Bestatin (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PKM pyruvate kinase, muscle 0.156083
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0877521
AHNAK AHNAK nucleoprotein 0.0874577
ZBTB20 zinc finger and BTB domain containing 20 0.0573542
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0438945
EGFR epidermal growth factor receptor 0.042418
ADAM10 ADAM metallopeptidase domain 10 0.0404504
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0362136
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.035688
DSCAM Down syndrome cell adhesion molecule 0.0356476
APP amyloid beta (A4) precursor protein 0.0351077
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0341396
LOC112694756 uncharaterized LOC112694756 0.0333577
ANK2 ankyrin 2, neuronal 0.0325346
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0315769
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0302676
B2M beta-2-microglobulin 0.0300502
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0290864
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0279003
EEF2 eukaryotic translation elongation factor 2 0.0267877
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0265895
SAMD4A sterile alpha motif domain containing 4A 0.0264602
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.026359
LDHA lactate dehydrogenase A 0.0262525
RPL3 ribosomal protein L3 0.0247703
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0227463
EML4 echinoderm microtubule associated protein like 4 0.0220425
PYGB phosphorylase, glycogen; brain 0.0219885
EEF1G eukaryotic translation elongation factor 1 gamma 0.0215585
KLF3 Kruppel-like factor 3 (basic) 0.0213699
HDAC9 histone deacetylase 9 0.0212597
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0212283
IFI6 interferon, alpha-inducible protein 6 0.0210964
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0210031
TMSB4X thymosin beta 4, X-linked 0.0208195
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0195317
TMEM14B transmembrane protein 14B 0.0193379
BCAS3 breast carcinoma amplified sequence 3 0.0192081
TBC1D5 TBC1 domain family, member 5 0.0190359
ARL15 ADP-ribosylation factor-like 15 0.0189229
ADAM9 ADAM metallopeptidase domain 9 0.0189046
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0186882
EZR ezrin 0.018644
LOXL3 lysyl oxidase-like 3 0.0177281
FBLN2 fibulin 2 0.0177099
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0175002
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0174876
METTL15 methyltransferase like 15 0.0174608
EIF4B eukaryotic translation initiation factor 4B 0.0172463
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.0170921
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0170753
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0170203
DARS1 aspartyl-tRNA synthetase 1 0.0166562
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0166006
ZFAND3 zinc finger, AN1-type domain 3 0.0165289
CALR calreticulin 0.016509
RPS18 ribosomal protein S18 0.0162401
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.016225
KDM5C lysine (K)-specific demethylase 5C 0.0157923
NARS1 asparaginyl-tRNA synthetase 1 0.0157089
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0156025
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0155026
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0154185
RO60 Ro60, Y RNA binding protein 0.0151779
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0151255
ARRDC3 arrestin domain containing 3 0.0151073
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0148533
PTPRG protein tyrosine phosphatase, receptor type, G 0.01482
TRAPPC9 trafficking protein particle complex 9 0.0148065
GYS1 glycogen synthase 1 (muscle) 0.0146444
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0146423
RNF213 ring finger protein 213 0.0146421
PLK2 polo-like kinase 2 0.0145317
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.013989
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0139763
FBXO42 F-box protein 42 0.0138346
BTBD9 BTB (POZ) domain containing 9 0.0137285
MIDEAS mitotic deacetylase associated SANT domain protein 0.0137259
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0135329
HOMER1 homer scaffolding protein 1 0.0134604
NDFIP1 Nedd4 family interacting protein 1 0.0133476
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0133183
MSL1 male-specific lethal 1 homolog (Drosophila) 0.0133122
DIAPH2 diaphanous-related formin 2 0.0132874
USO1 USO1 vesicle transport factor 0.0132591
FAM168A family with sequence similarity 168, member A 0.0132237
NFE2L1 nuclear factor, erythroid 2-like 1 0.0132039
PLPP3 phospholipid phosphatase 3 0.0131695
PDGFC platelet derived growth factor C 0.0131555
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0131314
BST2 bone marrow stromal cell antigen 2 0.0131044
TMEM65 transmembrane protein 65 0.0130396
HEG1 heart development protein with EGF-like domains 1 0.0130232
MACF1 microtubule-actin crosslinking factor 1 0.013015
NCEH1 neutral cholesterol ester hydrolase 1 0.0129369
TMEM135 transmembrane protein 135 0.0129158
