| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Bestatin (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.175659 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.138525 |
| TXNRD1 | thioredoxin reductase 1 | 0.104367 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0605497 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0490513 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0470007 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0423183 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0421848 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0355498 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0340143 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0331293 |
| PLEC | plectin | 0.0323428 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0301043 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0299779 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0289919 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.027124 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0269244 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0265874 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.026393 |
| PCBP2 | poly(rC) binding protein 2 | 0.025035 |
| SMAD3 | SMAD family member 3 | 0.0246886 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0244123 |
| ANXA5 | annexin A5 | 0.0242634 |
| MAGEA4 | melanoma antigen family A4 | 0.0239533 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0237013 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0236802 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0230966 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0227589 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0227316 |
| TPM3 | tropomyosin 3 | 0.0223896 |
| ANO6 | anoctamin 6 | 0.0222706 |
| CLTC | clathrin, heavy chain (Hc) | 0.0218139 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0212922 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0209004 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0208286 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0204175 |
| PGK1 | phosphoglycerate kinase 1 | 0.0202368 |
| OGA | O-GlcNAcase | 0.0201085 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0199983 |
| MYPN | myopalladin | 0.0199896 |
| PKM | pyruvate kinase, muscle | 0.0198912 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0197346 |
| KRT18 | keratin 18, type I | 0.0196762 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0195527 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0194302 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0193421 |
| IPO7 | importin 7 | 0.0191473 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0189818 |
| TJP1 | tight junction protein 1 | 0.0189092 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0187638 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0179969 |
| DST | dystonin | 0.0179542 |
| TUBA1C | tubulin, alpha 1c | 0.0177433 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0175733 |
| UBC | ubiquitin C | 0.0175516 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0173614 |
| RASAL2 | RAS protein activator like 2 | 0.0171912 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0169332 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0167166 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.016701 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.016691 |
| CLDN1 | claudin 1 | 0.0166471 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0165811 |
| STK4 | serine/threonine kinase 4 | 0.0164442 |
| IPO5 | importin 5 | 0.0162961 |
| MSH6 | mutS homolog 6 | 0.0161823 |
| LDHA | lactate dehydrogenase A | 0.0160414 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0160057 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0159829 |
| MCL1 | myeloid cell leukemia 1 | 0.0158443 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0158356 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0156599 |
| CUL3 | cullin 3 | 0.0155723 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0154453 |
| SEPTIN9 | septin 9 | 0.0152773 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0152248 |
| CCND1 | cyclin D1 | 0.0152031 |
| ARF3 | ADP-ribosylation factor 3 | 0.0149929 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.0148539 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0146427 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0145911 |
| CAPRIN2 | caprin family member 2 | 0.0145884 |
| AHNAK | AHNAK nucleoprotein | 0.0145584 |
| SQSTM1 | sequestosome 1 | 0.014553 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0144228 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0143934 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0143208 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | 0.0142774 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0140982 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.013918 |
| EZR | ezrin | 0.01375 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0137408 |
| SSR1 | signal sequence receptor, alpha | 0.0136936 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0136885 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0135654 |
| PCNX1 | pecanex 1 | 0.0134819 |
| LARP4 | La ribonucleoprotein domain family, member 4 | 0.0134216 |
