Bestatin (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.179528
SYT1 synaptotagmin I 0.0418953
TNS3 tensin 3 0.0413947
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0350748
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0349244
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0343992
WWOX WW domain containing oxidoreductase 0.0323218
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0276409
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0264825
AOPEP aminopeptidase O (putative) 0.0257052
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0255643
PROX1 prospero homeobox 1 0.0250779
ETNK1 ethanolamine kinase 1 0.0249358
HDAC4 histone deacetylase 4 0.0244739
DST dystonin 0.0235606
YAP1 Yes-associated protein 1 0.0226793
MACC1 metastasis associated in colon cancer 1 0.0216552
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0211918
SMYD3 SET and MYND domain containing 3 0.0211529
ATXN1 ataxin 1 0.0211043
RERE arginine-glutamic acid dipeptide (RE) repeats 0.021071
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.020172
EIF4B eukaryotic translation initiation factor 4B 0.0193323
TMEM163 transmembrane protein 163 0.0188071
FOXP1 forkhead box P1 0.0187143
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0182373
FAF1 Fas (TNFRSF6) associated factor 1 0.018234
BCL2L1 BCL2-like 1 0.0180244
RUNX1 runt-related transcription factor 1 0.0174612
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0172184
SFPQ splicing factor proline/glutamine-rich 0.0170073
SPATA13 spermatogenesis associated 13 0.0169838
CTNND1 catenin (cadherin-associated protein), delta 1 0.0168875
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0164489
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0163818
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0163353
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0156684
PDE4D phosphodiesterase 4D, cAMP-specific 0.0156095
VGLL4 vestigial-like family member 4 0.0156009
BCAS3 breast carcinoma amplified sequence 3 0.0154192
CDH13 cadherin 13 0.0153288
NCEH1 neutral cholesterol ester hydrolase 1 0.0153031
BMP5 bone morphogenetic protein 5 0.0150601
ARGLU1 arginine and glutamate rich 1 0.0148386
ACTN4 actinin, alpha 4 0.0147583
UTRN utrophin 0.0146309
GMDS GDP-mannose 4,6-dehydratase 0.0145896
LMO7 LIM domain 7 0.0144964
CEMIP2 cell migration inducing hyaluronidase 2 0.0144728
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0144134
RAD51B RAD51 paralog B 0.0141382
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0139977
SPRED2 sprouty-related, EVH1 domain containing 2 0.0136336
SESN3 sestrin 3 0.0135366
TCF12 transcription factor 12 0.0130736
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0130731
CD46 CD46 molecule, complement regulatory protein 0.0127165
C2CD5 C2 calcium-dependent domain containing 5 0.0124986
VMP1 vacuole membrane protein 1 0.0124133
MSI2 musashi RNA-binding protein 2 0.012351
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0122862
ZNRF3 zinc and ring finger 3 0.0121539
STK38L serine/threonine kinase 38 like 0.0119333
RBM26 RNA binding motif protein 26 0.0118894
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0118775
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0117227
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0117169
CEMIP cell migration inducing protein, hyaluronan binding 0.0116793
PCLO piccolo presynaptic cytomatrix protein 0.0115307
STK24 serine/threonine kinase 24 0.0115151
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0111086
FANCL Fanconi anemia, complementation group L 0.0110871
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0110111
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0109205
PTEN phosphatase and tensin homolog 0.0109166
ANKRD17 ankyrin repeat domain 17 0.0108574
TNRC18 trinucleotide repeat containing 18 0.0107663
PLEC plectin 0.0107049
ARHGAP42 Rho GTPase activating protein 42 0.0104987
GRIK5 glutamate receptor, ionotropic, kainate 5 0.010438
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0104353
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0103928
LRP6 low density lipoprotein receptor-related protein 6 0.0103669
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0102575
DNAH14 dynein, axonemal, heavy chain 14 0.0102233
ARL15 ADP-ribosylation factor-like 15 0.0101932
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.010162
SRSF1 serine/arginine-rich splicing factor 1 0.00993702
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00990649
FRAS1 Fraser extracellular matrix complex subunit 1 0.00980315
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00975477
PHF14 PHD finger protein 14 0.00949665
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.00944846
TRAF5 TNF receptor-associated factor 5 0.00941626
SP3 Sp3 transcription factor 0.00939231
