| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bestatin (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.250205 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.175969 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.166042 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.164767 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.139546 |
| PM20D1 | peptidase M20 domain containing 1 | 0.132486 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.12433 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.113709 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.112231 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0950153 |
| TXNRD1 | thioredoxin reductase 1 | 0.0898782 |
| GRAMD1B | GRAM domain containing 1B | 0.0861523 |
| VIM | vimentin | 0.0811489 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0694965 |
| MCL1 | myeloid cell leukemia 1 | 0.0678357 |
| KYNU | kynureninase | 0.0638558 |
| FTL | ferritin, light polypeptide | 0.0615702 |
| POTEF | POTE ankyrin domain family, member F | 0.0589475 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0586907 |
| FNDC3B | fibronectin type III domain containing 3B | 0.056951 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0563457 |
| LDHA | lactate dehydrogenase A | 0.0556069 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0555044 |
| NRG1 | neuregulin 1 | 0.0540188 |
| EGR1 | early growth response 1 | 0.0529436 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0520738 |
| CCNL1 | cyclin L1 | 0.0514408 |
| RPLP0 | ribosomal protein, large, P0 | 0.051216 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0507266 |
| HMGA1 | high mobility group AT-hook 1 | 0.0501062 |
| PCBP2 | poly(rC) binding protein 2 | 0.0500675 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0500204 |
| GLIS3 | GLIS family zinc finger 3 | 0.0489628 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0473617 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0465787 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0465105 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.045519 |
| TFG | TRK-fused gene | 0.0453645 |
| COPA | coatomer protein complex, subunit alpha | 0.0447154 |
| ASPH | aspartate beta-hydroxylase | 0.0444299 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0442994 |
| EFNA5 | ephrin-A5 | 0.0441632 |
| TMEM131 | transmembrane protein 131 | 0.0437765 |
| DST | dystonin | 0.0431118 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0429011 |
| OSMR | oncostatin M receptor | 0.0410643 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0402339 |
| PTK2 | protein tyrosine kinase 2 | 0.0397114 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0391412 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0389701 |
| FAM107B | family with sequence similarity 107, member B | 0.0384449 |
| PKM | pyruvate kinase, muscle | 0.0378336 |
| TPM4 | tropomyosin 4 | 0.0375414 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0371786 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0363295 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0358133 |
| ZNF207 | zinc finger protein 207 | 0.0357676 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0354129 |
| PFN1 | profilin 1 | 0.035098 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0344813 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0344704 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0344582 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0344351 |
| USP3 | ubiquitin specific peptidase 3 | 0.0341686 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0337451 |
| ANKRD11 | ankyrin repeat domain 11 | 0.033669 |
| TNPO1 | transportin 1 | 0.0328472 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0326994 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.032592 |
| NEGR1 | neuronal growth regulator 1 | 0.0324265 |
| YBX1 | Y box binding protein 1 | 0.0320838 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0318171 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0317861 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0312647 |
| WWOX | WW domain containing oxidoreductase | 0.0306836 |
| ITGAV | integrin, alpha V | 0.0305677 |
| PLS3 | plastin 3 | 0.0302879 |
| RAD51B | RAD51 paralog B | 0.0302474 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0301768 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0299094 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.029557 |
| UTRN | utrophin | 0.0291768 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.029152 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0290083 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.028954 |
| AK1 | adenylate kinase 1 | 0.0289456 |
| NTN4 | netrin 4 | 0.0289217 |
| PDE8A | phosphodiesterase 8A | 0.0286162 |
| OAZ1 | ornithine decarboxylase antizyme 1 | 0.0281076 |
| MYOF | myoferlin | 0.0273278 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.026782 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.026557 |
| WBP11 | WW domain binding protein 11 | 0.0264214 |
| CMIP | c-Maf inducing protein | 0.0259501 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0257865 |
| S100A10 | S100 calcium binding protein A10 | 0.0256382 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0255661 |
| FTO | fat mass and obesity associated | 0.0254107 |
| SDC4 | syndecan 4 | 0.0250494 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0247613 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.100868 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.096739 |
