Bestatin_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bestatin perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bestatin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.199204
RPS3 ribosomal protein S3 0.163552
PTMA prothymosin, alpha 0.157815
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.117506
IGFBP3 insulin-like growth factor binding protein 3 0.112079
RPL23 ribosomal protein L23 0.111802
RPS8 ribosomal protein S8 0.110308
RACK1 receptor for activated C kinase 1 0.109055
ERRFI1 ERBB receptor feedback inhibitor 1 0.100579
RPS12 ribosomal protein S12 0.0923232
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0853915
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0798141
CALR calreticulin 0.0732177
TMSB10 thymosin beta 10 0.0708903
RPL37A ribosomal protein L37a 0.0674802
RPS17 ribosomal protein S17 0.0651463
ASPH aspartate beta-hydroxylase 0.0649241
RPS2 ribosomal protein S2 0.0597754
RPL8 ribosomal protein L8 0.0582939
RPS29 ribosomal protein S29 0.0569062
GRB10 growth factor receptor-bound protein 10 0.055292
LAMB3 laminin, beta 3 0.0544312
BHLHE40 basic helix-loop-helix family, member e40 0.0542374
RPL37 ribosomal protein L37 0.0529752
LDHA lactate dehydrogenase A 0.0501584
G0S2 G0/G1 switch 2 0.049672
RPL32 ribosomal protein L32 0.0492924
RPL9 ribosomal protein L9 0.0479229
S100A10 S100 calcium binding protein A10 0.0479013
ISG15 ISG15 ubiquitin-like modifier 0.0466638
RPS23 ribosomal protein S23 0.0461341
RPS27A ribosomal protein S27a 0.045168
NACA nascent polypeptide-associated complex alpha subunit 0.0447023
RPL12 ribosomal protein L12 0.0442363
RPL18 ribosomal protein L18 0.0440881
SET SET nuclear proto-oncogene 0.0438969
RPL36 ribosomal protein L36 0.0430983
KRT18 keratin 18, type I 0.042813
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.042809
EIF1 eukaryotic translation initiation factor 1 0.0424464
PRRC2C proline-rich coiled-coil 2C 0.0414115
AREG amphiregulin 0.0395984
PLAU plasminogen activator, urokinase 0.0390472
PAPOLA poly(A) polymerase alpha 0.038936
RPS4X ribosomal protein S4, X-linked 0.0384187
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0377241
UPP1 uridine phosphorylase 1 0.0366275
RPL26 ribosomal protein L26 0.0364772
FLNB filamin B, beta 0.0358361
RPL5 ribosomal protein L5 0.0354474
RPL11 ribosomal protein L11 0.0349418
FBXO32 F-box protein 32 0.0341698
SQSTM1 sequestosome 1 0.034003
RPL31 ribosomal protein L31 0.0334873
GPBP1 GC-rich promoter binding protein 1 0.0334431
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0333145
ACTN1 actinin, alpha 1 0.0332343
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0319867
RPS27 ribosomal protein S27 0.031948
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0314763
CANX calnexin 0.0311173
CAPN2 calpain 2, (m/II) large subunit 0.0305635
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0304886
RPS6 ribosomal protein S6 0.0301339
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0297824
YBX1 Y box binding protein 1 0.0295303
GARS1 glycyl-tRNA synthetase 1 0.0292605
TMED2 transmembrane emp24 domain trafficking protein 2 0.0289703
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0285479
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0284661
ARHGAP29 Rho GTPase activating protein 29 0.0279707
PTPRF protein tyrosine phosphatase, receptor type, F 0.0275106
UBA6 ubiquitin-like modifier activating enzyme 6 0.0272398
COX6C cytochrome c oxidase subunit VIc 0.0270028
NAP1L1 nucleosome assembly protein 1-like 1 0.0269406
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0268312
GPX4 glutathione peroxidase 4 0.0266361
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0261667
MTPN myotrophin 0.025935
VIM vimentin 0.0257803
BZW1 basic leucine zipper and W2 domains 1 0.0254177
DDIT4 DNA-damage-inducible transcript 4 0.0253078
DSPP dentin sialophosphoprotein 0.0242977
RPL34 ribosomal protein L34 0.0242781
FXR1 fragile X mental retardation, autosomal homolog 1 0.0241193
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0240565
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0239336
RPL35 ribosomal protein L35 0.0238682
RPS24 ribosomal protein S24 0.0235414
UBC ubiquitin C 0.0234168
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0232999
RPS19 ribosomal protein S19 0.0232733
TPR translocated promoter region, nuclear basket protein 0.0231967
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0229548
RAI1 retinoic acid induced 1 0.0225624
RPS5 ribosomal protein S5 0.022387
SH3KBP1 SH3-domain kinase binding protein 1 0.0220782
NUP58 nucleoporin 58 0.0218875
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0217909
TM9SF2 transmembrane 9 superfamily member 2 0.021678

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.238912
POTEF POTE ankyrin domain family, member F -0.156894
