Bestatin (hydrochloride)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114164
PABPC1 poly(A) binding protein, cytoplasmic 1 0.102662
MCL1 myeloid cell leukemia 1 0.0909614
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.079983
FRMD6 FERM domain containing 6 0.0794802
AHNAK AHNAK nucleoprotein 0.0779186
CANX calnexin 0.0774674
MCTP1 multiple C2 domains, transmembrane 1 0.072735
EXT1 exostosin glycosyltransferase 1 0.0705784
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0696515
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.069203
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0689351
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0630213
APP amyloid beta (A4) precursor protein 0.0613778
MYH9 myosin, heavy chain 9, non-muscle 0.0569637
CALR calreticulin 0.0569275
ENO1 enolase 1, (alpha) 0.0554548
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0541769
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0500075
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.049526
APLP2 amyloid beta (A4) precursor-like protein 2 0.0489265
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0469033
EEF2 eukaryotic translation elongation factor 2 0.0458459
G0S2 G0/G1 switch 2 0.0454985
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0454164
PKM pyruvate kinase, muscle 0.0431016
SET SET nuclear proto-oncogene 0.0424971
TPM3 tropomyosin 3 0.0407347
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0406234
ASPH aspartate beta-hydroxylase 0.040045
RAD21 RAD21 homolog (S. pombe) 0.0386525
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0385091
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0377692
SP100 SP100 nuclear antigen 0.0369635
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0364802
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0357247
DLC1 DLC1 Rho GTPase activating protein 0.0355731
SAMD4A sterile alpha motif domain containing 4A 0.0355674
PTPRG protein tyrosine phosphatase, receptor type, G 0.0351469
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0346667
RPS18 ribosomal protein S18 0.0344965
HDAC9 histone deacetylase 9 0.0344567
JUN jun proto-oncogene 0.0338068
LDHA lactate dehydrogenase A 0.0331575
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0329669
PRRC2A proline-rich coiled-coil 2A 0.0327632
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0325766
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0323268
C2CD2 C2 calcium-dependent domain containing 2 0.0322436
HMGA2 high mobility group AT-hook 2 0.0316245
PGK1 phosphoglycerate kinase 1 0.0313914
B2M beta-2-microglobulin 0.0312884
TIMP1 TIMP metallopeptidase inhibitor 1 0.0312812
ZNF438 zinc finger protein 438 0.0307548
TM9SF3 transmembrane 9 superfamily member 3 0.0305582
CHD4 chromodomain helicase DNA binding protein 4 0.0295603
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0285034
EIF3A eukaryotic translation initiation factor 3, subunit A 0.028328
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0281741
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0280775
SDC4 syndecan 4 0.027589
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0274854
KDM5C lysine (K)-specific demethylase 5C 0.027439
NAV2 neuron navigator 2 0.0271279
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0269125
SGMS2 sphingomyelin synthase 2 0.0266003
CORO1C coronin, actin binding protein, 1C 0.0265492
WNK1 WNK lysine deficient protein kinase 1 0.0263453
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0260224
ARHGAP22 Rho GTPase activating protein 22 0.0259077
TOP2B topoisomerase (DNA) II beta 180kDa 0.0257501
RPL3 ribosomal protein L3 0.0256682
HSPA8 heat shock 70kDa protein 8 0.0254957
INTS6 integrator complex subunit 6 0.0253498
LOC112694756 uncharaterized LOC112694756 0.0250174
MX1 MX dynamin-like GTPase 1 0.0249305
USP34 ubiquitin specific peptidase 34 0.024824
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0247558
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0245949
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0244738
EIF4B eukaryotic translation initiation factor 4B 0.0241975
IFI6 interferon, alpha-inducible protein 6 0.0240236
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0239415
AKAP12 A kinase (PRKA) anchor protein 12 0.0234269
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0233139
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0232773
CENPF centromere protein F, 350/400kDa 0.0231248
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0230916
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0230795
STK4 serine/threonine kinase 4 0.0230707
MBNL1 muscleblind-like splicing regulator 1 0.0228012
ANO6 anoctamin 6 0.02279
GOLM1 golgi membrane protein 1 0.0226909
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0225854
