Bestatin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.133884
ERRFI1 ERBB receptor feedback inhibitor 1 0.0720005
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0644878
TM4SF1 transmembrane 4 L six family member 1 0.0599992
KRT18 keratin 18, type I 0.0538092
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.047934
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0445131
RBM39 RNA binding motif protein 39 0.0437045
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0434897
KDM3A lysine (K)-specific demethylase 3A 0.0427854
HSPA8 heat shock 70kDa protein 8 0.0425554
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0422732
TFPI2 tissue factor pathway inhibitor 2 0.0409558
NIPBL Nipped-B homolog (Drosophila) 0.0403122
IFI6 interferon, alpha-inducible protein 6 0.0399821
OSMR oncostatin M receptor 0.0399401
OGA O-GlcNAcase 0.0360043
CAMTA1 calmodulin binding transcription activator 1 0.0357103
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.030665
CUL3 cullin 3 0.0305272
BZW1 basic leucine zipper and W2 domains 1 0.0304387
YBX3 Y box binding protein 3 0.0294151
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0293806
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0292086
CTTNBP2NL CTTNBP2 N-terminal like 0.0287749
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0285413
KLF6 Kruppel-like factor 6 0.0280382
SPAG9 sperm associated antigen 9 0.0273514
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0271071
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0269008
HLA-B major histocompatibility complex, class I, B 0.0266589
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0264667
RPS4X ribosomal protein S4, X-linked 0.0258805
ZSWIM6 zinc finger, SWIM-type containing 6 0.0256139
FUS FUS RNA binding protein 0.0253825
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0253405
NUP153 nucleoporin 153kDa 0.0252556
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0249942
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0248469
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.024421
CAVIN1 caveolae associated protein 1 0.0244151
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.0243904
UBAP2L ubiquitin associated protein 2-like 0.023958
APP amyloid beta (A4) precursor protein 0.0238929
RTN4 reticulon 4 0.0238858
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0236639
USP34 ubiquitin specific peptidase 34 0.0232059
TOP1 topoisomerase (DNA) I 0.0231489
ZFC3H1 zinc finger, C3H1-type containing 0.0229505
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0229328
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0225883
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0223902
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0222905
BIRC6 baculoviral IAP repeat containing 6 0.0219822
PRELID2 PRELI domain containing 2 0.0218537
BASP1 brain abundant, membrane attached signal protein 1 0.0216449
AGFG1 ArfGAP with FG repeats 1 0.0215772
VMP1 vacuole membrane protein 1 0.0215127
IGF1R insulin-like growth factor 1 receptor 0.0211223
ANLN anillin, actin binding protein 0.0203827
DENR density-regulated protein 0.0203152
ANXA5 annexin A5 0.0202694
RRM2 ribonucleotide reductase M2 0.0201412
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0200716
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0199828
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.019931
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0199003
FMNL2 formin-like 2 0.0198786
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0198015
CLTC clathrin, heavy chain (Hc) 0.0197687
CSDE1 cold shock domain containing E1, RNA-binding 0.0195928
IPO7 importin 7 0.019509
ZFAND3 zinc finger, AN1-type domain 3 0.0192282
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0189467
CDK17 cyclin-dependent kinase 17 0.018892
WNK1 WNK lysine deficient protein kinase 1 0.0188541
TUBB tubulin, beta class I 0.0186596
MATR3 matrin 3 0.018579
MAPK8 mitogen-activated protein kinase 8 0.018189
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0177862
SERINC1 serine incorporator 1 0.0177523
SENP5 SUMO1/sentrin specific peptidase 5 0.0176487
VCP valosin containing protein 0.0175556
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0175241
GRAMD1B GRAM domain containing 1B 0.0173121
ELL2 elongation factor, RNA polymerase II, 2 0.017295
NONO non-POU domain containing, octamer-binding 0.017267
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.017211
PRRC2C proline-rich coiled-coil 2C 0.0171681
RAB7A RAB7A, member RAS oncogene family 0.0171322
CTNNBL1 catenin, beta like 1 0.0171249
TRIM33 tripartite motif containing 33 0.0170655
FUBP1 far upstream element (FUSE) binding protein 1 0.0168878
LUZP1 leucine zipper protein 1 0.0167425
ZNF217 zinc finger protein 217 0.0167001
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0166613
HSPH1 heat shock 105kDa/110kDa protein 1 0.0166081
ARHGAP5 Rho GTPase activating protein 5 0.0165433
