| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bestatin (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.215979 |
| TXNRD1 | thioredoxin reductase 1 | 0.204195 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0897585 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0848891 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0676198 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0670702 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0585127 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0563504 |
| CANX | calnexin | 0.0557614 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0527084 |
| EREG | epiregulin | 0.0487126 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0452432 |
| RAI1 | retinoic acid induced 1 | 0.0450246 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.044355 |
| MCL1 | myeloid cell leukemia 1 | 0.0430551 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0428921 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0410513 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0409762 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0384538 |
| AHNAK | AHNAK nucleoprotein | 0.0377359 |
| LDHA | lactate dehydrogenase A | 0.0363602 |
| UPP1 | uridine phosphorylase 1 | 0.0363074 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0344629 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0336227 |
| EMP1 | epithelial membrane protein 1 | 0.0329605 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0313041 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0304112 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0297918 |
| UBC | ubiquitin C | 0.0294988 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0293102 |
| RTN4 | reticulon 4 | 0.0288014 |
| TMEM41B | transmembrane protein 41B | 0.0287999 |
| EGR1 | early growth response 1 | 0.0287943 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0266259 |
| EZR | ezrin | 0.0264223 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0261862 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0258717 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.025861 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.025327 |
| ARRDC3 | arrestin domain containing 3 | 0.0251544 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.025078 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0246882 |
| RPS18 | ribosomal protein S18 | 0.024675 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0240291 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0235878 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0235032 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0233999 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0232391 |
| SFTPA2 | surfactant protein A2 | 0.0230158 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0227784 |
| IL6ST | interleukin 6 signal transducer | 0.0220618 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0217353 |
| JUN | jun proto-oncogene | 0.0214578 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0211238 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0209586 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0207439 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0200227 |
| ANGPTL4 | angiopoietin-like 4 | 0.0199269 |
| ERCC1 | excision repair cross-complementation group 1 | 0.0198051 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0197254 |
| NUP58 | nucleoporin 58 | 0.0195838 |
| CDCP1 | CUB domain containing protein 1 | 0.0193365 |
| PYGB | phosphorylase, glycogen; brain | 0.019295 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0192261 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0190994 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0190934 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0187546 |
| IPO7 | importin 7 | 0.0179994 |
| PLK2 | polo-like kinase 2 | 0.0179826 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0174799 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0174674 |
| TPM3 | tropomyosin 3 | 0.0173712 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0173011 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0170738 |
| HDLBP | high density lipoprotein binding protein | 0.0169585 |
| ANXA1 | annexin A1 | 0.0168667 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0166962 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0166243 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0166159 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.016405 |
| RPL3 | ribosomal protein L3 | 0.0163437 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0158139 |
| KLHL15 | kelch-like family member 15 | 0.0153791 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0153264 |
| TNPO1 | transportin 1 | 0.0152731 |
| YBX1 | Y box binding protein 1 | 0.0152716 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0152441 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0146586 |
| RCAN1 | regulator of calcineurin 1 | 0.0142779 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0141908 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0140384 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0139785 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0139484 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0139229 |
| SEC24A | SEC24 family member A | 0.0139197 |
| APP | amyloid beta (A4) precursor protein | 0.0138426 |
| GAN | gigaxonin | 0.0136481 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0135516 |
| CLIC4 | chloride intracellular channel 4 | 0.0133657 |
| ZBTB41 | zinc finger and BTB domain containing 41 | 0.0133643 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.184659 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.13371 |
| DST | dystonin | -0.112077 |
| PTMA | prothymosin, alpha | -0.107427 |
| CD44 | CD44 molecule (Indian blood group) | -0.106994 |
| TMSB10 | thymosin beta 10 | -0.102344 |
| MT2A | metallothionein 2A | -0.10081 |
| RAD51B | RAD51 paralog B | -0.0963812 |
| CADM2 | cell adhesion molecule 2 | -0.0927375 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0856648 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0843415 |
| HLA-B | major histocompatibility complex, class I, B | -0.0840524 |
| RNF213 | ring finger protein 213 | -0.0824091 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0787746 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0787109 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0782886 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0772276 |
| TNS3 | tensin 3 | -0.0735767 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0704018 |
| SP100 | SP100 nuclear antigen | -0.0692668 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0679958 |
| EXOC4 | exocyst complex component 4 | -0.0666097 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0658013 |
| EHBP1 | EH domain binding protein 1 | -0.0617479 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0616194 |
| RIGI | RNA sensor RIG-I | -0.061276 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0596018 |
| RPL35A | ribosomal protein L35a | -0.0588661 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0577599 |
| DPH6 | diphthamine biosynthesis 6 | -0.0569288 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0562159 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0543055 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0542905 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0530863 |
| FMNL2 | formin-like 2 | -0.0527397 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0510064 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0489523 |
| SMYD3 | SET and MYND domain containing 3 | -0.0480942 |
| RPS19 | ribosomal protein S19 | -0.0478027 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0471325 |
| RPL36 | ribosomal protein L36 | -0.045939 |
| PRELID2 | PRELI domain containing 2 | -0.0451717 |
| DNER | delta/notch-like EGF repeat containing | -0.0442546 |
| PLSCR1 | phospholipid scramblase 1 | -0.0425549 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0419915 |
| VCL | vinculin | -0.0412095 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0410862 |
| PTK2 | protein tyrosine kinase 2 | -0.040509 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0396928 |
| RBM25 | RNA binding motif protein 25 | -0.0395396 |
| RPL23 | ribosomal protein L23 | -0.0391873 |
| EFNA5 | ephrin-A5 | -0.0385164 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0380503 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0380015 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0378516 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0375807 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0369939 |
| PMP22 | peripheral myelin protein 22 | -0.0366019 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0363241 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0359712 |
| TPRG1 | tumor protein p63 regulated 1 | -0.0350036 |
| EPHA4 | EPH receptor A4 | -0.0349619 |
| VIM | vimentin | -0.0348406 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0344405 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0339694 |
| RPLP2 | ribosomal protein, large, P2 | -0.0335924 |
| RUNX1 | runt-related transcription factor 1 | -0.0333143 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0332538 |
| ZNF292 | zinc finger protein 292 | -0.0323724 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0314962 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0309072 |
| THOC2 | THO complex 2 | -0.0308432 |
| NF1 | neurofibromin 1 | -0.0305192 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.030158 |
| RPL26 | ribosomal protein L26 | -0.0301396 |
| COL5A2 | collagen, type V, alpha 2 | -0.0300072 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0297927 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0296443 |
| RPL12 | ribosomal protein L12 | -0.0294905 |
| RPL37A | ribosomal protein L37a | -0.0293398 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0289351 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0287416 |
| SRPK2 | SRSF protein kinase 2 | -0.0286811 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.028667 |
| RPL35 | ribosomal protein L35 | -0.0280585 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0280516 |
| RBM39 | RNA binding motif protein 39 | -0.0280113 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0279167 |
| ECE1 | endothelin converting enzyme 1 | -0.0278241 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0273461 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.027098 |
| GNAS | GNAS complex locus | -0.0266055 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0262136 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0258363 |
| DENND1A | DENN/MADD domain containing 1A | -0.0258152 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0256512 |
| RPS6 | ribosomal protein S6 | -0.025517 |
| RPL28 | ribosomal protein L28 | -0.0253203 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0251227 |
| B2M | beta-2-microglobulin | -0.0249304 |