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0225713
NUP58 nucleoporin 58 0.0223961
SAMD9 sterile alpha motif domain containing 9 0.0223945
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0218057
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.021713
NABP1 nucleic acid binding protein 1 0.0216459

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.27568
RPS6 ribosomal protein S6 -0.139576
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115392
RPL9 ribosomal protein L9 -0.0799774
RPL35A ribosomal protein L35a -0.0728604
RPL12 ribosomal protein L12 -0.0670948
TMSB10 thymosin beta 10 -0.0644788
RPS21 ribosomal protein S21 -0.0629072
RPLP1 ribosomal protein, large, P1 -0.0622608
RPL23 ribosomal protein L23 -0.0607339
RPL8 ribosomal protein L8 -0.059426
RPS8 ribosomal protein S8 -0.0587816
RPL37A ribosomal protein L37a -0.0572294
RPS19 ribosomal protein S19 -0.0562352
RPL7A ribosomal protein L7a -0.0548619
RPL30 ribosomal protein L30 -0.0541975
TPT1 tumor protein, translationally-controlled 1 -0.0501129
RPLP2 ribosomal protein, large, P2 -0.0485819
RPS29 ribosomal protein S29 -0.0462122
RPL26 ribosomal protein L26 -0.0450924
RPL11 ribosomal protein L11 -0.0449908
SRSF11 serine/arginine-rich splicing factor 11 -0.0446423
RPL32 ribosomal protein L32 -0.0441316
ACTG1 actin gamma 1 -0.0440339
RPS13 ribosomal protein S13 -0.0437498
PFN1 profilin 1 -0.0435774
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0425797
RPL19 ribosomal protein L19 -0.0420784
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0405294
RPS24 ribosomal protein S24 -0.0405036
CALD1 caldesmon 1 -0.0393435
IARS1 isoleucyl-tRNA synthetase 1 -0.0390624
RPL36 ribosomal protein L36 -0.0387096
RPL34 ribosomal protein L34 -0.0376962
RPL13A ribosomal protein L13a -0.0375428
RPS10 ribosomal protein S10 -0.0373277
FTL ferritin, light polypeptide -0.0369429
RPL38 ribosomal protein L38 -0.0355844
RPS23 ribosomal protein S23 -0.0355367
WSB1 WD repeat and SOCS box containing 1 -0.0350696
RPL10A ribosomal protein L10a -0.0346677
S100A9 S100 calcium binding protein A9 -0.0346005
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0341548
WDR43 WD repeat domain 43 -0.0339944
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0332714
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0330797
RPS20 ribosomal protein S20 -0.0330691
RPL5 ribosomal protein L5 -0.0330135
RPS12 ribosomal protein S12 -0.0328587
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0319299
RPL35 ribosomal protein L35 -0.0315705
JMJD1C jumonji domain containing 1C -0.0313579
RPS15 ribosomal protein S15 -0.0312962
RAD51B RAD51 paralog B -0.0310523
RPLP0 ribosomal protein, large, P0 -0.0307399
RPL28 ribosomal protein L28 -0.0303034
PNISR PNN-interacting serine/arginine-rich protein -0.0299347
MAPK8 mitogen-activated protein kinase 8 -0.029934
RPS5 ribosomal protein S5 -0.0297467
DIAPH3 diaphanous-related formin 3 -0.0280744
RPS11 ribosomal protein S11 -0.0279531
RPS16 ribosomal protein S16 -0.0279261
MT1X metallothionein 1X -0.0278904
HMGA1 high mobility group AT-hook 1 -0.027042
SRRM2 serine/arginine repetitive matrix 2 -0.0269011
RPS17 ribosomal protein S17 -0.0267543
ANKRD11 ankyrin repeat domain 11 -0.0267425
RPL36A ribosomal protein L36a -0.025981
PTK2 protein tyrosine kinase 2 -0.0259728
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -0.0259014
RPL37 ribosomal protein L37 -0.0258332
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0257845
RPS14 ribosomal protein S14 -0.0257554
RPS25 ribosomal protein S25 -0.0257005
PTBP2 polypyrimidine tract binding protein 2 -0.0256949
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0254567
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0246666
AKAP9 A kinase (PRKA) anchor protein 9 -0.0246642
STC1 stanniocalcin 1 -0.0246362
RBM25 RNA binding motif protein 25 -0.0246136
ATP5F1B ATP synthase F1 subunit beta -0.0243058
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0240877
NOP56 NOP56 ribonucleoprotein -0.0235757
GNAS GNAS complex locus -0.0235388
RPL21 ribosomal protein L21 -0.0234298
ZNF292 zinc finger protein 292 -0.0233496
TSC22D2 TSC22 domain family, member 2 -0.0232743
RPS27A ribosomal protein S27a -0.0231782
NKTR natural killer cell triggering receptor -0.0230117
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0229577
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0229177
USP3 ubiquitin specific peptidase 3 -0.0228445
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0228323
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -0.02251
ASTN2 astrotactin 2 -0.0224612
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0224362
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0223938
PRRC2C proline-rich coiled-coil 2C -0.0223602
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0214954
GTPBP4 GTP binding protein 4 -0.0213843