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0164274
MACF1 microtubule-actin crosslinking factor 1 0.0164205

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.118474
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0805385
RPS3 ribosomal protein S3 -0.0733728
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0547762
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0464341
EGFR epidermal growth factor receptor -0.0450525
FTL ferritin, light polypeptide -0.0436531
EGR1 early growth response 1 -0.0415153
RPS27 ribosomal protein S27 -0.040898
MT2A metallothionein 2A -0.0361235
WASF2 WAS protein family, member 2 -0.0354606
KTN1 kinectin 1 (kinesin receptor) -0.0348066
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0336764
RPS8 ribosomal protein S8 -0.0333867
EEF2 eukaryotic translation elongation factor 2 -0.0319765
ZBTB20 zinc finger and BTB domain containing 20 -0.0313307
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0303976
PFN1 profilin 1 -0.0299888
EXOC4 exocyst complex component 4 -0.0298198
PATJ PATJ crumbs cell polarity complex component -0.0293961
RPS12 ribosomal protein S12 -0.0289135
TMSB10 thymosin beta 10 -0.027564
RPL37A ribosomal protein L37a -0.0265449
PTMA prothymosin, alpha -0.0259935
RPL23 ribosomal protein L23 -0.025871
RPL37 ribosomal protein L37 -0.0257199
RPL5 ribosomal protein L5 -0.0257018
BBX bobby sox homolog (Drosophila) -0.0253856
PDE4D phosphodiesterase 4D, cAMP-specific -0.0251107
RPL12 ribosomal protein L12 -0.0250909
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0249028
RPS19 ribosomal protein S19 -0.0247823
COPA coatomer protein complex, subunit alpha -0.0246598
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0239237
NSD1 nuclear receptor binding SET domain protein 1 -0.0236509
THADA thyroid adenoma associated -0.0233783
BPTF bromodomain PHD finger transcription factor -0.0227465
ZNF638 zinc finger protein 638 -0.0226263
HDGF hepatoma-derived growth factor -0.0224765
SMIM44 small integral membrane protein 44 -0.0220984
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0220788
NBEAL1 neurobeachin-like 1 -0.022043
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0219643
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0219466
IGF2 insulin-like growth factor 2 -0.0218984
RPL36 ribosomal protein L36 -0.0215667
ATXN1 ataxin 1 -0.021478
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.021437
RPS23 ribosomal protein S23 -0.0214315
RPL32 ribosomal protein L32 -0.0207674
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0207451
SMC4 structural maintenance of chromosomes 4 -0.0206501
SETD5 SET domain containing 5 -0.0206063
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0204278
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0203876
RPL31 ribosomal protein L31 -0.0203574
ASXL2 additional sex combs like transcriptional regulator 2 -0.0202878
AKAP9 A kinase (PRKA) anchor protein 9 -0.0198981
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0198719
ATP5F1B ATP synthase F1 subunit beta -0.0196105
RPL35A ribosomal protein L35a -0.0193971
BCAS3 breast carcinoma amplified sequence 3 -0.0191866
NCOR2 nuclear receptor corepressor 2 -0.0191483
RPS29 ribosomal protein S29 -0.0191119
GOSR2 golgi SNAP receptor complex member 2 -0.0189737
RPL18 ribosomal protein L18 -0.0188533
TTC3 tetratricopeptide repeat domain 3 -0.0187099
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0186432
PDIA3 protein disulfide isomerase family A, member 3 -0.0185995
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0185878
ATM ATM serine/threonine kinase -0.0185213
RPS6 ribosomal protein S6 -0.0184836
CBX5 chromobox homolog 5 -0.0183454
GPX4 glutathione peroxidase 4 -0.0181203
MSRB3 methionine sulfoxide reductase B3 -0.0176519
RPS14 ribosomal protein S14 -0.0176518
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0175315
PHACTR4 phosphatase and actin regulator 4 -0.01745
NDRG1 N-myc downstream regulated 1 -0.0174403
TULP3 tubby like protein 3 -0.0173318
EHBP1 EH domain binding protein 1 -0.0172812
CLIP1 CAP-GLY domain containing linker protein 1 -0.0172613
BBS9 Bardet-Biedl syndrome 9 -0.017188
SMAD3 SMAD family member 3 -0.0171508
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.017138
RPL8 ribosomal protein L8 -0.0169708
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0169373
NSUN6 NOP2/Sun domain family, member 6 -0.0167984
SRSF11 serine/arginine-rich splicing factor 11 -0.0166782
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0166577
RPL9 ribosomal protein L9 -0.0166431
SRBD1 S1 RNA binding domain 1 -0.016633
POTEF POTE ankyrin domain family, member F -0.0166054
SYT1 synaptotagmin I -0.0165849
KMT2A lysine (K)-specific methyltransferase 2A -0.0164989
EIF1 eukaryotic translation initiation factor 1 -0.0163468
RPL26 ribosomal protein L26 -0.0163378
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -0.0162855
TAPBP TAP binding protein (tapasin) -0.0162677
VIM vimentin -0.0161815