Bestatin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.254708
PODXL podocalyxin-like 0.15382
RPS3 ribosomal protein S3 0.13741
PTMA prothymosin, alpha 0.12943
TIMP3 TIMP metallopeptidase inhibitor 3 0.11614
RPS8 ribosomal protein S8 0.0944616
TMSB10 thymosin beta 10 0.0883078
KRT6A keratin 6A, type II 0.0806975
B2M beta-2-microglobulin 0.080153
BCL2L1 BCL2-like 1 0.0770682
IGF2 insulin-like growth factor 2 0.0752766
RPS12 ribosomal protein S12 0.0743152
PRRC2C proline-rich coiled-coil 2C 0.0704942
ENO1 enolase 1, (alpha) 0.0697987
RACK1 receptor for activated C kinase 1 0.0696028
GUK1 guanylate kinase 1 0.0657445
MEF2A myocyte enhancer factor 2A 0.0649394
S100A10 S100 calcium binding protein A10 0.063962
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.057146
RPL23 ribosomal protein L23 0.0563606
RPL37A ribosomal protein L37a 0.0519119
RPL12 ribosomal protein L12 0.0516696
PLAT plasminogen activator, tissue 0.0511628
RPS2 ribosomal protein S2 0.0491571
RPS6 ribosomal protein S6 0.0482966
CALU calumenin 0.0471034
ITGA6 integrin, alpha 6 0.0467815
RPL11 ribosomal protein L11 0.0456973
RPS17 ribosomal protein S17 0.0447605
MORF4L2 mortality factor 4 like 2 0.044103
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0438899
SQLE squalene epoxidase 0.0424445
NRG1 neuregulin 1 0.0416733
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0415506
RPL26 ribosomal protein L26 0.0413485
RPS29 ribosomal protein S29 0.041343
YBX1 Y box binding protein 1 0.0413273
RPS27 ribosomal protein S27 0.0409727
RPS11 ribosomal protein S11 0.0400799
CNRIP1 cannabinoid receptor interacting protein 1 0.03918
MTSS1 metastasis suppressor 1 0.0375197
RPL31 ribosomal protein L31 0.0370166
NACA nascent polypeptide-associated complex alpha subunit 0.0356531
RPS24 ribosomal protein S24 0.0356427
RPL18 ribosomal protein L18 0.0355824
RPS4X ribosomal protein S4, X-linked 0.0355811
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0354576
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.03506
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.034817
S100A11 S100 calcium binding protein A11 0.0344544
RPL37 ribosomal protein L37 0.034274
RPL36 ribosomal protein L36 0.0340913
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0336662
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0325084
ZMIZ1 zinc finger, MIZ-type containing 1 0.0320905
RPN2 ribophorin II 0.0316579
CAPN2 calpain 2, (m/II) large subunit 0.0316191
SEC61G Sec61 gamma subunit 0.0307063
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0301227
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0300954
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0298913
RPS14 ribosomal protein S14 0.029884
S100A2 S100 calcium binding protein A2 0.0298492
TMF1 TATA element modulatory factor 1 0.0294908
GARS1 glycyl-tRNA synthetase 1 0.0290711
MXI1 MAX interactor 1, dimerization protein 0.0288117
PTPRF protein tyrosine phosphatase, receptor type, F 0.0287541
RPS23 ribosomal protein S23 0.0285637
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0284811
WSB1 WD repeat and SOCS box containing 1 0.0283739
THOC2 THO complex 2 0.0278779
SET SET nuclear proto-oncogene 0.0277161
EHF ets homologous factor 0.0276391
RPL35 ribosomal protein L35 0.0275486
CD9 CD9 molecule 0.0271398
DDIT4 DNA-damage-inducible transcript 4 0.0271256
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0264828
SPAG9 sperm associated antigen 9 0.0264803
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0263682
CALR calreticulin 0.0263637
RPS25 ribosomal protein S25 0.0263607
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0262055
RAB6A RAB6A, member RAS oncogene family 0.0260866
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0256686
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0256486
FTL ferritin, light polypeptide 0.0251381
RPL32 ribosomal protein L32 0.0249209
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.0248527
RPL5 ribosomal protein L5 0.0248068
ANGPTL4 angiopoietin-like 4 0.024737
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0245333
ARGLU1 arginine and glutamate rich 1 0.024008
OCIAD2 OCIA domain containing 2 0.0237648
ISG15 ISG15 ubiquitin-like modifier 0.0233806
KMT2A lysine (K)-specific methyltransferase 2A 0.0233256
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.023258
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0232273
RPLP2 ribosomal protein, large, P2 0.0230692
SAR1A secretion associated, Ras related GTPase 1A 0.0230629
TM9SF2 transmembrane 9 superfamily member 2 0.0229317

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.114739
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0868451
PDE4D phosphodiesterase 4D, cAMP-specific -0.0844803
CD44 CD44 molecule (Indian blood group) -0.0760939
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0699958
