Bestatin (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0887839
ERRFI1 ERBB receptor feedback inhibitor 1 0.0604589
MYH9 myosin, heavy chain 9, non-muscle 0.0500578
SFTPA2 surfactant protein A2 0.045697
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0441095
TXNRD1 thioredoxin reductase 1 0.0406104
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0403762
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0391915
SMAD3 SMAD family member 3 0.0372085
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0369976
ASPH aspartate beta-hydroxylase 0.0369363
ARRDC3 arrestin domain containing 3 0.0349379
CANX calnexin 0.0345336
ACTN4 actinin, alpha 4 0.0327637
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0318769
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0315657
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.031403
APP amyloid beta (A4) precursor protein 0.0286323
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0278617
APLP2 amyloid beta (A4) precursor-like protein 2 0.0273246
ENO1 enolase 1, (alpha) 0.0271114
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0246146
B2M beta-2-microglobulin 0.0245558
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0240307
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0239954
PLEC plectin 0.0225004
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0224046
CALR calreticulin 0.0223464
OGA O-GlcNAcase 0.021648
WWTR1 WW domain containing transcription regulator 1 0.0210596
NFE2L2 nuclear factor, erythroid 2-like 2 0.0207989
MCL1 myeloid cell leukemia 1 0.0205185
LDHA lactate dehydrogenase A 0.0191516
SERINC1 serine incorporator 1 0.0190007
AHNAK AHNAK nucleoprotein 0.0186924
NAMPT nicotinamide phosphoribosyltransferase 0.0186671
VCL vinculin 0.0186172
DSCAM Down syndrome cell adhesion molecule 0.0185985
IPO7 importin 7 0.0184206
CTNND1 catenin (cadherin-associated protein), delta 1 0.0183973
NCEH1 neutral cholesterol ester hydrolase 1 0.0180648
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0176917
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0169428
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0169312
TMEM41B transmembrane protein 41B 0.0168111
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0164936
NFE2L1 nuclear factor, erythroid 2-like 1 0.0155489
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0154068
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0152846
FBL fibrillarin 0.015271
PCBP2 poly(rC) binding protein 2 0.0152621
ICAM1 intercellular adhesion molecule 1 0.0148045
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0146909
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.014689
YBX1 Y box binding protein 1 0.0146059
MED29 mediator complex subunit 29 0.0144995
PGK1 phosphoglycerate kinase 1 0.0142688
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0141872
ADAM17 ADAM metallopeptidase domain 17 0.0141677
CCNL1 cyclin L1 0.0140389
VMP1 vacuole membrane protein 1 0.0138755
IL13RA1 interleukin 13 receptor, alpha 1 0.0136079
EIF4B eukaryotic translation initiation factor 4B 0.0134153
MATR3 matrin 3 0.0132094
AHNAK2 AHNAK nucleoprotein 2 0.0129617
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0128817
ARHGAP29 Rho GTPase activating protein 29 0.0128574
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.0128514
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0126275
EIF4A2 eukaryotic translation initiation factor 4A2 0.0126086
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0125245
ITGAV integrin, alpha V 0.0124671
TNIP1 TNFAIP3 interacting protein 1 0.0123962
ELOVL5 ELOVL fatty acid elongase 5 0.0123838
PRELID2 PRELI domain containing 2 0.0122852
ZNF292 zinc finger protein 292 0.0121374
SEC63 SEC63 homolog (S. cerevisiae) 0.0120862
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0120396
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0120357
DGKD diacylglycerol kinase, delta 130kDa 0.0119647
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0118339
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0117469
TPM3 tropomyosin 3 0.0115989
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0115392
AFAP1 actin filament associated protein 1 0.0115233
ARF4 ADP-ribosylation factor 4 0.01152
EPAS1 endothelial PAS domain protein 1 0.0114924
YAP1 Yes-associated protein 1 0.0114891
PDIA4 protein disulfide isomerase family A, member 4 0.0114888
LRP11 low density lipoprotein receptor-related protein 11 0.0114788
CSDE1 cold shock domain containing E1, RNA-binding 0.0112601
NCOR2 nuclear receptor corepressor 2 0.0112577
ZNHIT6 zinc finger, HIT-type containing 6 0.0111777
MED13L mediator complex subunit 13-like 0.0111648
SET SET nuclear proto-oncogene 0.011044
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0110114
