| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bestatin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.295728 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.253077 |
| MT2A | metallothionein 2A | 0.140433 |
| APOB | apolipoprotein B | 0.13165 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0919776 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0804248 |
| APOA2 | apolipoprotein A-II | 0.0761757 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0523814 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0499107 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0496697 |
| C3 | complement component 3 | 0.041543 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0409869 |
| ENO1 | enolase 1, (alpha) | 0.0353727 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0339958 |
| FTL | ferritin, light polypeptide | 0.0335752 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0333779 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0332089 |
| JMJD1C | jumonji domain containing 1C | 0.031465 |
| TPM4 | tropomyosin 4 | 0.0288135 |
| AFDN | afadin, adherens junction formation factor | 0.0275406 |
| RPS19 | ribosomal protein S19 | 0.0273807 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0273723 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0272762 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0269285 |
| RPS12 | ribosomal protein S12 | 0.0269228 |
| RPS6 | ribosomal protein S6 | 0.026524 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0262887 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0262475 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0257541 |
| MALT1 | MALT1 paracaspase | 0.0248866 |
| APOE | apolipoprotein E | 0.0245377 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0243 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0242349 |
| TMSB10 | thymosin beta 10 | 0.0237086 |
| BCL2L1 | BCL2-like 1 | 0.0235098 |
| RPL37A | ribosomal protein L37a | 0.0234493 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0231276 |
| RTN4 | reticulon 4 | 0.022881 |
| CDK19 | cyclin-dependent kinase 19 | 0.0226795 |
| PTMA | prothymosin, alpha | 0.0226681 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0221368 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0218423 |
| PHF21A | PHD finger protein 21A | 0.0217394 |
| PCBP2 | poly(rC) binding protein 2 | 0.0215915 |
| MATR3 | matrin 3 | 0.0213317 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0210035 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0208946 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0208447 |
| KIAA1217 | KIAA1217 | 0.0208426 |
| RRBP1 | ribosome binding protein 1 | 0.0207592 |
| ACTN1 | actinin, alpha 1 | 0.0207542 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0206913 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0204459 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0202449 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | 0.0188845 |
| CRLS1 | cardiolipin synthase 1 | 0.0187509 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0186119 |
| RPS29 | ribosomal protein S29 | 0.0185971 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0185676 |
| CALR | calreticulin | 0.018565 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0184679 |
| MKI67 | marker of proliferation Ki-67 | 0.0184264 |
| DSPP | dentin sialophosphoprotein | 0.0183712 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0178687 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0176221 |
| RPLP2 | ribosomal protein, large, P2 | 0.0175245 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0174076 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0172208 |
| PCM1 | pericentriolar material 1 | 0.0171218 |
| YAP1 | Yes-associated protein 1 | 0.0169426 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0167853 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.01678 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0167532 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0166688 |
| VIM | vimentin | 0.0163747 |
| RPL23 | ribosomal protein L23 | 0.0163615 |
| RPS14 | ribosomal protein S14 | 0.0163511 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0162929 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0162641 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | 0.0161729 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0160068 |
| NFIA | nuclear factor I/A | 0.0159475 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0158992 |
| SFTPA2 | surfactant protein A2 | 0.0157362 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0156522 |
| PKM | pyruvate kinase, muscle | 0.0154574 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0153763 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0152796 |
| LDHA | lactate dehydrogenase A | 0.0151804 |
| CDK6 | cyclin-dependent kinase 6 | 0.0151461 |
| APOA1 | apolipoprotein A-I | 0.0151244 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0150358 |
| B2M | beta-2-microglobulin | 0.0149711 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0148345 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0147887 |
| S100A9 | S100 calcium binding protein A9 | 0.0147191 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0145009 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.0144944 |
| PHKB | phosphorylase kinase, beta | 0.0143883 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.0143616 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.665772 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.129819 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0677678 |
| INTS6 | integrator complex subunit 6 | -0.0664773 |
| GPC6 | glypican 6 | -0.0643611 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0600734 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0548955 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0545723 |
| ASPH | aspartate beta-hydroxylase | -0.0536886 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.052441 |
| CP | ceruloplasmin (ferroxidase) | -0.0507171 |
| PDLIM5 | PDZ and LIM domain 5 | -0.049516 |
| ATXN1 | ataxin 1 | -0.0475093 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0446219 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0442526 |
| EHBP1 | EH domain binding protein 1 | -0.0415513 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0403599 |
| GK | glycerol kinase | -0.0401511 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0394354 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0380359 |
| STK17A | serine/threonine kinase 17a | -0.0372069 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0357175 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0352443 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0351239 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0348411 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0342841 |
| PEG3 | paternally expressed 3 | -0.0342785 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0329904 |
| SMAD3 | SMAD family member 3 | -0.0324261 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0320466 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0313311 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0312659 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0312225 |
| FAM107B | family with sequence similarity 107, member B | -0.0310227 |
| AHSG | alpha-2-HS-glycoprotein | -0.0305437 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0304605 |
| NPAS2 | neuronal PAS domain protein 2 | -0.03019 |
| FILIP1L | filamin A interacting protein 1-like | -0.0300489 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0300433 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0290438 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0279277 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0276611 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0261162 |
| MYO1E | myosin IE | -0.0259578 |
| PALLD | palladin, cytoskeletal associated protein | -0.0256104 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0254679 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0251831 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0249617 |
| GNAS | GNAS complex locus | -0.0242297 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0241547 |
| MYO6 | myosin VI | -0.0241487 |
| FMNL2 | formin-like 2 | -0.0241417 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0235528 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0232046 |
| DTNA | dystrobrevin, alpha | -0.02312 |
| PARD3 | par-3 family cell polarity regulator | -0.0229137 |
| MCL1 | myeloid cell leukemia 1 | -0.0226319 |
| HPCAL1 | hippocalcin-like 1 | -0.0224692 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.0223381 |
| SERTAD2 | SERTA domain containing 2 | -0.0217935 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0217258 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0208016 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0206451 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0205592 |
| RIGI | RNA sensor RIG-I | -0.019946 |
| GPC3 | glypican 3 | -0.0196551 |
| RNF213 | ring finger protein 213 | -0.0196325 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0196131 |
| MSI2 | musashi RNA-binding protein 2 | -0.019127 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0190856 |
| RYBP | RING1 and YY1 binding protein | -0.0190286 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0189233 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0188331 |
| RPS24 | ribosomal protein S24 | -0.0185719 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0185227 |
| PHF3 | PHD finger protein 3 | -0.0185139 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0184475 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0184442 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0183814 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0181551 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0181034 |
| TLE4 | transducin-like enhancer of split 4 | -0.0180319 |
| CLIC4 | chloride intracellular channel 4 | -0.0176646 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0176113 |
| HOMER1 | homer scaffolding protein 1 | -0.0170001 |
| FOXP1 | forkhead box P1 | -0.0167398 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0167385 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0165926 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0163448 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.0163342 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0162071 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0158602 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0156002 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0155717 |
| NABP1 | nucleic acid binding protein 1 | -0.015492 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | -0.0152482 |
| CADM1 | cell adhesion molecule 1 | -0.015191 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0150537 |
| USP53 | ubiquitin specific peptidase 53 | -0.0150178 |
| RPL4 | ribosomal protein L4 | -0.014816 |
