Bestatin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.123002
FAM13A family with sequence similarity 13, member A 0.0485486
MEF2A myocyte enhancer factor 2A 0.0482378
SOS1 son of sevenless homolog 1 (Drosophila) 0.0237944
ADGRG6 adhesion G protein-coupled receptor G6 0.0235282
SEPTIN9 septin 9 0.0233273
TOB1 transducer of ERBB2, 1 0.0225338
MXI1 MAX interactor 1, dimerization protein 0.0223478
UBAP2L ubiquitin associated protein 2-like 0.0220494
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0212433
ZMIZ1 zinc finger, MIZ-type containing 1 0.0208714
FNDC3B fibronectin type III domain containing 3B 0.0207057
RAB18 RAB18, member RAS oncogene family 0.0201798
ERRFI1 ERBB receptor feedback inhibitor 1 0.0199926
HELZ helicase with zinc finger 0.019384
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0190555
SBF2 SET binding factor 2 0.0186703
NRIP1 nuclear receptor interacting protein 1 0.0171552
ZNF654 zinc finger protein 654 0.0169909
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0169843
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0167466
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0164749
PCBP3 poly(rC) binding protein 3 0.0158239
C1ORF21 chromosome 1 open reading frame 21 0.0156212
PHC3 polyhomeotic homolog 3 (Drosophila) 0.014676
RAB6A RAB6A, member RAS oncogene family 0.014593
KLF6 Kruppel-like factor 6 0.0145189
TET2 tet methylcytosine dioxygenase 2 0.014512
SCLT1 sodium channel and clathrin linker 1 0.0143554
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 0.0142293
GPC5 glypican 5 0.013947
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0139352
PDS5B PDS5 cohesin associated factor B 0.013844
BLTP1 bridge-like lipid transfer protein family member 1 0.0136083
TNRC6A trinucleotide repeat containing 6A 0.0135492
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0133778
FNBP1 formin binding protein 1 0.013343
ARRDC3 arrestin domain containing 3 0.013337
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0131946
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0130777
SOCS5 suppressor of cytokine signaling 5 0.0130357
TENT2 terminal nucleotidyltransferase 2 0.0128193
MARCHF6 membrane associated ring-CH-type finger 6 0.0127723
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0127356
CENPC centromere protein C 0.0127155
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0126639
CEP95 centrosomal protein 95kDa 0.0126493
ESYT2 extended synaptotagmin-like protein 2 0.0126289
YME1L1 YME1-like 1 ATPase 0.0125792
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0125788
NEK7 NIMA-related kinase 7 0.0125295
NUP58 nucleoporin 58 0.01248
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0124424
SETD2 SET domain containing 2 0.0124333
NPEPPS aminopeptidase puromycin sensitive 0.0124002
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0123835
TOP2B topoisomerase (DNA) II beta 180kDa 0.0123606
UBA6 ubiquitin-like modifier activating enzyme 6 0.0123549
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0121684
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0121482
HDAC5 histone deacetylase 5 0.011973
ELL2 elongation factor, RNA polymerase II, 2 0.011969
INSIG2 insulin induced gene 2 0.0118945
IPMK inositol polyphosphate multikinase 0.0118639
AKAP10 A kinase (PRKA) anchor protein 10 0.0117879
RREB1 ras responsive element binding protein 1 0.0117619
NOTCH1 notch 1 0.0117009
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0114815
YEATS2 YEATS domain containing 2 0.0114686
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.0113651
EPAS1 endothelial PAS domain protein 1 0.0113199
ZNF292 zinc finger protein 292 0.011235
ANAPC5 anaphase promoting complex subunit 5 0.0111794
TEX10 testis expressed 10 0.0110425
PUM2 pumilio RNA-binding family member 2 0.0110361
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.0109781
CDK19 cyclin-dependent kinase 19 0.0109628
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0109367
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0109165
RYBP RING1 and YY1 binding protein 0.0108972
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0108796
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0108651
KCTD3 potassium channel tetramerization domain containing 3 0.0108516
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0108183
DDIT4 DNA-damage-inducible transcript 4 0.0108059
DAND5 DAN domain family member 5, BMP antagonist 0.0106031
FAM168B family with sequence similarity 168, member B 0.0105957
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0105535
ORC4 origin recognition complex, subunit 4 0.0104919
SNX13 sorting nexin 13 0.0104504
VIRMA vir like m6A methyltransferase associated 0.0104046
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0103705
MKI67 marker of proliferation Ki-67 0.0102508
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0101534
ITPKB inositol-trisphosphate 3-kinase B 0.0101383