TRIP12 thyroid hormone receptor interactor 12 0.0109773
DNMBP dynamin binding protein 0.0108846
BIRC2 baculoviral IAP repeat containing 2 0.0108694
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0107053

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.163839
RPS16 ribosomal protein S16 -0.120324
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0790976
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0742007
PTMA prothymosin, alpha -0.0708309
TMSB10 thymosin beta 10 -0.0694317
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0584948
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0484903
TRIO trio Rho guanine nucleotide exchange factor -0.0440144
THSD4 thrombospondin, type I, domain containing 4 -0.0395612
RPL35A ribosomal protein L35a -0.0352901
RNF220 ring finger protein 220 -0.0337307
HMGA2 high mobility group AT-hook 2 -0.0303804
RPLP2 ribosomal protein, large, P2 -0.0287967
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0269681
SDK1 sidekick cell adhesion molecule 1 -0.0264965
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0253894
HSPG2 heparan sulfate proteoglycan 2 -0.0242791
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0242554
CTSD cathepsin D -0.0240959
RPLP1 ribosomal protein, large, P1 -0.0214388
RPL37A ribosomal protein L37a -0.0209117
SLC35F3 solute carrier family 35, member F3 -0.020739
S100A6 S100 calcium binding protein A6 -0.0206834
RPS8 ribosomal protein S8 -0.0203606
PTK2 protein tyrosine kinase 2 -0.0199069
RPS25 ribosomal protein S25 -0.0194359
MAP1B microtubule-associated protein 1B -0.0191012
RPS6 ribosomal protein S6 -0.0185845
ACTG1 actin gamma 1 -0.0173599
RPL28 ribosomal protein L28 -0.0173323
EGFR epidermal growth factor receptor -0.0170621
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.016875
PDE10A phosphodiesterase 10A -0.0164086
NAV2 neuron navigator 2 -0.0159077
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0154751
SBF2 SET binding factor 2 -0.0154748
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0153256
WSB1 WD repeat and SOCS box containing 1 -0.0152752
RPS12 ribosomal protein S12 -0.0151659
PFN1 profilin 1 -0.0146816
CENPF centromere protein F, 350/400kDa -0.0146503
RPS13 ribosomal protein S13 -0.0144584
RPL38 ribosomal protein L38 -0.0143277
RPL34 ribosomal protein L34 -0.0142914
EHBP1 EH domain binding protein 1 -0.014093
RPS23 ribosomal protein S23 -0.0140615
RPS3 ribosomal protein S3 -0.0139078
RPS24 ribosomal protein S24 -0.0136368
HMGB1 high mobility group box 1 -0.0133047
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0132968
RPS17 ribosomal protein S17 -0.0132257
RPL11 ribosomal protein L11 -0.0129
HMGA1 high mobility group AT-hook 1 -0.0128191
RPS14 ribosomal protein S14 -0.0126808
RPS21 ribosomal protein S21 -0.0124127
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0122905
NHSL1 NHS-like 1 -0.0122111
RPL36A ribosomal protein L36a -0.0121658
RPL8 ribosomal protein L8 -0.0120775
RPL23 ribosomal protein L23 -0.012051
ARHGAP32 Rho GTPase activating protein 32 -0.0119721
RPL9 ribosomal protein L9 -0.0119422
MYO10 myosin X -0.0119345
CUX1 cut-like homeobox 1 -0.0118314
FBXO17 F-box protein 17 -0.0114198
MEF2A myocyte enhancer factor 2A -0.0113948
TBCA tubulin folding cofactor A -0.0113526
ATP5F1B ATP synthase F1 subunit beta -0.0113342
ATG7 autophagy related 7 -0.0112523
SAMD4B sterile alpha motif domain containing 4B -0.0111271
MT2A metallothionein 2A -0.0111151
RPL30 ribosomal protein L30 -0.0110569
ASTN2 astrotactin 2 -0.0109155
GNAS GNAS complex locus -0.0108802
RPL36 ribosomal protein L36 -0.0108039
S100A9 S100 calcium binding protein A9 -0.0106998
PDGFB platelet-derived growth factor beta polypeptide -0.0106104
RPL26 ribosomal protein L26 -0.0102442
TCF12 transcription factor 12 -0.0101686
RPL12 ribosomal protein L12 -0.0100578
RPS10 ribosomal protein S10 -0.00995275
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0098238
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.00960493
RPS27A ribosomal protein S27a -0.0095409
ANKRD11 ankyrin repeat domain 11 -0.00953498
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.00940898
RPS29 ribosomal protein S29 -0.0093866
RPL27A ribosomal protein L27a -0.00935185
KDM2A lysine (K)-specific demethylase 2A -0.00901007
RBMX RNA binding motif protein, X-linked -0.00898308
RPS19 ribosomal protein S19 -0.00895908
FBXO27 F-box protein 27 -0.00889555
RPL37 ribosomal protein L37 -0.00881307
PRKCA protein kinase C, alpha -0.00881149
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.00878082
QKI QKI, KH domain containing, RNA binding -0.00873301
AKAP12 A kinase (PRKA) anchor protein 12 -0.00872578
RPL35 ribosomal protein L35 -0.00860606
ANTXR2 anthrax toxin receptor 2 -0.00856475