Bestatin (hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.153445
FN1 fibronectin 1 0.152264
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.113689
TXNRD1 thioredoxin reductase 1 0.0978024
ASPH aspartate beta-hydroxylase 0.0974785
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0873753
GDA guanine deaminase 0.0793673
CANX calnexin 0.0772928
CXCL8 chemokine (C-X-C motif) ligand 8 0.0751171
MCL1 myeloid cell leukemia 1 0.0668662
PSD3 pleckstrin and Sec7 domain containing 3 0.0646858
TMX4 thioredoxin-related transmembrane protein 4 0.0641693
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0624282
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0610387
MYOF myoferlin 0.0598316
EFNA5 ephrin-A5 0.0568765
COL5A2 collagen, type V, alpha 2 0.0554287
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0547845
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0546925
SPTBN1 spectrin, beta, non-erythrocytic 1 0.049646
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0485193
KYNU kynureninase 0.0475274
PDLIM5 PDZ and LIM domain 5 0.0450405
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0432554
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0425459
INHBA inhibin, beta A 0.0424756
NEK7 NIMA-related kinase 7 0.0404388
SOD2 superoxide dismutase 2, mitochondrial 0.0397628
CD109 CD109 molecule 0.0389278
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0381895
SAMD4A sterile alpha motif domain containing 4A 0.0364689
CTSC cathepsin C 0.0360196
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0357255
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0353507
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0349675
FLNB filamin B, beta 0.0345808
ERRFI1 ERBB receptor feedback inhibitor 1 0.0341295
EZR ezrin 0.0340897
SFTPA2 surfactant protein A2 0.0338821
LDHA lactate dehydrogenase A 0.0329597
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0328311
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0322309
RAB3B RAB3B, member RAS oncogene family 0.0319149
GRAMD1B GRAM domain containing 1B 0.0308916
TRIO trio Rho guanine nucleotide exchange factor 0.0308687
DOCK4 dedicator of cytokinesis 4 0.0301615
ITPRID2 ITPR interacting domain containing 2 0.0300188
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0295745
APP amyloid beta (A4) precursor protein 0.0291994
APLP2 amyloid beta (A4) precursor-like protein 2 0.028928
EEF2 eukaryotic translation elongation factor 2 0.0284995
FNDC3B fibronectin type III domain containing 3B 0.0282292
STC2 stanniocalcin 2 0.0280604
PCBP2 poly(rC) binding protein 2 0.0270951
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0265244
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0262916
AHNAK AHNAK nucleoprotein 0.0261318
COL4A5 collagen, type IV, alpha 5 0.025995
TPM3 tropomyosin 3 0.0258409
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.025724
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0256985
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0248078
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0246483
ENO1 enolase 1, (alpha) 0.0241552
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.023961
MSN moesin 0.0237473
PGK1 phosphoglycerate kinase 1 0.0233227
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.023183
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.02301
IGFBP3 insulin-like growth factor binding protein 3 0.0227033
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0225118
RTN4 reticulon 4 0.0224396
LSAMP limbic system-associated membrane protein 0.0221597
SET SET nuclear proto-oncogene 0.0220695
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0218145
EIF4B eukaryotic translation initiation factor 4B 0.0213452
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0212402
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0210504
LAMB1 laminin, beta 1 0.0208894
SH3KBP1 SH3-domain kinase binding protein 1 0.0208718
TNIP1 TNFAIP3 interacting protein 1 0.0207476
PTGR1 prostaglandin reductase 1 0.0207136
PYGL phosphorylase, glycogen, liver 0.0204506
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0204047
USP9X ubiquitin specific peptidase 9, X-linked 0.020401
PDIA6 protein disulfide isomerase family A, member 6 0.0203551
RPL3 ribosomal protein L3 0.0202947
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0200054
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.019475
PKM pyruvate kinase, muscle 0.019282
MAML3 mastermind-like 3 (Drosophila) 0.0192559
ZBTB41 zinc finger and BTB domain containing 41 0.0192515
BZW1 basic leucine zipper and W2 domains 1 0.0192183
MAP1B microtubule-associated protein 1B 0.0191766
ZEB2 zinc finger E-box binding homeobox 2 0.0188848