DPYD dihydropyrimidine dehydrogenase -0.0682784
MYOF myoferlin -0.0619433
SMAD3 SMAD family member 3 -0.0611685
NDRG1 N-myc downstream regulated 1 -0.0608033
INTS6 integrator complex subunit 6 -0.0597915
LOC112694756 uncharaterized LOC112694756 -0.0567262
H1-0 H1.0 linker histone -0.0562703
FNDC3B fibronectin type III domain containing 3B -0.0539603
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0499878
OSMR oncostatin M receptor -0.0489921
TOP1 topoisomerase (DNA) I -0.0439341
MSN moesin -0.0423212
POTEF POTE ankyrin domain family, member F -0.0416939
SLC38A2 solute carrier family 38, member 2 -0.040633
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0402204
NRIP1 nuclear receptor interacting protein 1 -0.0388536
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0387123
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0381494
AHNAK AHNAK nucleoprotein -0.0380553
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0374963
RIGI RNA sensor RIG-I -0.0367721
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0363129
MBNL2 muscleblind-like splicing regulator 2 -0.0359558
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0349752
MAML2 mastermind-like 2 (Drosophila) -0.0346661
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0345097
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0343868
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0339023
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0336971
ABI3BP ABI family, member 3 (NESH) binding protein -0.033222
ZNFX1 zinc finger, NFX1-type containing 1 -0.0330753
RABGAP1L RAB GTPase activating protein 1-like -0.0322624
FBXO11 F-box protein 11 -0.0322388
PDLIM5 PDZ and LIM domain 5 -0.0321965
MRPS6 mitochondrial ribosomal protein S6 -0.0321043
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0317514
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0311357
PRELID2 PRELI domain containing 2 -0.0310292
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0309096
RUNX1 runt-related transcription factor 1 -0.0305059
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.029989
CLU clusterin -0.0298505
FTH1 ferritin, heavy polypeptide 1 -0.0296089
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0295152
SAMD9 sterile alpha motif domain containing 9 -0.0287471
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0286503
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0280085
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0279213
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0279015
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0276054
CAV1 caveolin 1, caveolae protein, 22kDa -0.0274594
PSD3 pleckstrin and Sec7 domain containing 3 -0.0273902
MACF1 microtubule-actin crosslinking factor 1 -0.027318
ACTN4 actinin, alpha 4 -0.0270072
RAB7A RAB7A, member RAS oncogene family -0.0267633
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0264284
SULF2 sulfatase 2 -0.0263208
EGR1 early growth response 1 -0.0261521
SLC45A4 solute carrier family 45, member 4 -0.0260887
FN1 fibronectin 1 -0.0259983
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0259524
SLC35F3 solute carrier family 35, member F3 -0.0257379
PICALM phosphatidylinositol binding clathrin assembly protein -0.0256314
PCDH1 protocadherin 1 -0.0253215
CYB5R3 cytochrome b5 reductase 3 -0.0251718
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0249206
FOXP1 forkhead box P1 -0.0244275
RASAL2 RAS protein activator like 2 -0.0243165
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0240706
HMGA2 high mobility group AT-hook 2 -0.0238928
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0236361
ECE1 endothelin converting enzyme 1 -0.0232705
FAF1 Fas (TNFRSF6) associated factor 1 -0.0229976
SETX senataxin -0.0227854
MON2 MON2 homolog (S. cerevisiae) -0.0226958
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.022669
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0223185
ERBIN erbb2 interacting protein -0.0221219
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0221127
MT1X metallothionein 1X -0.0218224
ASPH aspartate beta-hydroxylase -0.0215243
IFI44L interferon-induced protein 44-like -0.021515
MAGT1 magnesium transporter 1 -0.0214853
CORO2A coronin, actin binding protein, 2A -0.0214275
IFI16 interferon, gamma-inducible protein 16 -0.0214255
RAB22A RAB22A, member RAS oncogene family -0.0214085
RAD51B RAD51 paralog B -0.0213474
CLEC1B C-type lectin domain family 1, member B -0.0213242
AKAP13 A kinase (PRKA) anchor protein 13 -0.0212813
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0210528
ANXA1 annexin A1 -0.0210214
JMJD1C jumonji domain containing 1C -0.0209897
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0209175
TMSB4X thymosin beta 4, X-linked -0.0208418
STK24 serine/threonine kinase 24 -0.0208109