Bestatin_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.205242
KRT18 keratin 18, type I 0.130224
EIF1 eukaryotic translation initiation factor 1 0.104856
PTMA prothymosin, alpha 0.0950402
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0847724
MORF4L2 mortality factor 4 like 2 0.0760763
FTL ferritin, light polypeptide 0.0744421
RPS3 ribosomal protein S3 0.0742959
EMP1 epithelial membrane protein 1 0.0734399
RPL23 ribosomal protein L23 0.0704308
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.068542
ERRFI1 ERBB receptor feedback inhibitor 1 0.0564501
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.055817
SET SET nuclear proto-oncogene 0.0532406
RPS8 ribosomal protein S8 0.0516688
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0498916
ANXA1 annexin A1 0.0495446
RPL37A ribosomal protein L37a 0.0495121
B2M beta-2-microglobulin 0.0484957
CALR calreticulin 0.0469685
RPS4X ribosomal protein S4, X-linked 0.0468791
TPT1 tumor protein, translationally-controlled 1 0.0436992
AREG amphiregulin 0.0432741
ANLN anillin, actin binding protein 0.0430704
MKI67 marker of proliferation Ki-67 0.042242
PRRC2C proline-rich coiled-coil 2C 0.0419795
KDM3A lysine (K)-specific demethylase 3A 0.0399514
RPL26 ribosomal protein L26 0.0389992
RPL36A ribosomal protein L36a 0.0381663
HSPA8 heat shock 70kDa protein 8 0.0374149
RPL12 ribosomal protein L12 0.0373662
ESRP1 epithelial splicing regulatory protein 1 0.037221
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0367327
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0362386
GARS1 glycyl-tRNA synthetase 1 0.0361884
RPS12 ribosomal protein S12 0.0351183
RPS16 ribosomal protein S16 0.0349649
SPAG9 sperm associated antigen 9 0.0348586
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0344314
NDRG1 N-myc downstream regulated 1 0.0341808
ENO1 enolase 1, (alpha) 0.0340092
SERF2 small EDRK-rich factor 2 0.0335396
NACA nascent polypeptide-associated complex alpha subunit 0.0333752
RPL18 ribosomal protein L18 0.0331266
RACK1 receptor for activated C kinase 1 0.0330725
RPS2 ribosomal protein S2 0.0312805
RPS19 ribosomal protein S19 0.0306786
S100P S100 calcium binding protein P 0.0306605
SLFN5 schlafen family member 5 0.0305507
TMSB4X thymosin beta 4, X-linked 0.0304598
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0301099
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0300402
RPS6 ribosomal protein S6 0.0297629
WDR45B WD repeat domain 45B 0.0291756
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0291066
TMF1 TATA element modulatory factor 1 0.0288392
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0288171
RPL19 ribosomal protein L19 0.0283558
S100A10 S100 calcium binding protein A10 0.028284
TMSB10 thymosin beta 10 0.0282547
RPL8 ribosomal protein L8 0.0281964
RPS25 ribosomal protein S25 0.0280176
PAPOLA poly(A) polymerase alpha 0.0272866
SEC31A SEC31 homolog A (S. cerevisiae) 0.0272489
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.02718
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0270423
ANKHD1 ankyrin repeat and KH domain containing 1 0.0269456
RPS17 ribosomal protein S17 0.0263733
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0262433
TMED2 transmembrane emp24 domain trafficking protein 2 0.0260813
SFTPA2 surfactant protein A2 0.0260333
RPS29 ribosomal protein S29 0.0258294
EZR ezrin 0.0256242
RPL9 ribosomal protein L9 0.0254486
TPX2 TPX2, microtubule-associated 0.0251998
UBQLN1 ubiquilin 1 0.0251533
GRB2 growth factor receptor-bound protein 2 0.0249523
DCAF7 DDB1 and CUL4 associated factor 7 0.0249377
THOC2 THO complex 2 0.0248376
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0246208
LCN2 lipocalin 2 0.0246084
EIF4H eukaryotic translation initiation factor 4H 0.0245314
HLA-A major histocompatibility complex, class I, A 0.0244154
ZNF106 zinc finger protein 106 0.0244137
NARS1 asparaginyl-tRNA synthetase 1 0.0243282
SERINC1 serine incorporator 1 0.0242831
RPLP1 ribosomal protein, large, P1 0.0242295
GUK1 guanylate kinase 1 0.0241439
MTDH metadherin 0.0240998
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.023943
DDIT4 DNA-damage-inducible transcript 4 0.023888
SURF4 surfeit 4 0.023855
KLF5 Kruppel-like factor 5 (intestinal) 0.0237656
CALU calumenin 0.0237066
LDHA lactate dehydrogenase A 0.0233036
WSB1 WD repeat and SOCS box containing 1 0.0232437
CALCOCO2 calcium binding and coiled-coil domain 2 0.0231199
MXI1 MAX interactor 1, dimerization protein 0.0225466
SERINC3 serine incorporator 3 0.0224036
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0221528

decreased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase -0.232998
NPSR1 neuropeptide S receptor 1 -0.133969
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.109144
