Bestatin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0868344
ERRFI1 ERBB receptor feedback inhibitor 1 0.0419284
ARRDC3 arrestin domain containing 3 0.0411042
RPS4X ribosomal protein S4, X-linked 0.0389434
NDRG1 N-myc downstream regulated 1 0.0372403
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0329979
CXCL8 chemokine (C-X-C motif) ligand 8 0.0313652
RPS3 ribosomal protein S3 0.0306945
RPS12 ribosomal protein S12 0.0281313
UBA6 ubiquitin-like modifier activating enzyme 6 0.027363
SPAG9 sperm associated antigen 9 0.0271391
FTL ferritin, light polypeptide 0.0236571
NUP58 nucleoporin 58 0.0233415
RPS2 ribosomal protein S2 0.0223514
GUK1 guanylate kinase 1 0.0222314
PRRC2C proline-rich coiled-coil 2C 0.0216747
ADAM17 ADAM metallopeptidase domain 17 0.021022
BLZF1 basic leucine zipper nuclear factor 1 0.0208759
IGFBP3 insulin-like growth factor binding protein 3 0.0202962
PCBP2 poly(rC) binding protein 2 0.0201573
RPL11 ribosomal protein L11 0.0197497
RPS17 ribosomal protein S17 0.019549
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0191833
MORF4L2 mortality factor 4 like 2 0.0187065
GPBP1 GC-rich promoter binding protein 1 0.0183435
MCL1 myeloid cell leukemia 1 0.0177849
MKI67 marker of proliferation Ki-67 0.0170512
RACK1 receptor for activated C kinase 1 0.0168092
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0167242
RPL12 ribosomal protein L12 0.0166041
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0164652
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0161272
SUCO SUN domain containing ossification factor 0.0160532
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0157594
RPS27 ribosomal protein S27 0.0155212
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0151045
RPL37A ribosomal protein L37a 0.01508
KDM6A lysine (K)-specific demethylase 6A 0.0147577
CPE carboxypeptidase E 0.0147388
EEF2 eukaryotic translation elongation factor 2 0.0146094
TRA2A transformer 2 alpha homolog (Drosophila) 0.014559
CCNL1 cyclin L1 0.014469
ARGLU1 arginine and glutamate rich 1 0.014169
VMP1 vacuole membrane protein 1 0.0140698
SMTN smoothelin 0.0136949
RAD23B RAD23 homolog B (S. cerevisiae) 0.0136646
SERF2 small EDRK-rich factor 2 0.013504
BCL9L B-cell CLL/lymphoma 9-like 0.0133309
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.013132
BMP6 bone morphogenetic protein 6 0.0130812
ELOVL7 ELOVL fatty acid elongase 7 0.0128776
ATP13A3 ATPase type 13A3 0.0127575
OXSR1 oxidative stress responsive 1 0.0127171
YBX1 Y box binding protein 1 0.0126591
RPS8 ribosomal protein S8 0.0125468
EIF1 eukaryotic translation initiation factor 1 0.0124842
RPS19 ribosomal protein S19 0.0123762
MYO5B myosin VB 0.0121303
RPL31 ribosomal protein L31 0.0120775
YTHDC1 YTH domain containing 1 0.0118803
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0118791
AREG amphiregulin 0.0118148
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0116647
FAM162A family with sequence similarity 162, member A 0.011586
DDIT4 DNA-damage-inducible transcript 4 0.011577
NCKAP1 NCK-associated protein 1 0.0113979
ARL8B ADP-ribosylation factor-like 8B 0.0113167
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0111763
WDR45B WD repeat domain 45B 0.0111246
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0110163
RPS29 ribosomal protein S29 0.0109908
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0109285
WAC WW domain containing adaptor with coiled-coil 0.0108882
RNF24 ring finger protein 24 0.0107523
RPL36 ribosomal protein L36 0.0107082
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.010608
RNASEH2A ribonuclease H2, subunit A 0.0105221
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0104323
MXI1 MAX interactor 1, dimerization protein 0.0103774
MLF1 myeloid leukemia factor 1 0.0103556
UBAP2L ubiquitin associated protein 2-like 0.0103208
PAPOLA poly(A) polymerase alpha 0.010215
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0101861
RPL21 ribosomal protein L21 0.0100802
SEC61G Sec61 gamma subunit 0.0100563
PNN pinin, desmosome associated protein 0.0100316
MT2A metallothionein 2A 0.00987895
RAB6A RAB6A, member RAS oncogene family 0.00983104
RLF rearranged L-myc fusion 0.00982594
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00979726
TMED2 transmembrane emp24 domain trafficking protein 2 0.0097603
NACA nascent polypeptide-associated complex alpha subunit 0.00971799
HSPA8 heat shock 70kDa protein 8 0.00966362
MED14 mediator complex subunit 14 0.00955721
TBK1 TANK-binding kinase 1 0.00946344
RPL8 ribosomal protein L8 0.00944977
ELL2 elongation factor, RNA polymerase II, 2 0.00943743
CSNK1A1 casein kinase 1, alpha 1 0.00936182
SRP54 signal recognition particle 54kDa 0.00935576
BCL2L1 BCL2-like 1 0.00925555

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.357891
ASPH aspartate beta-hydroxylase -0.181712
THSD4 thrombospondin, type I, domain containing 4 -0.111806
LAMC2 laminin, gamma 2 -0.109448