| MT2A | metallothionein 2A | -0.0903911 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0831684 |
| RPS2 | ribosomal protein S2 | -0.0808022 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0654583 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.051854 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0406666 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.04053 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0402773 |
| CAVIN1 | caveolae associated protein 1 | -0.0336004 |
| RPS8 | ribosomal protein S8 | -0.0325385 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0322312 |
| MKI67 | marker of proliferation Ki-67 | -0.0320879 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.031383 |
| RBM39 | RNA binding motif protein 39 | -0.0307647 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0300282 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0299917 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0298567 |
| CLTC | clathrin, heavy chain (Hc) | -0.0294039 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0292502 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0284537 |
| RPL19 | ribosomal protein L19 | -0.0274501 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0274082 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0262664 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.026241 |
| RPL4 | ribosomal protein L4 | -0.0260672 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0258013 |
| TPD52 | tumor protein D52 | -0.0256461 |
| ANXA1 | annexin A1 | -0.0252445 |
| RPL7 | ribosomal protein L7 | -0.0251373 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0251174 |
| GOLT1B | golgi transport 1B | -0.0243717 |
| GOLGA4 | golgin A4 | -0.0236427 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0234319 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0233001 |
| MBTPS1 | membrane-bound transcription factor peptidase, site 1 | -0.022628 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0224325 |
| GOLGB1 | golgin B1 | -0.0221345 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.022132 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0215818 |
| STC1 | stanniocalcin 1 | -0.0215422 |
| RPL3 | ribosomal protein L3 | -0.0215316 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0215052 |
| BRD2 | bromodomain containing 2 | -0.0214609 |
| H1-4 | H1.4 linker histone, cluster member | -0.0212867 |
| CYTH1 | cytohesin 1 | -0.0208978 |
| STK4 | serine/threonine kinase 4 | -0.0208856 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0205358 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0202247 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0198488 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | -0.0195691 |
| RPS3 | ribosomal protein S3 | -0.0194049 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0188498 |
| RPL6 | ribosomal protein L6 | -0.0185685 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0184117 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.018372 |
| RPS27A | ribosomal protein S27a | -0.0183053 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0178366 |
| GON4L | gon-4-like (C. elegans) | -0.0175654 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0172831 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0172592 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0171531 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0171315 |
| PRPF3 | pre-mRNA processing factor 3 | -0.017051 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0170325 |
| RPL23 | ribosomal protein L23 | -0.0167658 |
| THOC2 | THO complex 2 | -0.0167482 |
| NOB1 | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) | -0.0167039 |
| SERF2 | small EDRK-rich factor 2 | -0.0166355 |
| RPL9 | ribosomal protein L9 | -0.016619 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0166155 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | -0.0166116 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0165936 |
| TRIM37 | tripartite motif containing 37 | -0.0165569 |
| RECQL | RecQ helicase-like | -0.016524 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | -0.0164775 |
| RPL26 | ribosomal protein L26 | -0.0164158 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0162572 |
| TMSB10 | thymosin beta 10 | -0.0162563 |
| CENPE | centromere protein E, 312kDa | -0.0160168 |
| MORF4L2 | mortality factor 4 like 2 | -0.0160144 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | -0.0159957 |
| EP400 | E1A binding protein p400 | -0.0158404 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0158305 |
| ADAR | adenosine deaminase, RNA-specific | -0.0158146 |
| MED6 | mediator complex subunit 6 | -0.0158093 |
| CENPF | centromere protein F, 350/400kDa | -0.015719 |
| PHF20 | PHD finger protein 20 | -0.015678 |
| RPL34 | ribosomal protein L34 | -0.0156619 |
| PPP4R3A | protein phosphatase 4 regulatory subunit 3A | -0.0156427 |
| FCHO2 | FCH domain only 2 | -0.0156139 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.015475 |
| S100A6 | S100 calcium binding protein A6 | -0.015423 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.015363 |
| OSBP | oxysterol binding protein | -0.015353 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0153301 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0153246 |
| PDCD11 | programmed cell death 11 | -0.015285 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0152759 |