LMO7 LIM domain 7 -0.100336
PDIA3 protein disulfide isomerase family A, member 3 -0.0892507
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0853235
CEMIP cell migration inducing protein, hyaluronan binding -0.076171
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0698178
MAML2 mastermind-like 2 (Drosophila) -0.0676239
SH3RF1 SH3 domain containing ring finger 1 -0.0628024
POTEF POTE ankyrin domain family, member F -0.0627456
PRSS3 protease, serine, 3 -0.062644
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0623519
TNIK TRAF2 and NCK interacting kinase -0.0594776
FNDC3B fibronectin type III domain containing 3B -0.0593825
MCU mitochondrial calcium uniporter -0.0585126
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0571744
ACTN4 actinin, alpha 4 -0.056259
LOC112694756 uncharaterized LOC112694756 -0.054729
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0536715
TNRC18 trinucleotide repeat containing 18 -0.0534544
WWC1 WW and C2 domain containing 1 -0.0525659
SAMD12 sterile alpha motif domain containing 12 -0.0518735
PLSCR1 phospholipid scramblase 1 -0.0514562
H1-0 H1.0 linker histone -0.0514318
LPP LIM domain containing preferred translocation partner in lipoma -0.0513282
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0478367
PRKCA protein kinase C, alpha -0.0458963
ETNK1 ethanolamine kinase 1 -0.0458248
ASPH aspartate beta-hydroxylase -0.0455035
YAP1 Yes-associated protein 1 -0.0446138
RAB7A RAB7A, member RAS oncogene family -0.044567
PTPRK protein tyrosine phosphatase, receptor type, K -0.0444086
JUP junction plakoglobin -0.0441189
FAT1 FAT atypical cadherin 1 -0.0439042
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0438357
CMIP c-Maf inducing protein -0.0438137
CAPN8 calpain 8 -0.0432079
C6ORF132 chromosome 6 open reading frame 132 -0.0426991
ATP11A ATPase, class VI, type 11A -0.0423718
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0423705
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0415416
RNF213 ring finger protein 213 -0.0408308
ADAM9 ADAM metallopeptidase domain 9 -0.040738
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0396822
COBL cordon-bleu WH2 repeat protein -0.0394845
ABHD2 abhydrolase domain containing 2 -0.0393773
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0393594
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0393315
SHROOM3 shroom family member 3 -0.0393113
ANXA2 annexin A2 -0.039217
ATXN1 ataxin 1 -0.0391967
FLNB filamin B, beta -0.0386418
ARHGAP32 Rho GTPase activating protein 32 -0.0381275
SHB Src homology 2 domain containing adaptor protein B -0.0380887
ARHGAP26 Rho GTPase activating protein 26 -0.0379878
MPRIP myosin phosphatase Rho interacting protein -0.036846
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0367399
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0360937
AOPEP aminopeptidase O (putative) -0.035608
EXOC4 exocyst complex component 4 -0.0353302
AHNAK AHNAK nucleoprotein -0.0352662
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0351276
KRT8 keratin 8, type II -0.035005
EHBP1 EH domain binding protein 1 -0.0346632
BTBD9 BTB (POZ) domain containing 9 -0.034441
RUNX1 runt-related transcription factor 1 -0.0344244
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0343593
MUC1 mucin 1, cell surface associated -0.034283
ETV6 ets variant 6 -0.0339186
RBM47 RNA binding motif protein 47 -0.0338641
PDLIM5 PDZ and LIM domain 5 -0.033777
INSIG1 insulin induced gene 1 -0.0335802
MYOF myoferlin -0.0334489
TMEM45B transmembrane protein 45B -0.0333666
CLDN4 claudin 4 -0.0324092
NCEH1 neutral cholesterol ester hydrolase 1 -0.0323867
MYO1D myosin ID -0.0323706
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0322577
CCNL1 cyclin L1 -0.0320746
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0318928
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0317102
ANXA11 annexin A11 -0.0314429
CUX1 cut-like homeobox 1 -0.0313779
CTBP2 C-terminal binding protein 2 -0.0313688
GSK3B glycogen synthase kinase 3 beta -0.0313567
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0312009
STK24 serine/threonine kinase 24 -0.0309098
DENND1A DENN/MADD domain containing 1A -0.0307286
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0307181
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0303332
OSBPL10 oxysterol binding protein-like 10 -0.0302574
MACC1 metastasis associated in colon cancer 1 -0.0301038
NFIB nuclear factor I/B -0.0300088
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.029866
UBASH3B ubiquitin associated and SH3 domain containing B -0.0298393
NCOR2 nuclear receptor corepressor 2 -0.0297042
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0286355
TMC5 transmembrane channel-like 5 -0.0284231
BAIAP2L1 BAI1-associated protein 2-like 1 -0.028339