Bestatin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.256984
TMSB10 thymosin beta 10 0.242447
MT2A metallothionein 2A 0.185899
VIM vimentin 0.167391
IGFBP3 insulin-like growth factor binding protein 3 0.135364
PODXL podocalyxin-like 0.129346
NDRG1 N-myc downstream regulated 1 0.109357
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.107058
PTMA prothymosin, alpha 0.106872
S100A10 S100 calcium binding protein A10 0.0846127
RPS3 ribosomal protein S3 0.0712439
FTL ferritin, light polypeptide 0.0631155
SQSTM1 sequestosome 1 0.0622289
RPL37A ribosomal protein L37a 0.0582224
FLNB filamin B, beta 0.0568945
PRRC2C proline-rich coiled-coil 2C 0.0565802
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0558115
RPS8 ribosomal protein S8 0.0555201
RPL23 ribosomal protein L23 0.0552074
EIF1 eukaryotic translation initiation factor 1 0.0532082
HLA-B major histocompatibility complex, class I, B 0.0521167
B2M beta-2-microglobulin 0.0513318
CALR calreticulin 0.04976
PLAT plasminogen activator, tissue 0.0479064
KLF6 Kruppel-like factor 6 0.0455406
RPS6 ribosomal protein S6 0.0454873
RPL12 ribosomal protein L12 0.0449869
IFITM3 interferon induced transmembrane protein 3 0.0419075
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0416564
MXI1 MAX interactor 1, dimerization protein 0.0414783
RPS19 ribosomal protein S19 0.0414657
TPT1 tumor protein, translationally-controlled 1 0.039272
LDHA lactate dehydrogenase A 0.0388439
CSTB cystatin B (stefin B) 0.038732
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0385675
RPLP2 ribosomal protein, large, P2 0.037607
RPL36 ribosomal protein L36 0.0373832
RPS12 ribosomal protein S12 0.0371362
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0364908
RACK1 receptor for activated C kinase 1 0.0364311
S100A6 S100 calcium binding protein A6 0.0364262
DDIT4 DNA-damage-inducible transcript 4 0.035509
CCL5 chemokine (C-C motif) ligand 5 0.0347775
WSB1 WD repeat and SOCS box containing 1 0.0335908
RPLP1 ribosomal protein, large, P1 0.0333005
ACBD3 acyl-CoA binding domain containing 3 0.0328014
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0314423
ERRFI1 ERBB receptor feedback inhibitor 1 0.0301184
GADD45B growth arrest and DNA-damage-inducible, beta 0.0299134
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0297737
RPL26 ribosomal protein L26 0.0293578
COL3A1 collagen, type III, alpha 1 0.0293009
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0291335
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0290428
LMNA lamin A/C 0.0289772
SEPTIN9 septin 9 0.0289219
ACTN1 actinin, alpha 1 0.0288332
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0287854
RPL31 ribosomal protein L31 0.0285052
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0284773
RPL35A ribosomal protein L35a 0.0282739
ENO1 enolase 1, (alpha) 0.02811
EEF2 eukaryotic translation elongation factor 2 0.0277194
NACA nascent polypeptide-associated complex alpha subunit 0.0272267
RPS14 ribosomal protein S14 0.0271363
FUS FUS RNA binding protein 0.0270537
DLG1 discs, large homolog 1 (Drosophila) 0.0267309
ZFP36L1 ZFP36 ring finger protein-like 1 0.026519
RPS27 ribosomal protein S27 0.0264492
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0264071
PLAUR plasminogen activator, urokinase receptor 0.0263641
S100A11 S100 calcium binding protein A11 0.0261905
RPS27A ribosomal protein S27a 0.0259185
RPL28 ribosomal protein L28 0.0256944
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0256422
RPL7A ribosomal protein L7a 0.0255058
APP amyloid beta (A4) precursor protein 0.0253719
SEC61G Sec61 gamma subunit 0.0251215
RPS17 ribosomal protein S17 0.0250707
RPS23 ribosomal protein S23 0.0250304
SERF2 small EDRK-rich factor 2 0.0248093
EZR ezrin 0.0247473
RPL11 ribosomal protein L11 0.0246319
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0243708
ELL2 elongation factor, RNA polymerase II, 2 0.0239529
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0239201
HELZ helicase with zinc finger 0.0238934
GUK1 guanylate kinase 1 0.0237258
NAP1L1 nucleosome assembly protein 1-like 1 0.0234899
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0234611
RPL35 ribosomal protein L35 0.0234598
RPS4X ribosomal protein S4, X-linked 0.0232748
RPS11 ribosomal protein S11 0.0232552
RPL32 ribosomal protein L32 0.0227265
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0227095
LOC102724023 ES1 protein homolog, mitochondrial 0.0226717
ADM adrenomedullin 0.0226349
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0225463
RPL37 ribosomal protein L37 0.0224084
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0224063

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.203249
LOX lysyl oxidase -0.10597
NAV1 neuron navigator 1 -0.100675
MAP1B microtubule-associated protein 1B -0.0925394
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0820962