HOOK2 hook microtubule-tethering protein 2 0.0101376
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0101144
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.0100628
USP12 ubiquitin specific peptidase 12 0.0100092
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.00994404

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.456428
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.193053
VIM vimentin -0.189088
PTMA prothymosin, alpha -0.11655
VCL vinculin -0.110564
RPL23 ribosomal protein L23 -0.102258
LSAMP limbic system-associated membrane protein -0.101612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101301
SYT1 synaptotagmin I -0.098303
NALF1 NALCN channel auxiliary factor 1 -0.0980142
ACTG1 actin gamma 1 -0.0971877
TPT1 tumor protein, translationally-controlled 1 -0.0955982
RPS6 ribosomal protein S6 -0.0827291
TMSB10 thymosin beta 10 -0.0789049
RPL19 ribosomal protein L19 -0.072524
FMN1 formin 1 -0.067324
RPLP1 ribosomal protein, large, P1 -0.0646732
BPTF bromodomain PHD finger transcription factor -0.0632594
PRKCA protein kinase C, alpha -0.0622597
RPL35A ribosomal protein L35a -0.0593325
FTL ferritin, light polypeptide -0.0583169
RPS27A ribosomal protein S27a -0.0581031
EEF2 eukaryotic translation elongation factor 2 -0.0576479
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0551555
RPL37A ribosomal protein L37a -0.0547207
COL1A1 collagen, type I, alpha 1 -0.0537785
RPL34 ribosomal protein L34 -0.0509532
RPL31 ribosomal protein L31 -0.0501831
RPS3 ribosomal protein S3 -0.0497969
RPS12 ribosomal protein S12 -0.0486799
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0470144
RPL9 ribosomal protein L9 -0.0460076
LPIN1 lipin 1 -0.0456731
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0449441
POTEF POTE ankyrin domain family, member F -0.0446391
EIF1 eukaryotic translation initiation factor 1 -0.0442147
PDIA3 protein disulfide isomerase family A, member 3 -0.0432311
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0431988
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0423315
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0417341
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0414964
AHNAK AHNAK nucleoprotein -0.0410493
RPS17 ribosomal protein S17 -0.0406295
VMP1 vacuole membrane protein 1 -0.0401428
RPS24 ribosomal protein S24 -0.0399329
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0398103
RPS19 ribosomal protein S19 -0.0390688
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0390005
DPH6 diphthamine biosynthesis 6 -0.0388419
UBC ubiquitin C -0.0387998
RPS14 ribosomal protein S14 -0.0386125
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0378511
RPS23 ribosomal protein S23 -0.0377809
TAS2R14 taste receptor, type 2, member 14 -0.0373267
TRIB2 tribbles pseudokinase 2 -0.0370982
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.036932
TLE4 transducin-like enhancer of split 4 -0.0368457
ZNF609 zinc finger protein 609 -0.0368421
ZFAND3 zinc finger, AN1-type domain 3 -0.0366517
RPS13 ribosomal protein S13 -0.0365726
KTN1 kinectin 1 (kinesin receptor) -0.0364646
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0362112
RPL12 ribosomal protein L12 -0.0358297
RPL7A ribosomal protein L7a -0.0356734
B2M beta-2-microglobulin -0.0351412
EXT1 exostosin glycosyltransferase 1 -0.0344076
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0342752
PDE4D phosphodiesterase 4D, cAMP-specific -0.0342647
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0341904
GNAS GNAS complex locus -0.0337226
MCL1 myeloid cell leukemia 1 -0.0337023
RNF213 ring finger protein 213 -0.0331163
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0327925
ATXN1 ataxin 1 -0.0326657
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0325812
ANKRD11 ankyrin repeat domain 11 -0.0322898
RPS27 ribosomal protein S27 -0.0322661
ENO1 enolase 1, (alpha) -0.0322209
EGR1 early growth response 1 -0.0320876
RPS16 ribosomal protein S16 -0.0320136
RPL11 ribosomal protein L11 -0.031918
RPS25 ribosomal protein S25 -0.0314861
FRMD4A FERM domain containing 4A -0.0313883
RPLP2 ribosomal protein, large, P2 -0.0309979
RPL13A ribosomal protein L13a -0.0309848
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0308115
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0307107
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0305359
NAP1L1 nucleosome assembly protein 1-like 1 -0.0302722
TPM1 tropomyosin 1 (alpha) -0.0298623
CHD9 chromodomain helicase DNA binding protein 9 -0.0297338
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0295089
RPS29 ribosomal protein S29 -0.0294303
ANXA2 annexin A2 -0.0293847
S100A9 S100 calcium binding protein A9 -0.0292663
RPS20 ribosomal protein S20 -0.029191
RPS8 ribosomal protein S8 -0.0291322
SLC38A2 solute carrier family 38, member 2 -0.029058
NPAS2 neuronal PAS domain protein 2 -0.0290437
RPL26 ribosomal protein L26 -0.0290182