Bestatin (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0848348
DSCAM Down syndrome cell adhesion molecule 0.0807142
FNDC3B fibronectin type III domain containing 3B 0.0741264
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0608033
SAMD4A sterile alpha motif domain containing 4A 0.0563918
EFNA5 ephrin-A5 0.0550067
ERBIN erbb2 interacting protein 0.0520595
PTK2 protein tyrosine kinase 2 0.0425339
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0386984
LPP LIM domain containing preferred translocation partner in lipoma 0.0384015
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0372185
MYH9 myosin, heavy chain 9, non-muscle 0.0353486
ASPH aspartate beta-hydroxylase 0.0336712
KDM6A lysine (K)-specific demethylase 6A 0.0336071
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0330265
MBNL1 muscleblind-like splicing regulator 1 0.0312277
EXT1 exostosin glycosyltransferase 1 0.0289288
CANX calnexin 0.028473
LIMCH1 LIM and calponin homology domains 1 0.0283181
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0272764
PARD3 par-3 family cell polarity regulator 0.0271431
TRIO trio Rho guanine nucleotide exchange factor 0.0269337
GRB10 growth factor receptor-bound protein 10 0.0266603
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0265675
ZFAND3 zinc finger, AN1-type domain 3 0.0263925
USP9X ubiquitin specific peptidase 9, X-linked 0.0259851
FNIP1 folliculin interacting protein 1 0.0258626
NAV2 neuron navigator 2 0.0256369
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.024868
STRN3 striatin, calmodulin binding protein 3 0.023897
GLS2 glutaminase 2 (liver, mitochondrial) 0.0224719
CAPN2 calpain 2, (m/II) large subunit 0.0223656
NRIP1 nuclear receptor interacting protein 1 0.0222433
GSK3B glycogen synthase kinase 3 beta 0.0219899
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0218329
KMT2C lysine (K)-specific methyltransferase 2C 0.021703
ZSWIM6 zinc finger, SWIM-type containing 6 0.0216493
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0215807
ARHGAP5 Rho GTPase activating protein 5 0.0210867
CCNL1 cyclin L1 0.0209932
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0209716
ARRDC3 arrestin domain containing 3 0.0208146
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0206674
SMAD3 SMAD family member 3 0.0198206
CHD1 chromodomain helicase DNA binding protein 1 0.0197758
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0196324
WDFY3 WD repeat and FYVE domain containing 3 0.0194313
ANKRD17 ankyrin repeat domain 17 0.0191683
NCKAP1 NCK-associated protein 1 0.0191671
VMP1 vacuole membrane protein 1 0.0190991
PAPOLA poly(A) polymerase alpha 0.0189651
OCLN occludin 0.0187578
ERRFI1 ERBB receptor feedback inhibitor 1 0.0187535
SFPQ splicing factor proline/glutamine-rich 0.0186942
COPA coatomer protein complex, subunit alpha 0.0186617
APP amyloid beta (A4) precursor protein 0.0185624
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0182407
JMJD1C jumonji domain containing 1C 0.0180032
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0179266
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0179044
GOLGA4 golgin A4 0.0177803
WAC WW domain containing adaptor with coiled-coil 0.0176003
ZNF148 zinc finger protein 148 0.017552
PCBP2 poly(rC) binding protein 2 0.0174341
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0173604
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0172559
STK24 serine/threonine kinase 24 0.0172333
PTBP3 polypyrimidine tract binding protein 3 0.0171698
DTNA dystrobrevin, alpha 0.017153
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0171526
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0168921
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0167049
CLTC clathrin, heavy chain (Hc) 0.016691
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0166731
BLTP1 bridge-like lipid transfer protein family member 1 0.0166507
CD109 CD109 molecule 0.016645
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0166209
PTEN phosphatase and tensin homolog 0.0166068
TPM3 tropomyosin 3 0.0165759
SH3RF1 SH3 domain containing ring finger 1 0.0164808
BIRC6 baculoviral IAP repeat containing 6 0.0162483
RUNX1 runt-related transcription factor 1 0.0161853
RASA2 RAS p21 protein activator 2 0.0161268
RNF145 ring finger protein 145 0.0159677
NF1 neurofibromin 1 0.0159611
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0158992
VCL vinculin 0.0158618
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0157368
ITCH itchy E3 ubiquitin protein ligase 0.0157056
PUM2 pumilio RNA-binding family member 2 0.0156849
YAP1 Yes-associated protein 1 0.0155882
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0155595
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0155387
CCNY cyclin Y 0.0154637
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0154536
MYO5B myosin VB 0.0154262
