Bestatin (hydrochloride)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.161513
TSC22D2 TSC22 domain family, member 2 0.109215
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0858941
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0796728
ZFAND3 zinc finger, AN1-type domain 3 0.0770387
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0765037
ATP5F1B ATP synthase F1 subunit beta 0.0623168
POTEF POTE ankyrin domain family, member F 0.0584807
PDGFC platelet derived growth factor C 0.0545957
PUM1 pumilio RNA-binding family member 1 0.0515215
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.049435
WDR43 WD repeat domain 43 0.0487336
PGAP1 post-GPI attachment to proteins 1 0.0483074
ADAM9 ADAM metallopeptidase domain 9 0.0467525
CDC73 cell division cycle 73 0.0447189
COL5A2 collagen, type V, alpha 2 0.0431898
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.043108
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0430201
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0398696
NOP58 NOP58 ribonucleoprotein 0.0390889
PEG10 paternally expressed 10 0.0383276
FNDC3B fibronectin type III domain containing 3B 0.0380798
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0376359
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0375263
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0369532
RYBP RING1 and YY1 binding protein 0.0368432
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0363243
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0363231
PFN1 profilin 1 0.0360137
MED13L mediator complex subunit 13-like 0.0360036
MEMO1 mediator of cell motility 1 0.0347809
ARHGAP15 Rho GTPase activating protein 15 0.0345878
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0345691
NUP58 nucleoporin 58 0.0342133
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0340512
SRP54 signal recognition particle 54kDa 0.0338191
PICALM phosphatidylinositol binding clathrin assembly protein 0.0331304
FAM171B family with sequence similarity 171, member B 0.0329123
ENAH enabled homolog (Drosophila) 0.0326943
MTF2 metal response element binding transcription factor 2 0.0321463
ZNF292 zinc finger protein 292 0.0318576
OLA1 Obg-like ATPase 1 0.0313762
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0311934
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0309002
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.030798
SHROOM3 shroom family member 3 0.030605
ZEB2 zinc finger E-box binding homeobox 2 0.0301647
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0298629
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0296427
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0290022
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0289897
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.028639
SFPQ splicing factor proline/glutamine-rich 0.0284918
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0284043
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0283978
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0281513
WAC WW domain containing adaptor with coiled-coil 0.0281505
ANKRD11 ankyrin repeat domain 11 0.0276447
NCKAP1 NCK-associated protein 1 0.0276044
USP3 ubiquitin specific peptidase 3 0.0276015
STRN3 striatin, calmodulin binding protein 3 0.0272735
PCBP2 poly(rC) binding protein 2 0.0272227
PRTG protogenin 0.0271415
DPYD dihydropyrimidine dehydrogenase 0.0271363
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0266375
RBM25 RNA binding motif protein 25 0.0266264
TFG TRK-fused gene 0.0264824
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0262444
XPO1 exportin 1 0.0260787
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0259914
TPM3 tropomyosin 3 0.0254135
GLS2 glutaminase 2 (liver, mitochondrial) 0.0251586
EVI5 ecotropic viral integration site 5 0.0251438
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0249817
ZC3H15 zinc finger CCCH-type containing 15 0.024567
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0243769
IWS1 IWS1 homolog (S. cerevisiae) 0.024277
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0240129
TRA2B transformer 2 beta homolog (Drosophila) 0.0238793
FXR1 fragile X mental retardation, autosomal homolog 1 0.0237848
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0236909
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0233709
PDE4D phosphodiesterase 4D, cAMP-specific 0.0233218
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0232763
YBX1 Y box binding protein 1 0.0231961
CRY1 cryptochrome circadian clock 1 0.0231473
METAP2 methionyl aminopeptidase 2 0.0230347
ADGRG6 adhesion G protein-coupled receptor G6 0.0229475
AKAP13 A kinase (PRKA) anchor protein 13 0.022783
PAWR PRKC, apoptosis, WT1, regulator 0.0227223
SRRM1 serine/arginine repetitive matrix 1 0.0227088
RHEB Ras homolog enriched in brain 0.0223515
MKI67 marker of proliferation Ki-67 0.0223341
SMC3 structural maintenance of chromosomes 3 0.0222944
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0222589
HDAC9 histone deacetylase 9 0.0220726