NDRG1 N-myc downstream regulated 1 -0.126539
ACTG1 actin gamma 1 -0.0751219
LOC112694756 uncharaterized LOC112694756 -0.0741691
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0729288
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0722929
IFI27 interferon, alpha-inducible protein 27 -0.0703882
EFNA5 ephrin-A5 -0.0698912
ERBIN erbb2 interacting protein -0.0644422
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0612332
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0593842
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.05347
GOLGA4 golgin A4 -0.0534241
HMGA1 high mobility group AT-hook 1 -0.0510092
TUBB4B tubulin, beta 4B class IVb -0.0487932
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0460806
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0458669
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0453019
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0440508
PARD3 par-3 family cell polarity regulator -0.0421829
TAPBP TAP binding protein (tapasin) -0.0420429
ADAM9 ADAM metallopeptidase domain 9 -0.041172
TSC22D2 TSC22 domain family, member 2 -0.0402816
CCNL1 cyclin L1 -0.0398078
EXT1 exostosin glycosyltransferase 1 -0.0389153
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0388992
TXNIP thioredoxin interacting protein -0.0387773
FAM3C family with sequence similarity 3, member C -0.0385262
BRD2 bromodomain containing 2 -0.038206
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0379668
CDCP1 CUB domain containing protein 1 -0.037631
PTK2 protein tyrosine kinase 2 -0.0359702
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0358828
OSMR oncostatin M receptor -0.0356508
SMAD3 SMAD family member 3 -0.0353619
PPARD peroxisome proliferator-activated receptor delta -0.0331388
CD47 CD47 molecule -0.0330056
MUC1 mucin 1, cell surface associated -0.032798
MSN moesin -0.0326663
NRIP1 nuclear receptor interacting protein 1 -0.032584
RCOR1 REST corepressor 1 -0.0324365
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0324136
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0323573
RAB7A RAB7A, member RAS oncogene family -0.0321343
ZNF207 zinc finger protein 207 -0.0312425
TUBA1C tubulin, alpha 1c -0.0311372
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0304976
CLDN4 claudin 4 -0.0304782
ANKRD28 ankyrin repeat domain 28 -0.0301952
MAP1B microtubule-associated protein 1B -0.0301304
AKAP13 A kinase (PRKA) anchor protein 13 -0.029374
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.02879
LCOR ligand dependent nuclear receptor corepressor -0.0287726
CD46 CD46 molecule, complement regulatory protein -0.02849
MT2A metallothionein 2A -0.0284867
TXNRD1 thioredoxin reductase 1 -0.0284083
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0283419
PLSCR1 phospholipid scramblase 1 -0.0282999
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0282151
MYO1E myosin IE -0.0280248
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0278303
UGCG UDP-glucose ceramide glucosyltransferase -0.0277692
MBNL1 muscleblind-like splicing regulator 1 -0.0277338
SMC4 structural maintenance of chromosomes 4 -0.0276255
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.027484
FN1 fibronectin 1 -0.0273104
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.0265459
PDIA3 protein disulfide isomerase family A, member 3 -0.0261962
SETD5 SET domain containing 5 -0.0261111
VCL vinculin -0.0258606
NAV2 neuron navigator 2 -0.0257201
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0253687
ATP11B ATPase, class VI, type 11B -0.025238
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0251811
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0251689
MYOF myoferlin -0.0251075
DSCAM Down syndrome cell adhesion molecule -0.0250937
CTSB cathepsin B -0.025011
WWTR1 WW domain containing transcription regulator 1 -0.0249797
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0248208
CD44 CD44 molecule (Indian blood group) -0.0248108
KIAA1217 KIAA1217 -0.0248057
VEGFA vascular endothelial growth factor A -0.0247422
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0244305
IFRD1 interferon-related developmental regulator 1 -0.0244252
AFF4 AF4/FMR2 family, member 4 -0.0243971
CTSD cathepsin D -0.0243215
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.024295
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0241827
SAMD12 sterile alpha motif domain containing 12 -0.0241217
VMP1 vacuole membrane protein 1 -0.0241077
ATXN1 ataxin 1 -0.0239271
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0236503
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0236404
EGR1 early growth response 1 -0.0236391
FHIT fragile histidine triad -0.0234584
ICAM1 intercellular adhesion molecule 1 -0.0233953
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0233829
YAP1 Yes-associated protein 1 -0.023123