamine-rich 0.0151684
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0150682
PGK1 phosphoglycerate kinase 1 0.0150603
DSCAM Down syndrome cell adhesion molecule 0.0150049
APP amyloid beta (A4) precursor protein 0.0149696

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.154004
RPLP1 ribosomal protein, large, P1 -0.151406
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.139622
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102962
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0998109
RPS6 ribosomal protein S6 -0.096351
RPS8 ribosomal protein S8 -0.07594
TMSB10 thymosin beta 10 -0.0725078
RPL34 ribosomal protein L34 -0.070496
RPL37A ribosomal protein L37a -0.0650833
RPL35A ribosomal protein L35a -0.0637447
RPL26 ribosomal protein L26 -0.0616746
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0598524
RPL4 ribosomal protein L4 -0.0584904
RPLP2 ribosomal protein, large, P2 -0.0583894
RPL13A ribosomal protein L13a -0.0572572
RPL23 ribosomal protein L23 -0.0568617
RPS24 ribosomal protein S24 -0.0501385
RPL12 ribosomal protein L12 -0.0497193
RPS19 ribosomal protein S19 -0.0493774
RPS25 ribosomal protein S25 -0.0476431
RPL9 ribosomal protein L9 -0.0459067
KLF5 Kruppel-like factor 5 (intestinal) -0.0452188
PRELID2 PRELI domain containing 2 -0.0447684
PTMA prothymosin, alpha -0.0432845
RPS21 ribosomal protein S21 -0.0413502
RRBP1 ribosome binding protein 1 -0.0413172
RPL11 ribosomal protein L11 -0.0409115
RPS12 ribosomal protein S12 -0.0403874
RPS16 ribosomal protein S16 -0.0394586
RPS27A ribosomal protein S27a -0.0390522
RPL37 ribosomal protein L37 -0.0365288
RPS20 ribosomal protein S20 -0.0364992
PRSS3 protease, serine, 3 -0.0353749
RPLP0 ribosomal protein, large, P0 -0.0352341
AGR2 anterior gradient 2 -0.0348113
RPL28 ribosomal protein L28 -0.0345622
RPS29 ribosomal protein S29 -0.0335187
GOLGA4 golgin A4 -0.0329132
RPL35 ribosomal protein L35 -0.032822
RPL27A ribosomal protein L27a -0.0322441
RPL32 ribosomal protein L32 -0.0321892
ACTG1 actin gamma 1 -0.0307492
RPL36 ribosomal protein L36 -0.0305181
RPL38 ribosomal protein L38 -0.0299711
RPS17 ribosomal protein S17 -0.0298175
RPL30 ribosomal protein L30 -0.0297086
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0296499
RPS5 ribosomal protein S5 -0.0292077
SERINC5 serine incorporator 5 -0.0284472
RPS13 ribosomal protein S13 -0.0273679
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0272109
AKAP9 A kinase (PRKA) anchor protein 9 -0.0267466
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0265691
RPL27 ribosomal protein L27 -0.0262672
RACK1 receptor for activated C kinase 1 -0.026044
PDIA3 protein disulfide isomerase family A, member 3 -0.0258924
PTPRR protein tyrosine phosphatase, receptor type, R -0.0254961
PKP2 plakophilin 2 -0.0252111
MT2A metallothionein 2A -0.0250374
RPS23 ribosomal protein S23 -0.0249367
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0242387
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0241968
SEC31A SEC31 homolog A (S. cerevisiae) -0.0237745
GOLGB1 golgin B1 -0.0236138
SEC24D SEC24 family member D -0.0235363
RPL5 ribosomal protein L5 -0.0235233
TAS2R14 taste receptor, type 2, member 14 -0.0234734
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0234316
HMGB1 high mobility group box 1 -0.0229396
TSPAN8 tetraspanin 8 -0.0228454
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0228391
RPS15 ribosomal protein S15 -0.0227528
PTPRK protein tyrosine phosphatase, receptor type, K -0.0224228
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0223357
PALLD palladin, cytoskeletal associated protein -0.0222746
RPS14 ribosomal protein S14 -0.0220297
HM13 histocompatibility (minor) 13 -0.0215705
RPL14 ribosomal protein L14 -0.0214831
PNISR PNN-interacting serine/arginine-rich protein -0.02112
SQSTM1 sequestosome 1 -0.0209111
S100A10 S100 calcium binding protein A10 -0.0208308
SENP5 SUMO1/sentrin specific peptidase 5 -0.0205364
NACA nascent polypeptide-associated complex alpha subunit -0.0204473
RPS2 ribosomal protein S2 -0.0204133
ALCAM activated leukocyte cell adhesion molecule -0.0202069
RAB1A RAB1A, member RAS oncogene family -0.0197046
RPS27 ribosomal protein S27 -0.0197014
ACBD3 acyl-CoA binding domain containing 3 -0.0196778
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0191937
MORF4L2 mortality factor 4 like 2 -0.0191391
MON2 MON2 homolog (S. cerevisiae) -0.0191026
THSD4 thrombospondin, type I, domain containing 4 -0.0190853
CALU calumenin -0.0190525
RPL19 ribosomal protein L19 -0.0190138
ANXA2 annexin A2 -0.0188263
RPS4X ribosomal protein S4, X-linked -0.0183951
RPL36A ribosomal protein L36a -0.0183813
RPS3 ribosomal protein S3 -0.0183253
GNAS GNAS complex locus -0.018315