Bestatin (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.126487
FN1 fibronectin 1 0.122516
AKAP12 A kinase (PRKA) anchor protein 12 0.121043
SFTPA2 surfactant protein A2 0.0880537
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0864886
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0812069
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0766678
FMN1 formin 1 0.0726202
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0710683
FNDC3B fibronectin type III domain containing 3B 0.0627177
ICAM1 intercellular adhesion molecule 1 0.0484941
IGFBP3 insulin-like growth factor binding protein 3 0.0415546
PKM pyruvate kinase, muscle 0.0406178
SOD2 superoxide dismutase 2, mitochondrial 0.040495
LSAMP limbic system-associated membrane protein 0.0402891
BACE2 beta-site APP-cleaving enzyme 2 0.0390443
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0381695
HDAC9 histone deacetylase 9 0.0379426
PLEC plectin 0.0375406
CXCL8 chemokine (C-X-C motif) ligand 8 0.036748
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0354935
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0326014
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0305695
LRMDA leucine rich melanocyte differentiation associated 0.0300709
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0299759
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0290761
MSN moesin 0.0290648
IFIH1 interferon induced with helicase C domain 1 0.0287957
CCND1 cyclin D1 0.0286573
C10ORF90 chromosome 10 open reading frame 90 0.0283474
HLA-A major histocompatibility complex, class I, A 0.0278448
DST dystonin 0.0266014
MAML2 mastermind-like 2 (Drosophila) 0.0265528
CADM1 cell adhesion molecule 1 0.0262756
NAMPT nicotinamide phosphoribosyltransferase 0.0255436
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.025306
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0248389
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0236163
KMT2E lysine (K)-specific methyltransferase 2E 0.0227832
SEPTIN9 septin 9 0.0227002
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0225743
SMAD3 SMAD family member 3 0.0223487
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0222618
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0219682
IFI6 interferon, alpha-inducible protein 6 0.0214373
LDHA lactate dehydrogenase A 0.0213175
ARRDC3 arrestin domain containing 3 0.021308
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0210403
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0207638
INPP5F inositol polyphosphate-5-phosphatase F 0.0205728
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0201027
CANX calnexin 0.0200634
SDC4 syndecan 4 0.0199976
TP63 tumor protein p63 0.0196054
LPP LIM domain containing preferred translocation partner in lipoma 0.019227
NPAS2 neuronal PAS domain protein 2 0.0190056
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.018774
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0185819
FBXO32 F-box protein 32 0.0184028
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.01774
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0176562
SOX6 SRY (sex determining region Y)-box 6 0.0176329
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 0.0175924
PAIP2 poly(A) binding protein interacting protein 2 0.0175639
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0175351
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0174548
UBASH3B ubiquitin associated and SH3 domain containing B 0.0174545
MACROD2 MACRO domain containing 2 0.0174509
UGCG UDP-glucose ceramide glucosyltransferase 0.0174447
NFE2L1 nuclear factor, erythroid 2-like 1 0.017149
HPS5 Hermansky-Pudlak syndrome 5 0.0167079
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0166046
IFI16 interferon, gamma-inducible protein 16 0.0164847
CA8 carbonic anhydrase VIII 0.0162471
MYH9 myosin, heavy chain 9, non-muscle 0.0162023
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0161178
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.0159162
NT5E 5'-nucleotidase, ecto (CD73) 0.0158783
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0158493
PGK1 phosphoglycerate kinase 1 0.0157663
KLF9 Kruppel-like factor 9 0.0157609
IGF1R insulin-like growth factor 1 receptor 0.0156279
CTSB cathepsin B 0.0156131
PHF21A PHD finger protein 21A 0.0155249
WWTR1 WW domain containing transcription regulator 1 0.0154935
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0154717
CSDE1 cold shock domain containing E1, RNA-binding 0.0153764
BCL6 B-cell CLL/lymphoma 6 0.0152824
BICD1 bicaudal D homolog 1 (Drosophila) 0.0151965
RNF145 ring finger protein 145 0.0151496
SAMD4A sterile alpha motif domain containing 4A 0.0150321
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0148827
KYNU kynureninase 0.0148811
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0147568
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0147181
BIRC3 baculoviral IAP repeat containing 3 0.0146893
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0146346
