| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bestatin (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.122184 |
| FN1 | fibronectin 1 | 0.104652 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0980889 |
| ASPH | aspartate beta-hydroxylase | 0.0915382 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0875276 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0722314 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0718384 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0687921 |
| FTL | ferritin, light polypeptide | 0.058778 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0551476 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0509743 |
| COL5A2 | collagen, type V, alpha 2 | 0.050855 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0500641 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0491867 |
| PTK2 | protein tyrosine kinase 2 | 0.048951 |
| CALD1 | caldesmon 1 | 0.0488997 |
| CANX | calnexin | 0.047193 |
| COPA | coatomer protein complex, subunit alpha | 0.0470476 |
| PHF21A | PHD finger protein 21A | 0.0464242 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0456383 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0451684 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0443778 |
| ATXN1 | ataxin 1 | 0.0443219 |
| GPC6 | glypican 6 | 0.0441803 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0439866 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0439772 |
| ENO1 | enolase 1, (alpha) | 0.0439134 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0436294 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0421169 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0414141 |
| PGK1 | phosphoglycerate kinase 1 | 0.0397398 |
| HELZ | helicase with zinc finger | 0.0393913 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0393162 |
| NF1 | neurofibromin 1 | 0.039091 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0389245 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0384807 |
| MEMO1 | mediator of cell motility 1 | 0.0377973 |
| SBF2 | SET binding factor 2 | 0.0374724 |
| TNRC6A | trinucleotide repeat containing 6A | 0.037435 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0374099 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0373494 |
| NAV1 | neuron navigator 1 | 0.0372896 |
| HM13 | histocompatibility (minor) 13 | 0.0370257 |
| FLNB | filamin B, beta | 0.0366529 |
| MAP1B | microtubule-associated protein 1B | 0.0364629 |
| DST | dystonin | 0.0362214 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0359342 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0352985 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0351456 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0348049 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.034293 |
| INHBA | inhibin, beta A | 0.03379 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0336981 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0334698 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0333202 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0329864 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.032681 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0326134 |
| EXOC4 | exocyst complex component 4 | 0.0325719 |
| SMYD3 | SET and MYND domain containing 3 | 0.0324676 |
| NAV2 | neuron navigator 2 | 0.032006 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0318755 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0318193 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.031755 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | 0.0315668 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0315394 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0315038 |
| USP34 | ubiquitin specific peptidase 34 | 0.0313669 |
| RTN4 | reticulon 4 | 0.0311172 |
| CALU | calumenin | 0.0310504 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0310231 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0309869 |
| UBXN4 | UBX domain protein 4 | 0.0309223 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0307798 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0305872 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0304477 |
| CD109 | CD109 molecule | 0.0302769 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0299497 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0298256 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.029766 |
| LDHA | lactate dehydrogenase A | 0.0295892 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0286066 |
| PCM1 | pericentriolar material 1 | 0.0285673 |
| CD44 | CD44 molecule (Indian blood group) | 0.0283497 |
| AUTS2 | autism susceptibility candidate 2 | 0.0282165 |
| RPL31 | ribosomal protein L31 | 0.0277518 |
| SMAD3 | SMAD family member 3 | 0.0276761 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.027523 |
| FAT1 | FAT atypical cadherin 1 | 0.0274835 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0274611 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0271153 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0271099 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0269873 |
| RSF1 | remodeling and spacing factor 1 | 0.0268328 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0267417 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0264852 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0260605 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0258752 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0254244 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0251726 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.187706 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.160382 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.150904 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.138236 |
| MYO1E | myosin IE | -0.130066 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.129255 |
| GRB10 | growth factor receptor-bound protein 10 | -0.124337 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.123136 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.12203 |
| LAMB3 | laminin, beta 3 | -0.119166 |
| LAMC2 | laminin, gamma 2 | -0.104531 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0999263 |
| SVIL | supervillin | -0.0965339 |
| ATOSA | atos homolog A | -0.0924605 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0793448 |
| CMIP | c-Maf inducing protein | -0.0782045 |
| PLAUR | plasminogen activator, urokinase receptor | -0.071769 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0699575 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0690031 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.059252 |
| MUC16 | mucin 16, cell surface associated | -0.0570483 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.056204 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.055645 |
| ERBIN | erbb2 interacting protein | -0.054891 |
| ABHD17C | abhydrolase domain containing 17C | -0.0525687 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0522025 |
| RBM47 | RNA binding motif protein 47 | -0.0519284 |
| EZR | ezrin | -0.0507937 |
| ANXA2 | annexin A2 | -0.0486071 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0466522 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0465067 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0458403 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.044898 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0448196 |
| STEAP4 | STEAP family member 4 | -0.0444395 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0443566 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0441218 |
| EGFR | epidermal growth factor receptor | -0.0439069 |
| MXD1 | MAX dimerization protein 1 | -0.043642 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0421425 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0419087 |
| DSCAM | Down syndrome cell adhesion molecule | -0.041253 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0405049 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0396829 |
| MCL1 | myeloid cell leukemia 1 | -0.0396602 |
| AFDN | afadin, adherens junction formation factor | -0.0390925 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0382558 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0379831 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0377406 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0367845 |
| CNKSR3 | CNKSR family member 3 | -0.0365661 |
| TJP2 | tight junction protein 2 | -0.036522 |
| TC2N | tandem C2 domains, nuclear | -0.0357684 |
| KRT17 | keratin 17, type I | -0.0356023 |
| ZBTB43 | zinc finger and BTB domain containing 43 | -0.0352143 |
| MYO6 | myosin VI | -0.0349368 |
| WDR26 | WD repeat domain 26 | -0.0341986 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0339529 |
| SSH2 | slingshot protein phosphatase 2 | -0.033617 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0329515 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0321376 |
| AK1 | adenylate kinase 1 | -0.0320641 |
| JUP | junction plakoglobin | -0.0319313 |
| NDRG1 | N-myc downstream regulated 1 | -0.0312084 |
| STC1 | stanniocalcin 1 | -0.0302913 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0295082 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0293429 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0291687 |
| FOXO1 | forkhead box O1 | -0.0282594 |
| SFTPA2 | surfactant protein A2 | -0.0281081 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0274122 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0270188 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0264976 |
| TJP1 | tight junction protein 1 | -0.0263665 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.025981 |
| SQSTM1 | sequestosome 1 | -0.0258694 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0255578 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0255408 |
| ITSN2 | intersectin 2 | -0.0250529 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0249649 |
| CDCP1 | CUB domain containing protein 1 | -0.0248801 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0248405 |
| OFD1 | oral-facial-digital syndrome 1 | -0.0244795 |
| ATP11A | ATPase, class VI, type 11A | -0.0242739 |
| KLF6 | Kruppel-like factor 6 | -0.0240924 |
| NPTN | neuroplastin | -0.0238727 |
| FMNL2 | formin-like 2 | -0.0229246 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0226654 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.022172 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0216765 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.021032 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0209965 |
| ADM | adrenomedullin | -0.0200543 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0199578 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0198991 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0198951 |
| ZNF638 | zinc finger protein 638 | -0.0197573 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0197543 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0193424 |
| TMEM165 | transmembrane protein 165 | -0.0188712 |
