Bestatin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.264524
MT2A metallothionein 2A 0.144325
VIM vimentin 0.108916
PTMA prothymosin, alpha 0.104008
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100651
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0917203
RAI1 retinoic acid induced 1 0.0915266
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0899898
KLF6 Kruppel-like factor 6 0.0852768
LDHA lactate dehydrogenase A 0.0812517
RPS4X ribosomal protein S4, X-linked 0.0784464
EZR ezrin 0.0781925
EREG epiregulin 0.0731624
ANXA1 annexin A1 0.0730602
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0692912
RACK1 receptor for activated C kinase 1 0.0684047
SET SET nuclear proto-oncogene 0.0666322
TM4SF1 transmembrane 4 L six family member 1 0.0660898
EIF1 eukaryotic translation initiation factor 1 0.0659528
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0658711
PRRC2C proline-rich coiled-coil 2C 0.0603516
TMSB4X thymosin beta 4, X-linked 0.0548616
YBX1 Y box binding protein 1 0.0529997
SPAG9 sperm associated antigen 9 0.0516021
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0499247
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0476613
RPS2 ribosomal protein S2 0.0462498
GARS1 glycyl-tRNA synthetase 1 0.0462096
MORF4L2 mortality factor 4 like 2 0.0460705
CXCL8 chemokine (C-X-C motif) ligand 8 0.0453904
RPL5 ribosomal protein L5 0.0449768
RPS3 ribosomal protein S3 0.0444925
RPL18 ribosomal protein L18 0.0444692
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0443122
NUP58 nucleoporin 58 0.0442093
RPL23 ribosomal protein L23 0.0438343
PLK2 polo-like kinase 2 0.0433464
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0421216
EEF2 eukaryotic translation elongation factor 2 0.0419812
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0417386
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0415137
SRGN serglycin 0.0408354
CALR calreticulin 0.0401255
DDIT4 DNA-damage-inducible transcript 4 0.0400887
APP amyloid beta (A4) precursor protein 0.0392231
NAMPT nicotinamide phosphoribosyltransferase 0.0390739
EIF4A1 eukaryotic translation initiation factor 4A1 0.0383346
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0381605
RPS8 ribosomal protein S8 0.0380493
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0376683
ANLN anillin, actin binding protein 0.0375338
FLNB filamin B, beta 0.0371932
ARRDC3 arrestin domain containing 3 0.0371325
MKI67 marker of proliferation Ki-67 0.0358862
KRT18 keratin 18, type I 0.0357587
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0356873
S100A10 S100 calcium binding protein A10 0.0355964
KDM3A lysine (K)-specific demethylase 3A 0.0347094
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0344779
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0335795
RPL12 ribosomal protein L12 0.0329894
CANX calnexin 0.0324472
HMOX1 heme oxygenase 1 0.0323012
HSPA8 heat shock 70kDa protein 8 0.0318063
KIF5B kinesin family member 5B 0.0315651
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0307123
RPS12 ribosomal protein S12 0.0306749
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0305331
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0304578
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0303285
FMNL2 formin-like 2 0.0301176
FUS FUS RNA binding protein 0.0300723
JUN jun proto-oncogene 0.0298221
TMSB10 thymosin beta 10 0.0296389
TXNRD1 thioredoxin reductase 1 0.0286045
TFRC transferrin receptor 0.0285121
SERINC1 serine incorporator 1 0.0273623
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0272596
WSB1 WD repeat and SOCS box containing 1 0.0270475
RSRC2 arginine/serine-rich coiled-coil 2 0.0269912
SEPTIN7 septin 7 0.0267996
PODXL podocalyxin-like 0.0266381
UBAP2L ubiquitin associated protein 2-like 0.0266119
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0264087
NACA nascent polypeptide-associated complex alpha subunit 0.0262339
EIF4H eukaryotic translation initiation factor 4H 0.0259283
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0258381
BZW1 basic leucine zipper and W2 domains 1 0.0257218
PTPRF protein tyrosine phosphatase, receptor type, F 0.0254327
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0250699
TMED2 transmembrane emp24 domain trafficking protein 2 0.0245002
FNBP1L formin binding protein 1-like 0.024383
NOP58 NOP58 ribonucleoprotein 0.0242797
ANGPTL4 angiopoietin-like 4 0.0242753
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0240004
PRDX1 peroxiredoxin 1 0.0238745
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0237655
CSDE1 cold shock domain containing E1, RNA-binding 0.0237275
EMP1 epithelial membrane protein 1 0.0236614
RPL26 ribosomal protein L26 0.0236406

decreased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 -0.1549
TP63 tumor protein p63 -0.153913
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.10961
