| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bestatin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0645366 |
| MT2A | metallothionein 2A | 0.0533276 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0406704 |
| ARRDC3 | arrestin domain containing 3 | 0.0326329 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.027977 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.027922 |
| MTSS1 | metastasis suppressor 1 | 0.0258139 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0246975 |
| MYO10 | myosin X | 0.022841 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0225746 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0218668 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0213209 |
| RPS2 | ribosomal protein S2 | 0.021111 |
| APP | amyloid beta (A4) precursor protein | 0.0206026 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0204856 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0204856 |
| JAG1 | jagged 1 | 0.0201007 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0194531 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0189123 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0185197 |
| SMAD3 | SMAD family member 3 | 0.0183011 |
| ACTN1 | actinin, alpha 1 | 0.0182774 |
| CLIC4 | chloride intracellular channel 4 | 0.0178529 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0176416 |
| RPS4X | ribosomal protein S4, X-linked | 0.0172984 |
| RPS12 | ribosomal protein S12 | 0.0168339 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0161464 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0156667 |
| FLNA | filamin A, alpha | 0.0153949 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0153023 |
| RASA2 | RAS p21 protein activator 2 | 0.0147633 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0144379 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.014428 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0142309 |
| HAS2 | hyaluronan synthase 2 | 0.014105 |
| SDF4 | stromal cell derived factor 4 | 0.0136443 |
| IRF1 | interferon regulatory factor 1 | 0.0135001 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.013276 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0129258 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0128107 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0126765 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0125571 |
| RACK1 | receptor for activated C kinase 1 | 0.0120616 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0118987 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0118189 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0117664 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0117247 |
| GPC6 | glypican 6 | 0.0115797 |
| HMOX1 | heme oxygenase 1 | 0.0113122 |
| ANGPTL4 | angiopoietin-like 4 | 0.0112637 |
| MSN | moesin | 0.0112484 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0111599 |
| TNS1 | tensin 1 | 0.0109634 |
| H2AC6 | H2A clustered histone 6 | 0.0109323 |
| SET | SET nuclear proto-oncogene | 0.0107315 |
| WWOX | WW domain containing oxidoreductase | 0.0106041 |
| RPL3 | ribosomal protein L3 | 0.0105195 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0104978 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.0103818 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.0103811 |
| NAV2 | neuron navigator 2 | 0.0103244 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0103164 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0103141 |
| SLC25A51 | solute carrier family 25, member 51 | 0.0102559 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0101625 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.010025 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00987278 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 0.00986756 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.00971526 |
| NOTCH2 | notch 2 | 0.00955562 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00954481 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.00954472 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.00952081 |
| YBX1 | Y box binding protein 1 | 0.00945869 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.00945248 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.00943741 |
| FAT1 | FAT atypical cadherin 1 | 0.00942955 |
| RNF24 | ring finger protein 24 | 0.00920225 |
| LAMB1 | laminin, beta 1 | 0.00919779 |
| RPL23 | ribosomal protein L23 | 0.00916739 |
| MX1 | MX dynamin-like GTPase 1 | 0.00914752 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.00914047 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.00910543 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.00904544 |
| NRP2 | neuropilin 2 | 0.00904075 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.00902451 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.00891516 |
| CCNL1 | cyclin L1 | 0.00889971 |
| MX2 | MX dynamin-like GTPase 2 | 0.00889933 |
| RNF19B | ring finger protein 19B | 0.00888064 |
| ANXA5 | annexin A5 | 0.00883936 |
| IFI44L | interferon-induced protein 44-like | 0.00873676 |
| EZR | ezrin | 0.00873207 |
| SEPTIN9 | septin 9 | 0.00869344 |
| RAB8B | RAB8B, member RAS oncogene family | 0.00869293 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.00867775 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | 0.00860828 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.00859269 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.00857841 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.00852156 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.290657 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.250561 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.225131 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.173487 |
| VIM | vimentin | -0.171589 |
| COL1A1 | collagen, type I, alpha 1 | -0.16562 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.141117 |
| COL1A2 | collagen, type I, alpha 2 | -0.139706 |
| FBN1 | fibrillin 1 | -0.10404 |
| LOX | lysyl oxidase | -0.10115 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0989987 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0985347 |
| CANX | calnexin | -0.0819395 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0730776 |
| NDRG1 | N-myc downstream regulated 1 | -0.0702406 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0669437 |
| CDH13 | cadherin 13 | -0.0642017 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0588643 |
| LMAN1 | lectin, mannose-binding, 1 | -0.058826 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0587297 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0552142 |
| EXT1 | exostosin glycosyltransferase 1 | -0.054692 |
| TMSB10 | thymosin beta 10 | -0.0545325 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0536081 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0531432 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.050674 |
| AHNAK | AHNAK nucleoprotein | -0.0501787 |
| GOLGA4 | golgin A4 | -0.0486659 |
| PTMA | prothymosin, alpha | -0.0455219 |
| TPM4 | tropomyosin 4 | -0.0453432 |
| FTL | ferritin, light polypeptide | -0.0452486 |
| CAVIN1 | caveolae associated protein 1 | -0.0450306 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0450252 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0448471 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0443949 |
| RRBP1 | ribosome binding protein 1 | -0.0436921 |
| COL5A1 | collagen, type V, alpha 1 | -0.0434863 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0417545 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0408736 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0407671 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0401216 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0398275 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0395961 |
| UBC | ubiquitin C | -0.039061 |
| HDLBP | high density lipoprotein binding protein | -0.0382607 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0382496 |
| CADM1 | cell adhesion molecule 1 | -0.0380325 |
| IER3 | immediate early response 3 | -0.0371954 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0369912 |
| GOLGB1 | golgin B1 | -0.0366721 |
| CALR | calreticulin | -0.0361277 |
| MTDH | metadherin | -0.0349628 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0344859 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0333954 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0331054 |
| WASF2 | WAS protein family, member 2 | -0.0326689 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0323985 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.031566 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0315411 |
| PGK1 | phosphoglycerate kinase 1 | -0.0313758 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0311092 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0310441 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.030983 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0307012 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0306529 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0298521 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0297543 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0297487 |
| TRAM1 | translocation associated membrane protein 1 | -0.0296835 |
| PDE10A | phosphodiesterase 10A | -0.0290374 |
| RPL35A | ribosomal protein L35a | -0.0290212 |
| ASPH | aspartate beta-hydroxylase | -0.0285989 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0283969 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0283681 |
| VEGFA | vascular endothelial growth factor A | -0.0281639 |
| VDAC1 | voltage-dependent anion channel 1 | -0.027904 |
| CA12 | carbonic anhydrase XII | -0.0277998 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.027784 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0277075 |
| H1-0 | H1.0 linker histone | -0.0274781 |
| ACTG1 | actin gamma 1 | -0.0273713 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0271453 |
| DST | dystonin | -0.0271408 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.026964 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0268977 |
| STC1 | stanniocalcin 1 | -0.0268747 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0267532 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0264766 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0263171 |
| CALD1 | caldesmon 1 | -0.0261178 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0260702 |
| VCAN | versican | -0.0260206 |
| COL6A2 | collagen, type VI, alpha 2 | -0.025969 |
| TMEM263 | transmembrane protein 263 | -0.0256215 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0254684 |
| ADM | adrenomedullin | -0.0251384 |
| BBX | bobby sox homolog (Drosophila) | -0.0250293 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0250058 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0249842 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0249714 |
