| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Bestatin perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Bestatin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.202052 |
| GRAMD1B | GRAM domain containing 1B | 0.181127 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.102824 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0776534 |
| RTN4 | reticulon 4 | 0.0774077 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0736104 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0726739 |
| USP3 | ubiquitin specific peptidase 3 | 0.0668906 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0654493 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0626088 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.06157 |
| FGB | fibrinogen beta chain | 0.0612391 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0590608 |
| VIM | vimentin | 0.0575292 |
| RAD21 | RAD21 homolog (S. pombe) | 0.057263 |
| WDR43 | WD repeat domain 43 | 0.0562598 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0558563 |
| APP | amyloid beta (A4) precursor protein | 0.0545278 |
| TPD52 | tumor protein D52 | 0.0524394 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0518199 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0494844 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0487515 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0479011 |
| NUP58 | nucleoporin 58 | 0.0471481 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0460727 |
| YBX3 | Y box binding protein 3 | 0.045774 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0446595 |
| RBM39 | RNA binding motif protein 39 | 0.0445104 |
| FAM168A | family with sequence similarity 168, member A | 0.0443196 |
| TMEM123 | transmembrane protein 123 | 0.0440716 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0439678 |
| TPM3 | tropomyosin 3 | 0.0433037 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0430766 |
| YME1L1 | YME1-like 1 ATPase | 0.0421415 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0407766 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0407698 |
| ZNF292 | zinc finger protein 292 | 0.0405615 |
| CCNL1 | cyclin L1 | 0.0388706 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0382304 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0380618 |
| MKI67 | marker of proliferation Ki-67 | 0.0376117 |
| MATR3 | matrin 3 | 0.037026 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0364221 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0364166 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.036415 |
| MORF4L1 | mortality factor 4 like 1 | 0.0357179 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0355847 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0354365 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0353389 |
| YBX1 | Y box binding protein 1 | 0.035262 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0344141 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0343804 |
| CANX | calnexin | 0.0342883 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0341535 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0341301 |
| TFG | TRK-fused gene | 0.034125 |
| TNPO1 | transportin 1 | 0.0337489 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0335736 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0334241 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0333687 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0333656 |
| CHN1 | chimerin 1 | 0.0332952 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0329142 |
| SPAG9 | sperm associated antigen 9 | 0.0329089 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0321509 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0321333 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0320728 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0319789 |
| ECT2 | epithelial cell transforming 2 | 0.0314992 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0314576 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0313116 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0310389 |
| TUBB | tubulin, beta class I | 0.0308908 |
| ANLN | anillin, actin binding protein | 0.0306516 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.030303 |
| CALR | calreticulin | 0.0302425 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.030135 |
| WTAP | Wilms tumor 1 associated protein | 0.0300601 |
| MTMR3 | myotubularin related protein 3 | 0.0300212 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.02961 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0292525 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0291489 |
| ENAH | enabled homolog (Drosophila) | 0.0289118 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0287044 |
| QKI | QKI, KH domain containing, RNA binding | 0.0284333 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0282399 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0281857 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0277566 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0276726 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0276093 |
| TPX2 | TPX2, microtubule-associated | 0.0275747 |
| RPL4 | ribosomal protein L4 | 0.0273362 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0273309 |
| WBP11 | WW domain binding protein 11 | 0.0272752 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0272636 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0272148 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0271433 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0269272 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0269071 |
| TPM4 | tropomyosin 4 | 0.0267885 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.298002 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.167438 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.119504 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.115192 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.108128 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0865187 |
| CMIP | c-Maf inducing protein | -0.0847306 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.081211 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0785747 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0734389 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0707216 |
| EGFR | epidermal growth factor receptor | -0.0669648 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0639446 |
| TMSB10 | thymosin beta 10 | -0.062808 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0609442 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0583653 |
| ATXN1 | ataxin 1 | -0.058255 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0580253 |
| FMNL2 | formin-like 2 | -0.0556571 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0555476 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0553906 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.055073 |
| FTL | ferritin, light polypeptide | -0.0548754 |
| MT2A | metallothionein 2A | -0.0545929 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0534168 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0515855 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0511759 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0491173 |
| RAD51B | RAD51 paralog B | -0.0486469 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.047738 |
| KYNU | kynureninase | -0.0464151 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0453357 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0445921 |
| FLNB | filamin B, beta | -0.0428261 |
| INTS6 | integrator complex subunit 6 | -0.0415541 |
| GLIS3 | GLIS family zinc finger 3 | -0.0413969 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0393171 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0388533 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0381302 |
| UTRN | utrophin | -0.0376924 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0372248 |
| EFNA5 | ephrin-A5 | -0.0369227 |
| EHBP1 | EH domain binding protein 1 | -0.0367229 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0357038 |
| NEBL | nebulette | -0.0356431 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.034822 |
| NLK | nemo-like kinase | -0.034809 |
| CTBP2 | C-terminal binding protein 2 | -0.0345595 |
| CUX1 | cut-like homeobox 1 | -0.0340228 |
| MYO1E | myosin IE | -0.0338275 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0338044 |
| ERBIN | erbb2 interacting protein | -0.033732 |
| DST | dystonin | -0.0335575 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0335452 |
| USP34 | ubiquitin specific peptidase 34 | -0.0331977 |
| EPAS1 | endothelial PAS domain protein 1 | -0.032978 |
| NDRG1 | N-myc downstream regulated 1 | -0.0324255 |
| CDK13 | cyclin-dependent kinase 13 | -0.0323325 |
| RPS8 | ribosomal protein S8 | -0.0318707 |
| RPL37A | ribosomal protein L37a | -0.0313585 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0313187 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0311007 |
| PCNX4 | pecanex 4 | -0.0305956 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0302071 |
| NEGR1 | neuronal growth regulator 1 | -0.030181 |
| NF1 | neurofibromin 1 | -0.030169 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0295786 |
| RPL36 | ribosomal protein L36 | -0.0295225 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0293559 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0289395 |
| SNX14 | sorting nexin 14 | -0.0282385 |
| FNIP1 | folliculin interacting protein 1 | -0.0282235 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0278521 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0278167 |
| EGR1 | early growth response 1 | -0.0278068 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0276415 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0275937 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0271441 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0270329 |
| RPL23 | ribosomal protein L23 | -0.0268254 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0263841 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0262906 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0262457 |
| RPS17 | ribosomal protein S17 | -0.0262326 |
| RPS19 | ribosomal protein S19 | -0.0262217 |
| SBF2 | SET binding factor 2 | -0.0261941 |
| EXOC6B | exocyst complex component 6B | -0.0261011 |
| COPA | coatomer protein complex, subunit alpha | -0.0259959 |
| RPL31 | ribosomal protein L31 | -0.02594 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.025899 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0258533 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0256814 |
| VCL | vinculin | -0.0255899 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0250887 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0250609 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0250366 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0246114 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.024339 |
| PRKCE | protein kinase C, epsilon | -0.0241268 |
| BRD2 | bromodomain containing 2 | -0.0240169 |