| ZYX | zyxin | 0.0133964 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0133794 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0133709 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.16368 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.160847 |
| TMSB10 | thymosin beta 10 | -0.0919356 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0732148 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0492784 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0485331 |
| RPS3 | ribosomal protein S3 | -0.048438 |
| RPS27 | ribosomal protein S27 | -0.0452735 |
| AFF3 | AF4/FMR2 family, member 3 | -0.043498 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0432585 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0421626 |
| RPS6 | ribosomal protein S6 | -0.0419438 |
| RPS21 | ribosomal protein S21 | -0.0408059 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0407729 |
| RPL37 | ribosomal protein L37 | -0.0401708 |
| MT2A | metallothionein 2A | -0.0385283 |
| RPS29 | ribosomal protein S29 | -0.0385211 |
| RAD51B | RAD51 paralog B | -0.0380984 |
| PTMA | prothymosin, alpha | -0.0379588 |
| RPS8 | ribosomal protein S8 | -0.0379104 |
| RPS12 | ribosomal protein S12 | -0.0369347 |
| RPL34 | ribosomal protein L34 | -0.0361312 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0348456 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0343963 |
| RPS19 | ribosomal protein S19 | -0.0339095 |
| RPL35A | ribosomal protein L35a | -0.0332186 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0326582 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.031978 |
| RPL37A | ribosomal protein L37a | -0.0315768 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0309768 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0305727 |
| VIM | vimentin | -0.0294185 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0291534 |
| RPL23 | ribosomal protein L23 | -0.0286784 |
| RPL11 | ribosomal protein L11 | -0.0284792 |
| RPLP1 | ribosomal protein, large, P1 | -0.0276458 |
| RPL36 | ribosomal protein L36 | -0.0274841 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0272577 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0271959 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0268501 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0261212 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0260316 |
| RPL26 | ribosomal protein L26 | -0.0251017 |
| PDE10A | phosphodiesterase 10A | -0.0241515 |
| PFN1 | profilin 1 | -0.0236853 |
| PHF21A | PHD finger protein 21A | -0.0233728 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0232817 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0231671 |
| RBM39 | RNA binding motif protein 39 | -0.0231525 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.022726 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0223702 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0223589 |
| RPL8 | ribosomal protein L8 | -0.0222367 |
| VMP1 | vacuole membrane protein 1 | -0.0220814 |
| YBX3 | Y box binding protein 3 | -0.0217909 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0216201 |
| CUX1 | cut-like homeobox 1 | -0.0211885 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0210606 |
| RPS25 | ribosomal protein S25 | -0.0210592 |
| RPL27 | ribosomal protein L27 | -0.0206886 |
| RPS14 | ribosomal protein S14 | -0.0205652 |
| HLA-B | major histocompatibility complex, class I, B | -0.0205271 |
| DENND5B | DENN/MADD domain containing 5B | -0.0203615 |
| FBXO11 | F-box protein 11 | -0.0201811 |
| RPL35 | ribosomal protein L35 | -0.02017 |
| RPLP2 | ribosomal protein, large, P2 | -0.0199636 |
| WWOX | WW domain containing oxidoreductase | -0.0196337 |
| ZNF638 | zinc finger protein 638 | -0.0195317 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0192878 |
| RPS24 | ribosomal protein S24 | -0.0192717 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0191225 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0186914 |
| RPS10 | ribosomal protein S10 | -0.0185262 |
| RPL28 | ribosomal protein L28 | -0.0185015 |
| EHBP1 | EH domain binding protein 1 | -0.0183802 |
| FTL | ferritin, light polypeptide | -0.0181657 |
| RNF213 | ring finger protein 213 | -0.0181123 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | -0.0180968 |
| S100A10 | S100 calcium binding protein A10 | -0.0177942 |
| PHF20 | PHD finger protein 20 | -0.0176507 |
| RYR3 | ryanodine receptor 3 | -0.0174669 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0174247 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0172378 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0170466 |
| TPM2 | tropomyosin 2 (beta) | -0.0170397 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0169969 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0168914 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0167932 |
| EGFR | epidermal growth factor receptor | -0.0166969 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0165271 |
| SSH2 | slingshot protein phosphatase 2 | -0.016474 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0164469 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0161759 |
| RPL19 | ribosomal protein L19 | -0.0161712 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0160634 |
| SETD5 | SET domain containing 5 | -0.016022 |
| RPS4X | ribosomal protein S4, X-linked | -0.0159745 |
| GPATCH2L | G patch domain containing 2-like | -0.0158951 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0155768 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.015201 |
