Bestatin (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

162 genes differentially expressed following the Bestatin (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.253681
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.118433
EFNA5 ephrin-A5 0.116391
TBC1D22A TBC1 domain family, member 22A 0.0950581
ERRFI1 ERBB receptor feedback inhibitor 1 0.093553
EPS8 epidermal growth factor receptor pathway substrate 8 0.0881892
EGFR epidermal growth factor receptor 0.0868113
GPHN gephyrin 0.0777863
TXNRD1 thioredoxin reductase 1 0.0757535
PTPRM protein tyrosine phosphatase, receptor type, M 0.0732622
MYO1E myosin IE 0.0723418
ANKRD12 ankyrin repeat domain 12 0.0722236
SYT1 synaptotagmin I 0.0695856
INTS6 integrator complex subunit 6 0.068862
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0671466
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0665161
CMIP c-Maf inducing protein 0.0663481
SLTM SAFB-like, transcription modulator 0.0657562
NKD1 naked cuticle homolog 1 (Drosophila) 0.0643604
DSCAM Down syndrome cell adhesion molecule 0.0621897
MT2A metallothionein 2A 0.0621716
CARD16 caspase recruitment domain family, member 16 0.0614823
FNIP1 folliculin interacting protein 1 0.0605518
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.054241
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0536861
PCBP2 poly(rC) binding protein 2 0.0534535
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0528312
EGR1 early growth response 1 0.0520073
SLC38A2 solute carrier family 38, member 2 0.0520023
RABGAP1L RAB GTPase activating protein 1-like 0.0511329
PCDH11X protocadherin 11 X-linked 0.0501309
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0492553
AKAP9 A kinase (PRKA) anchor protein 9 0.0488883
FTL ferritin, light polypeptide 0.0463384
NEBL nebulette 0.0458656
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0449223
ASPH aspartate beta-hydroxylase 0.0447482
PSD3 pleckstrin and Sec7 domain containing 3 0.0421415
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0405633
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0394848
MAML2 mastermind-like 2 (Drosophila) 0.0393545
TAS2R14 taste receptor, type 2, member 14 0.0386029
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0378929
PRKCA protein kinase C, alpha 0.0362725
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0361993
NAV2 neuron navigator 2 0.0344773
FNDC3B fibronectin type III domain containing 3B 0.0334939
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0322501
MSI2 musashi RNA-binding protein 2 0.031865
APP amyloid beta (A4) precursor protein 0.0287327
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0286417
PDE4D phosphodiesterase 4D, cAMP-specific 0.0272043
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0259373
PUM2 pumilio RNA-binding family member 2 0.0249086
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0229915
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0219497
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0217963
GSK3B glycogen synthase kinase 3 beta 0.0203293
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0199502
SOD2 superoxide dismutase 2, mitochondrial 0.0197473
EHBP1 EH domain binding protein 1 0.0172466
NIPBL Nipped-B homolog (Drosophila) 0.0146415
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0138378
RPLP2 ribosomal protein, large, P2 0.0134124
PDE10A phosphodiesterase 10A 0.0129416
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0128481
TTC3 tetratricopeptide repeat domain 3 0.0123141
DIAPH2 diaphanous-related formin 2 0.010709
TTC17 tetratricopeptide repeat domain 17 0.00983424
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00849424
PTK2 protein tyrosine kinase 2 0.0076755
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.00739875
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0069896
LMO7 LIM domain 7 0.00645215
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.00620003
TMEM165 transmembrane protein 165 0.0057008
TRIO trio Rho guanine nucleotide exchange factor 0.0055511
NGLY1 N-glycanase 1 0.00404777
USP34 ubiquitin specific peptidase 34 0.00400585
MBD5 methyl-CpG binding domain protein 5 0.00397579
FAT1 FAT atypical cadherin 1 0.0039711
HMGA2 high mobility group AT-hook 2 0.00384855
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0032094
JMJD1C jumonji domain containing 1C 0.00307115
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00268336
LDHA lactate dehydrogenase A 5.96907E-4
MORF4L2 mortality factor 4 like 2 1.6814E-4
RSF1 remodeling and spacing factor 1 4.24239E-5

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.119576
VIM vimentin -0.110691
RPL35A ribosomal protein L35a -0.0827633
EXT1 exostosin glycosyltransferase 1 -0.0774977
IGFBP3 insulin-like growth factor binding protein 3 -0.0740245
KMT2C lysine (K)-specific methyltransferase 2C -0.0677978
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0621149
GOLGA4 golgin A4 -0.0601529
RPS6 ribosomal protein S6 -0.0577784
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0565303
MACF1 microtubule-actin crosslinking factor 1 -0.0536877
FN1 fibronectin 1 -0.0505627
EEF2 eukaryotic translation elongation factor 2 -0.0498639
ACTG1 actin gamma 1 -0.0486967
TNS3 tensin 3 -0.0475077
PGK1 phosphoglycerate kinase 1 -0.0451956
VMP1 vacuole membrane protein 1 -0.0451179
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0450609
NDRG1 N-myc downstream regulated 1 -0.0443711
ZNF292 zinc finger protein 292 -0.0380804
RPS8 ribosomal protein S8 -0.0379206
MED13 mediator complex subunit 13 -0.0378772
PDLIM5 PDZ and LIM domain 5 -0.0377206
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0373803
LIMS1 LIM and senescent cell antigen-like domains 1 -0.035709
WSB1 WD repeat and SOCS box containing 1 -0.0352563
ACTN4 actinin, alpha 4 -0.0348482
GCC2 GRIP and coiled-coil domain containing 2 -0.0347085
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0343622
LOC102724023 ES1 protein homolog, mitochondrial -0.0342953
CANX calnexin -0.0339562
KMT2E lysine (K)-specific methyltransferase 2E -0.0335361
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0329473
SMYD3 SET and MYND domain containing 3 -0.032716
GPC6 glypican 6 -0.0322855
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0300617
DST dystonin -0.0299216
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0298885
ZFAND3 zinc finger, AN1-type domain 3 -0.0293683
COG5 component of oligomeric golgi complex 5 -0.0292487
NALF1 NALCN channel auxiliary factor 1 -0.025843
TPM4 tropomyosin 4 -0.0258247
NAP1L1 nucleosome assembly protein 1-like 1 -0.0254579
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0253579
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0227076
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0211375
RPL19 ribosomal protein L19 -0.0201672
RPS12 ribosomal protein S12 -0.0195849
PKM pyruvate kinase, muscle -0.0166138
EZR ezrin -0.0157777
TMSB10 thymosin beta 10 -0.0154424
TBC1D5 TBC1 domain family, member 5 -0.0137321
ARID1B AT rich interactive domain 1B (SWI1-like) -0.013612
AHNAK AHNAK nucleoprotein -0.0125448
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0125291
XPO1 exportin 1 -0.0123059
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0117304
ANXA2 annexin A2 -0.0109406
MBNL1 muscleblind-like splicing regulator 1 -0.00956364
AKAP13 A kinase (PRKA) anchor protein 13 -0.00942852
RPL37A ribosomal protein L37a -0.00763828
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.00659442
RPL11 ribosomal protein L11 -0.00641211
PTMA prothymosin, alpha -0.00637805
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00627611
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.00577163
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.00560588
MED13L mediator complex subunit 13-like -0.00520444
SPAG9 sperm associated antigen 9 -0.00517981
P4HB prolyl 4-hydroxylase, beta polypeptide -0.00320238
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.00282114
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.00135011
ZBTB20 zinc finger and BTB domain containing 20 -5.63036E-4
EIF3H eukaryotic translation initiation factor 3, subunit H -3.87564E-5