TAOK1 TAO kinase 1 0.015378
OSMR oncostatin M receptor 0.0152224
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0152097
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0151823

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.319333
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.248811
TMSB10 thymosin beta 10 -0.19554
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.142447
PTMA prothymosin, alpha -0.141786
ACTG1 actin gamma 1 -0.119186
S100A6 S100 calcium binding protein A6 -0.11041
MT2A metallothionein 2A -0.104794
LAMB3 laminin, beta 3 -0.0941617
TPT1 tumor protein, translationally-controlled 1 -0.0871254
NDRG1 N-myc downstream regulated 1 -0.0840553
S100A10 S100 calcium binding protein A10 -0.0824401
RPLP1 ribosomal protein, large, P1 -0.0821713
IFI27 interferon, alpha-inducible protein 27 -0.0799703
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0793413
RPL35A ribosomal protein L35a -0.0788262
RPS19 ribosomal protein S19 -0.072091
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.069956
ISG15 ISG15 ubiquitin-like modifier -0.069266
RPLP2 ribosomal protein, large, P2 -0.0684819
IFI6 interferon, alpha-inducible protein 6 -0.0647125
EIF1 eukaryotic translation initiation factor 1 -0.0645734
IFITM3 interferon induced transmembrane protein 3 -0.0606405
G0S2 G0/G1 switch 2 -0.0589896
RPL8 ribosomal protein L8 -0.05897
RPS8 ribosomal protein S8 -0.0587273
HMGA1 high mobility group AT-hook 1 -0.0576761
RPL34 ribosomal protein L34 -0.0574351
CSTB cystatin B (stefin B) -0.0555862
WSB1 WD repeat and SOCS box containing 1 -0.0517199
RPS29 ribosomal protein S29 -0.0509983
IFITM1 interferon induced transmembrane protein 1 -0.050636
RPL23 ribosomal protein L23 -0.0495393
S100A9 S100 calcium binding protein A9 -0.0490516
RPS3 ribosomal protein S3 -0.0486674
RPL32 ribosomal protein L32 -0.0462141
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0454505
IGFBP3 insulin-like growth factor binding protein 3 -0.0454099
RPL12 ribosomal protein L12 -0.0432605
HLA-B major histocompatibility complex, class I, B -0.0408675
RPS6 ribosomal protein S6 -0.0400127
RPS13 ribosomal protein S13 -0.039807
C15ORF48 chromosome 15 open reading frame 48 -0.0397503
RPL19 ribosomal protein L19 -0.0390647
RPS27 ribosomal protein S27 -0.0388936
HLA-A major histocompatibility complex, class I, A -0.0383038
FAM162A family with sequence similarity 162, member A -0.0382787
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0375752
RPL37A ribosomal protein L37a -0.0375565
VIM vimentin -0.0375447
RPS23 ribosomal protein S23 -0.037302
RPL36 ribosomal protein L36 -0.0369407
RPL28 ribosomal protein L28 -0.0365739
RPL37 ribosomal protein L37 -0.0364374
LMNA lamin A/C -0.0359682
TPI1 triosephosphate isomerase 1 -0.0355528
RPS14 ribosomal protein S14 -0.0353069
RPL9 ribosomal protein L9 -0.0352623
ENO1 enolase 1, (alpha) -0.0338726
RPL31 ribosomal protein L31 -0.033618
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0332847
TM4SF1 transmembrane 4 L six family member 1 -0.0322609
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0320589
GPX4 glutathione peroxidase 4 -0.0318327
RACK1 receptor for activated C kinase 1 -0.0312083
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0310172
IFI16 interferon, gamma-inducible protein 16 -0.0307252
S100A11 S100 calcium binding protein A11 -0.0306625
PGK1 phosphoglycerate kinase 1 -0.0306195
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0302251
RPL36A ribosomal protein L36a -0.0295878
B2M beta-2-microglobulin -0.0292693
RPS25 ribosomal protein S25 -0.0290013
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0289814
RPL11 ribosomal protein L11 -0.0288772
RPS21 ribosomal protein S21 -0.0283678
RPS16 ribosomal protein S16 -0.0283222
TSC22D2 TSC22 domain family, member 2 -0.0282498
LOC112694756 uncharaterized LOC112694756 -0.0282315
CD63 CD63 molecule -0.0279849
RPS10 ribosomal protein S10 -0.0277679
SDC4 syndecan 4 -0.0277278
GNAS GNAS complex locus -0.0274587
NPEPPS aminopeptidase puromycin sensitive -0.027129
HSPB1 heat shock 27kDa protein 1 -0.0269476
RPL15 ribosomal protein L15 -0.0268292
RPS27A ribosomal protein S27a -0.0264097
TMSB4X thymosin beta 4, X-linked -0.0262213
NPC2 Niemann-Pick disease, type C2 -0.026077
RPL18 ribosomal protein L18 -0.0260543
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.025998
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0258768
RPS15 ribosomal protein S15 -0.0258084
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0257399
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0253379
ENO2 enolase 2 (gamma, neuronal) -0.0251849
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0247867
TXNIP thioredoxin interacting protein -0.0247851
RPL27A ribosomal protein L27a -0.0246055
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0245954