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0992837
HLA-B major histocompatibility complex, class I, B -0.0964593
CD44 CD44 molecule (Indian blood group) -0.0875766
WARS1 tryptophanyl-tRNA synthetase 1 -0.0844932
CADM2 cell adhesion molecule 2 -0.081096
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0667459
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0660935
TNS3 tensin 3 -0.0628931
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0620714
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0592606
DST dystonin -0.0587334
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0579606
TSC22D1 TSC22 domain family, member 1 -0.0561189
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0556338
EGR1 early growth response 1 -0.0530939
PDE10A phosphodiesterase 10A -0.0521171
HMGA1 high mobility group AT-hook 1 -0.0510088
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0479558
POTEF POTE ankyrin domain family, member F -0.0473915
RIGI RNA sensor RIG-I -0.0452498
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0440632
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0428647
DPYD dihydropyrimidine dehydrogenase -0.042755
RPL35A ribosomal protein L35a -0.0408177
SDK1 sidekick cell adhesion molecule 1 -0.0403967
PTK2 protein tyrosine kinase 2 -0.0403586
CSMD3 CUB and Sushi multiple domains 3 -0.0395967
PLSCR1 phospholipid scramblase 1 -0.0393377
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.038637
EXOC4 exocyst complex component 4 -0.0373238
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0372556
HLA-A major histocompatibility complex, class I, A -0.0370893
RNF213 ring finger protein 213 -0.0370278
WWTR1 WW domain containing transcription regulator 1 -0.0361849
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0356783
RPL31 ribosomal protein L31 -0.0342233
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0338971
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0338395
PRRC2B proline-rich coiled-coil 2B -0.0335018
IFI6 interferon, alpha-inducible protein 6 -0.0329869
ENO2 enolase 2 (gamma, neuronal) -0.0329788
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0324491
EFNA5 ephrin-A5 -0.0324309
RAD51B RAD51 paralog B -0.0319708
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0319487
PRELID2 PRELI domain containing 2 -0.0316008
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0312525
TAPBP TAP binding protein (tapasin) -0.0308306
RPL28 ribosomal protein L28 -0.0307219
IFIH1 interferon induced with helicase C domain 1 -0.029902
DNER delta/notch-like EGF repeat containing -0.029728
LOC112694756 uncharaterized LOC112694756 -0.0296486
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0296233
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.02958
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0291915
VCL vinculin -0.0290672
INTS6 integrator complex subunit 6 -0.0289936
CFAP299 cilia and flagella associated protein 299 -0.0289856
TTC3 tetratricopeptide repeat domain 3 -0.0287557
TGM2 transglutaminase 2 -0.0281062
ECE1 endothelin converting enzyme 1 -0.028013
DPH6 diphthamine biosynthesis 6 -0.0270856
SP100 SP100 nuclear antigen -0.026753
EPHA4 EPH receptor A4 -0.0263329
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0262652
RUNX1 runt-related transcription factor 1 -0.0261348
CAPRIN2 caprin family member 2 -0.0260348
CMIP c-Maf inducing protein -0.0257584
COL5A2 collagen, type V, alpha 2 -0.0255463
EHBP1 EH domain binding protein 1 -0.0254586
RAB27B RAB27B, member RAS oncogene family -0.0248182
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0248173
WDR27 WD repeat domain 27 -0.0247502
AEBP2 AE binding protein 2 -0.0246977
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0246641
N4BP2L2 NEDD4 binding protein 2-like 2 -0.024494
TAS2R14 taste receptor, type 2, member 14 -0.0242804
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0241766
NPAS2 neuronal PAS domain protein 2 -0.024149
LPP LIM domain containing preferred translocation partner in lipoma -0.0239744
DLG1 discs, large homolog 1 (Drosophila) -0.0238841
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0238664
DENND1A DENN/MADD domain containing 1A -0.0238347
KDM4C lysine (K)-specific demethylase 4C -0.0236726
ANKRD11 ankyrin repeat domain 11 -0.0236165
RPS13 ribosomal protein S13 -0.0236119
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0235812
HDAC8 histone deacetylase 8 -0.0234051
PMP22 peripheral myelin protein 22 -0.0232529
SOD2 superoxide dismutase 2, mitochondrial -0.0231292
CFDP1 craniofacial development protein 1 -0.023126
BCAR3 breast cancer anti-estrogen resistance 3 -0.0226882
CALD1 caldesmon 1 -0.0226769
PDIA3 protein disulfide isomerase family A, member 3 -0.0224997
PCDH1 protocadherin 1 -0.0221422
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0220893
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0219018