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.0144252
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0143984
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0143589

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.301276
UBC ubiquitin C -0.173139
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.141569
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127293
NLGN1 neuroligin 1 -0.110187
CENPF centromere protein F, 350/400kDa -0.0969979
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0918417
NAV2 neuron navigator 2 -0.0854365
TMSB10 thymosin beta 10 -0.0745049
RPS27A ribosomal protein S27a -0.0744229
RPS3 ribosomal protein S3 -0.0687165
PTMA prothymosin, alpha -0.0677826
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0660285
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0655885
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0648215
MT2A metallothionein 2A -0.0639137
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0609435
ANLN anillin, actin binding protein -0.0580991
SMC4 structural maintenance of chromosomes 4 -0.0562312
ACTG1 actin gamma 1 -0.0561517
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0522442
ANKRD28 ankyrin repeat domain 28 -0.0504791
RPL23 ribosomal protein L23 -0.0497496
TM4SF1 transmembrane 4 L six family member 1 -0.048218
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0475057
SMYD3 SET and MYND domain containing 3 -0.0472001
MKI67 marker of proliferation Ki-67 -0.0471266
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0454259
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0438379
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0419124
GOLGA4 golgin A4 -0.04181
TPX2 TPX2, microtubule-associated -0.0370323
CD44 CD44 molecule (Indian blood group) -0.035669
CALU calumenin -0.0347362
RPL32 ribosomal protein L32 -0.0346375
AKAP10 A kinase (PRKA) anchor protein 10 -0.0343405
NKTR natural killer cell triggering receptor -0.03386
RPL34 ribosomal protein L34 -0.0336011
RASAL2 RAS protein activator like 2 -0.0330723
KIF4A kinesin family member 4A -0.0324086
MAP4 microtubule-associated protein 4 -0.0320799
SBF2 SET binding factor 2 -0.032011
EEF2 eukaryotic translation elongation factor 2 -0.0316143
ELL2 elongation factor, RNA polymerase II, 2 -0.0310605
CENPE centromere protein E, 312kDa -0.0309313
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0306631
RHOA ras homolog family member A -0.0306121
POU2F1 POU class 2 homeobox 1 -0.0305088
DLG1 discs, large homolog 1 (Drosophila) -0.0301364
FLNB filamin B, beta -0.0300474
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0299446
RPS13 ribosomal protein S13 -0.029869
RPS8 ribosomal protein S8 -0.0295751
EMP1 epithelial membrane protein 1 -0.0293826
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0292997
PTTG1 pituitary tumor-transforming 1 -0.0292168
CAMTA1 calmodulin binding transcription activator 1 -0.0291006
PRRC2C proline-rich coiled-coil 2C -0.0288488
RPS21 ribosomal protein S21 -0.0288113
EP300 E1A binding protein p300 -0.0287879
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0287099
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0286938
SENP5 SUMO1/sentrin specific peptidase 5 -0.0283123
RPL37A ribosomal protein L37a -0.0282012
RTN4 reticulon 4 -0.0273172
PNISR PNN-interacting serine/arginine-rich protein -0.0271818
CORO1C coronin, actin binding protein, 1C -0.0270687
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0266438
ASPH aspartate beta-hydroxylase -0.0265639
RPS12 ribosomal protein S12 -0.0264415
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0262887
EXOC4 exocyst complex component 4 -0.0261908
KDM3A lysine (K)-specific demethylase 3A -0.0261686
RPL4 ribosomal protein L4 -0.0261278
WSB1 WD repeat and SOCS box containing 1 -0.0261182
CTTN cortactin -0.0261128
NGLY1 N-glycanase 1 -0.0261011
SEPTIN7 septin 7 -0.0258954
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0257944
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0256649
CLINT1 clathrin interactor 1 -0.0256641
OGA O-GlcNAcase -0.0256623
GARS1 glycyl-tRNA synthetase 1 -0.0256016
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0255172
NUSAP1 nucleolar and spindle associated protein 1 -0.0252931
TRIO trio Rho guanine nucleotide exchange factor -0.0252631
TOP1 topoisomerase (DNA) I -0.0252341
RPLP1 ribosomal protein, large, P1 -0.0250867
HMGB2 high mobility group box 2 -0.024953
CKAP5 cytoskeleton associated protein 5 -0.0248163
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0246237
VMP1 vacuole membrane protein 1 -0.0246198
PCBP2 poly(rC) binding protein 2 -0.0243145
OXSR1 oxidative stress responsive 1 -0.0242752
NCKAP1 NCK-associated protein 1 -0.0242004
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0241956
SEC31A SEC31 homolog A (S. cerevisiae) -0.0240753
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0240396
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0237165
SLC39A11 solute carrier family 39, member 11 -0.0235109