| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bestatin (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.174587 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0816067 |
| MCL1 | myeloid cell leukemia 1 | 0.0747175 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0646748 |
| CES1 | carboxylesterase 1 | 0.0582478 |
| SLTM | SAFB-like, transcription modulator | 0.0512793 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0471085 |
| PLEC | plectin | 0.0465828 |
| EFNA5 | ephrin-A5 | 0.0457191 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0450608 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0410853 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0399976 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0393701 |
| SDC4 | syndecan 4 | 0.0382305 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0380095 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0371311 |
| ABLIM1 | actin binding LIM protein 1 | 0.034973 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0340569 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0336989 |
| RNF213 | ring finger protein 213 | 0.0319027 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0315573 |
| LMO7 | LIM domain 7 | 0.0305567 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0293739 |
| CANX | calnexin | 0.029099 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0286549 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0273415 |
| OSMR | oncostatin M receptor | 0.0271672 |
| CPE | carboxypeptidase E | 0.0270698 |
| B2M | beta-2-microglobulin | 0.0269554 |
| LAMB3 | laminin, beta 3 | 0.026518 |
| LAMC2 | laminin, gamma 2 | 0.0263857 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0258731 |
| CCNL1 | cyclin L1 | 0.0257068 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0253881 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0253518 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0247172 |
| TES | testin LIM domain protein | 0.0233898 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.022984 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0229738 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0225927 |
| VMP1 | vacuole membrane protein 1 | 0.0225153 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0224391 |
| EGR1 | early growth response 1 | 0.022301 |
| MX1 | MX dynamin-like GTPase 1 | 0.0215724 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0213306 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0212523 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0211323 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0207417 |
| KIAA1217 | KIAA1217 | 0.0206488 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0206127 |
| SMIM14 | small integral membrane protein 14 | 0.0196997 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0192483 |
| EZR | ezrin | 0.0188833 |
| MYO6 | myosin VI | 0.0185727 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0185119 |
| MKI67 | marker of proliferation Ki-67 | 0.0184664 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0182546 |
| JUP | junction plakoglobin | 0.0182248 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0181815 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.018018 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0178246 |
| FOXP1 | forkhead box P1 | 0.0177885 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0177212 |
| APP | amyloid beta (A4) precursor protein | 0.0176772 |
| CCND1 | cyclin D1 | 0.0176056 |
| SQSTM1 | sequestosome 1 | 0.0173582 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0172544 |
| TKT | transketolase | 0.0171966 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0171241 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.017029 |
| PCBP2 | poly(rC) binding protein 2 | 0.0168954 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.016841 |
| SMAD3 | SMAD family member 3 | 0.0167241 |
| ASPH | aspartate beta-hydroxylase | 0.0163918 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0163804 |
| FBXO11 | F-box protein 11 | 0.0159217 |
| SKIL | SKI-like proto-oncogene | 0.0158237 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0157851 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0157167 |
| AHNAK | AHNAK nucleoprotein | 0.0155348 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0154641 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0153434 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0152802 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0152566 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0150039 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0148278 |
| CCNG2 | cyclin G2 | 0.0144777 |
| PLSCR1 | phospholipid scramblase 1 | 0.0143878 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0143787 |
| PRKCE | protein kinase C, epsilon | 0.0143465 |
| ANXA2 | annexin A2 | 0.0142567 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0142372 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.014218 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0141843 |
| ARGLU1 | arginine and glutamate rich 1 | 0.014111 |
| SRCAP | Snf2-related CREBBP activator protein | 0.0140686 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0139114 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0138859 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0136661 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0136142 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.254534 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.126904 |
| EGFR | epidermal growth factor receptor | -0.120797 |
| TMSB10 | thymosin beta 10 | -0.0789424 |
| FAM13A | family with sequence similarity 13, member A | -0.0772277 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0770987 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0705554 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0624593 |
| S100A10 | S100 calcium binding protein A10 | -0.0576471 |
| MT2A | metallothionein 2A | -0.0561053 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0429848 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0429713 |
| GPC6 | glypican 6 | -0.0401367 |
| PTMA | prothymosin, alpha | -0.0396797 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0392496 |
| SEC61G | Sec61 gamma subunit | -0.0389078 |
| NGLY1 | N-glycanase 1 | -0.036964 |
| ACTG1 | actin gamma 1 | -0.0367985 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0359236 |
| MYOF | myoferlin | -0.0345353 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0328986 |
| NDRG1 | N-myc downstream regulated 1 | -0.0317748 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0316744 |
| SEPTIN2 | septin 2 | -0.0313096 |
| HELZ | helicase with zinc finger | -0.0311727 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0311099 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0306762 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0302736 |
| PYGL | phosphorylase, glycogen, liver | -0.0299174 |
| PDE8A | phosphodiesterase 8A | -0.0298318 |
| KRT18 | keratin 18, type I | -0.0275371 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0274597 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0271623 |
| RPS25 | ribosomal protein S25 | -0.0262819 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0260544 |
| NBEAL1 | neurobeachin-like 1 | -0.0256431 |
| RBM39 | RNA binding motif protein 39 | -0.0255575 |
| S100A6 | S100 calcium binding protein A6 | -0.0255316 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0253637 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0253168 |
| ANKRD37 | ankyrin repeat domain 37 | -0.024915 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.024349 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0242187 |
| RPL37A | ribosomal protein L37a | -0.0236362 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0236345 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.023628 |
| ANXA1 | annexin A1 | -0.0231991 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0228977 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0225333 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0222463 |
| OFD1 | oral-facial-digital syndrome 1 | -0.0222412 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0217653 |
| H1-0 | H1.0 linker histone | -0.0217038 |
| SUMF1 | sulfatase modifying factor 1 | -0.0215182 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0209518 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0206107 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0204086 |
| SRP54 | signal recognition particle 54kDa | -0.0202238 |
| STC1 | stanniocalcin 1 | -0.019993 |
| GOLGA4 | golgin A4 | -0.0199905 |
| OGA | O-GlcNAcase | -0.0197 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0196848 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.019602 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0195857 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0195384 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0195099 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.019295 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0192296 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0189957 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0189927 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0187102 |
| HDLBP | high density lipoprotein binding protein | -0.018662 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0186497 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0183524 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0179039 |
| RPS6 | ribosomal protein S6 | -0.0177199 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0177171 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0176167 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0173747 |
| GNAS | GNAS complex locus | -0.0173682 |
| MORF4L2 | mortality factor 4 like 2 | -0.0172541 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0171269 |
| TMF1 | TATA element modulatory factor 1 | -0.0169618 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0168347 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.016811 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0167817 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0162317 |
| BMP7 | bone morphogenetic protein 7 | -0.0162123 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0161548 |
| TPI1 | triosephosphate isomerase 1 | -0.0161117 |
| USP3 | ubiquitin specific peptidase 3 | -0.0161068 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0159744 |
| TLK1 | tousled-like kinase 1 | -0.0159278 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0158989 |
| CERT1 | ceramide transporter 1 | -0.0158395 |
| UBC | ubiquitin C | -0.0158285 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0157966 |
| RPL34 | ribosomal protein L34 | -0.0157926 |
| TOP1 | topoisomerase (DNA) I | -0.01569 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0156562 |