MEF2A myocyte enhancer factor 2A 0.0219981
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0219637
MEIS2 Meis homeobox 2 0.0218869
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0218535

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.142333
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141854
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.131834
PTMA prothymosin, alpha -0.130863
VIM vimentin -0.128909
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0885572
RPS16 ribosomal protein S16 -0.0822327
GPC3 glypican 3 -0.0800843
PCDH9 protocadherin 9 -0.0740492
TPT1 tumor protein, translationally-controlled 1 -0.0706249
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0695568
PCLO piccolo presynaptic cytomatrix protein -0.0695352
SPAG9 sperm associated antigen 9 -0.0675086
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0638885
COL3A1 collagen, type III, alpha 1 -0.0625217
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0589639
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0573177
LRRC4C leucine rich repeat containing 4C -0.0523617
RPS8 ribosomal protein S8 -0.050479
SNX6 sorting nexin 6 -0.0461199
RPLP1 ribosomal protein, large, P1 -0.0458098
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0443417
KDM3A lysine (K)-specific demethylase 3A -0.0440247
ANKRD12 ankyrin repeat domain 12 -0.0435281
ISG15 ISG15 ubiquitin-like modifier -0.0424651
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.041532
ADGRL2 adhesion G protein-coupled receptor L2 -0.0409585
B2M beta-2-microglobulin -0.0393308
SMYD3 SET and MYND domain containing 3 -0.0390898
MT2A metallothionein 2A -0.0381531
FNDC3A fibronectin type III domain containing 3A -0.0373419
RPL31 ribosomal protein L31 -0.0365476
RPS27A ribosomal protein S27a -0.034056
ENO1 enolase 1, (alpha) -0.0339563
RPL37 ribosomal protein L37 -0.0332678
PLPP1 phospholipid phosphatase 1 -0.0331155
RPL35A ribosomal protein L35a -0.0329091
NCAM2 neural cell adhesion molecule 2 -0.0328814
TTC28 tetratricopeptide repeat domain 28 -0.0327639
SYT1 synaptotagmin I -0.0322246
CALR calreticulin -0.0318984
PRELID2 PRELI domain containing 2 -0.031667
RPL11 ribosomal protein L11 -0.0309799
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0309678
WSB1 WD repeat and SOCS box containing 1 -0.0305952
TENM2 teneurin transmembrane protein 2 -0.0299159
CNRIP1 cannabinoid receptor interacting protein 1 -0.0298375
LOC102724023 ES1 protein homolog, mitochondrial -0.0296523
ACTG1 actin gamma 1 -0.0296412
RPS3 ribosomal protein S3 -0.0294538
RPS21 ribosomal protein S21 -0.0293115
PGK1 phosphoglycerate kinase 1 -0.0287292
RPL37A ribosomal protein L37a -0.0279689
RPL34 ribosomal protein L34 -0.0278685
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0277802
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0276287
EIF1 eukaryotic translation initiation factor 1 -0.0274333
ATXN1 ataxin 1 -0.0272405
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0267538
ANKRD33B ankyrin repeat domain 33B -0.0266614
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0261831
RPS19 ribosomal protein S19 -0.0260412
COL11A1 collagen, type XI, alpha 1 -0.0258655
MBD5 methyl-CpG binding domain protein 5 -0.0254634
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0254309
ZMYND8 zinc finger, MYND-type containing 8 -0.0253217
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0252956
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0252053
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0250462
CEP350 centrosomal protein 350kDa -0.0248463
NTM neurotrimin -0.0240035
TPM4 tropomyosin 4 -0.0235443
RPS12 ribosomal protein S12 -0.0234486
HSPB1 heat shock 27kDa protein 1 -0.0234325
SBF2 SET binding factor 2 -0.0233755
IFIH1 interferon induced with helicase C domain 1 -0.0232348
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0229712
RPLP0 ribosomal protein, large, P0 -0.0228098
MDK midkine (neurite growth-promoting factor 2) -0.0227271
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0225634
NEBL nebulette -0.0225499
RPL36A ribosomal protein L36a -0.0224072
RACK1 receptor for activated C kinase 1 -0.0221684
SQSTM1 sequestosome 1 -0.0220803
RFPL4B ret finger protein-like 4B -0.0220488
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0219052
ZNFX1 zinc finger, NFX1-type containing 1 -0.0217375
RPLP2 ribosomal protein, large, P2 -0.0216268
AKAP12 A kinase (PRKA) anchor protein 12 -0.0216256
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0213872
CUX1 cut-like homeobox 1 -0.0213692
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0211337
RPL28 ribosomal protein L28 -0.0210925
SRRM2 serine/arginine repetitive matrix 2 -0.0209744
SAMD4A sterile alpha motif domain containing 4A -0.0209301
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0208614
SUN1 Sad1 and UNC84 domain containing 1 -0.0208383
HMGB1 high mobility group box 1 -0.0207202
FBXL17 F-box and leucine-rich repeat protein 17 -0.0206194
RPS29 ribosomal protein S29 -0.0203691