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0129117
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0126491
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0125708
WASF2 WAS protein family, member 2 0.0125239

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.267703
PTMA prothymosin, alpha -0.225015
TPT1 tumor protein, translationally-controlled 1 -0.12589
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.108332
RPS6 ribosomal protein S6 -0.0927459
RPS8 ribosomal protein S8 -0.0834987
ACTG1 actin gamma 1 -0.0777649
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0695071
PDE4B phosphodiesterase 4B, cAMP-specific -0.0625404
MKI67 marker of proliferation Ki-67 -0.0607991
RPL34 ribosomal protein L34 -0.0600398
RPL35A ribosomal protein L35a -0.0596915
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0579385
RPL37A ribosomal protein L37a -0.0575485
SSBP2 single-stranded DNA binding protein 2 -0.0562766
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0544732
GOLGA4 golgin A4 -0.0544385
WSB1 WD repeat and SOCS box containing 1 -0.0539557
DLG1 discs, large homolog 1 (Drosophila) -0.0534844
RPLP1 ribosomal protein, large, P1 -0.0529026
CENPF centromere protein F, 350/400kDa -0.0519352
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0517279
RPL23 ribosomal protein L23 -0.0513716
NAP1L1 nucleosome assembly protein 1-like 1 -0.0461908
SMC4 structural maintenance of chromosomes 4 -0.0454931
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0452456
ZEB1 zinc finger E-box binding homeobox 1 -0.0451282
DIAPH3 diaphanous-related formin 3 -0.0450276
RPL12 ribosomal protein L12 -0.0442501
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0442166
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0442147
FLNB filamin B, beta -0.0440118
EVI5 ecotropic viral integration site 5 -0.0430129
RPS13 ribosomal protein S13 -0.0427864
NAV2 neuron navigator 2 -0.0424715
RPL26 ribosomal protein L26 -0.0407881
RPLP2 ribosomal protein, large, P2 -0.0403725
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0397674
RPL11 ribosomal protein L11 -0.0397578
RPLP0 ribosomal protein, large, P0 -0.0395754
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.038289
KPNB1 karyopherin (importin) beta 1 -0.0356255
RPS21 ribosomal protein S21 -0.0356141
RPS24 ribosomal protein S24 -0.0351435
RPS3 ribosomal protein S3 -0.0348454
RPS25 ribosomal protein S25 -0.0344135
RPL19 ribosomal protein L19 -0.0343461
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0340609
RPL9 ribosomal protein L9 -0.0336071
RBM39 RNA binding motif protein 39 -0.0334285
S100A9 S100 calcium binding protein A9 -0.0333433
HSPB1 heat shock 27kDa protein 1 -0.0332606
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0330116
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0328967
RPL37 ribosomal protein L37 -0.0326709
QKI QKI, KH domain containing, RNA binding -0.0319482
CAMTA1 calmodulin binding transcription activator 1 -0.0319462
RPS23 ribosomal protein S23 -0.0314905
TM4SF1 transmembrane 4 L six family member 1 -0.0311211
KDM3A lysine (K)-specific demethylase 3A -0.0311013
RPL38 ribosomal protein L38 -0.0305805
ECT2 epithelial cell transforming 2 -0.0304929
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0304527
RPL36 ribosomal protein L36 -0.03018
PFN1 profilin 1 -0.0301525
RFC3 replication factor C (activator 1) 3, 38kDa -0.0300257
NIPBL Nipped-B homolog (Drosophila) -0.0300226
MYL12B myosin, light chain 12B, regulatory -0.0296364
S100A4 S100 calcium binding protein A4 -0.0293895
RPS12 ribosomal protein S12 -0.0293326
RPS19 ribosomal protein S19 -0.0292943
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0285405
ZNF292 zinc finger protein 292 -0.0282443
NF1 neurofibromin 1 -0.0280022
RPS10 ribosomal protein S10 -0.0276943
RPL5 ribosomal protein L5 -0.0276371
RPS27A ribosomal protein S27a -0.0275708
CENPE centromere protein E, 312kDa -0.0274247
JMJD1C jumonji domain containing 1C -0.0273697
RPL7A ribosomal protein L7a -0.0272381
RPL30 ribosomal protein L30 -0.0269524
S100A10 S100 calcium binding protein A10 -0.0264977
TPX2 TPX2, microtubule-associated -0.02619
HMGB1 high mobility group box 1 -0.0261013
ASXL1 additional sex combs like transcriptional regulator 1 -0.0256319
RAB7A RAB7A, member RAS oncogene family -0.0254706
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0248275
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0247011
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0246825
RACK1 receptor for activated C kinase 1 -0.0246137
PUM2 pumilio RNA-binding family member 2 -0.0244541
MT2A metallothionein 2A -0.024192
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0241475
S100A6 S100 calcium binding protein A6 -0.0240243
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0239466
FNDC3B fibronectin type III domain containing 3B -0.0235742
GNAS GNAS complex locus -0.0234493
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0231893
RRM2 ribonucleotide reductase M2 -0.0229476
RPL32 ribosomal protein L32 -0.0227342