LCOR ligand dependent nuclear receptor corepressor 0.00936462
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00930798
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.00927093
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00920972
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00916865

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0801015
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0746445
KRT18 keratin 18, type I -0.0622411
ENO1 enolase 1, (alpha) -0.055894
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0508764
RPS3 ribosomal protein S3 -0.0498458
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0495504
PTMA prothymosin, alpha -0.0493216
TPT1 tumor protein, translationally-controlled 1 -0.048374
RPL35A ribosomal protein L35a -0.047598
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0468796
ANXA2 annexin A2 -0.0465962
VIM vimentin -0.0462583
RPS6 ribosomal protein S6 -0.0444208
LDHA lactate dehydrogenase A -0.0417039
RPS19 ribosomal protein S19 -0.0387752
PGK1 phosphoglycerate kinase 1 -0.0386123
RPL37A ribosomal protein L37a -0.0375403
RPL23 ribosomal protein L23 -0.0371862
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0360494
AKAP12 A kinase (PRKA) anchor protein 12 -0.0355803
RPS12 ribosomal protein S12 -0.0324582
MT2A metallothionein 2A -0.0323751
KRT8 keratin 8, type II -0.0323655
NDRG1 N-myc downstream regulated 1 -0.0315653
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0307615
RACK1 receptor for activated C kinase 1 -0.0291032
RPS8 ribosomal protein S8 -0.0288201
RPL26 ribosomal protein L26 -0.0283672
DDIT4 DNA-damage-inducible transcript 4 -0.0276122
TPI1 triosephosphate isomerase 1 -0.0274915
RPL12 ribosomal protein L12 -0.0272261
EZR ezrin -0.027044
ACTG1 actin gamma 1 -0.0265317
ESYT2 extended synaptotagmin-like protein 2 -0.0264513
TPM4 tropomyosin 4 -0.0262073
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0257289
S100A6 S100 calcium binding protein A6 -0.0250304
GOLGA4 golgin A4 -0.0244568
PDGFA platelet-derived growth factor alpha polypeptide -0.0242579
S100A10 S100 calcium binding protein A10 -0.0241091
RPL18 ribosomal protein L18 -0.0238018
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.023627
RPS25 ribosomal protein S25 -0.0235566
RPLP1 ribosomal protein, large, P1 -0.0233788
FTL ferritin, light polypeptide -0.0233563
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0230315
MRPS6 mitochondrial ribosomal protein S6 -0.0229199
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0228617
RPL19 ribosomal protein L19 -0.0221414
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0220172
AKAP9 A kinase (PRKA) anchor protein 9 -0.02098
ANO1 anoctamin 1, calcium activated chloride channel -0.0204368
RPL27A ribosomal protein L27a -0.0201379
KRT19 keratin 19, type I -0.0199986
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0199184
RPS16 ribosomal protein S16 -0.0196196
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0194644
RPLP0 ribosomal protein, large, P0 -0.0194537
DUSP6 dual specificity phosphatase 6 -0.0192395
RPL36 ribosomal protein L36 -0.0189709
EMP1 epithelial membrane protein 1 -0.0189126
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.018838
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0181187
RPL7A ribosomal protein L7a -0.0181141
HMGA1 high mobility group AT-hook 1 -0.018097
RPL37 ribosomal protein L37 -0.0180589
SDK1 sidekick cell adhesion molecule 1 -0.0180417
RPL35 ribosomal protein L35 -0.0179961
MORF4L2 mortality factor 4 like 2 -0.0177709
FLNB filamin B, beta -0.0172802
RPL11 ribosomal protein L11 -0.0167572
KMT2E lysine (K)-specific methyltransferase 2E -0.0165931
RPS4X ribosomal protein S4, X-linked -0.0165823
RPL28 ribosomal protein L28 -0.0164376
SET SET nuclear proto-oncogene -0.0163708
SMC4 structural maintenance of chromosomes 4 -0.016346
RPLP2 ribosomal protein, large, P2 -0.0163289
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0162995
NAP1L1 nucleosome assembly protein 1-like 1 -0.0162006
CALR calreticulin -0.0161948
IGFBP3 insulin-like growth factor binding protein 3 -0.0161596
PFN1 profilin 1 -0.0161575
RPL5 ribosomal protein L5 -0.0161296
TMSB4X thymosin beta 4, X-linked -0.0160695
KPNB1 karyopherin (importin) beta 1 -0.0160141
ASPH aspartate beta-hydroxylase -0.0159308
RPL7 ribosomal protein L7 -0.0156014
KIZ kizuna centrosomal protein -0.0155212
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0153281
IER3 immediate early response 3 -0.0153227
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0153194
GNAS GNAS complex locus -0.0151232
RPS14 ribosomal protein S14 -0.0150526
RPL32 ribosomal protein L32 -0.0147198
MYOF myoferlin -0.0146209
ARF4 ADP-ribosylation factor 4 -0.0145663
RPL36A ribosomal protein L36a -0.0145618
KDM3A lysine (K)-specific demethylase 3A -0.014548
RPS27A ribosomal protein S27a -0.0143859