TGFBR1 transforming growth factor, beta receptor 1 0.0186703
COL4A6 collagen, type IV, alpha 6 0.0186558
COL8A1 collagen, type VIII, alpha 1 0.0185579
TNPO1 transportin 1 0.0183819
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0183138

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152324
TPT1 tumor protein, translationally-controlled 1 -0.146515
TMSB10 thymosin beta 10 -0.104147
VIM vimentin -0.0913251
RPLP1 ribosomal protein, large, P1 -0.0876757
RPS6 ribosomal protein S6 -0.0829293
RPL37A ribosomal protein L37a -0.0815543
PTMA prothymosin, alpha -0.0792035
RPL35A ribosomal protein L35a -0.0771701
RPS8 ribosomal protein S8 -0.0714646
RPS24 ribosomal protein S24 -0.0696698
RPL31 ribosomal protein L31 -0.0613621
RPL26 ribosomal protein L26 -0.0610515
RPS12 ribosomal protein S12 -0.0592761
RPL9 ribosomal protein L9 -0.0592415
RPL34 ribosomal protein L34 -0.0550084
RPS29 ribosomal protein S29 -0.0532349
RPS23 ribosomal protein S23 -0.0529351
RPS19 ribosomal protein S19 -0.0529336
RPL7A ribosomal protein L7a -0.047972
RPL37 ribosomal protein L37 -0.0472146
RPS27A ribosomal protein S27a -0.0469885
RPLP2 ribosomal protein, large, P2 -0.0454625
PDE4D phosphodiesterase 4D, cAMP-specific -0.0451881
WSB1 WD repeat and SOCS box containing 1 -0.0445859
RPL38 ribosomal protein L38 -0.0445313
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0444739
RPS25 ribosomal protein S25 -0.0442815
RPL19 ribosomal protein L19 -0.0441578
RPS3 ribosomal protein S3 -0.0439557
RPL12 ribosomal protein L12 -0.0437349
RPS21 ribosomal protein S21 -0.0432499
RPL36A ribosomal protein L36a -0.0431735
HLA-B major histocompatibility complex, class I, B -0.0431342
RPL11 ribosomal protein L11 -0.0428516
S100A10 S100 calcium binding protein A10 -0.0394668
RPS13 ribosomal protein S13 -0.0393904
RPL36 ribosomal protein L36 -0.0382541
RPL13A ribosomal protein L13a -0.037782
VCL vinculin -0.0375826
RPL23 ribosomal protein L23 -0.0372216
RPS16 ribosomal protein S16 -0.0368555
ACTG1 actin gamma 1 -0.0360563
NALF1 NALCN channel auxiliary factor 1 -0.0348417
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0331988
S100A6 S100 calcium binding protein A6 -0.0323835
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0322598
GNAS GNAS complex locus -0.0316177
MT2A metallothionein 2A -0.0307475
RPS17 ribosomal protein S17 -0.0305629
RPL28 ribosomal protein L28 -0.0300669
RPL35 ribosomal protein L35 -0.0299132
EIF1 eukaryotic translation initiation factor 1 -0.0298784
STC1 stanniocalcin 1 -0.0288801
RPS14 ribosomal protein S14 -0.0286489
RPS10 ribosomal protein S10 -0.0283836
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0269513
RPS11 ribosomal protein S11 -0.0262909
SMYD3 SET and MYND domain containing 3 -0.0260653
PRKN parkin RBR E3 ubiquitin protein ligase -0.0257807
RPL27 ribosomal protein L27 -0.0252797
RPL32 ribosomal protein L32 -0.0250934
RPL30 ribosomal protein L30 -0.0247668
RPS20 ribosomal protein S20 -0.0236709
FTL ferritin, light polypeptide -0.0236012
RPS27 ribosomal protein S27 -0.0221687
RPLP0 ribosomal protein, large, P0 -0.0214632
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0213229
RPL10A ribosomal protein L10a -0.0205295
RPS28 ribosomal protein S28 -0.0202823
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0202416
RPS15 ribosomal protein S15 -0.020132
RPS5 ribosomal protein S5 -0.0198833
RPL27A ribosomal protein L27a -0.0198197
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0195576
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0194206
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.019225
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0192188
TAS2R14 taste receptor, type 2, member 14 -0.0187933
RPL8 ribosomal protein L8 -0.0184874
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0184159
NT5C2 5'-nucleotidase, cytosolic II -0.0183134
PCNX4 pecanex 4 -0.0179728
PRSS23 protease, serine, 23 -0.01795
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0177523
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0173053
ISG15 ISG15 ubiquitin-like modifier -0.0168632
HMGB1 high mobility group box 1 -0.0167954
RACK1 receptor for activated C kinase 1 -0.0163212
NAP1L1 nucleosome assembly protein 1-like 1 -0.0160201
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0158801
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0156848
TBCA tubulin folding cofactor A -0.0156586
VDAC1 voltage-dependent anion channel 1 -0.0154876
NDRG1 N-myc downstream regulated 1 -0.0153761
WARS1 tryptophanyl-tRNA synthetase 1 -0.0153561
MRPL13 mitochondrial ribosomal protein L13 -0.0153162
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0152715
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0151759
TUBB4B tubulin, beta 4B class IVb -0.0149014