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.107749
TXNRD1 thioredoxin reductase 1 -0.10465
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0881027
PTPRM protein tyrosine phosphatase, receptor type, M -0.0822977
H1-0 H1.0 linker histone -0.0822607
LMO7 LIM domain 7 -0.0796209
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.078537
PDE4D phosphodiesterase 4D, cAMP-specific -0.0783895
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0783115
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0768591
MCTP1 multiple C2 domains, transmembrane 1 -0.0761381
EFNA5 ephrin-A5 -0.0743961
SMAD3 SMAD family member 3 -0.0741108
LOC112694756 uncharaterized LOC112694756 -0.0722702
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0697741
FNDC3B fibronectin type III domain containing 3B -0.0671938
SLTM SAFB-like, transcription modulator -0.0665885
LRP1B low density lipoprotein receptor-related protein 1B -0.0665835
GRAMD1B GRAM domain containing 1B -0.0624559
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0620281
OSMR oncostatin M receptor -0.0580063
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0554196
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0549052
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0548624
ZMYND8 zinc finger, MYND-type containing 8 -0.0536067
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0526264
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0522606
RNF213 ring finger protein 213 -0.0514868
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0509698
AHNAK AHNAK nucleoprotein -0.0491982
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0489189
STC1 stanniocalcin 1 -0.047785
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0468153
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0447441
ARHGAP32 Rho GTPase activating protein 32 -0.0436147
MYOF myoferlin -0.0430902
LAMB3 laminin, beta 3 -0.0427591
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0413318
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0406174
NAMPT nicotinamide phosphoribosyltransferase -0.0404787
GPC6 glypican 6 -0.0393666
PGK1 phosphoglycerate kinase 1 -0.0390145
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0378882
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0375879
LPP LIM domain containing preferred translocation partner in lipoma -0.0365337
CAV1 caveolin 1, caveolae protein, 22kDa -0.0364665
FRY furry homolog (Drosophila) -0.0359109
GRB10 growth factor receptor-bound protein 10 -0.0358948
ANXA2 annexin A2 -0.035652
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0355402
SUMF1 sulfatase modifying factor 1 -0.0352147
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0345992
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0341084
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0333671
SDC4 syndecan 4 -0.0332672
TNRC6B trinucleotide repeat containing 6B -0.0328129
PRKCA protein kinase C, alpha -0.0321858
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0321804
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0317207
CANX calnexin -0.0314445
ZNF638 zinc finger protein 638 -0.0311804
LRP12 low density lipoprotein receptor-related protein 12 -0.0311505
BZW1 basic leucine zipper and W2 domains 1 -0.0309425
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0306818
NPAS2 neuronal PAS domain protein 2 -0.0304598
PKM pyruvate kinase, muscle -0.0303061
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.030271
RAB27B RAB27B, member RAS oncogene family -0.0302555
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.030251
NRIP1 nuclear receptor interacting protein 1 -0.0301665
ANKRD12 ankyrin repeat domain 12 -0.0301146
ACTG1 actin gamma 1 -0.030056
PATJ PATJ crumbs cell polarity complex component -0.0298718
ANKRD11 ankyrin repeat domain 11 -0.0298229
CES1 carboxylesterase 1 -0.0297403
HDLBP high density lipoprotein binding protein -0.0296378
GCLC glutamate-cysteine ligase, catalytic subunit -0.029607
SOD2 superoxide dismutase 2, mitochondrial -0.0295434
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0294246
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0291481
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0288512
TAS2R14 taste receptor, type 2, member 14 -0.0286451
INTS6 integrator complex subunit 6 -0.0285769
LAMA4 laminin, alpha 4 -0.0285099
PDIA3 protein disulfide isomerase family A, member 3 -0.0283436
RAB1A RAB1A, member RAS oncogene family -0.0283378
UGDH UDP-glucose 6-dehydrogenase -0.0282869
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0280585
RPS24 ribosomal protein S24 -0.0275405
SHTN1 shootin 1 -0.0275372
MACF1 microtubule-actin crosslinking factor 1 -0.0275159
BRWD3 bromodomain and WD repeat domain containing 3 -0.0274361
SEPTIN2 septin 2 -0.027384
KRT7 keratin 7, type II -0.027164
BIRC3 baculoviral IAP repeat containing 3 -0.0270736
FNIP1 folliculin interacting protein 1 -0.0270386