COL5A2 collagen, type V, alpha 2 -0.0818732
AHNAK AHNAK nucleoprotein -0.072122
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0693161
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0671906
AKAP12 A kinase (PRKA) anchor protein 12 -0.0640187
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0596566
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0544316
FBN1 fibrillin 1 -0.0543503
MX2 MX dynamin-like GTPase 2 -0.0543272
CD44 CD44 molecule (Indian blood group) -0.0543159
COL8A1 collagen, type VIII, alpha 1 -0.0530248
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0525904
COL5A1 collagen, type V, alpha 1 -0.0518589
CDH13 cadherin 13 -0.0503846
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0489292
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0473972
FBXL7 F-box and leucine-rich repeat protein 7 -0.0466268
FSTL1 follistatin-like 1 -0.0456166
SAMD9 sterile alpha motif domain containing 9 -0.0441927
RIGI RNA sensor RIG-I -0.0427796
FNDC3B fibronectin type III domain containing 3B -0.0425855
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0421552
LOC112694756 uncharaterized LOC112694756 -0.0416429
POTEF POTE ankyrin domain family, member F -0.0403708
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0385391
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.038311
COPA coatomer protein complex, subunit alpha -0.0369254
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0361912
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0360401
SLC39A11 solute carrier family 39, member 11 -0.0360253
MEIS2 Meis homeobox 2 -0.0359845
ADAM9 ADAM metallopeptidase domain 9 -0.0359616
GLIS3 GLIS family zinc finger 3 -0.0358792
FN1 fibronectin 1 -0.0351828
TAGLN2 transgelin 2 -0.0346248
ZBTB20 zinc finger and BTB domain containing 20 -0.0339371
PBX3 pre-B-cell leukemia homeobox 3 -0.0337892
RAI14 retinoic acid induced 14 -0.0328353
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0327576
DCLK2 doublecortin-like kinase 2 -0.0319967
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0314352
RNF213 ring finger protein 213 -0.0310314
TAPBP TAP binding protein (tapasin) -0.0309361
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0308509
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0308239
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0302885
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0300818
RUNX1 runt-related transcription factor 1 -0.0294235
ABI3BP ABI family, member 3 (NESH) binding protein -0.0290011
PLXNA2 plexin A2 -0.0286179
EFNA5 ephrin-A5 -0.0284496
VEGFC vascular endothelial growth factor C -0.0282433
SAMD9L sterile alpha motif domain containing 9-like -0.0281256
SUCNR1 succinate receptor 1 -0.0280494
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0275962
PRELID2 PRELI domain containing 2 -0.0271298
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0270942
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0265015
DST dystonin -0.026356
TRIO trio Rho guanine nucleotide exchange factor -0.0263451
TENM3 teneurin transmembrane protein 3 -0.0261777
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0258903
ANKRD36 ankyrin repeat domain 36 -0.0257917
GLS2 glutaminase 2 (liver, mitochondrial) -0.0252947
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0251888
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0250306
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0249846
WARS1 tryptophanyl-tRNA synthetase 1 -0.0246511
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0245268
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0245017
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0244978
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0242273
SOD2 superoxide dismutase 2, mitochondrial -0.0241162
MACF1 microtubule-actin crosslinking factor 1 -0.023976
PLSCR1 phospholipid scramblase 1 -0.0236073
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0235553
FNIP1 folliculin interacting protein 1 -0.0232758
PDIA3 protein disulfide isomerase family A, member 3 -0.0232745
EGFR epidermal growth factor receptor -0.0229638
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0229114
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0229093
VMP1 vacuole membrane protein 1 -0.0228769
MBD5 methyl-CpG binding domain protein 5 -0.0228306
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0227362
SP100 SP100 nuclear antigen -0.0227137
CENPF centromere protein F, 350/400kDa -0.0223478
DPYSL2 dihydropyrimidinase-like 2 -0.0222013
DPYSL3 dihydropyrimidinase-like 3 -0.0221019
MB21D2 Mab-21 domain containing 2 -0.0219113
CEP170 centrosomal protein 170kDa -0.0218199
TAOK1 TAO kinase 1 -0.0218029
MYOF myoferlin -0.0217829
ZNF207 zinc finger protein 207 -0.0216731
TPM1 tropomyosin 1 (alpha) -0.021368
ANXA2 annexin A2 -0.0211511